ライフサイエンスコーパス: puberty

1 ory peptides are the ultimate gatekeepers of puberty.

2 communities on skin profoundly shift during puberty.

3 have reduced mammary ductal outgrowth during puberty.

4 s the polymorphic variant may resolve around puberty.

5 rt for transgender children below the age of puberty.

6 significantly lower adjusted BMR/RMR during puberty.

7 xin-like, have been linked to alterations in puberty.

8 f the decreased seizure-like activity during puberty.

9 th, with the majority of oocytes lost before puberty.

10 dioxin-like PCBs advance, the timing of male puberty.

11 ing behaviors that are often observed during puberty.

12 involved in epigenetic repression of primate puberty.

13 ber of APP-positive spheroids found prior to puberty.

14 testis of a non-human primate occurs before puberty.

15 ymal epithelium and appear with the onset of puberty.

16 loci but fully restored imprinting prior to puberty.

17 ates Zinc finger (ZNF) genes in timing human puberty.

18 Bs) that form at ductal tips at the onset of puberty.

19 assumed to be minimal before later stages of puberty.

20 al patterns of development to the effects of puberty.

21 duce testosterone do not differentiate until puberty.

22 ced proliferation of epithelial cells during puberty.

23 accurately reflect blood levels during mini-puberty.

24 ation, ductal outgrowth and branching during puberty.

25 ntries, with peak incidence near the time of puberty.

26 orrelations between prepubertal BMI and male puberty.

27 mmary epithelial cell proliferation in early puberty.

28 arious diseases, including rare disorders of puberty.

29 delay or arrest in follicle development and puberty.

30 Little is known about genes regulating male puberty.

31 ed by proportionate increases in dw/dt until puberty.

32 cts, a block to mammary ductal elongation at puberty.

33 required for mammary gland morphogenesis at puberty.

34 reproductive cascades, such as the onset of puberty.

35 mbers of 15 families with central precocious puberty.

36 ately before puberty, and remained low after puberty.

37 hylation of their promoters increased before puberty.

38 d in the absence of nicotine, at least until puberty.

39 ke MFLD values by the species-typical age at puberty.

40 ala, suggesting that expression arises after puberty.

41 y-gonadal axis results in central precocious puberty.

42 ts with CAIS should remain gonadectomy after puberty.

43 erlying the neuroendocrine control of female puberty.

44 the development of the mammary gland during puberty.

45 d the second round commences at the onset of puberty.

46 s adolescent height growth and the timing of puberty.

47 ressing to atrophy and ovarian dysgenesis at puberty.

48 wave inversion decreases significantly after puberty.

49 nclear whether this inequality changes after puberty.

50 ior in NMRs given the opportunity to undergo puberty.

51 ed a size increase of this protrusion during puberty.

52 ding of internal calendar time from birth to puberty.

53 to fast skeletal growth during childhood and puberty.

54 sence of AgRP neuron leptin signaling delays puberty.

55 y dynamic reorganization of the brain during puberty.

56 different trajectories, before the onset of puberty.

57 eclining physical functions before attaining puberty.

58 static cancer, endometriosis, and precocious puberty.

59 ngthened with age and the transition through puberty.

60 tion control-related disorders emerge during puberty.

61 releasing hormone to determine initiation of puberty.

62 valuated for interactions with age, sex, and puberty.

63 heir relative size increased markedly during puberty.

64 ess AIRE (mRNA and protein) than males after puberty.

65 rowth hormone deficiency (12.5%), precocious puberty (12.2%), thyroid-stimulating hormone deficiency

66 of age were subsequently transplanted during puberty (5 weeks) or at maturation (10 weeks) with synge

67 zed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years).

68 nt, Ptprb expression is downregulated during puberty, a period of extensive ductal outgrowth and bran

69 in males before puberty but decreased during puberty, abolishing the sex difference.

70 and show that PcG proteins repress Kiss1, a puberty-activating gene.

71 ovaries and reduced follicle numbers during puberty/adulthood; as similar changes were found for F2

72 kout restores developmental transcription at puberty, alters luminal epithelial homoeostasis, yet rem

73 for both FTM and MTF can be started in early puberty, although long-term effects are not known.

74 y have a physiological role for the onset of puberty and a genetic basis for sexual maturation in hum

75 d as a critical permissive signal triggering puberty and a major regulator of the adult female hypoth

76 ulin resistance that are seen at the time of puberty and adolescence.

77 The transition to puberty and adult fertility both require a minimum level

78 changes in GnRH expression are essential for puberty and adult fertility.

79 vated by kisspeptin to regulate the onset of puberty and adult reproductive function, is enriched in

80 Studies of rare human disorders of puberty and animal models point to a complex hypothalami

81 These changes begin during puberty and are generally more aggravated in the knockou

82 king leptin or its receptor fail to complete puberty and are infertile.

83 es, as well as specific associations between puberty and CBF.

84 adotropin-releasing hormone release, delayed puberty and compromised fecundity.

85 rized by hypogonadism with delayed or absent puberty and dysfunctional olfaction.

86 to adulthood that begins around the onset of puberty and ends with relative independence from the par

87 endocrine responses, including modulation of puberty and estrous; control of reproduction, aggression

88 prefrontal cortex continues to mature after puberty and into early adulthood, mirroring the time cou

89 ow-up should try to establish the effects of puberty and later dietary or social transitions on these

90 ed in the hypothalamus and are essential for puberty and maintenance of reproductive function.

91 ogenous sex hormones over the lifespan (e.g. puberty and menopause), exogenous sex hormones (e.g. hor

92 s similar between males and females in early puberty and only diverged in midpuberty, with CBF actual

93 ed delays in mammary tissue expansion during puberty and pregnancy, accompanied by increased luminal

94 particularly robust in mammary tissue during puberty and pregnancy, accounting for 34-40% of detected

95 to HDR defects in mammary epithelium during puberty and pregnancy, including in different epithelial

96 ng the miR-193b locus was accelerated during puberty and pregnancy, which coincided with the loss of

97 poptosis and alveolar cell maturation during puberty and pregnancy.

98 elf-renewal of the mammary epithelium during puberty and pregnancy.

99 rate morphogenesis of the ductal tree during puberty and pregnancy.

100 r requirement during the expansion phases of puberty and pregnancy.

101 rganizational effects of ovarian hormones at puberty and provide a potential mechanism by which gonad

102 on the effects that the age of onset of male puberty and rates of spermatogenesis have likely had in

103 hypothalamic-pituitary-gonadal axis controls puberty and reproduction and is tightly regulated by a c

104 key players in the neuroendocrine control of puberty and reproduction, at least in mammals.

105 perform working memory tasks reliably during puberty and show modest improvement in adulthood.

106 ease with an onset commonly immediately post-puberty and stabilization by 40 to 50 years of age.

107 morphogenesis to form branching ducts during puberty and terminate in secretory alveoli during lactat

108 al compartments for ductal elongation during puberty and that loss of RIP140 leads to a catastrophic

109 : The male predominance in prevalence before puberty and the "sex-shift" towards females after pubert

110 time difference between their appearance in puberty and the editing of the lymphocyte repertoire aro

111 t puberty will allow for selection on age at puberty and traits correlated with sow lifetime producti

112 hey show sexual dimorphism, major changes in puberty and typically more pronounced species difference

113 dence, notably in girls, rises sharply after puberty and, by the end of adolescence, the 1 year preva

114 y, premature aging, ovulation, late onset of puberty, and abnormal estrous cycle).

115 ith age at menarche, a late manifestation of puberty, and body mass, little is known about these vari

116 aracterized by fibrous dysplasia, precocious puberty, and cafe au lait spots.

117 increased susceptibility to mortality after puberty, and identify peritoneal cells as mediators of p

118 ovulation, embryonic implantation, onset of puberty, and parturition.

119 epubertal mice, decreased immediately before puberty, and remained low after puberty.

120 r the relationship between neurodevelopment, puberty, and social functioning.

121 ry, housed under laboratory conditions until puberty, and subsequently used to establish offspring po

122 include maintenance of growth, navigation of puberty, and transition to adult services for long-term

123 lar nature of seminiferous tubules and after puberty androgens may further reinforce this feature.

124 om low calcium intake, stunting, and delayed puberty are common.

125 Mycobiome shifts during puberty are likely due to alterations in sebaceous gland

126 ch into whether the neuroendocrine events of puberty are mechanistically linked to cortical maturatio

127 e mechanisms underlying social inhibition of puberty are not well understood.

128 l environment as children transition through puberty, as well as evaluate the potential for reverse c

129 causes hypogonadotropic hypogonadism (failed puberty associated with low or apulsatile luteinizing ho

130 me, a syndrome of growth failure and delayed puberty associated with massive liver enlargement from g

131 Delayed puberty at >/= 1,000x may have been secondary to reduced

132 e signaling system implicated in gatekeeping puberty becomes operative in the embryo.

133 immunoreactivity peaks prior to the onset of puberty before declining markedly to adult levels, where

134 At puberty, both genes were widely expressed throughout the

135 A3, CRF1 binding was greater in males before puberty but decreased during puberty, abolishing the sex

136 Schizophrenia typically onsets after puberty but is often preceded by observable childhood ne

137 (HBsAg), DNA, and RNA levels in mice before puberty, but its effect on HBV after puberty was apparen

138 Mechanistically, prevention of puberty by hormonal blockade or acceleration of puberty

139 AD1 or ZNF573 to the rat hypothalamus delays puberty by impairing the transition of a transcriptional

140 erty by hormonal blockade or acceleration of puberty by oestrogen treatment led to increased or decre

141 d children were prospectively followed after puberty by using a newly standardized MeDALL Core Questi

142 omatosensory cortex, suggesting that earlier puberty can advance cortical maturation in a regionally

143 ecause changes in the hormonal milieu during puberty can lead to inadequate suppression of adrenal an

144 the downregulation of CUX2 in male liver at puberty contributes to the developmental changes establi

145 c, CRH overexpression during early-life (pre-puberty, CRHOEdev) in double-mutant mice (Camk2a-rtta2 x

146 ds were retrospectively reviewed and data on puberty, dialysis, and immunosuppressive medication were

147 ion of breeding females and gilts that reach puberty earlier tend to stay in the herd longer and be m

148 7.82) as sites where pads were provided with puberty education (Rural M = 89.74, SD = 9.34; Periurban

149 After 5 months, puberty education alone improved attendance to a similar

150 oped additional brief paroxysmal episodes in puberty, either dystonic/dyskinetic or "shivering" attac

151 Earlier puberty, especially in girls, is associated with physica

152 structure in children during early stages of puberty, extending our understanding of genotype-phenoty

153 Results show that, until puberty, female and male pelves exhibit only moderate se

154 The ages of puberty, first sexual intercourse and first birth signif

155 neurogenesis and volume increase, peaking at puberty followed by selective elimination and myelinatio

156 ant, albeit slight, effects included delayed puberty for F1 females, reduced caput epidydimal sperm c

157 ecifically sexual abuse, prior to and during puberty has specific implications for personality develo

158 r defects associated with central precocious puberty have been identified.

159 signals in or near genes involved in delayed puberty, highlighting the first molecular links between

160 With the onset of puberty, however, the female trajectory diverges substan

161 steroid hormone titers and delayed onset of puberty; however the pathway by which this occurs remain

162 alamo-pituitary-gonadal axis such as delayed puberty, hypothalamic amenorrhea, and hypogonadotropic h

163 sm through which diet-induced obesity during puberty imposes its long-lasting effects on sleep-wake b

164 ocorticoid exposure influences the timing of puberty in animal models, but the human relevance of tho

165 opment in ChCs, but increases rapidly before puberty in BCs, with an earlier time course in deeper-la

166 iking properties matured before the onset of puberty in both cell types, but following cell type-spec

167 Data regarding the onset of puberty in children receiving mammalian target of rapamy

168 oid hormones, leading to abnormal growth and puberty in children, and affecting general wellbeing and

169 GABAergic inhibition increases at puberty in female mice due to expression of extrasynapti

170 Age at menarche is a marker of timing of puberty in females.

171 This first longitudinal study of puberty in girls with serum POPs measurements (to our kn

172 tes mellitus (GDM) was associated with early puberty in girls.

173 eficiency of MKRN3 causes central precocious puberty in humans.

174 in the uterotrophic assay and did not alter puberty in male and female rats or mammary gland develop

175 vation of GnRH neurons results in precocious puberty in mice and humans, but the mechanisms underlyin

176 Puberty in pigs is usually defined as the female's first

177 al repression times the initiation of female puberty in rats.

178 We also adjusted for puberty in the body composition regression model.

179 me the block to mammary ductal elongation at puberty in the mes mouse.

180 ssociations previously identified for age at puberty in the pig and loci for age at menarche in human

181 nal programs that accompany both weaning and puberty in WT mice.

182 Working memory ability matures after puberty, in parallel with structural changes in the pref

183 behavioral response inhibition mature after puberty, in tandem with structural changes in the prefro

184 nts who had developed HNF1A-like diabetes in puberty, indicating early beta-cell failure.

185 characterised by failure to progress through puberty, indicating the involvement of this newly descri

186 evidence suggests that calcium intake before puberty influences adolescent height growth and the timi

187 varies between individuals and the timing of puberty initiation is associated with several health out

188 pubertal markers, epidemiological trends of puberty initiation over time, and the mechanisms whereby

189 es the normal GnRH-fuelled run-up to correct puberty initiation, and interfering with this process di

190 hildhood, and its reactivation culminates in puberty initiation.

191 .86) and 0.86 (0.79-0.94), respectively (sex-puberty interaction P = .089).

192 -0.81 and 0.81, 0.64-1.02, respectively (sex-puberty interaction P = .327).

193 e after puberty onset (0.89, 0.74-1.04); sex-puberty interaction: P < .001.

194 cortex in monkeys as they transitioned from puberty into adulthood and compared activity at differen

195 ctivity in monkeys as they transitioned from puberty into adulthood.

196 The timing of puberty is a highly polygenic childhood trait that is ep

197 Because age at puberty is a predictive factor for sow longevity and lif

198 Puberty is a time of rapid growth and changing energy re

199 Puberty is a transition period of reproductive developme

200 Puberty is already delayed and some compromises have to

201 , based in part on animal work, suggest that puberty is associated with neural-level changes that fac

202 Puberty is characterized by dynamic tissue remodeling in

203 The timing of puberty is controlled by many genes.

204 The onset of puberty is first detected as an increase in pulsatile se

205 Puberty is the defining biological process of adolescent

206 In primates, puberty is unleashed by increased GnRH release from the

207 lometric growth by the mammary glands around puberty is widely held to be estrogen (E)-dependent.

208 equired for mammary gland development during puberty, it is not clear whether its overexpression alte

209 ifferences and the relation to the timing of puberty jointly explained 67% of the between-subject var

210 ce after the initial formation of the BTB at puberty leads to infertility.

211 The present work shows that obesity during puberty leads to persistently dysregulated patterns of s

212 es reportedly disrupted in rare disorders of puberty, LEPR and KAL1.

213 After puberty, male mice recover, but female corticalization i

214 Puberty marks the end of childhood and is a period when

215 rgely shaped by transitional periods such as puberty, menopause and pregnancy, while daily fluctuatio

216 ale JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litte

217 hift towards a sex-balanced prevalence after puberty onset (0.89, 0.74-1.04); sex-puberty interaction

218 idity showed the strongest sex effect before puberty onset (female-male-OR 0.55, 0.46-0.64) and a con

219 However, puberty onset and estrogen negative feedback were normal

220 nutritional imbalance may therefore suppress puberty onset and fertility in an individual.

221 rons) plays a critical role in the timing of puberty onset and is involved in fertility regulation th

222 signaling in AgRP neurons is sufficient for puberty onset and normal adult fecundity in both sexes w

223 x transgenics, and the downstream effects on puberty onset and reproduction were examined.

224 AgRP neurons are required and sufficient for puberty onset and subsequent fertility.

225 neurons), but also into neurons critical for puberty onset and the regulation of reproductive functio

226 and as multimorbid diseases before and after puberty onset in longitudinal cohort data.

227 atal loss, pregnancy rate, gestation length, puberty onset in males, growth, estrous cycles, hormone

228 No significant differences in male puberty onset or adult fecundity in either sex were obse

229 The age of puberty onset varies between individuals and the timing

230 ty and the "sex-shift" towards females after puberty onset were strongest in multimorbid patients who

231 re-pubertal hormone treatment to model early puberty onset, a phenomenon increasingly observed in gir

232 wider range of deficits, including advanced puberty onset, abnormal negative feedback, and abolished

233 es were morbidly obese and exhibited delayed puberty onset, no evidence of estrous cycles, and minima

234 development, showing dramatic changes after puberty onset, yet few experiments have directly tested

235 neurons in the developing brain well before puberty onset.

236 males and males showed significantly delayed puberty onset.

237 without global CREM deletion revealed normal puberty onset.

238 ten affected than boys both before and after puberty onset: 0.71, 0.63-0.81 and 0.81, 0.64-1.02, resp

239 girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males

240 e stress exposure occurred either throughout puberty or in adulthood.

241 lated mechanisms similar to those underlying puberty or seasonal breeding in other species.

242 At the onset of puberty, ovarian hormones increase inhibitory tone in th

243 epuberty (P=2.86x10(-8)) and rs872256 during puberty (P=8.67x10(-9)).

244 ice, possibly contributing to their advanced puberty phenotype.

245 irthdate marker bromodeoxyuridine throughout puberty (postnatal day 28-49).

246 rapid increases in albumin excretion during puberty precede the development of microalbuminuria and

247 Further, induction of puberty regimens lack an evidence base or even clear gui

248 GATAD1 represses transcription of two key puberty-related genes, KISS1 and TAC3, directly, and red

249 other potential factors such as growth- and puberty-related hormones.

250 e of NKB-NK3R signaling in the initiation of puberty remains unknown.

251 egion in the brain, in relation to change in puberty (self-report and testosterone levels), laborator

252 rodevelopmental trajectories associated with puberty, self-evaluations, and the presumed social reori

253 ed significantly higher absolute TDEE during puberty (SMD: 0.46-9.55).

254 significantly higher absolute BMR/RMR during puberty (SMD: 1.10-5.93), and all of the studies favored

255 bidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific se

256 ng children according to age, gender, and/or puberty status.

257 s and childhood growth in 940 girls from the Puberty Study of the Breast Cancer and Environment Resea

258 nile pheromone produced by young mice before puberty, termed exocrine-gland secreting peptide 22 (ESP

259 vior and undergoes structural changes during puberty that may be driven by gonadal hormone secretion

260 During puberty, the brain goes through extensive remodeling, in

261 Upon puberty, the branching epithelium orients along these fi

262 During puberty, the mouse mammary gland develops into a highly

263 During puberty, the serum levels of growth hormone (GH) and its

264 In contrast, before puberty there is no detectable alpha-cell conversion, al

265 with increased interest in the other sex at puberty, these early emerging biases might help explain

266 -cells can reprogram to produce insulin from puberty through to adulthood, and also in aged individua

267 imals, and no other members exhibit signs of puberty throughout their lives unless they are removed f

268 ntal stages (prenatal time, early childhood, puberty time and adulthood).

269 es with the greatest number (4,164 genes) at puberty time.

270 We find five novel loci for puberty timing (P<5 x 10(-8)), in addition to nine signa

271 ate shared aetiologies in both sexes between puberty timing and body mass index, fasting insulin leve

272 ndependent of body mass index (BMI), between puberty timing and risks for breast and endometrial canc

273 the complexity of the genetic regulation of puberty timing and support causal links with cancer susc

274 ancestry, we found that variants that delay puberty timing are associated with a longer parental lif

275 Understanding of the genetic regulation of puberty timing has come largely from studies of rare dis

276 , we report the largest genomic analysis for puberty timing in 55,871 men, based on recalled age at v

277 analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earl

278 74, P=2.7 x 10(-70)) between male and female puberty timing.

279 adjusting the timing of artificially induced puberty to optimise overall outcome with respect to stat

280 se cells change their properties during late puberty to young adulthood, when bone growth and accrual

281 hesis in a large sample of children in early puberty, to compare regional gray matter volumes among i

282 At puberty, Twsg1 is expressed in the myoepithelium and in

283 l stages of development occur postnatally at puberty under the influence of hormonal cues.

284 imary spongiosa of long bone in mice at late puberty undergo normal programmed senescence, characteri

285 before puberty, but its effect on HBV after puberty was apparent, with HBV replicating approximately

286 Onset of puberty was assessed using study clinic-based Tanner sta

287 Onset of puberty was delayed at 1,000x and 2,000x.

288 Puberty was measured by physical exam.

289 use children have less sebaceous skin before puberty, we compared the fungal communities of primary c

290 or energy intake (EI) for >/=2 categories of puberty were included.

291 ian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of m

292 During puberty, when young people are completing their educatio

293 current, reduced activity in 8.5 mM K(+) at puberty, while blockade of alpha5-GABARs had no effect.

294 boy, with a diagnosis of CAH and precocious puberty, who was referred to our department for an ultra

295 Genetic markers associated with age at puberty will allow for selection on age at puberty and t

296 ging a developmental pathway linking earlier puberty with reduced pubertal growth (P = 4.6 x 10(-5))

297 Patients typically present at puberty with tender subcutaneous nodules that can progre

298 Beginning at puberty, women develop mood disorders twice as often as

299 genes involved in regulation of the onset of puberty would allow for the improvement of reproductive

300 ition during pregnancy, early childhood, and puberty would avoid not only obesity, but also accelerat

301 ations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevale