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1 entions may be beneficial for this important public health problem.
2 ive impairment is a prevalent individual and public health problem.
3 ed hearing loss (NIHL) is a major unresolved public health problem.
4 , where vitamin A deficiency remains a major public health problem.
5   It is targeted for global elimination as a public health problem.
6 sening chronic heart failure (HF) is a major public health problem.
7 and fatality, leading it to become a serious public health problem.
8 se strains present an important clinical and public health problem.
9 of US children and is a growing clinical and public health problem.
10                Tobacco addiction is a global public health problem.
11             Head-louse infestation remains a public health problem.
12 es of zinc and iron are a substantial global public health problem.
13        Childhood obesity remains a prominent public health problem.
14   In-hospital cardiac arrest is an important public health problem.
15 us (OP) compound poisoning is a major global public health problem.
16                     WNV remains an important public health problem.
17 esistant Gram-negative pathogens is a global public health problem.
18 ls (DAAs) could be an important clinical and public health problem.
19                           Suicide is a major public health problem.
20 easing in prevalence and has become a global public health problem.
21 ncreasing worldwide representing an emerging public health problem.
22 ciplinary approach to address this important public health problem.
23 eople who inject drugs remains a challenging public health problem.
24                         Obesity is a growing public health problem.
25 lation by 2000 to eliminate the disease as a public health problem.
26 s oocyst burden represents a major potential public health problem.
27 a syndrome (SFTS) have made it a significant public health problem.
28 a significant, albeit challenging to detect, public health problem.
29 currently approved for treating this serious public health problem.
30    Hepatitis C virus (HCV) is a major global public health problem.
31 ic septic shock continues to be an important public health problem.
32 k to households, thereby generating a costly public health problem.
33                 Tuberculosis (TB) is a major public health problem.
34 es a major contribution, is becoming a major public health problem.
35     Motor vehicle crashes (MVCs) are a major public health problem.
36  drug reactions in children are an important public health problem.
37 ividuals and society, and represents a major public health problem.
38 erapies at present position AD as a dominant public health problem.
39 lting complications are a significant global public health problem.
40                 Prostate cancer is a growing public health problem.
41 treat malaria and to eradicate this dramatic public health problem.
42  resistance among human pathogens is a major public health problem.
43 s C virus, and HIV constitute a major global public health problem.
44                  Alcoholism is a significant public health problem.
45                         PAD is a significant public health problem.
46 alleviate some of the burden of this growing public health problem.
47            Suicide bombs in Iraq are a major public health problem.
48 matic brain injury (mTBI) represents a major public health problem.
49             Ischemic stroke remains a vexing public health problem.
50  increasingly common, is a leading pediatric public health problem.
51      Chronic kidney disease (CKD) is a major public health problem.
52   Opioid use disorder (OUD) is a significant public health problem.
53 ognised as a violation of human rights and a public health problem.
54 fections (IFIs) as an increasingly important public health problem.
55                          Bullying is a major public health problem.
56       Chronic heart failure (CHF) is a major public health problem.
57 Ejection Fraction (HFpEF) represents a major public health problem.
58 neral population, and represent an important public health problem.
59 epatitis B virus (HBV) infection is a global public health problem.
60      Osteoporosis is an enormous and growing public health problem.
61 ensive to treat, and are therefore a serious public health problem.
62 coccus aureus (MRSA) infections are a global public health problem.
63                        Leprosy persists as a public health problem.
64 e a nutritional deficiency and/or identify a public health problem.
65 ium falciparum malaria remains a devastating public health problem.
66               Syphilis remains a significant public health problem.
67                           Obesity is a major public health problem.
68 s may represent a previously underrecognized public-health problem.
69 o facilitate new approaches to address major public health problems.
70 iral respiratory tract diseases pose serious public health problems.
71 s could be used to address environmental and public health problems.
72  for anxiety and depression, which are major public health problems.
73 ement (CQI), a process often used to address public health problems.
74                Obesity and AF are increasing public health problems.
75  disease surveillance tailored to addressing public health problems.
76 is currently one of the world's most serious public health problems.
77               HIV/AIDS is the largest global public health problem; about 76 million people have been
78      In the United States, sepsis is a major public health problem accounting for over 200,000 annual
79 f new infections, representing a significant public health problem across Latin America and internati
80 etabolic syndrome (MetS) has become a global public health problem affecting all nations and races.
81 Vitamin A deficiency continues to be a major public health problem affecting developing countries whe
82                           Obesity is a major public health problem affecting overall physical and emo
83      Hepatitis C virus (HCV) remains a major public health problem, affecting approximately 130 milli
84  is a common headache disorder and a serious public health problem all over the world.
85               Pneumonia remains an important public health problem among elderly nursing home residen
86        AMD continues to remain a significant public health problem among Europeans.
87 opheles mosquitoes transmit malaria, a major public health problem among many African countries.
88                        Depression is a major public health problem and a common cause of disability.
89        Chronic pain after surgery is a major public health problem and a major concern for perioperat
90 icidal behaviours in adolescents are a major public health problem and evidence-based prevention prog
91   Metabolic syndrome has become an important public health problem and has reached epidemic proportio
92  deficiency disorders (IDD) is still a major public health problem and iodized salt remains the most
93                Nicotine addiction is a major public health problem and is associated with primary glu
94                           Dengue is a global public health problem and is caused by four dengue virus
95            Childhood asthma is a significant public health problem and severe exacerbations can resul
96 mon neurodegenerative disorder, is a growing public health problem and still lacks effective treatmen
97 in endemic regions, which causes significant public health problems and enormous economic losses.
98 ion in recurrent depression is a significant public health problem, and antidepressants are the curre
99      Mortality due to snakebite is a serious public health problem, and available therapeutics are kn
100 iate medications in seniors is a significant public health problem, and cancer treatment escalates it
101  Methamphetamine (MA) addiction is a serious public health problem, and current methods to abate addi
102 irearm violence among youth is a substantial public health problem, and emergency department (ED) phy
103 SCA) in the young remains a largely unsolved public health problem, and sports activity is an establi
104      Aortic valve disease (AVD) is a growing public health problem, and the pathogenesis underlying A
105 ese malformations, NTDs remain a substantial public health problem, and we are only now beginning to
106 otine dependence and cocaine abuse are major public health problems, and most cocaine abusers also sm
107 otine dependence and cocaine abuse are major public health problems, and most cocaine abusers also sm
108 gue hemorrhagic fever are significant global public health problems, and understanding the overall im
109                Patients with asthma, a major public health problem, are at high risk for serious dise
110        Dengue is an increasingly significant public health problem as its mosquito vectors spread ove
111               Binge-eating disorder (BED), a public health problem associated with psychopathological
112 an epidemic and is a staggering clinical and public health problem, associated with significant morta
113           Binge eating disorder represents a public health problem at least equal to BN.
114 evaluating interventions that target serious public health problems; be transparent about the value j
115                 Food allergy is an important public health problem because it affects children and ad
116       Binge alcohol drinking is a tremendous public health problem because it leads to the developmen
117 pic dermatitis (AD) has become a significant public health problem because of increasing prevalence,
118 ion during pregnancy has emerged as a global public health problem because of its ability to cause se
119       Childhood asthma has become a critical public health problem because of its high morbidity and
120                 Dengue remains a significant public health problem, because protection conferred by t
121          Globally, pollen allergy is a major public health problem, but a fundamental unknown is the
122 c brain injury (TBI) is a significant global public health problem, but has received minimal attentio
123 ease is a substantial worldwide clinical and public health problem, but information about available c
124      Gram-positive bacteria are an important public health problem, but it is unclear how they cause
125 ce (IPV) and heavy drinking are co-occurring public health problems, but integrated brief interventio
126        Childhood overweight is a substantial public-health problem, but little is known about predict
127  filariasis is targeted for elimination as a public health problem by 2020.
128                   Childhood obesity, a major public health problem, can lead to cardiovascular diseas
129   West Nile virus (WNV) remains an important public health problem causing annual epidemics in the Un
130 patitis C virus (HCV) infection is a complex public health problem, characterized by a high prevalenc
131 EW: Adolescent alcohol use is a considerable public health problem, contributing to the leading cause
132            Iron deficiency is a major global public health problem despite decades of efforts with ir
133 cide remains a clear, present and increasing public health problem, despite being a potentially preve
134                                   This major public health problem disproportionately affects low-inc
135          Loa loa has emerged as an important public health problem due to the occurrence of immune-me
136 is, which is becoming an increasingly global public health problem due to the rise of drug-resistant
137                Ebolaviruses pose significant public health problems due to their high lethality, unpr
138 ergic rhinitis (PAR) represents a global and public health problem, due to its prevalence, morbidity,
139  prescription opioids (POs) is a significant public health problem, few experimental studies have inv
140    Primary dysmenorrhea (PDM), a significant public health problem for adolescents and young women, i
141                  Depression is a significant public health problem for which currently available medi
142  1 (HIV-1) infection is a significant global public health problem for which development of an effect
143     Traumatic brain injury is a major global public health problem for which specific therapeutic int
144 aine addiction continues to be a significant public health problem for which there are currently no e
145             Cocaine use disorder is a global public health problem for which there are no Food and Dr
146                   Cervical cancer is a major public health problem for women in sub-Saharan Africa.
147 as and will remain a formidable clinical and public health problem for years to come.
148 ute illness phase, chikungunya constitutes a public health problem given its chronic disease phase, w
149 s in women of reproductive age, pose a major public health problem given their high frequency, associ
150 ive age (WRA) (age range: 15-49 y) remains a public health problem globally, and reducing anemia in w
151                            Dengue is a major public health problem globally.
152 e during pregnancy should be recognised as a public health problem globally.
153                              Dengue is major public health problem, globally.
154 f the surgical burden of disease as a global public health problem has been slow but is also increasi
155        The application of geospatial data to public health problems has expanded significantly with i
156         Despite the fact that numerous major public health problems have plagued American Indian comm
157                             HIV-1 is a major public health problem; however, the virus-host interacti
158                   Low vision is an important public health problem; however, very few low vision clin
159 ing about the extent and seriousness of this public health problem impeded current efforts to prevent
160        In addition, confirmation whether the public health problem in Brazil extends to other regions
161  caused by HEV, hepatitis E, is an important public health problem in developing countries of Asia an
162 apy (HAART), while it has emerged as a major public health problem in developing countries, particula
163 r caused by Salmonella Typhi remains a major public health problem in developing countries.
164              Vitamin A deficiency is a major public health problem in developing countries.
165 virus (DENV) infection is considered a major public health problem in developing tropical countries w
166           Yellow fever (YF) is still a major public health problem in endemic regions of Africa and S
167               External ocular infection is a public health problem in Ethiopia.
168      Celiac disease represents a significant public health problem in large parts of the world.
169 on infectious cause of blindness and a major public health problem in many developing countries.
170                          Syphilis is a major public health problem in many regions of China, with inc
171 yme disease, represent an increasingly large public health problem in North America and Europe.
172                  Gastric cancer is a serious public health problem in Northern Brazil and in the worl
173                              It has become a public health problem in part because the standard cultu
174 ella enterica serovar Typhi, is an important public health problem in resource-limited settings and,
175 cultural pesticide self-poisoning is a major public health problem in rural Asia.
176 ablished to address epidemic meningitis as a public health problem in sub-Saharan Africa and, to that
177        Urogenital schistosomiasis is a major public health problem in sub-Saharan Africa, and routine
178  Onchocerciasis (river blindness) is a major public health problem in sub-Saharan Africa.
179                      Diabetes is an emerging public health problem in sub-Saharan Africa.
180              We face a profound and emerging public health problem in the form of acute and chronic b
181                      Malaria remains a major public health problem in the Peruvian Amazon where the p
182                    Diabetes is an increasing public health problem in the UK and globally.
183                       Hepatitis C is a major public health problem in the United States and worldwide
184    Traumatic brain injury (TBI) is a serious public health problem in the United States, yet no treat
185 uries related to firearms constitute a major public health problem in the United States.
186 Hepatitis C virus (HCV) infection is a major public health problem in the United States.
187 n epidemic of teen pregnancy remains a major public health problem in the United States.
188 a and Algeria, and constitutes a significant public health problem in this region.
189 more than 100 countries and is an increasing public health problem in tropical and subtropical region
190       Low birth weight (LBW) is an important public health problem in undernourished populations.
191    Heart failure is an important and growing public health problem in women.
192              Self-harm and suicide are major public health problems in adolescents, with rates of sel
193    Child stunting and anemia are intractable public health problems in developing countries and have
194 agic fever arenaviruses (HFA) pose important public health problems in regions where they are endemic
195 f morbidity and mortality and pose important public health problems in regions where they are endemic
196 gic fever arenaviruses (HFAs) pose important public health problems in regions where they are endemic
197 with drug-resistance mutations (DRMs) causes public health problems in resource-rich countries.
198 er disease in humans and represent important public health problems in the regions where these viruse
199  morbidity and mortality, and pose important public health problems in the regions where they are end
200 or neurological manifestations, constituting public health problems in their endemic regions.
201 gic fever disease in humans and pose serious public health problems in their geographic regions of en
202 kewise might be utilized in other refractory public health problems in which communication and educat
203 esponsible for diseases causing major global public health problems, including meningitis, pneumonia
204 of-hospital cardiac arrest (OHCA) is a major public health problem, individual paramedics are rarely
205          Hepatitis C virus (HCV) is a global public health problem involving chronic infection of the
206 he emergence of food allergy as an important public health problem, it has become clear that there is
207 atocellular carcinoma (HCC) is an escalating public health problem, it has not been rigorously estima
208 igarette smoking during pregnancy is a major public health problem leading to adverse health outcomes
209 hepatitis B virus (HBV) infection, a serious public health problem leading to cirrhosis and hepatocel
210                Heart failure (HF) is a major public health problem leading to frequent hospitalizatio
211 st antibiotic-resistant bacteria is a global public health problem leading to prolonged treatment and
212                         Suicide is a complex public health problem of global importance.
213 e of resistance to treatment complicates the public health problem of head-louse infestations and dri
214 ons." The same report identifies asthma as a public health problem of high priority.
215 ith regulatory officials around the emerging public health problem of vapor intrusion (VI).
216    Traumatic brain injury (TBI) is a serious public health problem, often with devastating consequenc
217 een targeted by the WHO for elimination as a public health problem on the Indian subcontinent by 2017
218 nella infection is an increasingly important public health problem owing to the emergence of multidru
219 le burden of malnutrition (DBM) has become a public health problem, particularly in countries such as
220 ith intestinal helminth parasites is a major public health problem, particularly in the developing wo
221                           Obesity is a major public health problem, predisposing subjects to metaboli
222                     Obesity is a significant public health problem reaching epidemic proportions worl
223 nic steroid (AAS) abuse, though an important public health problem, remains inadequately studied.
224               Insufficient sleep is a global public health problem resulting in catastrophic accident
225                    Atopic diseases are major public health problems resulting in significant disabili
226                Nicotine addiction is a major public health problem, resulting in primary glutamatergi
227                      Hypertension is a major public health problem rising across the globe.
228 d alumni were remarkably active in frontline public health problem-solving, as well as launching publ
229                    Peanut allergy is a major public health problem that affects 1% of the population
230 nic and organic arsenic compounds is a major public health problem that affects hundreds of millions
231                     It is a major and global public health problem that affects maternal and child mo
232                   Dry eye disease is a major public health problem that affects millions of people wo
233 fluenza viral infection represents a serious public health problem that causes contagious respiratory
234      Cocaine abuse and dependence is a major public health problem that continues to challenge medica
235 nic kidney disease (CKD) remains a prevalent public health problem that disproportionately affects Af
236              Child maltreatment is a serious public health problem that disproportionately affects in
237                  Ocular allergy is a growing public health problem that greatly impacts the day-to-da
238            Iron deficiency (ID) is an urgent public health problem that has devastating effects on ma
239 al smoking in pregnancy remains an important public health problem that impacts child health in a myr
240                           Malaria is a major public health problem that is actively being addressed i
241      Sinus node dysfunction (SND) is a major public health problem that is associated with sudden car
242                 Gonorrhoea is a major global public health problem that is exacerbated by drug resist
243                 Cocaine addiction is a major public health problem that is particularly difficult to
244                    Dengue disease is a large public health problem that mainly afflicts tropical and
245 eas, Brucella infections represent a serious public health problem that results in significant morbid
246 shift towards its recognition as a worldwide public health problem that should be managed in its earl
247 r disease (CVD) and osteoporosis are 2 major public health problems that share common pathophysiologi
248 nd other arthropod-borne viruses are a major public health problem, the mechanisms of antiviral immun
249           And, on top of the breadth of this public health problem, there remain important gaps in sc
250 e Plasmodium falciparum (Pf) remains a major public health problem throughout the developing world.
251 e data on person, place, and time of a major public health problem, together with information on path
252 such, to evaluate the true magnitude of this public health problem, we performed a systematic literat
253 patitis B virus (HBV) infection is a serious public health problem, which can be transmitted through
254 king this protein, thus posing a significant public health problem, which could be moderated by using
255 ecently gained appreciation as a significant public health problem, which has highlighted just how li
256 lving emerging opioid compounds is a growing public health problem, which was highlighted recently by
257           Tuberculosis (TB) remains a global public health problem whose effects have major impact in
258  as common in women as in men; it is a major public health problem whose neurobiological basis is unk
259                       Anemia is a widespread public health problem with 1/4 1/3 of the world's popul
260                   Prostate cancer is a major public health problem with considerable uncertainties ab
261               Celiac disease (CD) is a major public health problem with estimated 1-3% prevalence in
262 preserved ejection fraction (HFpEF), a major public health problem with high morbidity and mortality
263 disease often causes severe low-back pain, a public health problem with huge economic and life qualit
264            Childhood obesity is an important public health problem with increasing prevalence.
265          Fibrosis of vital organs is a major public health problem with limited therapeutic options.
266                  Heart failure is a pressing public health problem with no curative treatment current
267 Traumatic brain injury (TBI) is an important public health problem with potentially serious long-term
268 itis C virus (HCV) is a burgeoning worldwide public health problem, with 170 million infected individ
269 fluenza viral infections represent a serious public health problem, with influenza virus causing a co
270 fluenza viral infections represent a serious public health problem, with influenza virus causing a co
271 re neuropathy (SFN) represents a significant public health problem, with no cause apparent in one-hal
272 Pediatric severe sepsis remains a burdensome public health problem, with prevalence, morbidity, and m
273                Tuberculosis (TB) is a global public health problem, with the highest burden occurring
274 carcinoma in situ (DCIS) constitutes a major public health problem, with up to half of screen-detecte
275        Atrial fibrillation (AF) is a growing public health problem without adequate therapies.
276 er of cartilage and periarticular bone, is a public health problem without effective medical treatmen
277                Arsenic toxicity is a serious public health problem worldwide that brings more than 10
278     Chronic exposure continues to be a major public health problem worldwide, affecting hundreds of m
279      Chronic kidney disease (CKD) is a major public health problem worldwide.
280 heumatic heart disease (RHD) remains a major public health problem worldwide.
281  Cystic echinococcosis (CE) is a significant public health problem worldwide.
282 iliary (HPB) system constitute a significant public health problem worldwide.
283 tions (LRTIs) are a persistent and pervasive public health problem worldwide.
284 is C virus (HCV) infection remains a serious public health problem worldwide.
285 eptibility to tuberculosis, which is a major public health problem worldwide.
286  Visceral leishmaniasis (VL) remains a major public health problem worldwide.
287          Influenza virus infection remains a public health problem worldwide.
288 esult in shock and organ failure are a major public health problem worldwide.
289       Chronic renal failure (CRF) is a major public health problem worldwide.
290           Hepatitis C Virus (HCV) is a major public health problem worldwide.
291 es, herpesviruses) that constitute a serious public health problem worldwide.
292       Hepatitis B virus infection is a major public health problem worldwide; roughly 30% of the worl
293 E Dengue virus poses one of the most serious public health problems worldwide, and the incidence of d
294 ciated infections is one of the most serious public health problems worldwide, as there is no widely
295 in or spinal cord is one of the most serious public health problems worldwide.
296 ment (VI) and blindness continue to be major public health problems worldwide.
297              Bladder cancer is a significant public health problem, worldwide.
298 rsenic (iAs) from drinking water is a global public health problem, yet much remains unknown about th
299          Cocaine dependence is a significant public health problem, yet no validated pharmacological
300          Cocaine dependence is a substantial public health problem, yet there are no clearly effectiv

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