ライフサイエンスコーパス: pulmonary surfactant

1 otal roles in the adsorption and function of pulmonary surfactant.

2 cal properties and physiological function of pulmonary surfactant.

3 line (DPPC), the most prevalent component of pulmonary surfactant.

4 (AP) were originally isolated from an ovine pulmonary surfactant.

5 cal properties and physiological function of pulmonary surfactant.

6 crucial role in the effective functioning of pulmonary surfactant.

7 including blood serum, nasal secretions, and pulmonary surfactant.

8 II pneumocytes, which synthesize and secrete pulmonary surfactant.

9 ycerols, which are major lipid components of pulmonary surfactant.

10 ls and Clara cells, the primary producers of pulmonary surfactant.

11 BCA3 may play a similar role in transporting pulmonary surfactant.

12 pids, and proteins, a composition similar to pulmonary surfactants.

13 dones (PVPs) of various molecular weights to pulmonary surfactants.

14 vely in the respiratory epithelium including pulmonary surfactant A, B, C and Clara cell secretory pr

15 e, it likely reacts with target molecules in pulmonary surfactant, a lipid-rich material that lines t

16 Pulmonary surfactant, a lipid/protein complex that lines

17 key regulator of neonatal lung inflation is pulmonary surfactant, a lipoprotein complex which increa

18 n A (SP-A) is the major protein component of pulmonary surfactant, a material secreted by the alveola

19 alveolar patency at end expiration requires pulmonary surfactant, a mixture of phospholipids and pro

20 Pulmonary surfactant, a mixture of proteins and phosphol

21 Pulmonary surfactant, a thin lipid/protein film lining m

22 Long-chain acylcarnitines co-localize with pulmonary surfactant, a unique film of phospholipids and

23 cterized by myeloid dysfunction resulting in pulmonary surfactant accumulation and respiratory failur

24 hances the molecular-level interpretation of pulmonary surfactant action and facilitates the developm

25 estigate the mechanisms by which vesicles of pulmonary surfactant adsorb to an air-liquid interface,

26 s a receptor to mediate bacterial binding to pulmonary surfactant and alveolar epithelial cells.

27 Pulmonary surfactant and its components are essential fo

28 helial cells through which the cell packages pulmonary surfactant and regulates its secretion.

29 ein B (SP-B) is essential to the function of pulmonary surfactant and to alveolar type 2 cell phenoty

30 ein B (SP-B) is essential to the function of pulmonary surfactant and to lamellar body genesis in alv

31 oline (DPPC), the most abundant component of pulmonary surfactant, and higher and less variable with

32 tidylinositol, which are minor components of pulmonary surfactant, and synthetic dimyristoylphosphati

33 ely the surface tension-lowering activity of pulmonary surfactants, and this effect may be important

34 directly inhibits the surface adsorption of pulmonary surfactant as well as its ability to reduce su

35 ed mice: fatty acid synthase, transketolase, pulmonary surfactant-associated protein C (SP-C), L-plas

36 (SP-A), one of four proteins associated with pulmonary surfactant, binds with high affinity to alveol

37 t proteins and lipids that together form the pulmonary surfactant complex necessary for lung function

38 the exact mode of interaction between model pulmonary surfactant components.

39 We observed that pulmonary surfactant containing SP-A1 reaches lower surf

40 Pulmonary surfactant contains homeostatic and antimicrob

41 Pulmonary surfactant deposited in vitro on liquid layers

42 If pulmonary surfactant develops a dysfunction, its ability

43 lar epithelium, leads to alveolar oedema and pulmonary surfactant dysfunction.

44 es in lung mechanics were found to be due to pulmonary surfactant dysfunction.

45 Pulmonary surfactant enters the interface by a process a

46 lecular dynamics simulation to study a model pulmonary surfactant film interacting with a carbonaceou

47 the formation and biophysical properties of pulmonary surfactant films at the air-water interface.

48 Pulmonary surfactant forms a lipid-rich monolayer that c

49 icroscopy to test the classical model of how pulmonary surfactant forms films that are metastable at

50 our knowledge, the biophysical properties of pulmonary surfactant from individual humanized transgeni

51 We conclude that SP-A protects pulmonary surfactant from inhibition by fibrinogen in vi

52 participate in cholesterol mobilization and pulmonary surfactant homeostasis at the alveolar interfa

53 rminal differentiation and immune functions, pulmonary surfactant homeostasis, and lung host defense.

54 hey play very important roles in maintaining pulmonary surfactant homeostasis.

55 investigating whether LPCAT1 is required for pulmonary surfactant homeostasis.

56 g, such as dipalmitoylphosphatidylcholine in pulmonary surfactant; however, many of the roles of spec

57 factor in the disruption of the structure of pulmonary surfactant in neonates of ICP.

58 Films of pulmonary surfactant in the lung are metastable at surfa

59 Dysfunction of pulmonary surfactant in the lungs is associated with res

60 ovided fundamental insights into the role of pulmonary surfactant in the pathogenesis and treatment o

61 econium) that interfere with the activity of pulmonary surfactant in vitro may also be important in t

62 Many of these metabolites belonged to pulmonary surfactants, indicating IVI-induced aberration

63 Pulmonary surfactant is a complex mixture of lipids and

64 Pulmonary surfactant is a complex mixture of lipids and

65 Pulmonary surfactant is a complex of lipids and proteins

66 Pulmonary surfactant is a lipid-protein complex that low

67 Pulmonary surfactant is a lipoprotein complex that lower

68 Pulmonary surfactant is a lipoprotein complex that reduc

69 Ovine pulmonary surfactant is bactericidal for Pasteurella hae

70 is of early-onset disease, particularly when pulmonary surfactant is deficient.

71 The pulmonary surfactant is modeled as a dipalmitoylphosphat

72 e most critical and abundant phospholipid in pulmonary surfactant is saturated phosphatidylcholine (S

73 Pulmonary surfactant is secreted as a complex mixture of

74 Pulmonary surfactant isolated from gene-targeted surfact

75 epithelial cells that synthesize and secrete pulmonary surfactant lipids and proteins, reducing the c

76 lectasis, hyaline membranes, and the lack of pulmonary surfactant lipids and proteins.

77 Pulmonary surfactant lipoproteins lower the surface tens

78 iratory distress syndrome is associated with pulmonary surfactant loss that alters alveolar mechanics

79 bloodstream infections but is inactivated by pulmonary surfactant, making it of no use in the therapy

80 Fetal pulmonary surfactant matures more slowly in white than i

81 to tune ionic and lipidic flows through the pulmonary surfactant membrane network at the alveolar su

82 6 (Prdx6), a host factor that contributes to pulmonary surfactant metabolism and lung defense against

83 surfactant proteins affect the stability of pulmonary surfactant monolayers at an air/water interfac

84 shown previously that lateral compression of pulmonary surfactant monolayers initially induces separa

85 cture and dynamics of membrane arrays in the pulmonary surfactant network that covers the respiratory

86 methodology may guide further development of pulmonary surfactant pharmaceuticals that better mimic t

87 Thus LPLA2 may be a major enzyme of pulmonary surfactant phospholipid degradation by alveola

88 The minor pulmonary surfactant phospholipid, palmitoyl-oleoyl-phos

89 Recently, we determined that the minor pulmonary surfactant phospholipid, palmitoyl-oleoyl-phos

90 ly, several investigators have reported that pulmonary surfactant phospholipids and SP-A are present

91 Instead, one of the major and most important pulmonary surfactant phospholipids, dipalmitoylphosphati

92 arkers were all chlorohydrins of unsaturated pulmonary surfactant phospholipids; phosphatidylglycerol

93 ins (termed collectins) present in blood and pulmonary surfactant play a role in initial host defense

94 The pulmonary surfactant prevents alveolar collapse and is r

95 es regulating the production and function of pulmonary surfactant prior to and after birth.

96 lar cells, there was no evidence of abnormal pulmonary surfactant production by type 2 pneumocytes in

97 surfactant requirement is met by the leptin pulmonary surfactant production pathway which normally a

98 Although many studies have shown that pulmonary surfactant protein (SP)-A functions in innate

99 Pulmonary surfactant protein (SP)-A is an endogenously p

100 Pulmonary surfactant protein (SP)-B plays a vital role i

101 We have also engineered MASP binding into a pulmonary surfactant protein (SP-A), which has the same

102 Expression of the rabbit pulmonary surfactant protein A (SP-A) gene is lung-speci

103 Pulmonary surfactant protein A (SP-A) is involved in inn

104 Pulmonary surfactant protein A (SP-A) plays a key role i

105 Nitrated pulmonary surfactant protein A (SP-A) was also detected

106 Pulmonary surfactant protein A (SP-A), a member of the c

107 Pulmonary surfactant protein A (SP-A), an alveolar glyco

108 the collectin family of proteins, including pulmonary surfactant protein A (SP-A), we hypothesized t

109 iates resistance to antibacterial effects of pulmonary surfactant protein A (SP-A).

110 otein C1q, mannose-binding lectin (MBL), and pulmonary surfactant protein A (SPA) are structurally si

111 C1q, mannose-binding lectin (MBL), and pulmonary surfactant protein A (SPA) interact with human

112 Rat pulmonary surfactant protein A is an oligomer of 18 poly

113 e location and depth of each residue of lung pulmonary surfactant protein B (SP-B(1-25)) in a phospho

114 For identification of structural changes of pulmonary surfactant protein B (SP-B) due to the heterog

115 Pulmonary surfactant protein B (SP-B) is an essential pr

116 Bovine pulmonary surfactant protein C (SP-C) is a hydrophobic,

117 along with a peptide model for collagen and pulmonary surfactant protein C have been simulated very

118 human serum mannose-binding lectin (MBL) and pulmonary surfactant protein D (SP-D) have distinctive m

119 sed on our previous studies documenting that pulmonary surfactant protein D (SP-D) protects C. neofor

120 Pulmonary surfactant protein D (SP-D), a lung host defen

121 Pulmonary surfactant protein D (SP-D), a member of the c

122 domains of a collagenous C-type lectin, rat pulmonary surfactant protein D (SP-D), are sufficient to

123 ram-negative and gram-positive bacteria than pulmonary surfactant protein D (SP-D).

124 of viral infection, and, when combined with pulmonary surfactant protein D, their antiviral effects

125 ell differentiation marked by the absence of pulmonary surfactant protein gene expression.

126 been suggested to mimic some aspects of the pulmonary surfactant protein SP-B and has been tested cl

127 5), which is a truncated version of the full pulmonary surfactant protein SP-B, with dipalmitoylphosp

128 rfactant protein A (SP-A), the most abundant pulmonary surfactant protein, is implicated in multiple

129 TGF-beta represses transcription of pulmonary surfactant protein-B gene in lung epithelial c

130 Pulmonary surfactant protein-D (SP-D) is a member of the

131 Pulmonary surfactant proteins (SP-) A and D are innate i

132 We hypothesized that collectins, such as pulmonary surfactant proteins (SPs) SP-A and SP-D and se

133 Pulmonary surfactant proteins and lipids are required fo

134 the conformational organization of the lung pulmonary surfactant proteins in the environment that mi

135 n spectroscopy to in-situ IR spectroscopy of pulmonary surfactant proteins SP-B and SP-C in lipid-pro

136 Pulmonary surfactant (PS) is an essential complex of lip

137 nd ozone (O(3)) can cause dysfunction of the pulmonary surfactant (PS) layer in the human lung, resul

138 re syndrome characterized by accumulation of pulmonary surfactant, respiratory insufficiency, and inc

139 ptomycin was shown to interact in vitro with pulmonary surfactant, resulting in inhibition of antibac

140 and misaligned pulmonary veins, and reduced pulmonary surfactant secretion.

141 Pulmonary surfactant spreads on the thin ( approximately

142 ve elevated pulmonary bile acids and altered pulmonary surfactant structure.

143 l cells at E18.5, concomitant with decreased pulmonary surfactant, suggesting a delay or an arrest in

144 This review considers the pulmonary surfactant system and the genetic causes of ac

145 s, indicating IVI-induced aberrations of the pulmonary surfactant system might play an important role

146 airment, at least in part, by disrupting the pulmonary surfactant system.

147 t protein A (SP-A) is an abundant protein in pulmonary surfactant that has been shown to alter severa

148 cells lining the peripheral lung synthesize pulmonary surfactant that reduces surface tension at the

149 With advent of the availability of pulmonary surfactants, the prevalence of wheezing at age

150 emature infants are known to be deficient in pulmonary surfactant, there is limited information regar

151 e conclude that the presence of SP-A1 allows pulmonary surfactant to adopt a particularly favorable s

152 ns SP-B and SP-C promote rapid adsorption of pulmonary surfactant to an air/water interface by an unk

153 ns SP-B and SP-C promote rapid adsorption of pulmonary surfactant to an air/water interface.

154 hase transitions that precede compression of pulmonary surfactant to high surface pressure.

155 lted in an inflammatory reaction that caused pulmonary surfactant to lose some of its ability to main

156 rmodynamic barriers that limit adsorption of pulmonary surfactant to the air-water interface.

157 HA) on the structure and surface behavior of pulmonary surfactant to understand the mechanism for HA-

158 erved dose-dependent interaction of Psa with pulmonary surfactant was blocked by ChoP.

159 atidylcholine (DPPC), the major component of pulmonary surfactant, was investigated as a function of

160 ich has been shown to degrade and inactivate pulmonary surfactant, was significantly increased in LCA

161 lateral phase separation occurs in films of pulmonary surfactant, we used epifluorescence microscopy

162 Samples of pulmonary surfactant were obtained from the lungs of 18

163 peptide (AP) originally isolated from ovine pulmonary surfactant, were prepared and used to assess t

164 Psa also bound to pulmonary surfactant, which covers the alveolar surface

165 understanding the structure and function of pulmonary surfactant, which has informed understanding o