ライフサイエンスコーパス: pulposus

1 ss and the resulting prolapse of the nucleus pulposus.

2 tervertebral disc, especially in the nucleus pulposus.

3 ed to measure CCN3 expression in the nucleus pulposus.

4 the intervertebral disc, called the nucleus pulposus.

5 tiation and function of cells of the nucleus pulposus.

6 ed to measure CTGF expression in the nucleus pulposus.

7 regulator of CTGF expression in the nucleus pulposus.

8 ory protein, TonEBP, in cells of the nucleus pulposus.

9 of sciatica secondary to a herniated nucleus pulposus.

10 ho are suspected of having herniated nucleus pulposus.

11 e was a significant increase in both nucleus pulposus and annulus fibrosus MR elastography-derived sh

12 Cells of the nucleus pulposus and annulus fibrosus of rat disc tissue express

13 raphy-derived shear stiffness of the nucleus pulposus and annulus fibrosus regions of all lumbar IVDs

14 he other Notch receptors in both the nucleus pulposus and annulus fibrosus.

15 long forms of alpha1(IX) from bovine nucleus pulposus and articular cartilage.

16 d pro-angiogenic phenotype in bovine nucleus pulposus and cartilage endplate cells at the gene level.

17 tracted from the anulus fibrosus and nucleus pulposus, and of these aggrecan preparations following e

18 d yet unstained samples resolved the nucleus pulposus, annulus fibrosus and constituent lamellae, and

19 hibitory than that isolated from the nucleus pulposus, but enzymic pretreatments to reduce the glycos

20 ease may restore NOTCH signaling and nucleus pulposus cell function.

21 romoter activity was observed in rat nucleus pulposus cells after TGFbeta treatment.

22 n promoter activity was seen both in nucleus pulposus cells and in N1511 chondrocytes.

23 re used to measure ANK expression in nucleus pulposus cells from rats and humans.

24 d the suppression of CCN2 by CCN3 in nucleus pulposus cells further the paradigm that these CCN prote

25 ptional coactivator of HIF-1alpha in nucleus pulposus cells independent of the PKM2-JMJD5 axis.

26 Adenovirus-mediated gene transfer to nucleus pulposus cells may be the initial stage of a new form of

27 Adaptive response to hypoxia in nucleus pulposus cells of the intervertebral disc is regulated b

28 rough controlling ADAMTS activity in nucleus pulposus cells of the intervertebral disc.

29 l the PHDs is maintained in isolated nucleus pulposus cells regardless of the disease state.

30 Since nucleus pulposus cells reside under conditions of hypoxia, we de

31 sion of HIF-1alpha and HIF-2alpha in nucleus pulposus cells resulted in a significant suppression of

32 cally in disc tissue, and numbers of nucleus pulposus cells staining positive for ADAMTS 4, 5, 9, and

33 expression in Smad3-null mice and in nucleus pulposus cells transduced with lentiviral short hairpin

34 Above 330 mosmol/kg, cultured nucleus pulposus cells up-regulated target genes TauT, BGT-1, an

35 pendent changes in ANK expression in nucleus pulposus cells were minimal.

36 sults of this study indicate that in nucleus pulposus cells, HIF-2 and HIF-1 modulate their own trans

37 Here, we show that in nucleus pulposus cells, hypoxia robustly induces PHD3 expression

38 ed GlcAT-1 promoter activity only in nucleus pulposus cells, suggesting a cell type-specific regulati

39 oter activity and expression only in nucleus pulposus cells.

40 suppressed its promoter activity in nucleus pulposus cells.

41 ent decrease in the proliferation of nucleus pulposus cells.

42 nd that this regulation is unique to nucleus pulposus cells.

43 HIFs on GlcAT-1 promoter function in nucleus pulposus cells.

44 human studies focusing primarily on nucleus pulposus cells.

45 rget gene for HIF-1 and HIF-2 in the nucleus pulposus cells.

46 s indicate that the matrix of bovine nucleus pulposus contains only the short form of alpha1(IX) that

47 e notochord from the surrounding the nucleus pulposus, especially in murine models.

48 (IX)COL3 domain purified from bovine nucleus pulposus gave a different sequence to that of the long a

49 easing Pfirrmann degeneration grade (nucleus pulposus grade 1, 12.5 kPa +/- 1.3; grade 5, 16.5 kPa +/

50 of the annulus fibrosus and into the nucleus pulposus in 21 (46%) and ten (22%) samples, respectively

51 , function, and fate of cells of the nucleus pulposus in the intervertebral disk.

52 robust expression of GlcAT-I in the nucleus pulposus in vivo.

53 The nucleus pulposus is an aggrecan-rich hydrated tissue that permit

54 ors of cells that populate the adult nucleus pulposus (NP) and are an important source of secreted si

55 tion of proinflammatory molecules by nucleus pulposus (NP) and other disc cells.

56 cell therapies for regenerating the nucleus pulposus (NP) are hindered by the lack of specific marke

57 regulation of ADAMTS-4 expression in nucleus pulposus (NP) cells and its role in aggrecan degradation

58 in regulating HIF-1 activity in the nucleus pulposus (NP) cells and the control of this regulation b

59 tor LPS and IL-1 in bovine and human nucleus pulposus (NP) cells by assessing matrix-degrading enzyme

60 ments and combined therapy on bovine nucleus pulposus (NP) cells by assessing proteoglycan (PG) accum

61 Nucleus pulposus (NP) cells cultured with UCNPs are viable both

62 Human nucleus pulposus (NP) cells derived from nondegenerated and dege

63 Monolayer cultures of nucleus pulposus (NP) cells from the intervertebral discs (IVD)

64 extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche.

65 However, in nucleus pulposus (NP) cells of the healthy intervertebral disc,

66 Nucleus pulposus (NP) cells of the intervertebral disc are essen

67 Nucleus pulposus (NP) cells reside in a physiologically hyperosm

68 ls HIF-1 transcriptional activity in nucleus pulposus (NP) cells through the pyruvate kinase muscle (

69 Bovine nucleus pulposus (NP) cells were treated with BMP-7 and IGF-1.

70 SOX9 binding to the Ctgf promoter in nucleus pulposus (NP) cells.

71 pendent catabolic gene expression in nucleus pulposus (NP) cells.

72 control NOTCH signaling activity in nucleus pulposus (NP) cells.

73 set of genes characterizing immature nucleus pulposus (NP) cells.

74 form a regulatory network in hypoxic nucleus pulposus (NP) cells.

75 F)-alpha degradation and activity in nucleus pulposus (NP) cells.

76 The nucleus pulposus (NP) of the intervertebral disc (IVD) demonstra

77 The nucleus pulposus (NP) of the intervertebral disc develops from t

78 VD consists of a central semi-liquid nucleus pulposus (NP) surrounded by a multi-layered fibrocartila

79 osus (AF), transition zone (TZ), and nucleus pulposus (NP), respond to osmotic stress with altered bi

80 roteoglycan and water content in the nucleus pulposus of intervertebral discs.

81 tiation; and directly by forming the nucleus pulposus of intervertebral discs.

82 roteins (MMP-13 and ADAMTS-5) in the nucleus pulposus of the disc.

83 From nucleus pulposus of the intervertebral disc (in which the bulk c

84 , and it becomes embedded within the nucleus pulposus of the intervertebral disc (IVD) during maturat

85 r third of the annulus fibrosus, the nucleus pulposus, or both was seen in four (25%) of 16 biopsy sa

86 n unconfirmed diagnosis of herniated nucleus pulposus, outcome at 2-year follow-up was no better in p

87 d afternoon imaging results for both nucleus pulposus (R = 0.92) and annulus fibrosus (R = 0.83) regi

88 lus fibrosus regions and modestly in nucleus pulposus regions.

89 (n = 8) from the anulus fibrosus and nucleus pulposus regions.

90 Analysis of human nucleus pulposus samples indicated a trend toward increasing CTG

91 es occupied in type IX collagen from nucleus pulposus showed that usage of the short alpha1(IX) trans

92 ineered IVD composed of a gelatinous nucleus pulposus surrounded by an aligned collagenous annulus fi

93 ertebral discs, normally composed by nucleus pulposus surrounded by the annulus fibrosus, were often

94 Nucleus pulposus, the central zone of the intervertebral disc, i

95 s GlcAT-I expression in cells of the nucleus pulposus through a signaling network comprising both act

96 Finally, analysis of human nucleus pulposus tissue showed that while ANK was expressed in n

97 We conclude that in nucleus pulposus, TNF-alpha and IL-1beta regulate SDC4 expressio

98 As in cartilage, type IX collagen of nucleus pulposus was heavily cross-linked to type II collagen an