ライフサイエンスコーパス: pulsatile

1 n open artery, the CONDOR signal was clearly pulsatile.

2 surface membrane depolarization, is rapidly pulsatile.

3 laints of severe abdominal pain and palpable pulsatile abdominal mass located in the left epigastric

4 e hypothalamus, Kiss1(ARH)), which drive the pulsatile activity of gonadotropin-releasing hormone (Gn

5 Slow pulsatile administration of (90)Y-resin microspheres wit

6 in response to dopaminergic denervation and pulsatile administration of L-DOPA.

7 and biochemical markers and optimization of pulsatile administration.

8 rial elastance (Ea) represents resistive and pulsatile afterload of the heart derived from the pressu

9 rologous TrkA receptor system results in non-pulsatile, amplitude-modulated activation of ERK.

10 Our results demonstrate that pulsatile and constant hormone stimulations induce uniqu

11 This pattern was observed with both pulsatile and continuous-flow devices.

12 deterioration in eGFR was observed with both pulsatile and continuous-flow devices.

13 Glucose-stimulated insulin secretion is pulsatile and driven by intrinsic oscillations in metabo

14 ptible to the deleterious effects of greater pulsatile and early arterial load on diastolic function

15 ignificantly different between patients with pulsatile and nonpulsatile flow.

16 Plasma insulin is pulsatile and reflects oscillatory insulin secretion fro

17 al afterload-as reflected in blood pressure, pulsatile and resistive load-is associated with adverse

18 described, including devices that allow for pulsatile and sequential delivery.

19 at individual genes in single cells is often pulsatile and stochastic.

20 exhibit the ability to differentiate between pulsatile and sustained signals in the regulation of dow

21 Hormone signaling is often pulsatile, and multiparameter deconvolution procedures h

22 METHODS AND Total, pulsatile, and resistive arterial load were measured in

23 er function to assess integrated measures of pulsatile aortic load, including arterial compliance, re

24 Abnormal pulsatile aortic loading during exercise occurs in HFpEF

25 e hybrid bypass graft was investigated under pulsatile arterial flow conditions.

26 his study sought to test whether measures of pulsatile arterial function are useful for diagnosing he

27 Measures of pulsatile arterial hemodynamics may complement TDE for t

28 d models that included SBP, higher total and pulsatile arterial load were associated with increased m

29 Increased pulsatile arterial load, rather than blood pressure, may

30 al-time recording of hemodynamic parameters [pulsatile arterial pressure (PAP) and heart rate (HR)].

31 We record membrane pulsatile behavior and actomyosin dynamics during zebraf

32 of an apical medial actomyosin network whose pulsatile behavior in wild-type embryos drives the apica

33 quantitative understanding of the essential pulsatile behavior of GUVs under hypotonic conditions by

34 The pulsatile bioreactor culture, under regulated gradual in

35 ery using a novel hemodynamically-equivalent pulsatile bioreactor.

36 es of vascular cells using the physiological pulsatile bioreactor.

37 onduit from the left ventricle that delivers pulsatile blood distally in either a compliant or stiffe

38 We conclude that pulsatile blood flow conditions the phasic program of ge

39 Cyclic mechanical strain produced by pulsatile blood flow regulates the orientation of endoth

40 ional alignment of the FN pillars depends on pulsatile blood flow through the dorsal aortae.

41 occurs simultaneously with rapid changes in pulsatile blood flow, ventricular function, and downstre

42 igned to withstand biomechanical forces from pulsatile blood.

43 her as an episodic process, characterized by pulsatile bursts, or as a constitutive process, characte

44 First-generation devices were pulsatile, but they had poor longevity and durability.

45 mpening, which are critically important in a pulsatile circulatory system.

46 ssure-independent increase in the steady and pulsatile components of the arterial load in patients wi

47 Intraportal insulin infusions (pulsatile, constant, or reproducing that in T2DM) indica

48 that in this model milk is ejected by way of pulsatile contractions of these alveolar units.

49 produce testosterone in the testes under the pulsatile control of pituitary luteinizing hormone (LH).

50 omotes sexual maturation, which requires the pulsatile, coordinated delivery of gonadotropin-releasin

51 ethods based on PRCs under the assumption of pulsatile coupling to predict the delays that synchroniz

52 Cells respond dynamically to pulsatile cytokine stimulation.

53 We show that such a pulsatile delayed feedback stimulation can effectively a

54 seed the growing population, thus leading to pulsatile delivery cycles.

55 ld nanoshells was designed as a platform for pulsatile delivery of cancer therapeutics.

56 We show that controlled pulsatile delivery of glutamate into the subsurface of e

57 cular toxicity may be related to the pH, the pulsatile delivery, or the chemotherapeutic drugs used.

58 lated cardiomyopathy receiving a Heartmate I pulsatile device.

59 device failure at 2 years as compared with a pulsatile device.

60 es head-up tilt) compared with patients with pulsatile devices (24+/-7 and 35+/-8 bursts/min; P<0.01)

61 The pulsatile devices have been replaced with newer-generati

62 ssist devices have replaced first-generation pulsatile devices.

63 ared the results with previous estimates for pulsatile devices.

64 1 women (pulsatile devices=78) and 1535 men (pulsatile devices=402) from 89 institutions who were pro

65 There were 401 women (pulsatile devices=78) and 1535 men (pulsatile devices=40

66 We optimize pulsatile direct current electrical stimulation paramete

67 Lastly, pulsatile dosing schedules are being pursued to accompli

68 polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and

69 titutional scaling relationships between the pulsatile dynamics and GUV properties over multiple time

70 We found that pulsatile dynamics and noise are sufficient to coordinat

71 Pulsatile dynamics are thought to be widespread, and sin

72 Thus, pulsatile dynamics is emerging as a central, and still l

73 icate that the system's ability to translate pulsatile dynamics is limited by two constraints.

74 showed either a delayed gradual increase or pulsatile dynamics of Fus3 activity.

75 feedback loop to generate the characteristic pulsatile dynamics of Msn2.

76 Taken together, these results suggest that pulsatile dynamics play a pervasive role in yeast and ma

77 tor profiles, including constant expression, pulsatile dynamics, and noisy expression.

78 ange for which the network is able to decode pulsatile dynamics.

79 of the individual and interactive effects of pulsatile electrical field stimulation and substrate top

80 turing cardiac cells with the application of pulsatile electrical fields designed to mimic those pres

81 tigation of the sensorimotor interactions in pulsatile electrolocation shows, for the first time, tha

82 The properties of the active pulsatile electrolocation system in Gnathonemus petersii

83 at supports potent, more sustained, and less pulsatile elevation of hematocrit in a human EPOR-expres

84 hereby facilitates transmission of excessive pulsatile energy into the cerebral microcirculation, lea

85 f patrolling monocytes in the high shear and pulsatile environment of large arteries in healthy, hype

86 that respond to EGF with frequency-modulated pulsatile ERK activity, stimulation through a heterologo

87 GFR)-ERK network, but the mechanisms driving pulsatile ERK kinetics are unknown.

88 Moreover, Gata2 reporter pulsatile expression is dramatically altered in Gata2(+/

89 Our novel finding of dynamic pulsatile expression of Gata2 suggests a highly unstable

90 ranscripts in individual worms, we show that pulsatile expression of the microRNA (miRNA) lin-4 maint

91 nstrate that this insulation is optimal when pulsatile expression of the miRNA and its target is sync

92 in-releasing hormone (GnRH) is secreted in a pulsatile fashion by hypothalamic neurons, and alteratio

93 ormone (GH) secretion--males secrete GH in a pulsatile fashion, while females secrete GH continuously

94 vity was not different between patients with pulsatile flow and controls (P=0.34).

95 y(glycerol sebacate) (PGS) and cultured in a pulsatile flow bioreactor for 3 wk.

96 A pulsatile flow circuit was used to perfuse arterial segm

97 for gravity-driven, integrated, microfluidic pulsatile flow circuits.

98 ure of embryonic valve tissue under specific pulsatile flow conditions.

99 r rates (8 to 12 dynes/cm2) occurred only in pulsatile flow conditions.

100 y has improved significantly relative to the pulsatile flow devices.

101 nd DT (n = 638) and 114 DT patients with the pulsatile flow HeartMate XVE (Thoratec Corporation).

102 h temporal resolution to resolve the dynamic pulsatile flow in collecting lymphatic vessels.

103 siological effects of the chronic absence of pulsatile flow in humans.

104 gned to mimic the human heart by producing a pulsatile flow in parallel with the patient's heart, new

105 Subjecting endothelial cells to pulsatile flow in the presence of the ADAM10 inhibitor c

106 he risk of 90-day in-hospital mortality with pulsatile flow LVAD as destination therapy (DT).

107 and mechanical properties were assessed in a pulsatile flow model.

108 ge-vessel phantoms were constructed, using a pulsatile flow pump, and absolute diameter and percentag

109 r in ECs exposed to physiologically relevant pulsatile flow than pathophysiologically relevant oscill

110 ntricular assist devices, the restoration of pulsatile flow through modulations in pump speed leads t

111 ught to determine whether the restoration of pulsatile flow through modulations in pump speed would r

112 , whereas passing WSS at peak systole of the pulsatile flow waveform does.

113 When cultured under pulsatile flow, developing valve tissues upregulated fib

114 Nonreversing pulsatile flow, generally considered protective of ather

115 ative number of leukocyte TEM as compared to pulsatile flow, whereas passing WSS at peak systole of t

116 and perfused with blood under high-pressure pulsatile flow.

117 icant sex difference in mortality for either pulsatile-flow (P=0.82) or continuous-flow (P=0.95) devi

118 ice (134 patients) or the currently approved pulsatile-flow device (66 patients).

119 2 700 per quality-adjusted life year for the pulsatile-flow device.

120 ients with continuous-flow devices than with pulsatile-flow devices (62 of 134 [46%] vs. 7 of 66 [11%

121 are smaller and may be more durable than the pulsatile-flow devices.

122 es compared with patients implanted with the pulsatile-flow HeartMate XVE.

123 quality of life when treated with implanted pulsatile-flow left ventricular assist devices as compar

124 In the first era, mortality of pulsatile-flow LVAD patients was higher than in status 2

125 nuous-flow LVAD are smaller and quieter than pulsatile-flow LVADs.

126 urgency status 1A, 1B, and 2; patients with pulsatile-flow LVADs; and patients with continuous-flow

127 A novel Pulsatile-Flow Ventilation (PFV) system reducing respira

128 ial-flow ventricular assist devices, and (5) pulsatile-flow ventricular assist devices.

129 d by atherosclerotic plaque rupture, complex pulsatile flows through stenotic regions producing high

130 nism for low-density particles in steady and pulsatile flows through T-shaped junctions.

131 crete significant VEGF in response to 5 h of pulsatile fluid shear stress (PFSS; 5 dynes/cm(2) at 1 H

132 of developmental endpoints alone, including pulsatile frequency-modulated signaling associated with

133 Adding measures of pulsatile function to TDE resulted in an increase in AUC

134 Moreover, pulsatile GH administration resulted in a male clotting

135 it) mice were protected from thrombosis, and pulsatile GH given to lit mice restored the male clottin

136 with germline loss of the MC4R, we assessed pulsatile GH release and insulin-like growth factor-1 (I

137 1, and Y2 receptor knock-out mice) to assess pulsatile GH secretion under both fed and fasting condit

138 reversed the fasting-induced suppression of pulsatile GH secretion.

139 simply based on the GH input signal pattern: pulsatile GH stimulation in males versus near-continuous

140 ular mechanisms by which various patterns of pulsatile GnRH regulate gonadotrope responsiveness remai

141 Our results indicate that the resurgence in pulsatile GnRH release at the termination of the juvenil

142 yed by a neurobiological switch that arrests pulsatile GnRH release during infancy and then triggered

143 ) in governing this postnatal development of pulsatile GnRH release in primates and therefore the tim

144 e Kiss1 neurons and a possible disruption of pulsatile GnRH release.

145 factor in gonadotropin-induced abolition of pulsatile GnRH release.

146 nd subsequently inhibits cAMP production and pulsatile GnRH release.

147 rons in the brain of the mouse and to reduce pulsatile GnRH secretion in female pubertal monkeys; the

148 back information from the gonads to modulate pulsatile GnRH secretion.

149 ys a critical role in pubertal activation of pulsatile GnRH secretion.

150 was not detected under basal conditions, but pulsatile GnRH stimulated ICER to a greater extent at hi

151 G(q) signaling in response to continuous or pulsatile GnRH using fluorescence resonance energy trans

152 lated at low rather than high frequencies of pulsatile GnRH.

153 systems coupled to a profound inhibition of pulsatile GnRH/LH secretion.

154 Pulsatile gonadotropin-releasing hormone (GnRH) release

155 emerged as important in modulating the tonic pulsatile gonadotropin-releasing hormone (GnRH) release.

156 Pubertal onset, initiated by pulsatile gonadotropin-releasing hormone (GnRH), only oc

157 ion of EED from the Kiss1 promoter disrupted pulsatile gonadotropin-releasing hormone release, delaye

158 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increa

159 This pulsatile hemodynamic abnormality contributes independen

160 d by complex mechanical signals generated by pulsatile hemodynamic loading.

161 edback regulators could be the origin of the pulsatile HIF dynamics.

162 pigs (25-30 kg body weight) and preserved by pulsatile HMP for 21 hr.

163 It is applicable to other pulsatile hormone concentration time series and many oth

164 system sensitivity to different features of pulsatile hormone input.

165 mination and synchronization responsible for pulsatile hormone release from neuroendocrine cells.

166 We demonstrate that pulsatile hypothalamic activity is not required for gene

167 teinizing hormone (LH), under the control of pulsatile hypothalamic gonadotropin-releasing hormone (G

168 itary growth hormone (GH) secretory profiles-pulsatile in males and persistent in females-regulate th

169 < 0.001) and correlated with continuous and pulsatile indices of arterial load.

170 s factor-alpha at various intervals to mimic pulsatile inflammatory signals.

171 Although pulsatile insulin and glucagon release are in opposite p

172 plantation effectively restores the liver to pulsatile insulin delivery.

173 ls recruit non-oscillating islets to enhance pulsatile insulin output from the pancreas.

174 intracellular free calcium oscillations and pulsatile insulin release in isolated islets, however a

175 ate glucose-induced calcium oscillations and pulsatile insulin secretion across the islet.

176 that in T2DM) indicated that the pattern of pulsatile insulin secretion delivered via the portal vei

177 t insulin levels are oscillatory, reflecting pulsatile insulin secretion from individual islets.

178 Pulsatile insulin secretion is governed by islet oscilla

179 We report that coordinate pulsatile insulin secretion is reestablished in islet tr

180 that correlated with a progressive defect of pulsatile insulin secretion.

181 n diabetes is likely in part due to impaired pulsatile insulin secretion.

182 ides, and are thus instrumental in mediating pulsatile insulin secretion.

183 id induced lipotoxicity in islets eliminates pulsatile insulin secretion.

184 llator endogenous to islet beta-cells drives pulsatile insulin secretion.

185 nd mice, where plasma GH profiles are highly pulsatile (intermittent) in male animals versus more fre

186 Large pulsatile left ventricular assist devices have been the

187 Large pulsatile left ventricular assist devices have been used

188 Time-lapse imaging reveals rapid pulsatile level changes in Gata2 reporter expression in

189 de an insight into how GnRH neurons generate pulsatile LH secretion in vivo.

190 e found to be near-perfectly correlated with pulsatile LH secretion.

191 sory feature dependent inputs that mimic the pulsatile-like A1 responses to tones in the ABA- triplet

192 lity than those with high 30-day SBP and low pulsatile load (26.1% versus 8.1%; hazard ratio, 3.62; 9

193 Patients with low 30-day SBP and high pulsatile load had a 3-fold higher mortality than those

194 impedance (Z(c)), total arterial compliance (pulsatile load), and systemic vascular resistance index

195 large artery stiffening of left ventricular pulsatile load.

196 wedge pressure, augmenting right ventricular pulsatile load.

197 an enhanced pulmonary vascular resistive and pulsatile loading.

198 s activation of these neurons would generate pulsatile luteinizing hormone (LH) secretion in vivo.

199 Pulsatile luteinizing hormone secretion and spermatogene

200 Pulsatile LVADs have limitations in design precluding th

201 ) and subsequent reconditioning by 90 min of pulsatile machine perfusion (PP) (30/20 mm Hg) or nonpul

202 It also reviews pulsatile machine perfusion and normothermic perfusion f

203 All kidneys underwent continuous hypothermic pulsatile machine perfusion until transplant: 69 with si

204 in-releasing hormone (GnRH) is released in a pulsatile manner that is dependent on circulating 17beta

205 s are known to be endogenously secreted in a pulsatile manner.

206 secreting insulin into the bloodstream in a pulsatile manner.

207 pation revealed epigastric pain and palpable pulsatile mass above the umbilicus.

208 ous mitral valve repair device in an ex vivo pulsatile model of FTR.

209 Respiratory and pulsatile movements have hampered in vivo visualization

210 ition of planar polarity leads to asymmetric pulsatile Myosin II accumulation in the basal, proximal

211 We evaluated patients with pulsatile (n=6) and nonpulsatile (n=11) LVADs and health

212 Due to the pulsatile nature of the flow regimes in arterioles, data

213 The pulsatile nature of the stimuli enabled characterization

214 Pulsatile neuropeptide secretion is associated with burs

215 istinct Msn2 activation dynamics: Msn2 shows pulsatile nuclear activation with dose-dependent frequen

216 vestigation is the effect of local blocks on pulsatile ocular blood flow.

217 Different centrifugal, pulsatile or nonpulsatile (axial) flow pumps are availab

218 Recent work suggests that pulsatile or oscillatory dynamics can facilitate timer f

219 ing), depending on whether calcium influx is pulsatile or sustained.

220 bleeding, or device malfunction with either pulsatile- or continuous-flow LVADs.

221 Lymph hearts are pulsatile organs, present in lower vertebrates, that fun

222 hat this homeostatic challenge confronts all pulsatile organs, we developed a high resolution imaging

223 r assemblage of GnRH1 neurons to produce the pulsatile output necessary for activation of the pituita

224 Three exceptional genes are transcribed in a pulsatile pattern in a variety of CDK-APC/C arrests.

225 tal delivery of insulin in a constant versus pulsatile pattern led to delayed and impaired activation

226 eleasing hormone (GnRH) neurons generating a pulsatile pattern of gonadotropin secretion.

227 We conclude that the physiological pulsatile pattern of insulin delivery is important in he

228 Growth hormone (GH) is secreted in a pulsatile pattern to promote body growth and metabolism.

229 ps, but more ECD kidneys were preserved with pulsatile perfusion (P < 0.01).

230 The role of pulsatile perfusion (PP) across different cold ischemic

231 Assessment of pulsatile perfusion (PP) is limited to measurements of f

232 Conflicting literature on the benefit of pulsatile perfusion (PP) over cold storage (CS) warrants

233 Survival for pulsatile perfusion and cold storage were 95% and 88% (g

234 splant dialysis was 5% and 30% (P<0.01), for pulsatile perfusion and cold storage, respectively.

235 ere identified in which one kidney underwent pulsatile perfusion and transplantation at our center, w

236 This included commonality of protocols, pulsatile perfusion of kidneys, centralization of data a

237 Use of pulsatile perfusion to optimize outcomes in deceased don

238 ioning, 34 on preservation fluids, and 21 on pulsatile perfusion.

239 These data support routine use of pulsatile perfusion.

240 nt outcome when organs are preserved through pulsatile perfusion; however, the underlying mechanisms

241 cells is oscillatory and are consistent with pulsatile PFK1 being the mediator of slow glycolytic osc

242 We find that pulsatile pharmacoperone therapy restores E(90)K from ER

243 one concentration time series and many other pulsatile phenomena.

244 The lysis strain exhibits pulsatile population dynamics in vivo, with mean bacteri

245 od diluted to 20% hematocrit and driven with pulsatile pressure to prevent clogging of the channels w

246 For small children, paracorporeal pneumatic pulsatile pumps (e.g., Berlin Heart EXCOR VAD, Berlin He

247 bing dental pain-a prevalent condition whose pulsatile quality is widely regarded a primary sensation

248 net right ventricular afterload by elevating pulsatile, relative to resistive, load and may contribut

249 e for the episodic firing pattern underlying pulsatile release and the effects of E2 and glucose on t

250 and Y-receptors in regulating the endogenous pulsatile release of GH does not exist.

251 ectly on hypothalamic centers regulating the pulsatile release of GnRH, or indirectly by circulating

252 ian puberty requires a sustained increase in pulsatile release of gonadotrophin releasing hormone (Gn

253 pon a neuroendocrine circuit that evokes the pulsatile release of gonadotropin hormones (luteinizing

254 Pulsatile release of gonadotropin-releasing hormone (GnR

255 regulating vertebrate reproduction requires pulsatile release of gonadotropin-releasing hormone (GnR

256 he mechanisms responsible for generating the pulsatile release of gonadotropins from the pituitary gl

257 The pulsatile release of luteinizing hormone (LH) is critica

258 Here we describe the controlled pulsatile release of the polypeptide leuprolide from mic

259 identity of the neuronal network generating pulsatile reproductive hormone secretion remains unprove

260 Negative feedback produces a pulsatile response that is tunable, while positive feedb

261 ypoglycemia and that paracrine factors shape pulsatile secretion in hyperglycemia.

262 s inhibitory effect on the GnRH/LH surge and pulsatile secretion is mediated by its receptor in the k

263 pothalamus, followed by proper synthesis and pulsatile secretion of GnRH, functions absent in patient

264 us followed by the appropriate synthesis and pulsatile secretion of GnRH.

265 puberty is first detected as an increase in pulsatile secretion of gonadotropin-releasing hormone (G

266 rons in the Arc to synchronize and shape the pulsatile secretion of kisspeptin and drive the release

267 esis that progesterone inhibits LH surge and pulsatile secretion via its receptor in the ARC and/or A

268 e for kisspeptin in GnRH neuron firing, GnRH pulsatile secretion, negative feedback by gonadal steroi

269 pin-sorting determinant in vivo that directs pulsatile secretion.

270 e islet plays a major role in coordinating a pulsatile secretory response at elevated glucose and sup

271 EC growth arrest induced by pulsatile shear (PS) flow is an important feature for fl

272 Pulsatile shear (PS) is associated with an atheroprotect

273 time polymerase chain reaction revealed that pulsatile shear flow decreased the functional targeting

274 helial cells exposed to the atheroprotective pulsatile shear flow than under atheroprone oscillatory

275 osed to either oscillatory or unidirectional pulsatile shear for 2 days and 3 &7 days in regular and

276 eeding for 12 h, the cells were subjected to pulsatile shear stress (12+/-4 dyn/cm2) parallel or perp

277 associated oscillatory shear stress (OSS) or pulsatile shear stress (PSS) lead to differential respon

278 -4-carboxamide ribonucleotide, metformin, or pulsatile shear stress induces PARP-1 dissociation from

279 ascular endothelium in response to increased pulsatile shear stress.

280 delivery of a dopaminergic drug will prevent pulsatile stimulation and avoid motor complications.

281 tions are associated with non-physiological, pulsatile stimulation of dopamine receptors.

282 ights regarding the mapping between periodic pulsatile stimulation parameters such as amplitude and f

283 , variable across-ear channel selection, and pulsatile stimulation were simulated using uncorrelated

284 several days' history of painful, enlarging, pulsatile subcutaneous masses.

285 Because these cases of pulsatile tinnitus can be both induced and suppressed by

286 persistent, unilateral, treatment-resistant pulsatile tinnitus caused by a small dural arteriovenous

287 tent case, while her tinnitus was absent her pulsatile tinnitus could be induced by somatic testing.

288 Hypertension, headache, and pulsatile tinnitus were the most common presenting sympt

289 Symptoms can include headaches, visual loss, pulsatile tinnitus, and back and neck pain, but the clin

290 ws for establishing the cause of unilateral, pulsatile tinnitus.

291 release profiles that could be adjusted from pulsatile to sustained in real time.

292 Although specific pulsatile transcription factors have been identified in

293 f Saccharomyces cerevisiae, we show that the pulsatile transcription factors Msn2 and Mig1 combinator

294 ucose limitation and osmotic stress, and its pulsatile translocation is largely abrogated.

295 hough physiological steroid levels are often pulsatile (ultradian), the genomic effects of this pulsa

296 n aortic endothelial cells were subjected to pulsatile undisturbed flow or oscillatory DF containing

297 ell culture chamber with a pump, collapsible pulsatile valve and an adjustable resistance element (he

298 s with refractory heart failure, but current pulsatile volume-displacement devices have limitations (

299 four patients undergoing implantation with a pulsatile, volume displacement pump operating in a full-

300 The efficacy of this design compared with pulsatile, volume displacement pumps, with respect to ch