ライフサイエンスコーパス: purge

1 iation due to classically theorized 'genetic purging'.

2 ed into conscious awareness and needed to be purged.

3 ies intruded into awareness and needed to be purged.

4 alpha-hypersensitive Fancc-/- stem cells are purged.

5 able to multiple cycles of nitrogen/ethylene purges.

6 lera is distinct, with pronounced diarrhoeal purging.

7 n, and consequently their escape from thymic purging.

8 utations and leading to their more efficient purging.

9 ar menstrual cycles, without binge eating or purging.

10 rent under short-circuit condition) in an Ar-purged 0.02 M K(2)SO(4) solution.

11 In contrast to purging, 10-year progression-free survival (PFS) was 48%

12 d with an immune deficiency is not likely to purge a persistent infection using endogenous mechanisms

13 We focus this perspective on PURGE, a water suppression technique, and PROJECT presat

14 ents receiving FBT (16 [39%]) were binge-and-purge abstinent compared with those receiving SPT (7 [18

15 may also benefit populations by efficiently purging accumulated damage and rejuvenating newborn cell

16 hances the effectiveness of population-level purging across generations.

17 ire recipient dendritic cells to effectively purge an established persistent viral infection.

18 Purge and cold-trap with crushed ice serving as condensa

19 isotopic composition using a continuous flow purge and cryogenic trap system coupled to an isotope ra

20 e, flushing, static extraction time, solvent-purge and sample weight.

21 chosen: solid phase micro extraction (SPME); Purge and Trap extraction and solvent assisted flavour e

22 chromatography-olfactometry for SPME and for Purge and Trap extracts, or by sniffing for the aqueous

23 matoes were characterized and compared using purge and trap gas chromatography-mass spectrometry (PT-

24 rous oxide is then analyzed using an on-line purge and trap system coupled to an isotope ratio mass s

25 Here we describe a cryogenic purge and trap system coupled to continuous flow compoun

26 The measurements were made by a modified purge and trap technique developed in our laboratory on

27 by combining the high enrichment capacity of purge and trap with aqueous phenylation derivatization.

28 hromium reactor has been incorporated into a purge and trap-CSIA method that is suitable for CSIA of

29 reflect overdominance, potentially reducing purging and increasing allele persistence probability.

30 at EVs and exosomes could play a role in the purging and intercellular transfer of excess free RNAs,

31 there appeared to be an interaction between purging and stress-induced physiological damage.

32 A dynamic headspace purge-and-trap (DHS-P&T) methodology for the determinati

33 e methodology is based on the application of purge-and-trap extraction followed by gas chromatography

34 ersus the nonpurgeable fraction by combining purge-and-trap extraction with SPE.

35 DBPs explained almost the entire AOX in the purge-and-trap extracts, but <16% in the SPE extracts de

36 The purgeable DBP fraction enriched with the purge-and-trap method exerted a lower oxidative stress r

37 Our measurements were made using a purge-and-trap method that employs benchmark chemicals t

38 he fully automated method is based on heated purge-and-trap preconcentration and gas chromatography/m

39 sed between the restricting and binge eating/purging anorexia nervosa subtypes over time; one-third c

40 loacetonitriles and approximately 60-90% for purged AOX from tap water.

41 In this study, we report a fill-and-purge approach to the layer-by-layer fabrication of bioc

42 ver, suggesting that the fitness benefits of purging are rarely appreciable.

43 ed with wetland sediment and suspended in N2-purged artificial groundwater.

44 In a tumor purging assay, in which tumor:bone marrow cell mixtures

45 prepared via melt-quench method in an argon-purged atmosphere.

46 ive chemoradiotherapy and immunomagnetically purged autologous bone marrow transplantation has been s

47 l investigation including the possibility of purged autologous hematopoietic cell transplants.

48 d serum autoantibody and reduced capacity to purge autoreactive immature and transitional B cells.

49 , we report a novel alternative approach for purging autoreactive T cells that spares beneficial immu

50 The change in inbreeding depression due to purging averaged across the 119 populations is <1%, howe

51 efficacy and safety of rituximab as in vivo purging before transplantation and as maintenance treatm

52 een female adolescents with binge eating and purging behaviors (i.e., bulimia nervosa or anorexia ner

53 were randomly assigned to undergo autologous purged bone marrow transplantation (ABMT) or to receive

54 l effective population size limits efficient purge by natural selection.

55 xyl radical generation when the solution was purged by air.

56 qually throughout the genome and are rapidly purged by natural selection from gene-rich regions becau

57 ve positively selected thymocytes from being purged by negative selection remains unclear.

58 t the residual CML LSC pool can be gradually purged by the glitazones, antidiabetic drugs that are ag

59 we conclude that methods aimed at enhancing purging by intentional inbreeding should not be generall

60 n captive breeding programmes and shows that purging cannot be relied upon to remove deleterious alle

61 re2 prions, whereas overexpression of Hsp104 purges cells of Sup35 prions, but not Ure2 prions.

62 iridium strip resistance heater in an argon-purged chamber.

63 ymmetry is soon broken: The best cooperators purge cheaters and continue to grow, whereas the best ch

64 ced via life cycles that either embraced, or purged, cheating types.

65 tes and product isolation can be overcome by purging CO(2) from the system.

66 volvement of a downregulation mechanism that purges contents from conscious awareness.

67 Moreover, systemic Ly6G+ cell depletion purged CXCR2-dependent tumor-associated leukocytes, supp

68 enhances the ability of natural selection to purge deleterious mutations after recombination brings t

69 It is often argued that a reduced ability to purge deleterious mutations condemns asexual lineages to

70 g linkage limits the ability of selection to purge deleterious mutations.

71 een proposed that this could be exploited in purging deleterious alleles from threatened inbred popul

72 ign of epistasis can speed up the process of purging deleterious mutations in eukaryotic organisms.

73 leviating effects of clonal interference and purging deleterious mutations.

74 Under stringent selection, they efficiently purge destabilizing amino acid changes.

75 partial- or full-criteria bulimia nervosa or purging disorder and 2.9% had partial or full-criteria b

76 significantly elevated in participants with purging disorder and bulimia nervosa compared with contr

77 Future studies on the psychobiology of purging disorder are needed to understand the propensity

78 Participants with purging disorder demonstrated significantly greater post

79 wever, more data are needed to determine how purging disorder differs from bulimia nervosa.

80 Findings support further consideration of purging disorder for inclusion in the classification of

81 Purging disorder is a clinically significant disorder of

82 Participants with purging disorder reported significantly greater postpran

83 Recent data suggest that purging disorder, a recently characterized form of eatin

84 We have re-curated previous entries to purge DisProt from conflicting cases, and also upgraded

85 eral hypotheses, including a bottleneck that purged diversity in the German isolates, variation in mu

86 es that could independently suppress EAE, we purged draining lymph node cells from MOG-immunized, iTr

87 extrinsic manner by infiltrating phagocytes purging dying cells.

88 Our results show that genetic purging efficiently removes the inbreeding load of both

89 However, purging endogenous 24,25-dihydrolanosterol, lanosterol,

90 ent densities greater than 1 mA in an oxygen-purged environment.

91 Abstinence from binge-and-purge episodes as measured by the Eating Disorder Examin

92 crossed equilibrium collapses sharply to the purged equilibrium genetic variance.

93 In the GAM a second stable equilibrium, the purged equilibrium, exists for any positive selfing rate

94 Pretransplantation rituximab in vivo purging, even in rituximab-naive patients, failed to imp

95 ion system has been demonstrated with a tank-purging experiment and has been directly compared with a

96 factors (sample weight, extraction time, and purge flow) on extraction efficiency has been studied an

97 ilation air (VA) flow rate, temperature, and purging fluids.

98 hat the contents of the intestinal tract are purged following exposure to a pathogen.

99 A purge-free controlled living polymerization method, acti

100 We report here the employment of a purge-free controlled/"living" polymerization reaction,

101 s were Eating Disorder Examination binge-and-purge frequency and Eating Disorder Examination subscale

102 A sample of CaL spent sorbent, purged from a 200 kWth pilot facility, was tested as a r

103 To determine whether LCMV could be purged from a novel target selection in the absence of a

104 a memory that has entered the aware state be purged from consciousness if it is not currently desired

105 The CO(2) is continuously purged from solution and collected by two sequential min

106 logic analysis confirmed that the cells were purged from surviving mice after ganciclovir treatment.

107 tion still needs to be loaded, unloaded, and purged from the cell culture during the measurements.

108 h sequence disparities between ecotypes were purged from the data.

109 nce but inhibits biofilm formation, had been purged from the genome.

110 infrequently, and deleterious mutations are purged from the population by purifying selection.

111 erance induction because individual TRAs are purged from the total repertoire secondary to a decline

112 Nitrous oxide is purged from the water sample and trapped cryogenically u

113 ls specific for alpha345NC1 hexamers are not purged from their repertoire.

114 s controlling whether TEs are preferentially purged from, or are retained by, genetic drift or positi

115 detector cell with a radius of 1.1 cm and a purge gas flow of 500 mL/min.

116 tant effect of oxidation of Fe(2+) under air purge gas that occurs prior to dehydroxylation and leads

117 The imposed heating rate, type of purge gas, type of comminution and sample mass all influ

118 ees C and 50 mbar(abs) without dilution by a purge gas, yielding a purity exceeding 94.4%.

119 n of the heating vessel and flow rate of the purge gas.

120 Moreover, acute induction of EphA2 may purge genetically susceptible cells, thereby uncovering

121 nt with sex and meiosis being mechanisms for purging genomic parasites.

122 e purged group versus 36% (30-42) in the non-purged group (p=0.77); 5-year overall survival was 50% (

123 d group compared with 51% (44-57) in the non-purged group (p=0.81).

124 oidal obstructive syndrome (12 of 177 in the purged group and 17 of 191 in the non-purged group), acu

125 non-purged group, and 180 patients from the purged group and 192 from the non-purged group received

126 SC were collected from 229 patients from the purged group and 236 patients from the non-purged group,

127 ng both induction (87 of 242 patients in the purged group and 93 of 243 patients in the non-purged gr

128 creased cardiac function (four of 242 in the purged group and five of 243 in the non-purged group) an

129 p) and 12 during consolidation (eight in the purged group and four in the non-purged group).

130 ecreased cardiac function (one of 177 in the purged group and four of 191 in the non-purged group).

131 roup), acute vascular leak (11 of 177 in the purged group and nine of 191 in the non-purged group), a

132 n 15 patients during induction (eight in the purged group and seven in the non-purged group) and 12 d

133 and elevated creatinine (five of 242 in the purged group and six of 243 non-purged group) and during

134 erall survival was 50% (95% CI 43-56) in the purged group compared with 51% (44-57) in the non-purged

135 s from the purged group and 192 from the non-purged group received transplant.

136 -free survival was 40% (95% CI 33-46) in the purged group versus 36% (30-42) in the non-purged group

137 group) and consolidation (131 of 177 in the purged group vs 145 of 191 in the non-purged group).

138 ght in the purged group and seven in the non-purged group) and 12 during consolidation (eight in the

139 rged group and 93 of 243 patients in the non-purged group) and consolidation (131 of 177 in the purge

140 f 242 in the purged group and six of 243 non-purged group) and during consolidation were sinusoidal o

141 the purged group and five of 243 in the non-purged group) and elevated creatinine (five of 242 in th

142 in the purged group and 17 of 191 in the non-purged group), acute vascular leak (11 of 177 in the pur

143 the purged group and nine of 191 in the non-purged group), and decreased cardiac function (one of 17

144 ight in the purged group and four in the non-purged group).

145 in the purged group vs 145 of 191 in the non-purged group).

146 the purged group and four of 191 in the non-purged group).

147 e purged group and 236 patients from the non-purged group, and 180 patients from the purged group and

148 The binge eating/purging group showed significantly greater activation th

149 gnetite stoichiometries (0.29 < x < 0.50) in purged headspace reactors and unpurged low headspace rea

150 histone deacetylase inhibitors (HDACis) may purge HIV in the latent viral reservoir.

151 to reactivation, raising the possibility of purging HIV-1 by redox modulators without triggering det

152 sing random genomic deletions in CRISPR loci purges immunological controls on long-lived viral sequen

153 r are needed to understand the propensity to purge in the absence of binge eating.

154 a randomised study of tumour-selective PBSC purging in stem-cell transplantation for patients with h

155 decline in mTEC(high) cell pool size, which purges individual tissue-restricted peripheral self-anti

156 agents (LRAs) with targeted immunotherapy to purge infected cells.

157 ter myeloablative therapy, but the effect of purging is unknown.

158 h the population in beneficial mutations and purge it from deleterious mutations.

159 e anaerobic culture with argon (which should purge it of nitric oxide) before it was exposed to air.

160 However, the development of HDACI to purge latent HIV-1 requires knowledge of the HDAC isofor

161 n of a combinatorial therapeutic approach to purge latent HIV-1.

162 ectively blocks viral replication but cannot purge latent provirus.

163 ly as part of a "shock-and-kill" strategy to purge latent reservoirs of HIV.

164 CR pathways can be dissected and utilized to purge latent virus.

165 t merits consideration as a new strategy for purging latent HIV proviruses from their cellular reserv

166 h deleterious mutations are more efficiently purged later during HIV infection when the larger effect

167 Cl 13 infection in TLR7(+/+) mice failed to purge LCMV Cl 13 infection in TLR7(-/-) mice, demonstrat

168 MHC I could be therapeutically corrected, we purged LCMV carrier mice of their persistent infection u

169 tion in solid tumors, including nitrogen gas-purged lysis buffer, the addition of proteasome inhibito

170 ories of strong versus weak sexual selection purge mutation load and resist extinction differently.

171 REGRES) and performed genetic backcrosses to purge mutations not required for Cit(+) from an evolved

172 gh pulsed electric fields (PEFs) effectively purges myeloma cells without sacrificing functional stem

173 diting is believed to play the major role in purging newly formed B cell compartments of autoreactivi

174 (500 muL) with high sensitivity, no need for purging, no added oxidant, and a limit of detection of 5

175 ntercellular competition) can delay aging by purging nonfunctioning cells.

176 te (>/=3.0 L) to severe (>/=5.0 L) diarrheal purge, occurred in 39 of 66 (59.1%) placebo controls but

177 otherapy (N=34) had stopped binge eating and purging (odds ratio=13.40, 95% confidence interval [CI]=

178 hotherapy group had stopped binge eating and purging (odds ratio=4.34, 95% CI=1.33-14.21; p=0.02).

179 ty indicate that lineage 1 has experienced a purge of genetic variation that was not observed in the

180 This treatment was equivalent to a purge of nitrogen used to remove oxygen and thus minimis

181 data sets including our data that have been purged of all detectable sequencing errors and in data s

182 CD34-selected PBSCs and a defined dose of TM purged of CD45RA+ TN.

183 ynthesis pathway in Saccharomyces cerevisiae purged of its endogenous glycogen-metabolic enzymes.

184 gococcal vaccines may be more efficacious if purged of subversive immunogens such as H.8.

185 tions were responsible for the enigmatic ice purges of the last ice age.

186 In particular, the purging of autoreactive T cells and the development of i

187 Receptor editing contributed to the purging of cells displaying anti-GPI BCRs, and significa

188 hydrogenation can be greatly accelerated by purging of CO(2) or trapping with nucleophilic secondary

189 The results suggest that the purging of deleterious alleles has had some influence on

190 d sets of loci by outcrossing, the efficient purging of deleterious recessive alleles with selfing an

191 g NK cells was evident, suggesting selective purging of dividing cells.

192 However, purging of immature and mature self-reactive T and B cel

193 parameter more relevant to selection and the purging of inbreeding depression than previous measures.

194 ulations, we evaluate the effects of genetic purging of inbreeding load in small populations, assumin

195 As complementation delays the purging of less-fit mutations, coinfection may be detrim

196 Immunomagnetic purging of PBSC for autologous stem-cell transplantation

197 post-integrated latent HIV-1 proviruses for purging of reservoir cells.

198 ous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from

199 of minimal residual disease through in-vivo purging of stem cells may translate into more durable re

200 ature of coreceptor-induced remission is the purging of T cells from the pancreatic lymph nodes (PLN)

201 resistance to CDC, probably by facilitating purging of the C5b-9 complexes by endocytosis and exo-ve

202 s simplex virus thymidine kinase), to enable purging of the cells when desired, and a bioluminescence

203 Third, some purging of the deleterious recessive alleles that underp

204 g a stirred aqueous solution with continuous purging of the headspace above the solution.

205 ction of remission involved selective T-cell purging of the pancreas and draining pancreatic lymph no

206 Lymph node purging of tumor cells was possible even in virus-immune

207 pted for transmission spectroscopy in vacuum-purged optics, we show that minute spectral shifts induc

208 ystem (in a 1:1 ratio) to receive either non-purged or immunomagnetically purged PBSC.

209 al (OS) was not improved by either rituximab purging or maintenance.

210 Infrequent binge eating or purging or overeating without a loss of control were rep

211 prove outcome, perhaps because of incomplete purging or residual tumour in patients.

212 uctural purposes, because they have not been purged out by evolution, but at the same time they put p

213 eleterious mutations have been ineffectively purged, owing to limited recombination in the cassava ge

214 signed using a factorial design to rituximab purging (P+; 375 mg/m(2) once per week for 4 weeks) or o

215 y reseed the viral reservoirs it is meant to purge, particularly under conditions of suboptimal drug

216 ed to treatment: 243 patients to receive non-purged PBSC and 243 to received purged PBSC.

217 Non-purged PBSC are acceptable for support of myeloablative

218 eive either non-purged or immunomagnetically purged PBSC.

219 receive non-purged PBSC and 243 to received purged PBSC.

220 For purging, PBSC were mixed with carbonyl iron and phagocyt

221 erapies to reanimate the immune response and purge persistent viruses have been largely unsuccessful.

222 ed enzyme-based oxygen scavenging systems or purging procedures.

223 t cause gene expression changes appear to be purged rapidly by purifying selection.

224 not occur when groups reproduced via a cheat-purging regime.

225 Then, efficacy of purging (removal of CD138(-)20(+) and CD138(+) cells) wa

226 erived HSC must be characterized, methods to purge residual teratoma-forming cells from differentiate

227 xpression while obviating a cleanup phase to purge residual traces of vector.

228 that the extension is evolving under relaxed purging selection, a pattern inconsistent with the conse

229 These peptidic arrays are used to purge self-reactive T cells, thereby averting autoimmuni

230 lays a fundamental and unanticipated role in purging self-reactive immature and transitional B cells

231 en unable to purge the mutation burden; such purging should be a key target in future cassava breedin

232 In the "argon-purged" solution, the terminal nu(CO) band on Au(110)-(1

233 ed to assess the in vivo efficacy of latency-purging strategies.

234 vant in vivo models that can be used to test purging strategies.

235 dly neutralizing antibodies in HIV-reservoir-purging strategies.

236 Here we report a sequential purging strategy targeting mature and immature clonogeni

237 We used our ex vivo purging strategy to treat frozen aphereses from 16 patie

238 is of anorexia nervosa (restricting or binge-purging subtype) and a demonstrated history of chronicit

239 Purifying selection is thought to purge TE insertions from the genome, and TE sequences ar

240 A modified gas-purging technique was used for the determination of Henr

241 was more effective in relieving binging and purging than psychoanalytic psychotherapy and was genera

242 tness correlations facilitate stress-induced purging that increases the average fitness of survivors

243 n and cross-presentation by dendritic cells, purge the developing T cell repertoire of autoimmune spe

244 xpressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of self-re

245 Clinical strategies aim to purge the latent CD4+ T cell reservoir by activating vir

246 Efforts to purge the latent reservoir have focused on reactivating

247 d immune surveillance strategies designed to purge the latent viral reservoir.

248 e heterozygous state but have been unable to purge the mutation burden; such purging should be a key

249 les in regulating anti-DNA B cells: it helps purge the peripheral repertoire of autoreactive cells, y

250 r ability to produce antiviral cytokines and purge the persistent infection.

251 ill permitting the antiviral memory cells to purge the persistent infection.

252 tency-reversing agents (LRAs) may be able to purge the persistent reservoir of latent virus in restin

253 therapeutic antiviral T cells can completely purge the persistently infected brain without causing bl

254 ly, slow-dividing stem cells proliferate and purge the population of the fast-dividing - older - cell

255 cess against freshly disaggregated tumors to purge the repertoire, in combination with in vivo biopan

256 likely require novel clinical approaches to purge the reservoir of latently infected cells from a pa

257 To purge the reservoir, pharmacological reactivation of lat

258 atter of seconds, but it takes far longer to purge the system of oxygen by changing the ambient atmos

259 roaches both to curtail CMV infection and to purge the virus from organ transplants.

260 all on millennial climate perturbations that purged the deep sea of sequestered carbon dioxide via a

261 ChaC1(CtoS) purged the ER of glutathione eliciting the expected kine

262 ns aimed at modulating immune activation and purging the HIV reservoir.

263 ellular miRNAs could be a novel approach for purging the HIV-1 reservoir.

264 Current approaches to purging the latent reservoir involve pharmacologic induc

265 need to be answered to adopt strategies for purging the latent viral reservoirs.

266 n to mTECs and provide a direct strategy for purging the peripheral repertoire of self-reactive T cel

267 frequencies that decreased upon irradiation, purging the population of subclonal variants.

268 igands lacking the thioether group, however, purging the solutions of the thioether-containing adduct

269 the disease, modified by the anti-FcmuR CAR, purged their autologous CLL cells in vitro without reduc

270 A major therapeutic challenge is to purge this reservoir.

271 to critical value, [Formula: see text], the purging threshold, which approximately equals the mean f

272 idirectional transcription and over time are purged through mutation or retained to enable new functi

273 Low-pressure nitrogen gas was then purged through the separation and field gradient-generat

274 Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit h

275 ce to devise strategies to noncytopathically purge tissues of infectious agents.

276 Acid is added, and the WOR is purged to measure dissolved CO(2) or inorganic carbonate

277 ia nervosa or anorexia nervosa, binge eating/purging type);14 with anorexia nervosa, restricting type

278 g of stress affects ID and the potential for purging using inbred and outbred Drosophila melanogaster

279 n of primary tumor and CTCs, and laser blood purging using noninvasive or hemodialysis-like schematic

280 We test the purge valve in the production of polyhydroxybutyryl biop

281 Here we design a simple purge valve module for maintaining NADP(+)/NADPH balance

282 The molecular purge valve provides a step towards developing continuou

283 IV that needs to be eliminated to completely purge virus from antiretroviral drug-treated patients.

284 The memory cells purged virus from the periphery as well as the CNS, but

285 However, some focal evidence of allele purging was detected including a suggestive QTL for litt

286 in 14 populations and a significant trend of purging was found across populations.

287 Purging was found to be significant in 14 populations an

288 he evolution of inbreeding depression (i.e., purging), we need quantitative genetic interpretations o

289 CD8+ T cell activation and T suppressor cell purge were mediated primarily by IL-12 and required IFN-

290 analyses (1606 AN restricting; 1445 AN binge-purge) were performed.

291 in ID are consistent with intragenerational purging, whereas for abiotic stressors, there appeared t

292 itness recovery is due to 'intragenerational purging' whereby fitness correlations facilitate stress-

293 he nonpurgeable DBPs enriched with SPE after purging, while contributions of both fractions to bacter

294 Analysis of aqueous morpholine solutions purged with different gas-phase NO and NO(2) concentrati

295 (-1) when the measurement cell was sealed or purged with filtered air, relative standard deviations >

296 produced when microaerophilic cultures were purged with nitrogen gas to displace oxygen and CO(2).

297 reaction is accelerated when the solution is purged with O2 gas at 1 atm.

298 emoved from the aqueous reaction mixture via purging with an inert gas, allowing for the preparation

299 ppa(1)-N(O)SR), which reversibly loses NO on purging with an inert gas.

300 , investigational strategies such as in vivo purging with rituximab and the use of radioimmunotherapy