ライフサイエンスコーパス: purging

1 iation due to classically theorized 'genetic purging'.

2 dependent 'curative' mechanisms (i.e. viral purging).

3 th self-induced vomiting as the sole form of purging.

4 ee survival if the graft has undergone tumor purging.

5 mphasis on the emerging technique of in vivo purging.

6 th complete abstinence from binge eating and purging.

7 ing novel conditioning regimens or by tumour purging.

8 ive procedure to achieve complete tumor cell purging.

9 , most engaged in recurrent binge eating and purging.

10 total body irradiation and bone marrow (BM) purging.

11 onoamine activity when they are bingeing and purging.

12 onset of extreme dieting, binge eating, and purging.

13 eful for cancer gene therapy and bone marrow purging.

14 ing new approach towards ex vivo bone marrow purging.

15 cells were detectable by PCR after TALL-104 purging.

16 f positive stem cell selection as a means of purging.

17 lera is distinct, with pronounced diarrhoeal purging.

18 n, and consequently their escape from thymic purging.

19 utations and leading to their more efficient purging.

20 ar menstrual cycles, without binge eating or purging.

21 In contrast to purging, 10-year progression-free survival (PFS) was 48%

22 After 8H9-based purging, a 2- to 3-log reduction in contaminating Ewing'

23 may also benefit populations by efficiently purging accumulated damage and rejuvenating newborn cell

24 hances the effectiveness of population-level purging across generations.

25 t multimutated HSV-1 vector, as a biological purging agent for breast cancer in the setting of stem c

26 iller T-cell line (TALL-104) as a new marrow purging agent in a clinical setting.

27 ons for the use of shiga toxin as an ex vivo purging agent in autologous stem cell transplantation.

28 ther explored for their potential as ex vivo purging agents of autologous hematopoietic stem cell tra

29 r deleterious alleles but was ineffective in purging alleles with minor fitness effects and did not a

30 cal strategies including gene therapy, tumor purging and graft engineering.

31 of 10(5) CFU, 8 of 10 volunteers experienced purging and had a positive stool culture for V. cholerae

32 reflect overdominance, potentially reducing purging and increasing allele persistence probability.

33 at EVs and exosomes could play a role in the purging and intercellular transfer of excess free RNAs,

34 provides a tool to evaluate modifications of purging and stem cell collection procedures that may be

35 there appeared to be an interaction between purging and stress-induced physiological damage.

36 before and after ex vivo immunomagnetic bead purging, and results were compared to immunocytological

37 pplications such as gene therapy, tumor cell purging, and stem cell transplantation.

38 sed between the restricting and binge eating/purging anorexia nervosa subtypes over time; one-third c

39 ver, suggesting that the fitness benefits of purging are rarely appreciable.

40 In a tumor purging assay, in which tumor:bone marrow cell mixtures

41 , we report a novel alternative approach for purging autoreactive T cells that spares beneficial immu

42 The change in inbreeding depression due to purging averaged across the 119 populations is <1%, howe

43 es for stem cell transplantation, tumor cell purging before autologous transplantation, and ex vivo c

44 consolidation therapy as a method of in vivo purging before marrow collection.

45 efficacy and safety of rituximab as in vivo purging before transplantation and as maintenance treatm

46 take without the presence of binge-eating or purging behavior.

47 een female adolescents with binge eating and purging behaviors (i.e., bulimia nervosa or anorexia ner

48 inued to engage in recurrent binge eating or purging behaviors (incidence rate, 0.026 cases per perso

49 shes among individuals with binge eating and purging behaviors.

50 current episodes of binge eating but without purging behaviors.

51 rs in cancer gene therapy as a mechanism for purging bone marrow cells of possible breast cancer cont

52 we conclude that methods aimed at enhancing purging by intentional inbreeding should not be generall

53 A cutoff point based on reduction of purging by session 6 usefully differentiates patients wh

54 killing by ganciclovir can be exploited for purging cancer cells from hematopoietic stem cell popula

55 ns regarding clinical efficacy of ODN marrow purging cannot be drawn from this small pilot study.

56 n captive breeding programmes and shows that purging cannot be relied upon to remove deleterious alle

57 tes and product isolation can be overcome by purging CO(2) from the system.

58 These results demonstrate a new approach for purging contaminated cellular products of Ewing's sarcom

59 een proposed that this could be exploited in purging deleterious alleles from threatened inbred popul

60 ign of epistasis can speed up the process of purging deleterious mutations in eukaryotic organisms.

61 leviating effects of clonal interference and purging deleterious mutations.

62 tion of organisms to new environments and in purging deleterious mutations.

63 partial- or full-criteria bulimia nervosa or purging disorder and 2.9% had partial or full-criteria b

64 significantly elevated in participants with purging disorder and bulimia nervosa compared with contr

65 Future studies on the psychobiology of purging disorder are needed to understand the propensity

66 Participants with purging disorder demonstrated significantly greater post

67 wever, more data are needed to determine how purging disorder differs from bulimia nervosa.

68 Findings support further consideration of purging disorder for inclusion in the classification of

69 Purging disorder is a clinically significant disorder of

70 Participants with purging disorder reported significantly greater postpran

71 Recent data suggest that purging disorder, a recently characterized form of eatin

72 nation of low weight and multiple methods of purging distinguishes among individuals with binge eatin

73 llele frequencies; i.e., there is no genetic purging during the experiment.

74 extrinsic manner by infiltrating phagocytes purging dying cells.

75 , consistent with the hypothesized diversity-purging effects of an evolutionarily recent Wolbachia sw

76 Assessment of purging efficacy with additional samples from NB patient

77 Our results show that genetic purging efficiently removes the inbreeding load of both

78 However, purging endogenous 24,25-dihydrolanosterol, lanosterol,

79 Pretransplantation rituximab in vivo purging, even in rituximab-naive patients, failed to imp

80 ction (PCR) for bcl2/IgH rearrangement after purging experienced longer freedom from recurrence than

81 ion system has been demonstrated with a tank-purging experiment and has been directly compared with a

82 ilation air (VA) flow rate, temperature, and purging fluids.

83 Similarly, purging frequency in the previous 28 days declined from

84 nt with sex and meiosis being mechanisms for purging genomic parasites.

85 The binge eating/purging group showed significantly greater activation th

86 term culture-initiating cells suggested that purging had been accomplished at a primitive cell level

87 al clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm

88 to reactivation, raising the possibility of purging HIV-1 by redox modulators without triggering det

89 There may be a benefit to graft purging in autologous transplantation.

90 a randomised study of tumour-selective PBSC purging in stem-cell transplantation for patients with h

91 onal consideration of antibody-based in vivo purging in subsequent clinical trials.

92 ter myeloablative therapy, but the effect of purging is unknown.

93 These results suggest that purging latent cells from infected individuals on highly

94 t merits consideration as a new strategy for purging latent HIV proviruses from their cellular reserv

95 nervosa with the use of multiple methods of purging; LC3, restricting AN without obsessive-compulsiv

96 may contribute to lymphoma relapse, and that purging may be beneficial for patients undergoing autolo

97 the use of monoclonal antibodies as in vivo purging mechanisms and nonmyeloablative and radioimmunoc

98 s to develop a viral-directed enzyme prodrug purging method that specifically targets neuroblastoma c

99 Therefore, effective purging methods are needed.

100 Current purging methods are useful when fewer than 1% tumor cell

101 ic cells, it overcomes a limitation of other purging methods that result in delayed reconstitution of

102 Different purging methods to obtain sources of stem cells free of

103 After purging, Myb mRNA levels declined substantially in appro

104 diting is believed to play the major role in purging newly formed B cell compartments of autoreactivi

105 (500 muL) with high sensitivity, no need for purging, no added oxidant, and a limit of detection of 5

106 After ex vivo purging, none of the BM cells was immunocytology-positiv

107 ntercellular competition) can delay aging by purging nonfunctioning cells.

108 g-term recovery (>1 year with no bingeing or purging, normal weight, and regular menstrual cycles) fr

109 otherapy (N=34) had stopped binge eating and purging (odds ratio=13.40, 95% confidence interval [CI]=

110 hotherapy group had stopped binge eating and purging (odds ratio=4.34, 95% CI=1.33-14.21; p=0.02).

111 In particular, the purging of autoreactive T cells and the development of i

112 We analysed data on the purging of B cells by use of antibodies in the setting o

113 n of hematological malignancies, and ex vivo purging of cancer cells in autologous transplantation.

114 and effective approach for the detection and purging of carcinoma cells in hematopoietic stem cell pr

115 Receptor editing contributed to the purging of cells displaying anti-GPI BCRs, and significa

116 a promising technology for rapid tumor cell purging of clinical progenitor cell preparations.

117 Therefore, 8H9-based purging of clinical samples is predicted to reduce tumor

118 hydrogenation can be greatly accelerated by purging of CO(2) or trapping with nucleophilic secondary

119 The results suggest that the purging of deleterious alleles has had some influence on

120 compensation can effectively counteract the purging of deleterious alleles within consanguineous pop

121 d sets of loci by outcrossing, the efficient purging of deleterious recessive alleles with selfing an

122 g NK cells was evident, suggesting selective purging of dividing cells.

123 vant cell separation problems, including the purging of human breast cancer cells from normal T-lymph

124 However, purging of immature and mature self-reactive T and B cel

125 parameter more relevant to selection and the purging of inbreeding depression than previous measures.

126 ulations, we evaluate the effects of genetic purging of inbreeding load in small populations, assumin

127 poor outcome was predicted by a reduction in purging of less than 70% by treatment session 6, allowin

128 As complementation delays the purging of less-fit mutations, coinfection may be detrim

129 c NK cells was an effective means of ex vivo purging of leukemia-contaminated bone marrow and that th

130 ctor WT1 is an ideal target for CTL-mediated purging of leukemic progenitor cells in vitro and for an

131 apse), the source of stem cells, and whether purging of malignant cells from autologous stem cells is

132 Immunomagnetic purging of PBSC for autologous stem-cell transplantation

133 post-integrated latent HIV-1 proviruses for purging of reservoir cells.

134 ous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from

135 of minimal residual disease through in-vivo purging of stem cells may translate into more durable re

136 ature of coreceptor-induced remission is the purging of T cells from the pancreatic lymph nodes (PLN)

137 With this technique, rigorous physical purging of the bowel was not necessary before structural

138 resistance to CDC, probably by facilitating purging of the C5b-9 complexes by endocytosis and exo-ve

139 s simplex virus thymidine kinase), to enable purging of the cells when desired, and a bioluminescence

140 Third, some purging of the deleterious recessive alleles that underp

141 g a stirred aqueous solution with continuous purging of the headspace above the solution.

142 ction of remission involved selective T-cell purging of the pancreas and draining pancreatic lymph no

143 With Argon purging of the sulfoxide sample before photolysis, the m

144 Purging of tumor cells and selection of stem cells are k

145 , better ablative regimens, more efficacious purging of tumor cells from autografts, and enhancement

146 Thus, in this approach, purging of tumor cells from the graft is key to the prev

147 Lymph node purging of tumor cells was possible even in virus-immune

148 ic induction, achieved either by neutral gas purging or by sulfur deprivation of the cultures.

149 al (OS) was not improved by either rituximab purging or maintenance.

150 Infrequent binge eating or purging or overeating without a loss of control were rep

151 prove outcome, perhaps because of incomplete purging or residual tumour in patients.

152 signed using a factorial design to rituximab purging (P+; 375 mg/m(2) once per week for 4 weeks) or o

153 For purging, PBSC were mixed with carbonyl iron and phagocyt

154 immune privilege of the anterior chamber by purging potential inflammatory cells.

155 ed enzyme-based oxygen scavenging systems or purging procedures.

156 Treatment with photodynamic cell purging process (PDP) inhibited antihost responses measu

157 nd other applications in gene therapy, tumor purging, production of dendritic cells for immunotherapy

158 In contrast, the purging protocol did not affect the number or type of co

159 Improved marrow purging protocols are needed in autologous bone marrow t

160 developed diarrhea but with a lower average purging rate than required for the model.

161 not occur when groups reproduced via a cheat-purging regime.

162 Then, efficacy of purging (removal of CD138(-)20(+) and CD138(+) cells) wa

163 Also, after "purging," RNA for neuroblastoma cell markers (tyrosine h

164 that the extension is evolving under relaxed purging selection, a pattern inconsistent with the conse

165 application of this approach to bone marrow purging, selective killing of human lymphoma U937 cells

166 lays a fundamental and unanticipated role in purging self-reactive immature and transitional B cells

167 en unable to purge the mutation burden; such purging should be a key target in future cassava breedin

168 l of the TALL-104 cell line in future marrow purging strategies against lysis-susceptible and -resist

169 Purging strategies that are able to remove these contami

170 dly neutralizing antibodies in HIV-reservoir-purging strategies.

171 ed to assess the in vivo efficacy of latency-purging strategies.

172 vant in vivo models that can be used to test purging strategies.

173 Here we report a sequential purging strategy targeting mature and immature clonogeni

174 We used our ex vivo purging strategy to treat frozen aphereses from 16 patie

175 is of anorexia nervosa (restricting or binge-purging subtype) and a demonstrated history of chronicit

176 A modified gas-purging technique was used for the determination of Henr

177 was more effective in relieving binging and purging than psychoanalytic psychotherapy and was genera

178 tness correlations facilitate stress-induced purging that increases the average fitness of survivors

179 Thus, by purging the acetate primer units that otherwise dominate

180 ns aimed at modulating immune activation and purging the HIV reservoir.

181 ellular miRNAs could be a novel approach for purging the HIV-1 reservoir.

182 Current approaches to purging the latent reservoir involve pharmacologic induc

183 need to be answered to adopt strategies for purging the latent viral reservoirs.

184 filaggrin through passage 10 were induced by purging the monolayer cultures of growth factors, then a

185 n to mTECs and provide a direct strategy for purging the peripheral repertoire of self-reactive T cel

186 frequencies that decreased upon irradiation, purging the population of subclonal variants.

187 iting, apoptosis and anergy in normal mice - purging the repertoire of autoreactive cells.

188 igands lacking the thioether group, however, purging the solutions of the thioether-containing adduct

189 , in terms of survival benefit, the value of purging, the presence of graft-versus-leukemia effect, a

190 stratification by risk factors, the value of purging, the role of radiotherapy after transplantation,

191 to critical value, [Formula: see text], the purging threshold, which approximately equals the mean f

192 th complete abstinence from binge eating and purging to cognitive behavioral therapy.

193 g's sarcoma was shown by real-time PCR, with purging to PCR negativity at levels of contamination of

194 stem cell harvests use positive selection or purging to provide a product that will engraft only norm

195 photodynamic action is a novel approach for purging tumor cells from autologous remission bone marro

196 ia nervosa or anorexia nervosa, binge eating/purging type);14 with anorexia nervosa, restricting type

197 who met DSM-IV criteria for bulimia nervosa, purging type, were assigned to single-blind treatment wi

198 g of stress affects ID and the potential for purging using inbred and outbred Drosophila melanogaster

199 n of primary tumor and CTCs, and laser blood purging using noninvasive or hemodialysis-like schematic

200 scence nitric oxide analyzer with a standard purging vessel.

201 Purging was accomplished using immunomagnetic-based depl

202 Among low-grade NHL patients, the use of purging was associated with significantly better disease

203 However, some focal evidence of allele purging was detected including a suggestive QTL for litt

204 in 14 populations and a significant trend of purging was found across populations.

205 Purging was found to be significant in 14 populations an

206 No in vitro purging was used.

207 he evolution of inbreeding depression (i.e., purging), we need quantitative genetic interpretations o

208 osa (they had no episodes of binge eating or purging, were at normal weight, and had regular menstrua

209 in ID are consistent with intragenerational purging, whereas for abiotic stressors, there appeared t

210 itness recovery is due to 'intragenerational purging' whereby fitness correlations facilitate stress-

211 he nonpurgeable DBPs enriched with SPE after purging, while contributions of both fractions to bacter

212 emoved from the aqueous reaction mixture via purging with an inert gas, allowing for the preparation

213 ppa(1)-N(O)SR), which reversibly loses NO on purging with an inert gas.

214 mpletely reversible when CO(2) is removed by purging with argon.

215 ll malignancies, we found that immunological purging with complement-mediated lysis eradicated PCR-de

216 , investigational strategies such as in vivo purging with rituximab and the use of radioimmunotherapy

217 irst complete remission, the role of in vivo purging with rituximab, the utility of radioimmunotherap

218 f 10(6) CFU, 14 of 15 volunteers experienced purging, with a geometric mean stool volume of 5,621 g.