ライフサイエンスコーパス: putative

1 The viperin putative active site contains several conserved positive

2 tyl-CoA, and structure-guided mutagenesis of putative active site residues identified Asn(24) and Asp

3 We concluded that BeauIII binds to a putative active site responsible for SOAT1 that is locat

4 Putative adducts included Cys34 oxidation products, mixe

5 used by mutations in genes encoding EpCAM, a putative adhesion molecule, and HAI-2, a cell surface pr

6 tors that were commonly-regulated, including putative AKT substrates.

7 Beta-glucosidase with putative algicidal capability was identified from the Ps

8 V) as a model system, we sought to dissect a putative allosteric network linking a cryptic site at th

9 The putative alternative proteins translated from altORFs ha

10 asal ganglia (BG) has been investigated as a putative anatomical biomarker in MR-based studies of Mn

11 ighly conserved and identical to that of the putative ancestral insect.

12 er, and there have been scattered reports of putative angiosperms from Triassic and Jurassic rocks.

13 BPA exposure increased Nrf2 binding to a putative antioxidant response element consensus sequence

14 haliana We present a compendium of known and putative Arabidopsis peptidases and inhibitors, and comp

15 is new tool, we demonstrate the existence of putative auxin binding sites in the cell walls of expand

16 Rrp2 encodes a putative bacterial enhancer binding protein (bEBP) in Bo

17 , we perform a pairwise comparison of 90,000 putative binding pockets detected in 3,700 proteins, and

18 Among several putative binding proteins, we identified tripartite moti

19 SNP rs2227473 is located within a putative binding site for the aryl hydrocarbon receptor,

20 The method focused on a putative binding site in GPR39 for synthetic ligands and

21 rimary sequence, but cluster into a small 3D putative binding site.

22 n-ATP competitive mode of action and a novel putative binding site; is weakly cytotoxic towards human

23 developed a pharmacophore model and used the putative bioactive conformation of a xanthine inhibitor

24 e prioritized SNPs in IFITM3 on the basis of putative biological function and identified rs34481144 i

25 , integrated biomarker prediction identified putative biomarkers from different data platforms that d

26 udies has limited a precise understanding of putative brain regions that integrate with the LC to reg

27 buted to the extreme electrophilicity of the putative C-NacNac adducts.

28 Putative cancer stem cells (CSCs) have been identified i

29 riant prompted us to consider this gene as a putative candidate for DD.

30 Complementary analyses suggested novel putative candidates carrying validated variants which we

31 chratoxin A (OTA) is a fungal metabolite and putative carcinogen which can contaminate a variety of f

32 ht to unravel the molecular mechanism of the putative caspase-9 activation by phosphorylation.

33 suggest that CSmetaPred_poc is able to rank putative catalytic residues at lower (better) ranked pos

34 the third intron of the PHACTR1 gene, as the putative causal variant.

35 e of VV disease, with the aim of identifying putative cellular pathways of disease pathogenesis.

36 f eliciting bnAbs via immunizations, and the putative central roles of Tfh cells and GC in the genera

37 ically, we created a strain that lacks all 7 putative chitinases and from this strain, generated a pa

38 and functional approaches, we identified two putative cholesterol-binding sites in the transmembrane

39 internal NHERF-binding region contains both putative Class I (-(592)SAV-) and Class II (-(595)CLDM-)

40 ence that PlrS most likely functions via the putative cognate response regulator PlrR.

41 date an Hfq-dependent mRNA repression of the putative colonization factor PrpB by the two trans-actin

42 sal association between obesity and its many putative complications.

43 Instead, mTOMT binds to putative components of the mechanotransduction channel i

44 to the mango cuticle biogenesis and identify putative cuticle-associated genes, we analyzed the trans

45 r, 2-fluoro-2-nitrovinylbenzene, to trap the putative cyclo-addition intermediate, thereby demonstrat

46 These strained cycloalkynes, formed via the putative cycloalkylidenecarbenes, were intercepted as Di

47 Using a LC-MS method, putative cytochrome P450 metabolites of NMP were identif

48 Previously identified putative de novo mutations failed to complement yeast st

49 We identify putative degradation targets and components of the slow

50 Putative deleterious sequence variants co-segregating wi

51 e teleosts and we identified the presence of putative Delta4 Fads2 in a further 11 species and confir

52 l from wastewater, and it further suggests a putative denitrifying PAO niche for Accumulibacter clade

53 ic reticulum Ca(2+) transporting PfATP6 as a putative determinant of resistance to SC81458 and SC8328

54 , binding of the ligand-activated AHR to the putative dioxin response elements in the EBF1 promoter w

55 hold dendritic membrane potential (DMP) from putative distal-most dendrites using tetrodes in freely

56 ved in periplasmic Cu(+) homeostasis and its putative DNA recognition sequence.

57 mine residues and a beta-hairpin within this putative DNA-binding cleft that are essential for cataly

58 alysis of 264 T-ALL cases, we identified 106 putative driver genes, half of which had not previously

59 Our analyses identify 55 putative driver genes, including 17 genes not previously

60 ext bias would open the door to identify all putative drug resistance mutations in cancer models.

61 Screening the putative E3 ligases for interaction with LYK5 identified

62 The putative effect of laropiprant on limiting hematoma expa

63 rulence traits, including secretion systems, putative effectors, and lipopolysaccharides (LPSs), as w

64 L. pneumophila encodes more than 300 putative effectors, which are translocated into the host

65 the best time for intervention and evaluate putative efficacy in the absence of clinical symptoms.

66 We identified more than 900 putative encapsulin systems in bacterial and archaeal ge

67 patterns are investigated when interpreting putative endocrine disruption in Arctic wildlife with po

68 e confirm that Lhx2 binds a highly conserved putative enhancer of Dmrt5, suggesting an evolutionarily

69 We identified an emerging program of putative enhancers that revise H3.3 occupancy during reg

70 lopmental stages and could thereby represent putative enhancers.

71 ry genes under the control of at least seven putative enhancers.

72 ially regulated genes, most of which encoded putative envelope proteins.

73 ectopic expression of ChREBP but not by its putative enzymatic product 13,14-dihydroretinol, suggest

74 transcriptional profiling include those for putative enzymes and a carbohydrate metabolism enzyme, a

75 This putative equivalence, commonly referred to as Peters' ru

76 To identify putative 'escape from X-inactivation tumor-suppressor' (

77 Putative excitatory regular-spiking (RS) and inhibitory

78 interactions break reward-seeking habits, a putative factor in multiple psychopathologies.

79 This study identifies putative factors affecting morbidity and mortality in pa

80 A model based on a putative feedforward loop orchestrated by Akt consistent

81 identified and functionally characterised a putative ferulate 5-hydroxylase gene through overexpress

82 ion and entry of several molecules through a putative fluid-phase macropinocytotic mechanism.

83 pulation movement and replacement and locate putative focal areas for a set of tales that are spread

84 sterol metabolism in Acanthamoeba, provide a putative framework for their further study and validate

85 lel to elucidate IgE and IgG reactivity, and putative function analyses were performed in silico acco

86 cycle, providing hints on the evolution and putative function of their genes and empowering studies

87 nown expression quantitative trait loci with putative functional consequences for NT5DC1, NT5DC2, and

88 Investigations of putative functional interactions between these regions a

89 At all three loci we highlight putative functionally relevant SNPs.

90 Putative functions could be assigned to 35,029 transcrip

91 ests model specific gene expression for nine putative fungal secreted proteins.

92 fMRI analyses reveal that putative gain signals affecting maintenance and retrieva

93 A total of 39,902 putative genes were assigned annotations, and 936 and 22

94 ypes, which are more closely associated with putative genetic effects, was touted as a strategy leadi

95 We examined two putative genetic mechanisms underlying this sex bias: se

96 but we observed a sexual monomorphism of the putative genital protrusion in all species, similar to p

97 The relative size of the putative genital protrusion varied more than 3-fold betw

98 e induces the recruitment of ACTN4 and GR to putative GREs in dexamethasone-transactivated promoters,

99 Structures of putative GusR orthologs from GUS-encoding Firmicutes spe

100 Especially, we identified a putative H3K36me3-regulated AS event leading to a nonsen

101 enhanced bioaccessibility of compounds with putative health benefit.

102 Omecamtiv mecarbil (OM), a putative heart failure therapeutic, increases cardiac co

103 Two putative heat-responsive genes, ssl2245 and sll1130, con

104 lii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the v

105 that A-ZIP53 inhibited three bZIPs and their putative heterodimers-mediated transactivation of GUS re

106 observe a correlation between the number of putative hidden orthologs in a lineage and its "average"

107 ome long evolutionary distances and identify putative hidden orthologs in large transcriptomic databa

108 ssion in vivo Expression of 45 confirmed and putative HIV/SIV restriction factors was analyzed in CD4

109 on to the lateral tuberal nucleus (NLT), the putative homolog of the mammalian arcuate nucleus.

110 es from cheese rinds, we identified over 200 putative horizontally transferred genomic regions contai

111 Putative identification of a total of 32 metabolites was

112 One such example is a putative immunosuppressive activity, which has been mapp

113 ne expression to categorize the A. fumigatus putative in vivo secretome.

114 d at evaluating overall outcomes, direct and putative indirect effects of CMV, possible impact of vir

115 In addition, we discriminated between putative inhibitory and excitatory neurons and found tha

116 This putative inhibitory function could serve to increase the

117 identifying a subset of aromatase neurons as putative inhibitory interneurons.

118 were predominantly composed of fast-spiking, putative inhibitory neurons, which displayed unusually s

119 es in cellular morphology are related to the putative interactions revealed in the Y2H screen is uncl

120 The ability to detect proximal proteins and putative interactors in intact tissues, and to quantify

121 tially expressed genes showed enrichment for putative interactors of the first three identified COPD

122 rategy to unravel the mode of action of this putative interkingdom signal.

123 Putative interneurons were discriminated from principal

124 n mRNA transcriptome identified thousands of putative intramolecular RG4s that readily assemble in vi

125 site mutation, likely due to the action of a putative intronic splicing enhancer present in intron 25

126 Here, Bull et al. show that VRS3 encodes a putative Jumonji C-type histone demethylase that regulat

127 Mutagenesis of each of the putative K-turns singly or in combination decreased the

128 hosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1) and Parkin-dependent degradati

129 In silico analysis identified that several putative Klf5 binding sites in the promoter and first in

130 gh-frequency tones (>8 kHz), well beyond the putative limit of phase locking.

131 pipeline identified 7029 canonically-spliced putative lincRNA genes on 2596 genomic loci (at an avera

132 Here we show that the putative liquid-liquid transition in n-butanol is in fac

133 enes, 78 novel protein-coding genes, and 567 putative long intergenic noncoding RNAs.

134 Putative loss-of-function polymorphisms within the START

135 When applied to de novo putative loss-of-function variants in autism-affected fa

136 c variants in >6500 cancer exomes shows that putative loss-of-function variants predicted to be delet

137 tal factors, evaluating the effectiveness of putative manipulation syndromes under field conditions,

138 l diagnostic and prognostic potential of the putative marker of microglial activation chitotriosidase

139 nique prefrontal and striatal circuitry as a putative marker of successful treatment and a target for

140 ently cross-reactive between a newly defined putative MCMV epitope sequence, M57727-734, and the norm

141 Persistent neural activity is a putative mechanism for the maintenance of working memori

142 W), on child anthropometrics, and to explore putative mediators of weight loss outcomes.

143 o comprehensively evaluate the optimality of putative metabolic exchange reactions between heterocyst

144 r and photosynthetic capacity as well as its putative metabolic impacts.

145 steine, and significant depletion of 1 other putative metabolite in resistant strains.

146 ed with carbonate in direct contact with the putative microfossils.

147 croRNAs of known microRNA loci and 495 novel putative microRNA loci.

148 osin contractility, and the integrity of the putative microtubule-based barrier at the filopodium bas

149 complex that includes at least 140 different putative mimics from four arthropod orders including ant

150 Putative miRNA binding sites on the 3'UTRs of the CYPs w

151 Additionally, we were able to identify putative molybdopterin synthase association pathways and

152 s and primary cultures, and we evaluated the putative morphological, electrophysiological, and synapt

153 his mechanism, we exploited beta-lactones as putative mycolic acid mimics to block serine hydrolases

154 Also, the exact nature of various putative myocyte-producing progenitor cells remains elus

155 sly uncharacterized myosin-binding proteins, putative myosin adaptors that belong to two unrelated fa

156 glycan most likely to predominate at all the putative N-glycosylation sites in the parasite proteome.

157 in a process that can be antagonized by its putative natural ligand, desmosterol (and possibly chole

158 A putative neural mechanism that strongly influences how i

159 We have identified a putative neurobiological mechanism underlying the potent

160 surrounds the issue of bilingualism and its putative neuroprotective effects.

161 s are needed to elucidate the provenance and putative neurotoxicity of fibrin(ogen), and its potentia

162 aea with mat depth will enable resolution of putative niches in these systems.

163 conserved serine/threonine kinase [8], as a putative novel anillin interactor.

164 is issue of JEM, Marciniak et al. identify a putative novel function of tau protein as a regulator of

165 Additionally, a putative novel species of Thiomicrospira was isolated an

166 A paralogous operon involves a putative nuclease (CinB) rather than a DUB.

167 Conservation of putative NusB/E binding sites upstream of Nus factor gen

168 ass C G protein-coupled receptor GPRC6A is a putative nutrient-sensing receptor and represents a poss

169 DBTO was employed as a putative O((3)P)-precursor.

170 spread environmental endocrine disruptor and putative obesogen.

171 g in breast tumors is linked to increases in putative oncogenic metabolites that may contribute to ma

172 d localized but scrambled blocks of genes in putative orthologous relationships with other green alga

173 he OGCleaner), a tool designed for filtering putative orthology groups as homology or non-homology cl

174 ethod that allowed the identification of 906 putative palmitoylation sites on 641 proteins from mouse

175 ctivity could not be detected for a range of putative para-hydroxybenzoic acid substrates tested.

176 All of the 70 most frequent putative pathogenic T cell clones were alphabeta T cells

177 genotyping, and linkage analysis to identify putative pathogenic variants in candidate disease genes

178 RNA-seq/PVG PCR detected previously missed, putative pathogens in 34% of patients.

179 of Nothapodytes nimmoniana unravels several putative pathway genes, transcription factors and CYPs r

180 the human orthologous were interrogated for putative periodontitis-associated variants using existin

181 Here we report that the putative periplasmic oxidoreductase PvdO of Pseudomonas

182 databases, we found three genes that encode putative PGKs.

183 hat CK2 interacts with Brg1, and mutation of putative phosphorylation sites to non-phosphorylatable (

184 sorders, and Alberta Infant Motor Score) and putative physiological and molecular biomarkers were ass

185 o large circular chromosomes and two smaller putative plasmids.

186 ted but unexpectedly included genes encoding putative pluripotency factors expressed at the onset of

187 ive ARF1 in fibroblasts induced formation of putative podosome precursors: actin-rich puncta coincidi

188 We compared modern fallow deer putative populations across a broad geographic range usi

189 Putative positions and aa that specify DNA recognition w

190 In mice, the putative precursor pepcan-23 (SALSDLHAHKLRVDPVNFKLLSH) w

191 -epithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in 50% of

192 -seco-17,14-friedo-lanostane, along with its putative precursor, compound 2 were isolated from the me

193 castellanii is ergosterol and identify novel putative precursors and intermediate sterols in its prod

194 nguish between an approaching predator and a putative prey.

195 so identify age-onset rhythmicity in several putative primary piRNA transcripts overlapping antisense

196 ambiae complex suggests that, apart from the putative primary sex-determiner, no other genes are cons

197 iched in Proteobacteria, exoelectrogens, and putative producers of electron shuttle mediators.

198 calculate the energy difference between the putative product-determining isomeric transition states

199 myocytes but not from the differentiation of putative progenitor cells.

200 We also investigated the putative prohemorrhagic effect of NAC in a mouse model o

201 The putative promoter of Ss-riok-2 contains a number of cons

202 ation of PfHsp70x with components of PTEX, a putative protein translocon within the membrane of the p

203 that the cooperation of G4 and the adjacent putative protein-binding sites within the 5' UTR was nec

204 hensive yeast two-hybrid analysis of all the putative proteins encoded by the Bam35 genome.

205 gene encoding a glycine-rich protein as the putative PSS1 gene.

206 Because a protein with multiple residues for putative PTMs is expected to undergo more than one PTM i

207 ur model differentiates many widely accepted putative quadruplex sequences that do not actually form

208 Null mutants of bciD, which encodes a putative radical S-adenosyl-l-methionine (SAM) protein,

209 re S. pennellii-like expression profiles for putative regulators of cell shape and meristem determina

210 al patients for copy number variation of the putative regulatory elements and found an overlapping de

211 This approach identified putative regulatory elements that control MYB expression

212 ulation, which enabled the identification of putative regulatory elements.

213 ective value-related activity; however, this putative regulatory pattern was abolished as psychopathy

214 e c loop of the expansion segment 7 (ES7), a putative regulatory region located on the surface of the

215 chromatin immunoprecipitation, STAT1 bound a putative regulatory sequence in the ULK1 5'-flanking reg

216 DNaseI-seq identified putative regulatory sites around genes enriched in Serto

217 has been linked to large body size, but this putative relationship has only been explored for select

218 oceptive glutamatergic and calbindin-labeled putative Renshaw cell synapses on their soma and proxima

219 With the premise that accumulation of putative resistance-conferring SNPs, potentially in comb

220 ugh its nuclear translocation and binding to putative responsive elements on IL-10 promoter.

221 The PT modification genes and an adjacent putative restriction enzyme (RE) operon likely form a re

222 measured the expression of 45 confirmed and putative restriction factors in primary CD4(+) T cells f

223 measurements of many of these confirmed and putative restriction factors in primary cells or during

224 mac239, the expression of most confirmed and putative restriction factors substantially increased in

225 NA, silences the AtRAP gene, which encodes a putative RNA binding protein.

226 onserved across 31 TCGA cancers suggesting a putative role for TET2 as an energy sensor (of 2-OG) tha

227 nd biotin in metabolism and human disease, a putative role for the enzyme in histone biotinylation, a

228 Gosmann et al. (2017) reveal a putative role for the vaginal microbiome in modulating h

229 nd Haiti and report evidence in favor of the putative role of human mobility in facilitating recombin

230 A putative role of mtDNA as a new biomarker of stroke-asso

231 ch also has significant implications for the putative role of Type II cryptochromes in animal photoma

232 alue of this approach for distinguishing the putative role(s) of the native lipid composition in modu

233 of C9, as present in the MAC, hints at their putative roles in pore formation or receptor interaction

234 ture and provide a foundation for evaluating putative roles of CP in Ni(II) homeostasis at the host-m

235 YbMgGaO4 the first experimental system where putative RVB correlations restricted to nearest neighbou

236 Anbu subunits have the Ntn-hydrolase fold, a putative S1 pocket and conserved candidate catalytic res

237 eckpoint kinase at DNA lesions; however, the putative scaffold interactions involving the N-terminal

238 Although many chloroplast mRNAs harbor putative SDs in their 5' untranslated regions and the aS

239 A total of 343485 MITE putative sequences, including canonical, diverse and par

240 We studied putative serotype 35B clinical isolates to assess the un

241 eptide encompassing residues surrounding the putative sessile arginyl residue and found stimulated pl

242 tween the sexes, with only a small number of putative sex-specific hotspots.

243 the identification and validation of 234,452 putative single nucleotide polymorphisms in-silico, of w

244 A second line included these 17 putative sites plus the five previously identified phosp

245 GWA analysis identified a putative SNP on Bos taurus autosomes (BTA) 2 associated

246 ttribution of cases of zoonotic infection to putative sources of infection.

247 is of the chromosome sequences identified 49 putative specialized metabolite biosynthetic gene cluste

248 misidentification of population structure as putative species, our work raises questions about the pr

249 RNA binding motif protein 25 (RBM25) is a putative splicing factor strongly conserved across eukar

250 The expression patterns of known and putative SSP genes based on 144 RNA sequencing data sets

251 We identified 417 plant-encoded putative SSPs that were significantly regulated during t

252 her in groups that are correlated with their putative stage of urban development as measured by a ser

253 In contrast to RPMI, DMEM both expressed the putative stem cell marker Bmi-1 and yielded cell colonie

254 Putative stem cell markers were detected in cultures gro

255 The putative substrate binding and processing site is locate

256 as and the motor region of the striatum as a putative substrate for the observed behavioral alteratio

257 b927.10.8820) is a component of the HC and a putative substrate of polo-like kinase (TbPLK), which is

258 hat amino acid residues corresponding to the putative subtilisin-like catalytic triad are important b

259 onal pipeline that simultaneously identifies putative subtype-specific enhancers and their cognate TF

260 dritic compartments and colocalized with the putative synaptic markers in young neurons derived from

261 omatin helicase DNA-binding factor CHD1 as a putative synthetic-essential gene in PTEN-deficient canc

262 se hammerhead ribozymes could be restored by putative t2M/t4M refolding of stem secondary structure o

263 urotransmission and support the sigma1R as a putative target for the treatment of methamphetamine add

264 Among them, 16 lncRNAs were identified as putative target mimics of cassava known miRNAs.

265 e, based on frequency of cleavage sequences, putative target mRNAs for these VapCs were identified; t

266 transcripts which were considered to be the putative target of alternative splicing-coupled nonsense

267 an systems as a strategy for the creation of putative, targeted-VLP delivery systems.

268 e page for rapid identification of known and putative targets in BGCs.

269 clinical model for therapeutic inhibition of putative targets in VS, archived tumor specimens, fresh

270 in-like peptides 7 and 8 (ilp7 and ilp8) are putative targets of miR-277; RNA immunoprecipitation and

271 Our studies show that the levels of two putative targets of miR-424 that function in DNA damage

272 ytochemicals identified proanthocyanidins as putative targets to ameliorate obesity.

273 iR7 were experimentally validated, and their putative targets were computationally predicted.

274 ed at characterizing ChIP peaks, identifying putative targets, predicting TF responsive enhancers, re

275 eq to identify splicing regulators and their putative targets.

276 -IR synapses, and Type I PV-IR synapses from putative thalamocortical terminals comprised the remaini

277 ver biopsy atlas with the aim of identifying putative therapeutic targets in the context of liver ste

278 nked pathways in opportunistic pathogens are putative therapeutic targets that may be associated with

279 xygen sensors and increasingly considered as putative therapeutic targets.

280 n tau burden over time for the evaluation of putative therapies.

281 s characterization led to the selection of a putative tomato ORE1 as target gene for RNA interference

282 Escherichia coli contains at least 36 putative toxin-antitoxin gene pairs, and some pathogens

283 to identify several candidate genes encoding putative trans-chrysanthemol and trans-chrysanthemal deh

284 ts of a nucleic acid binding motif (RRM1) of putative transcription factor hnRNP LL containing nucleo

285 ther, transcriptome data pool presented 1683 putative transcription factors of which transcripts corr

286 genome-scale integrative analysis to propose putative transcriptional and post-translational regulato

287 rier family 2 member 14 (SLC2A14) gene, is a putative transporter for dehydroascorbic acid and glucos

288 es in our understanding of TREM2 and discuss putative TREM2-ligand interactions and their potential r

289 G islands, some of which are associated with putative tumor suppressor genes.

290 toma is the high level of DNA methylation of putative tumor suppressors.

291 cetyl-CoA carboxylase, and three out of five putative type II diglyceride acyltransferases (DGATs), t

292 f the phagocyte NADPH oxidase (NOX2), as the putative underlying causal variant that drives a strong

293 ty of VAR2CSA's ID1-DBL2x region, containing putative vaccine targets and estimated associations of s

294 lected set of 10 Giles proteins, including a putative virion assembly protein (gp17), the phage integ

295 Metagenomic recruitment also reveals the putative virus region and PT modification and RE genes a

296 ession as well as regulated titration of the putative Wag31 target demonstrated that the wild-type al

297 Thirteen putative WGDs and 27 diversification shifts could be map

298 We phylogenetically mapped putative WGDs as identified from analyses on transcripto

299 A putative xylitol dehydrogenase, encoded by Clo1313_0076,

300 we predicted and subsequently validated many putative zDHHC17 interactors.