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1 inhibitors (IC(50)s decrease 10-20-fold with putrescine).
2 he lowest measured concentration of 1mg/L of putrescine.
3 increase in synthesis of polyamines such as putrescine.
4 etyl-3-aminopropanaldehyde and spermidine or putrescine.
5 ells was inhibited by high concentrations of putrescine.
6 ese acidic residues modulates the effects of putrescine.
7 hibition by high exogenous concentrations of putrescine.
8 ecause it was prevented by administration of putrescine.
9 involved in the conversion of agmatine into putrescine.
10 in xylem even when plants were treated with putrescine.
11 defect were only observed with the polyamine putrescine.
12 esence of alpha-difluoromethylornithine plus putrescine.
13 which was reversed by addition of exogenous putrescine.
14 osis could be partially rescued by exogenous putrescine.
15 ity when incubated with spermidine, NAD, and putrescine.
16 onversion of spermidine and spermine back to putrescine.
17 n plant foods by the external application of putrescine.
18 oline and citrulline, and polyamines such as putrescine.
19 cued in culture by the addition of exogenous putrescine.
20 d slightly decreased levels of intracellular putrescine.
21 acid (0.1-7.5), cis-ChA (1.1-2.2), caffeoyl putrescine (0.6-2.5), sinapoyl hexose (0.1-1.8), N(1),N(
24 e (2.9-fold), N-acetylputrescine (1.8-fold), putrescine (2.7-fold) and cadaverine (28-fold), which de
26 (-10)) < hydrogen sulphide (6.4 x 10(-10)) < putrescine (9.1 x 10(-10)) < dimethyl disulphide (5.9 x
29 at catalyzes the decarboxylation of l-Orn to putrescine, a rate-limiting step in the formation of pol
31 duct of putrescine catabolism and shows that putrescine accumulates in puuA, puuB, and puuC mutants b
32 novo and therefore obligatorily relies upon putrescine acquisition from the host to meet its nutriti
33 the putrescine binding site, suggesting that putrescine activates the enzyme through electrostatic ef
34 f the enzyme, congruent with the role of the putrescine activator of the mammalian AdoMet decarboxyla
36 hown to encode a hydroxycinnamoyl-coenzyme A:putrescine acyltransferase responsible for caffeoylputre
39 tic measurements indicated that spuC encodes putrescine aminotransferase with pyruvate as the amino g
44 contributing factors include high levels of putrescine and acetylated polyamines, a 50% reduction in
46 s in a similar position to that observed for putrescine and alpha-difluoromethylornithine in previous
48 lmethionine decarboxylases in the absence of putrescine and are consistent with previously proposed m
49 The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential class of meta
50 h-affinity transporters that recognized both putrescine and cadaverine but not spermidine or spermine
53 ved in the presence of the reaction products putrescine and cadaverine to 1.7 and 2.15A, respectively
54 were detected in the 300MPa treatments, but putrescine and cadaverine were detected in the control a
56 nly carried by two small aliphatic diamines, putrescine and cadaverine, which are generated by bacter
58 a, CO2, and ATP while converting agmatine to putrescine and is proposed to augment the acid resistanc
59 ulation of the GP pathway shows induction by putrescine and not by a product of putrescine catabolism
60 al, but not plasma, levels of the polyamines putrescine and spermidine as well as the collagen breakd
62 of hydroxycinnamic acids and two polyamines, putrescine and spermidine, is regulated by this transcri
63 1 to be a high affinity transporter for both putrescine and spermidine, whereas expression of LmPOT1
65 utants were expressed and dialyzed to remove putrescine and studied biochemically using X-ray crystal
66 al structure of the mutants with and without putrescine and their complexes with S-adenosylmethionine
67 ine) when compared to FD (from 1mgkg(-1) for putrescine and tyramine to 4mgkg(-1) for histamine); MS/
68 gmatine serves as the precursor compound for putrescine (and hence spermidine and spermine), which wa
69 els of polyamines (spermidine, spermine, and putrescine) and PGE2, treatment regimens, and risk of CR
70 up-regulation of polyamines (spermidine and putrescine) and potassium may mitigate oxidative stress
73 ine, tyramine, phenylethylamine, tryptamine, putrescine, and cadaverine) and two polyamines (spermidi
76 d levels of dephosphocoenzyme A, spermidine, putrescine, and phosphatidylethanolamines and elevated a
78 enzyme was fully processed in the absence of putrescine, and the rate of this reaction was not stimul
79 tly decreased the levels of inosine, lysine, putrescine, and xanthine at the gingivitis sites as earl
80 s of DFMO, RS1-Reg mutants, the ODC1 product putrescine, and/or glucose on SGLT1 expressed in oocytes
83 access to host spermidine pools, while host putrescine appears to be unavailable for salvage by the
84 ggest that polyamine metabolism and secreted putrescine are linked to host cell adherence and cytotox
88 level of biofilm correlated to the level of putrescine as measured by high-performance liquid chroma
96 d was observed, with histamine, tyramine and putrescine being the most abundant in Pignoletto wines.
98 e residues that link the active site and the putrescine binding site, suggesting that putrescine acti
99 sible for the majority of the activity ([14C]putrescine-binding assay) in whole brain and liver homog
101 vidence for coupling between residues in the putrescine-binding site and the active site, consistent
102 suggests that this inhibitor binds both the putrescine-binding site and the active site, providing e
105 the active site, providing evidence that the putrescine-binding site of the T. cruzi enzyme has broad
108 at swarming in response to the cues required putrescine biosynthesis and pathways involved in amino a
109 n TRV-infected plants and that impairment of putrescine biosynthesis promoted virus multiplication.
112 osed of two citric acid residues linked by a putrescine bridge and thus is identical in structure to
113 tic enzyme ornithine decarboxylase, depleted putrescine but did not produce synergistic cell killing.
114 The oxidative deamination of methylated putrescine by a diamine oxidase activity (DAO) is an imp
115 of the triamine spermidine from the diamine putrescine by fusion enzymes from beta-proteobacterium D
117 riamide-44 partially inhibited the uptake of putrescine by PlaP and decreased both putrescine stimula
119 nopropyl group donor to form spermidine from putrescine by the key enzymes S-adenosylmethionine decar
123 e detection of various biogenic amines (i.e. putrescine, cadaverine) and in the monitoring of spoilag
124 ogenic amines (tryptamine, phenylethylamine, putrescine, cadaverine, histamine, serotonine, tyramine,
128 cally active molecules which have aliphatic (putrescine, cadaverine, spermine, spermidine), aromatic
131 (GP) pathway but instead induces genes for a putrescine catabolic pathway that starts with a transami
132 termine if dual control regulates a complete putrescine catabolic pathway, we examined expression of
134 uction by putrescine and not by a product of putrescine catabolism and shows that putrescine accumula
136 basic clusters that are very closely spaced (putrescine cleavage) or less closely spaced (Nfo protein
138 from cells resistant to growth inhibition by putrescine compared with transport in inverted vesicles
139 biosensors could be used in determination of putrescine concentration in meat samples but improvement
143 Finally, we showed that increments in the putrescine content in TRV-infected plants correlated wit
144 d disA, that restored swarming motility to a putrescine-deficient speA mutant of Proteus mirabilis.
146 ced approximately 1 double-strand break: 1.3 putrescine-detected abasic clusters: 0.8 Nfo-detected ab
147 Extracellular spermine, spermidine, and putrescine directly activated TRPV1 in a charge-dependen
148 yamines that directly modulate ion channels, putrescine exerted its effect by altering the balance of
149 rotozoal parasite Trypanosoma cruzi requires putrescine for maximal enzyme activity, but not for proc
152 n does not induce genes of this glutamylated putrescine (GP) pathway but instead induces genes for a
153 is likely to be a factor in the finding that putrescine has no role in processing of the T. cruzi enz
154 on of flagellar rotation and accumulation of putrescine have been proposed to be sensory mechanisms.
155 factory receptors that detect cadaverine and putrescine have not been identified in any species so fa
157 significantly correlated with their sum were putrescine, histamine and tyramine, even if reached leve
158 yramine was the prevalent amine, followed by putrescine, histamine, phenylethylamine and cadaverine.
159 Eight biogenic amines (spermine, spermidine, putrescine, histamine, tyramine, phenylethylamine, cadav
160 a macrocyclic dimer of N-hydroxy-N-succinyl-putrescine (HSP) and is structurally related to desferri
165 C activity and the resultant accumulation of putrescine in PKC epsilon transgenic mice are linked to
166 transporter capable of exporting the diamine putrescine in the Chinese hamster ovary (CHO) cells sele
169 ibition was prevented by supplying exogenous putrescine in the presence of alpha-difluoromethylornith
170 g enzyme in the conversion of ornithine into putrescine in the synthesis of polyamines, is reduced in
172 found that spermidine remained unchanged and putrescine increased by 2.5-fold after 15 h and then dec
178 ediated by an atypical pathway that converts putrescine into GABA, which then activates presynaptic G
182 n animal cells and indicate that the diamine putrescine is exported by an arginine transporter contai
183 yamines avidly, with a marked preference for putrescine (Kd=10 nM) over spermidine (Kd=430 nM), but t
184 tor substrate, especially for spermidine and putrescine (Km values of 33 mum and 3.9 mm, respectively
185 l ornithine decarboxylase (ODC) activity and putrescine levels approximately 3-4-fold more in PKC eps
187 se in TPA-induced epidermal ODC activity and putrescine levels than their wild-type littermates.
188 4-hydroxytamoxifen (4OHT), ODC activity and putrescine levels were dramatically increased in the epi
189 putrescine-treated plants, so the exogenous putrescine likely accelerated disease indirectly by affe
190 e underlying type of infection, showing that putrescine, lysoPCaC18:0 and SM C16:1 are associated wit
191 addition, this previous study suggested that putrescine may act as a cell-to-cell signaling molecule.
196 the JA-responsive genes is NtPMT1a, encoding putrescine N-methyl transferase, a key regulatory enzyme
198 ed transcription of NtPMT1a, a gene encoding putrescine N-methyltransferase, the first committed step
201 of ornithine or micromolar concentrations of putrescine or by complementation with either glycosomal
202 macological supplementation, either with low putrescine or high ornithine or spermidine concentration
204 yzed, spermine concentration was higher than putrescine or spermidine; however, the differential was
206 matic oxidation to 4-aminobutyraldehyde with putrescine oxidase or diamine oxidase as catalysts.
208 with greatly reduced levels of intracellular putrescine, plaP was required for the putrescine-depende
210 ic mice, prostatic N(1)-acetylspermidine and putrescine pools were remarkably increased relative to T
211 roxyproline, glycine, leucine+isoleucine and putrescine proved to be useful for differentiating Canno
212 pauA5 was found to be inducible by diamines putrescine (PUT) and cadaverine (CAD) but not by diamino
213 rations increased with time, tyramine (TYR), putrescine (PUT) and cadaverine (CAD) were the most abun
215 e-harvest foliar spraying of grapevines with putrescine (Put) and spermidine (Spd) (0, 1, 2mM) was ev
217 mended with a single PA model compound, i.e. putrescine (PUT) or spermidine (SPD), or with no additio
219 Organic broccoli showed higher levels of putrescine (Put), and cooking resulted in lowering the o
220 polyamines, including diaminopropane (DAP), putrescine (Put), cadaverine (Cad), and spermidine (Spd)
221 amines; spermine (SPM), spermidine (SPD) and putrescine (PUT), or electrochemical investigation of th
222 Copper amine oxidases oxidize the polyamine putrescine (Put), producing an aldehyde, ammonia, and hy
223 studies have involved three biogenic amines: putrescine (Put), spermidine (Spd) and spermine (Spm), a
225 se and racemase coupled with SpuC, the major putrescine-pyruvate transaminase, were key components to
233 Oaz1, regulates synthesis of the polyamines putrescine, spermidine and spermine by controlling stabi
236 to the sequential appearance of fluorinated putrescine, spermidine, acetylated spermidine, and sperm
240 ompanied by reduced levels of the polyamines putrescine, spermidine, and spermine in mutant infloresc
241 e studied the ability of natural polyamines (putrescine, spermidine, and spermine) and a series of th
245 ferase (vPAT), acetylates polyamines such as putrescine, spermidine, cadaverine, and homospermidine p
246 Thus, interactions of natural polyamines (putrescine, spermidine, spermine) and polyamine-like pot
247 d) because of the following: (i) addition of putrescine, spermidine, spermine, or N(1)-AcSpd did not
250 es (cadaverine, histamine, phenylethylamine, putrescine, spermine, spermidine, tyramine and tryptamin
251 ake of putrescine by PlaP and decreased both putrescine stimulated swarming and urothelial cell invas
255 e identified residues that are important for putrescine stimulation of activity (F7 and T245), while
256 nteract with the distal primary amine in the putrescine substrate as well as the internal and distal
258 We wanted to examine the effect of decreased putrescine synthesis by inhibition of ornithine decarbox
259 egrade arginine and ornithine, precursors of putrescine synthesis, are activated by either regulators
262 t was grown in the presence of extracellular putrescine, the intracellular levels of putrescine were
265 fects of DFMO were reversible with exogenous putrescine, thus indicating that they are specifically m
266 or E15A and E256A mutants were stimulated by putrescine to a smaller extent than the wild-type enzyme
267 tive Cdk5 abolishes the ability of dbcAMP or putrescine to enhance neurite outgrowth in the presence
269 speC mutant required >/= 15 microM exogenous putrescine to grow and could not grow alone in xylem eve
272 synthase (SPDSYN), the enzyme that converts putrescine to spermidine, was created by double-targeted
273 ndent sets of enzymes can completely degrade putrescine to succinate and that their relative importan
277 tent with previously proposed models for how putrescine together with the buried, negatively charged
280 em putrescine concentration was unchanged in putrescine-treated plants, so the exogenous putrescine l
282 h, generation of toxic metabolites (H2O2 and putrescine), upregulation of HO-1, disruption of cell an
283 ing short hairpin RNA, caused an increase in putrescine uptake and a decrease in arginine uptake acti
284 n of LmPOT1 in Trypanosoma brucei stimulated putrescine uptake that was sensitive to inhibition by pe
288 capable of robust growth only when exogenous putrescine was supplied in the culture medium, confirmin
292 inine catabolites citrulline, ornithine, and putrescine were detected in supernatants, indicating act
293 ular putrescine, the intracellular levels of putrescine were greatly reduced compared with the speA m
295 s of the SpeA and SpeB enzymes (agmatine and putrescine) were tested for repression of cmr437::lacZ.
296 spermidine and diamine oxidase specific for putrescine, were co-immobilized onto a novel chitosan/co
297 the levels of the polyamines, spermidine and putrescine, were found to be increased which is an indic
298 ed at average concentrations <10mg/L, except putrescine which reached 20.5 +/- 10.2mg/L in Cannonau w
299 he aguBA operon that metabolizes agmatine to putrescine, which can be subsequently converted into oth
300 monas aeruginosa in response to agmatine and putrescine with an emphasis in polyamine catabolism.
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