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   1 inhibitors (IC(50)s decrease 10-20-fold with putrescine).                                            
     2 he lowest measured concentration of 1mg/L of putrescine.                                             
     3  increase in synthesis of polyamines such as putrescine.                                             
     4 etyl-3-aminopropanaldehyde and spermidine or putrescine.                                             
     5 ells was inhibited by high concentrations of putrescine.                                             
     6 ese acidic residues modulates the effects of putrescine.                                             
     7 hibition by high exogenous concentrations of putrescine.                                             
     8 ecause it was prevented by administration of putrescine.                                             
     9  involved in the conversion of agmatine into putrescine.                                             
    10  in xylem even when plants were treated with putrescine.                                             
    11 defect were only observed with the polyamine putrescine.                                             
    12 esence of alpha-difluoromethylornithine plus putrescine.                                             
    13  which was reversed by addition of exogenous putrescine.                                             
    14 osis could be partially rescued by exogenous putrescine.                                             
    15 ity when incubated with spermidine, NAD, and putrescine.                                             
    16 onversion of spermidine and spermine back to putrescine.                                             
    17 n plant foods by the external application of putrescine.                                             
    18 oline and citrulline, and polyamines such as putrescine.                                             
    19 cued in culture by the addition of exogenous putrescine.                                             
    20 d slightly decreased levels of intracellular putrescine.                                             
    21  acid (0.1-7.5), cis-ChA (1.1-2.2), caffeoyl putrescine (0.6-2.5), sinapoyl hexose (0.1-1.8), N(1),N(
  
  
    24 e (2.9-fold), N-acetylputrescine (1.8-fold), putrescine (2.7-fold) and cadaverine (28-fold), which de
  
    26 (-10)) < hydrogen sulphide (6.4 x 10(-10)) < putrescine (9.1 x 10(-10)) < dimethyl disulphide (5.9 x 
  
  
    29 at catalyzes the decarboxylation of l-Orn to putrescine, a rate-limiting step in the formation of pol
  
    31 duct of putrescine catabolism and shows that putrescine accumulates in puuA, puuB, and puuC mutants b
    32  novo and therefore obligatorily relies upon putrescine acquisition from the host to meet its nutriti
    33 the putrescine binding site, suggesting that putrescine activates the enzyme through electrostatic ef
    34 f the enzyme, congruent with the role of the putrescine activator of the mammalian AdoMet decarboxyla
  
    36 hown to encode a hydroxycinnamoyl-coenzyme A:putrescine acyltransferase responsible for caffeoylputre
  
  
    39 tic measurements indicated that spuC encodes putrescine aminotransferase with pyruvate as the amino g
  
  
  
  
    44  contributing factors include high levels of putrescine and acetylated polyamines, a 50% reduction in
  
    46 s in a similar position to that observed for putrescine and alpha-difluoromethylornithine in previous
  
    48 lmethionine decarboxylases in the absence of putrescine and are consistent with previously proposed m
    49   The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential class of meta
    50 h-affinity transporters that recognized both putrescine and cadaverine but not spermidine or spermine
  
  
    53 ved in the presence of the reaction products putrescine and cadaverine to 1.7 and 2.15A, respectively
    54  were detected in the 300MPa treatments, but putrescine and cadaverine were detected in the control a
  
    56 nly carried by two small aliphatic diamines, putrescine and cadaverine, which are generated by bacter
  
    58 a, CO2, and ATP while converting agmatine to putrescine and is proposed to augment the acid resistanc
    59 ulation of the GP pathway shows induction by putrescine and not by a product of putrescine catabolism
    60 al, but not plasma, levels of the polyamines putrescine and spermidine as well as the collagen breakd
  
    62 of hydroxycinnamic acids and two polyamines, putrescine and spermidine, is regulated by this transcri
    63 1 to be a high affinity transporter for both putrescine and spermidine, whereas expression of LmPOT1 
  
    65 utants were expressed and dialyzed to remove putrescine and studied biochemically using X-ray crystal
    66 al structure of the mutants with and without putrescine and their complexes with S-adenosylmethionine
    67 ine) when compared to FD (from 1mgkg(-1) for putrescine and tyramine to 4mgkg(-1) for histamine); MS/
    68 gmatine serves as the precursor compound for putrescine (and hence spermidine and spermine), which wa
    69 els of polyamines (spermidine, spermine, and putrescine) and PGE2, treatment regimens, and risk of CR
    70  up-regulation of polyamines (spermidine and putrescine) and potassium may mitigate oxidative stress 
  
  
    73 ine, tyramine, phenylethylamine, tryptamine, putrescine, and cadaverine) and two polyamines (spermidi
  
  
    76 d levels of dephosphocoenzyme A, spermidine, putrescine, and phosphatidylethanolamines and elevated a
  
    78 enzyme was fully processed in the absence of putrescine, and the rate of this reaction was not stimul
    79 tly decreased the levels of inosine, lysine, putrescine, and xanthine at the gingivitis sites as earl
    80 s of DFMO, RS1-Reg mutants, the ODC1 product putrescine, and/or glucose on SGLT1 expressed in oocytes
  
  
    83  access to host spermidine pools, while host putrescine appears to be unavailable for salvage by the 
    84 ggest that polyamine metabolism and secreted putrescine are linked to host cell adherence and cytotox
  
  
  
    88  level of biofilm correlated to the level of putrescine as measured by high-performance liquid chroma
  
  
  
  
  
  
  
    96 d was observed, with histamine, tyramine and putrescine being the most abundant in Pignoletto wines. 
  
    98 e residues that link the active site and the putrescine binding site, suggesting that putrescine acti
    99 sible for the majority of the activity ([14C]putrescine-binding assay) in whole brain and liver homog
  
   101 vidence for coupling between residues in the putrescine-binding site and the active site, consistent 
   102  suggests that this inhibitor binds both the putrescine-binding site and the active site, providing e
  
  
   105 the active site, providing evidence that the putrescine-binding site of the T. cruzi enzyme has broad
  
  
   108 at swarming in response to the cues required putrescine biosynthesis and pathways involved in amino a
   109 n TRV-infected plants and that impairment of putrescine biosynthesis promoted virus multiplication.  
  
  
   112 osed of two citric acid residues linked by a putrescine bridge and thus is identical in structure to 
   113 tic enzyme ornithine decarboxylase, depleted putrescine but did not produce synergistic cell killing.
   114      The oxidative deamination of methylated putrescine by a diamine oxidase activity (DAO) is an imp
   115  of the triamine spermidine from the diamine putrescine by fusion enzymes from beta-proteobacterium D
  
   117 riamide-44 partially inhibited the uptake of putrescine by PlaP and decreased both putrescine stimula
  
   119 nopropyl group donor to form spermidine from putrescine by the key enzymes S-adenosylmethionine decar
  
  
  
   123 e detection of various biogenic amines (i.e. putrescine, cadaverine) and in the monitoring of spoilag
   124 ogenic amines (tryptamine, phenylethylamine, putrescine, cadaverine, histamine, serotonine, tyramine,
  
  
  
   128 cally active molecules which have aliphatic (putrescine, cadaverine, spermine, spermidine), aromatic 
  
  
   131 (GP) pathway but instead induces genes for a putrescine catabolic pathway that starts with a transami
   132 termine if dual control regulates a complete putrescine catabolic pathway, we examined expression of 
  
   134 uction by putrescine and not by a product of putrescine catabolism and shows that putrescine accumula
  
   136 basic clusters that are very closely spaced (putrescine cleavage) or less closely spaced (Nfo protein
  
   138 from cells resistant to growth inhibition by putrescine compared with transport in inverted vesicles 
   139 biosensors could be used in determination of putrescine concentration in meat samples but improvement
  
  
  
   143    Finally, we showed that increments in the putrescine content in TRV-infected plants correlated wit
   144 d disA, that restored swarming motility to a putrescine-deficient speA mutant of Proteus mirabilis.  
  
   146 ced approximately 1 double-strand break: 1.3 putrescine-detected abasic clusters: 0.8 Nfo-detected ab
   147      Extracellular spermine, spermidine, and putrescine directly activated TRPV1 in a charge-dependen
   148 yamines that directly modulate ion channels, putrescine exerted its effect by altering the balance of
   149 rotozoal parasite Trypanosoma cruzi requires putrescine for maximal enzyme activity, but not for proc
  
  
   152 n does not induce genes of this glutamylated putrescine (GP) pathway but instead induces genes for a 
   153 is likely to be a factor in the finding that putrescine has no role in processing of the T. cruzi enz
   154 on of flagellar rotation and accumulation of putrescine have been proposed to be sensory mechanisms. 
   155 factory receptors that detect cadaverine and putrescine have not been identified in any species so fa
  
   157 significantly correlated with their sum were putrescine, histamine and tyramine, even if reached leve
   158 yramine was the prevalent amine, followed by putrescine, histamine, phenylethylamine and cadaverine. 
   159 Eight biogenic amines (spermine, spermidine, putrescine, histamine, tyramine, phenylethylamine, cadav
   160  a macrocyclic dimer of N-hydroxy-N-succinyl-putrescine (HSP) and is structurally related to desferri
  
  
  
  
   165 C activity and the resultant accumulation of putrescine in PKC epsilon transgenic mice are linked to 
   166 transporter capable of exporting the diamine putrescine in the Chinese hamster ovary (CHO) cells sele
  
  
   169 ibition was prevented by supplying exogenous putrescine in the presence of alpha-difluoromethylornith
   170 g enzyme in the conversion of ornithine into putrescine in the synthesis of polyamines, is reduced in
  
   172 found that spermidine remained unchanged and putrescine increased by 2.5-fold after 15 h and then dec
  
  
  
  
  
   178 ediated by an atypical pathway that converts putrescine into GABA, which then activates presynaptic G
  
  
  
   182 n animal cells and indicate that the diamine putrescine is exported by an arginine transporter contai
   183 yamines avidly, with a marked preference for putrescine (Kd=10 nM) over spermidine (Kd=430 nM), but t
   184 tor substrate, especially for spermidine and putrescine (Km values of 33 mum and 3.9 mm, respectively
   185 l ornithine decarboxylase (ODC) activity and putrescine levels approximately 3-4-fold more in PKC eps
  
   187 se in TPA-induced epidermal ODC activity and putrescine levels than their wild-type littermates.     
   188  4-hydroxytamoxifen (4OHT), ODC activity and putrescine levels were dramatically increased in the epi
   189  putrescine-treated plants, so the exogenous putrescine likely accelerated disease indirectly by affe
   190 e underlying type of infection, showing that putrescine, lysoPCaC18:0 and SM C16:1 are associated wit
   191 addition, this previous study suggested that putrescine may act as a cell-to-cell signaling molecule.
  
  
  
  
   196 the JA-responsive genes is NtPMT1a, encoding putrescine N-methyl transferase, a key regulatory enzyme
  
   198 ed transcription of NtPMT1a, a gene encoding putrescine N-methyltransferase, the first committed step
  
  
   201 of ornithine or micromolar concentrations of putrescine or by complementation with either glycosomal 
   202 macological supplementation, either with low putrescine or high ornithine or spermidine concentration
  
   204 yzed, spermine concentration was higher than putrescine or spermidine; however, the differential was 
  
   206 matic oxidation to 4-aminobutyraldehyde with putrescine oxidase or diamine oxidase as catalysts.     
  
   208 with greatly reduced levels of intracellular putrescine, plaP was required for the putrescine-depende
  
   210 ic mice, prostatic N(1)-acetylspermidine and putrescine pools were remarkably increased relative to T
   211 roxyproline, glycine, leucine+isoleucine and putrescine proved to be useful for differentiating Canno
   212  pauA5 was found to be inducible by diamines putrescine (PUT) and cadaverine (CAD) but not by diamino
   213 rations increased with time, tyramine (TYR), putrescine (PUT) and cadaverine (CAD) were the most abun
  
   215 e-harvest foliar spraying of grapevines with putrescine (Put) and spermidine (Spd) (0, 1, 2mM) was ev
  
   217 mended with a single PA model compound, i.e. putrescine (PUT) or spermidine (SPD), or with no additio
  
   219     Organic broccoli showed higher levels of putrescine (Put), and cooking resulted in lowering the o
   220  polyamines, including diaminopropane (DAP), putrescine (Put), cadaverine (Cad), and spermidine (Spd)
   221 amines; spermine (SPM), spermidine (SPD) and putrescine (PUT), or electrochemical investigation of th
   222  Copper amine oxidases oxidize the polyamine putrescine (Put), producing an aldehyde, ammonia, and hy
   223 studies have involved three biogenic amines: putrescine (Put), spermidine (Spd) and spermine (Spm), a
  
   225 se and racemase coupled with SpuC, the major putrescine-pyruvate transaminase, were key components to
  
  
  
  
  
  
  
   233  Oaz1, regulates synthesis of the polyamines putrescine, spermidine and spermine by controlling stabi
  
  
   236  to the sequential appearance of fluorinated putrescine, spermidine, acetylated spermidine, and sperm
  
  
  
   240 ompanied by reduced levels of the polyamines putrescine, spermidine, and spermine in mutant infloresc
   241 e studied the ability of natural polyamines (putrescine, spermidine, and spermine) and a series of th
  
  
  
   245 ferase (vPAT), acetylates polyamines such as putrescine, spermidine, cadaverine, and homospermidine p
   246    Thus, interactions of natural polyamines (putrescine, spermidine, spermine) and polyamine-like pot
   247 d) because of the following: (i) addition of putrescine, spermidine, spermine, or N(1)-AcSpd did not 
  
  
   250 es (cadaverine, histamine, phenylethylamine, putrescine, spermine, spermidine, tyramine and tryptamin
   251 ake of putrescine by PlaP and decreased both putrescine stimulated swarming and urothelial cell invas
  
  
  
   255 e identified residues that are important for putrescine stimulation of activity (F7 and T245), while 
   256 nteract with the distal primary amine in the putrescine substrate as well as the internal and distal 
  
   258 We wanted to examine the effect of decreased putrescine synthesis by inhibition of ornithine decarbox
   259 egrade arginine and ornithine, precursors of putrescine synthesis, are activated by either regulators
  
  
   262 t was grown in the presence of extracellular putrescine, the intracellular levels of putrescine were 
  
  
   265 fects of DFMO were reversible with exogenous putrescine, thus indicating that they are specifically m
   266 or E15A and E256A mutants were stimulated by putrescine to a smaller extent than the wild-type enzyme
   267 tive Cdk5 abolishes the ability of dbcAMP or putrescine to enhance neurite outgrowth in the presence 
  
   269 speC mutant required >/= 15 microM exogenous putrescine to grow and could not grow alone in xylem eve
  
  
   272  synthase (SPDSYN), the enzyme that converts putrescine to spermidine, was created by double-targeted
   273 ndent sets of enzymes can completely degrade putrescine to succinate and that their relative importan
  
  
  
   277 tent with previously proposed models for how putrescine together with the buried, negatively charged 
  
  
   280 em putrescine concentration was unchanged in putrescine-treated plants, so the exogenous putrescine l
  
   282 h, generation of toxic metabolites (H2O2 and putrescine), upregulation of HO-1, disruption of cell an
   283 ing short hairpin RNA, caused an increase in putrescine uptake and a decrease in arginine uptake acti
   284 n of LmPOT1 in Trypanosoma brucei stimulated putrescine uptake that was sensitive to inhibition by pe
  
  
  
   288 capable of robust growth only when exogenous putrescine was supplied in the culture medium, confirmin
  
  
  
   292 inine catabolites citrulline, ornithine, and putrescine were detected in supernatants, indicating act
   293 ular putrescine, the intracellular levels of putrescine were greatly reduced compared with the speA m
  
   295 s of the SpeA and SpeB enzymes (agmatine and putrescine) were tested for repression of cmr437::lacZ. 
   296  spermidine and diamine oxidase specific for putrescine, were co-immobilized onto a novel chitosan/co
   297 the levels of the polyamines, spermidine and putrescine, were found to be increased which is an indic
   298 ed at average concentrations <10mg/L, except putrescine which reached 20.5 +/- 10.2mg/L in Cannonau w
   299 he aguBA operon that metabolizes agmatine to putrescine, which can be subsequently converted into oth
   300 monas aeruginosa in response to agmatine and putrescine with an emphasis in polyamine catabolism.    
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