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1 for development and has been a morphogenetic puzzle.
2  SQUIDs and qubits is still a major unsolved puzzle.
3 t disturbance, this remained a centuries-old puzzle.
4 t host specificity have been a long-standing puzzle.
5 ture of the material, resolve an outstanding puzzle.
6 uonic hydrogen, amplifying the proton radius puzzle.
7      Unconditional generosity in humans is a puzzle.
8 ying accretion rates-has been a longstanding puzzle.
9 ausal representation and inference remains a puzzle.
10 ess commensal organisms remains an important puzzle.
11 obesity, we propose one missing piece of the puzzle.
12 trees has long been a fascinating biological puzzle.
13  How to reconcile the results has reminded a puzzle.
14 e human sense of fairness is an evolutionary puzzle.
15 oinduction continues to remain an unresolved puzzle.
16 d quantitative experimentation to solve this puzzle.
17 t on a critical piece of the coronal heating puzzle.
18 for correct steering remains a long-standing puzzle.
19 imiting step of this process--has remained a puzzle.
20  density ns on the overdoped side is a major puzzle.
21  auditory processing has been a longstanding puzzle.
22  piece in the IL-1beta-mediated inflammation puzzle.
23 l piece of understanding to the evolving K2P puzzle.
24 ethnographically, represents an evolutionary puzzle.
25 eral intelligence poses a major evolutionary puzzle.
26 of life, but how has been a long-outstanding puzzle.
27 gage diverse ligands remains a controversial puzzle.
28 matic turnover, thereby solving longstanding puzzles.
29 ant for the recycling of motors, remain open puzzles.
30 o discover something new and to tackle tough puzzles.
31 f human aggression helps solve two important puzzles.
32 egulate YAP1's nuclear localization is still puzzling.
33 e the direction of illumination has remained puzzling.
34 droitin without sulfation has therefore been puzzling.
35 r Roux-en-Y gastric bypass (RYGBP) are still puzzling.
36  phenotypes that involve optic neuropathy is puzzling.
37 e ecologically ubiquitous but evolutionarily puzzling.
38 ul Metropolitan Area (SMA), South Korea, are puzzling.
39 Earthquake faulting at 600 km depth remains puzzling.
40 ral lifespan is a long-standing evolutionary puzzle [1-4].
41 dehydrogenases, and sources of the observed "puzzling" 2 degrees KIE behaviors in these enzymes are d
42                              A long-standing puzzle(2) is that trees capable of nitrogen fixation are
43 ed actinide material, remain a long standing puzzle, a result of strong coupling between magnetism an
44 ing hormone (GnRH) represents a longstanding puzzle about extracellular signal decoding mechanisms.
45 ses to humans have occurred, leaving experts puzzled about molecular causes for such efficient crossi
46        This mechanism resolves long-standing puzzles about CaM/CaMK-dependent signaling to the nucleu
47  allowed us to resolve several long-standing puzzles about the atomistic OER mechanism.
48 atically the current knowledge and remaining puzzles about the retinal circuit with a focus on the mo
49    Whilst the scientific community was still puzzling about the cause of the aborted EN event in 2014
50 etween selective pressures in other cases of puzzling adaptive polymorphism.
51    Previous empirical attempts to solve this puzzle all presuppose that formal or informal institutio
52 e very uniqueness of human culture is both a puzzle and a problem.
53 screening strategy solves this long-standing puzzle and identifies NACHO, a transmembrane protein of
54 n, but their role has remained an intriguing puzzle and, up until now, no molecular system has provid
55 e also highlight open questions, theoretical puzzles and problems shared with computer science and in
56  a knotted structure remains one of the most puzzling and fascinating features of protein folding.
57                              One of the most puzzling and important facts about communication is that
58 ms of archaeal DNA transport have remained a puzzling and underinvestigated topic.
59 , were crucial in solving the solar neutrino puzzle, and allowed the determination of the smallest mi
60  0.035) in the affect recognition, geometric puzzle, and block construction scores, respectively.Vita
61 ocery list [P = .03], filling in a crossword puzzle answer [P = .003]), a score indicating satisfacti
62 ronze Age Minoan and Mycenaean cultures have puzzled archaeologists for more than a century.
63           The assessment metrics used in RNA-Puzzles are briefly described.
64                                          The puzzle arises because research into the factors that lim
65              This explains the long-standing puzzle as to why the neutralization of the intracellular
66                                        It is puzzling as to why more species have not adopted this ma
67                                      This is puzzling, as cooperation is vulnerable to exploitation b
68                                   One of the puzzling aspects in the visual attention literature is t
69                   Our results reveal several puzzling aspects of Drosophila dot chromosome biology to
70                              One of the most puzzling aspects of the prion diseases is the intricate
71  the past decade have elucidated many of the puzzles associated with coronavirus-receptor interaction
72 main evolutionary narratives for this rather puzzling association.
73 t in such contradictory ways has long been a puzzle at the molecular level.
74 young, hotter white dwarfs, which has been a puzzle because magnetic fields are expected to decay wit
75     The mechanism of this process remained a puzzle because no ternary complex was observed, and stru
76 ng these distinctive transport mechanisms is puzzling because CLC channels and transporters are expec
77                                     This was puzzling because S is thought to somehow correlate with
78                       These observations are puzzling because the seasonal H1N1 viruses circulating d
79                                      This is puzzling because the tissue at the anatomically defined
80    Bacteria represent an especially striking puzzle, because closely related strains possess radicall
81  processed in the brain has been an enduring puzzle, because there doesn't appear to be a single "pai
82 ng is a clinical concern, but its causes are puzzling, because alcohol (ethanol) is a calorie-dense n
83 cal basis for smaller lesions, they remained puzzling; because K1 antagonizes NF-kappaB in vitro, ant
84 w that the resulting model accounts well for puzzling behavioral data on human participants and makes
85        Our findings explain three previously puzzling behaviors seen in brown dwarf brightness variat
86  Our results thus help to explain a range of puzzling behaviors, such as extreme altruism, the use of
87  placodes in early branching vertebrates has puzzled biologists for over a century.
88  traditions for opening a bidirectional door puzzle box in replicate subpopulations of the great tit
89                                 We presented puzzle boxes, baited with food and scaled to accommodate
90 e an important piece of the obesity epidemic puzzle but little is known about the mechanism underlyin
91 al communicates across its network remains a puzzle, but Physarum polycephalum has emerged as a novel
92           Here we resolve this long-standing puzzle by atomic-scale observation of electron-gas forma
93        Herein, we resolved this longstanding puzzle by combining a detailed product analysis, with re
94  cellular decision-making aims to solve this puzzle by focusing on quantitative understanding of the
95 In this work, we finally complete the jigsaw puzzle by reporting the isolation of the first low valen
96 tionary game-theoretic models, we solve this puzzle by showing for the first time that out-group host
97  from spontaneous coronary vasospasm and was puzzled by these dramatic alterations in vasomotion.
98 w work provides a framework for solving such puzzles, by generation and analysis of whole genome asse
99 up to 188 nucleotides, including a blind RNA-puzzle challenge, the lariat-capping ribozyme.
100       In this review, we discuss some of the puzzling characteristics of VWF strings, and we debate w
101 nobstructive coronary arteries (MINOCA) is a puzzling clinical entity with no previous evaluation of
102 alanaerobiales and the Negativicutes shows a puzzling combination of monoderm and diderm features.
103 ds and considerations exhibits the otherwise puzzling combination of objective and subjective element
104 , group of inborn immunodeficiencies, with a puzzling complexity of cellular and molecular processes
105                           One of the central puzzles concerning the interaction of low Reynolds numbe
106 crustal composition; its north pole displays puzzling dark terrain.
107                                The seemingly puzzling datum that behavior decreases after punishing s
108 chers have often observed an unpredicted and puzzling decrease with repeated assessment.
109                One of the most inspiring and puzzling developments in the organic electronics communi
110  association with AMD and the reason for the puzzling difference with AD are unknown.
111 te improved knowledge, IBM continues to be a puzzling disease and the pathogenesis remains to be clar
112 n the BRaliBase benchmark, one can observe a puzzling drop in accuracy in the 40-60% sequence identit
113 strom macroglobulinemia (WM), a longstanding puzzle due to conflicting and incomplete data.
114 cleation of nanoclusters are a long-standing puzzle, due to the experimental difficulties in characte
115                             To explore these puzzling effects and their mechanisms further, we repeat
116 upra-exponential growth can thus explain the puzzling emergence of supermassive BHs that power lumino
117 on transmission and a framework to reconcile puzzling epidemiological features of certain prion disor
118 han at the indole nitrogen, this behavior is puzzling, even if the stabilizing effect of the V61K mut
119                              One of the most puzzling events in evolution is the reduction and loss o
120 re (PSAP)] that required rats to solve a new puzzle every day to gain access to cocaine, which they t
121 in MSO neurons, and it reconciles previously puzzling evoked potential results in humans and animals.
122  size and the mother's pelvic dimensions has puzzled evolutionary scientists for decades.
123 hus providing a possible explanation for the puzzling existence of two proteins sharing the same fold
124 f this idea provides insights into a host of puzzling experimental data, including savings and meta-l
125 aviour at low temperatures, but also explain puzzling experimental observations of coronene dating ba
126 e-induced biogenic control also explains the puzzling fact that the two extremes of high October ozon
127 an old concept that has lately become both a puzzling factor and a feature that should be harnessed t
128  some spectacular successes, along with some puzzling failures.
129                                            A puzzling feature of IDH1 mutation is the selective manif
130 ustaining extracellular matrix (D-ECM), is a puzzling feature of pancreatic ductal adenocarcinoma (PD
131 cellular prion protein of the host, PrP(C) A puzzling feature of prion formation is that certain PrP(
132                                            A puzzling feature of the long QT syndrome (LQTS) is that
133 to tension provided insights into previously puzzling features of the experimental response.
134                              One of the most puzzling features of the prehistoric record of hominid s
135                     This study addresses the puzzling finding that the direct entorhinal cortical inp
136 sitive GABAA receptors was paralleled by the puzzling findings suggesting that substantial separation
137 enetic clock") have the potential to address puzzling findings surrounding mortality rates and incide
138 as a key 'missing piece' of the aetiological puzzle for complex phenotypes across the biomedical scie
139            Progress towards unravelling this puzzle for Earth is hindered by the scarcity of well-pre
140 species has been a long-standing theoretical puzzle for ecologists.
141 of our moral cognition represents a profound puzzle for evolutionary approaches to human moral psycho
142  learning domain, this phenomenon has been a puzzle for learning models that operate exclusively on e
143                             We approach this puzzle from a reinforcement learning perspective: what k
144            Most research has approached this puzzle from the top down, using aggregate measures such
145 lly isolated and others are not is therefore puzzling from an evolutionary perspective.
146 rface aminopeptidase N (APN or CD13) has two puzzling functions unrelated to its enzymatic activity:
147 the uplift of intracontinental mountains has puzzled geologists for decades.
148 he clinical manifestations of some otherwise puzzling GGCX gene mutations in humans that cause phenot
149                Such effects are particularly puzzling given that the mitochondrial genes involved are
150 NAs across different species continues to be puzzling, given that they can exert similar functions wi
151                              A long-standing puzzle has been why the AU dincucleotide at the 5'-end o
152                                 Particularly puzzling has been the apparent lack of cooperativity in
153 piece of the endoplasmic reticulum targeting puzzle, highlighting how the targeting apparatus of the
154 pital in 1884 with an obscure condition that puzzled his contemporaries, and fascinates clinicians to
155 acks are large and heterogeneous, it remains puzzling how GRASP65 physically links Golgi stacks into
156 evalence of E-boxes in a genome, it has been puzzling how individual bHLH proteins selectively recogn
157                                        It is puzzling how nematodes can achieve this, seemingly witho
158                              It is even more puzzling how translocation is avoided after the primer s
159 d or impaired learning, raising a conceptual puzzle: how enhanced plasticity can yield opposite learn
160               In the light of this empirical puzzle, I argue that Van Lange et al.'s CLASH model woul
161                              This presents a puzzle: if the function of petals is to attract pollinat
162  long appreciated, this duality continues to puzzle immunologists and has implications for the develo
163 thus suggest a resolution to a long-standing puzzle in auditory neuroscience.
164 eezing point of water, remains a fundamental puzzle in biocatalysis.
165                                      A major puzzle in biology is how mammalian sperm maintain the co
166                                One recurring puzzle in both intra- and inter-species studies is the h
167 ng a molecular explanation for a 50-year-old puzzle in cancer biology.
168 of novel traits is a central but challenging puzzle in evolutionary biology.
169 homeostasis, or channelostasis, is a complex puzzle in neurons with extensive dendritic arborization,
170 very new study unveils an extra piece of the puzzle in our search for an understanding of allostery t
171                                  An enduring puzzle in the neuroscience of voluntary action is the or
172 WM) impairment in schizophrenia remain a key puzzle in understanding the cognitive deficits and dysfu
173 learning, a DNC can complete a moving blocks puzzle in which changing goals are specified by sequence
174  provides a unified account of long-standing puzzles in 3D vision at the physiological and perceptual
175 social religions and apply it to resolve two puzzles in human psychology and cultural history: (1) th
176 nt molecular-level insights on long-standing puzzles in nanochemistry, including LaMer growth, aggreg
177 anisms may clarify longstanding evolutionary puzzles in sexual selection and speciation.
178  of study, it remains one of the fundamental puzzles in the field of crystal growth.
179                         One of the important puzzles in virology is how viruses assemble the protein
180 g at such low stoichiometries has remained a puzzle, in part because of the large RNA-binding surface
181                          We describe the RNA-Puzzles initiative, which is a community-wide, blind ass
182    A missing and fundamental element of this puzzle is an understanding of how the sex composition of
183 rbed climate simulations, we argue that this puzzle is explained by weaker atmospheric circulation in
184                                          The puzzle is that the propensity for aggressive behavior wa
185               A key missing piece of the VO2 puzzle is the role of lattice vibrations.
186                                   The bigger puzzle is their lower frequency among the affluent.
187                           This long-standing puzzle is usually explained by charge inhomogeneity.
188 the neutrino mass hierarchy and to solve the puzzling issue of sterile neutrinos.
189 s of at least tens of kiloparsecs) are major puzzles largely unconstrained by observations.
190 ron pyrite single crystals to understand its puzzling low VOC.
191 eloped a semi-automated software tool-Genome Puzzle Master (GPM)-that enables the integration of addi
192                                          The puzzle may be solved by quantitative historical evidence
193                The resulting chicken-and-egg puzzle might be resolved if farming had been much more p
194                                            A puzzling observation is that amino acid starvation trigg
195   This theory, however, is questioned by the puzzling observation that some aHUS-associated mutations
196                                         This puzzling observation was ascribed to the dissociation of
197  an increasing number of data has revealed a puzzling observation, e.g., the delta(57)Fe for silicic
198 cid helices into aggregates produced several puzzling observations.
199            Efforts to solve the evolutionary puzzle of altruism have a lengthy history, and recent ye
200 egated during mitosis and meiosis is a major puzzle of biology and biophysics.
201                                      A major puzzle of decision making is how the brain decides which
202 enescence in mid-lifespan is an evolutionary puzzle of enduring interest because it should be inheren
203                                 It is also a puzzle of enormous medical importance given the incidenc
204 ion is not only fundamental in resolving the puzzle of homochirality, but also instructive in chiral
205                                          The puzzle of how hydrophobic free energy can be proportiona
206 ize minus ends, providing a key piece to the puzzle of how these minus ends are formed and stabilized
207 discovery provides an important piece to the puzzle of how zinc buffering occurs in a large number of
208                                    A central puzzle of nitrogenase function is an apparently obligato
209 o the host interferon response and solve the puzzle of the lack of translational shutdown observed in
210 osed mechanism add an important piece to the puzzle of the mechanism of FDTS and suggest a new class
211 that the proposed mechanism may, unravel the puzzle of the origin of ultra high energy cosmic ray ele
212 as pivotal to the evolution of life, but the puzzle of when and how atmospheric oxygen (O2) first app
213 ically very old; 5) solved the long-standing puzzle of where memory traces are formed in the brain wh
214 rovides an explanation for the long-standing puzzle of why strong correlations between speech underst
215 ter in the Universe remains one of the prime puzzles of cosmology and particle physics today-80 y aft
216 sland of Madagascar remains one of the great puzzles of Indo-Pacific prehistory.
217           This can resolve the long-standing puzzle on progression from Human T-cell Lymphotropic Vir
218 cient supercontinent Gondwana - except for a puzzling outpost in southeast Asia.
219 The Spanish artist Diego Velazquez created a puzzle-painting 360 years ago that to this day remains u
220           This mechanism explains previously puzzling phenomena, including the adaptation of the peri
221 nly experimentally confirmed example of this puzzling phenomenon is expression of the bacteriophage T
222 ree volume gradient, helps to understand the puzzling phenomenon of photoinduced macroscopic material
223 curs despite adequate oxygen availability, a puzzling phenomenon termed aerobic glycolysis.
224 ative behavior, a natural, pervasive and yet puzzling phenomenon, can be significantly enhanced by ne
225 n wall-bounded shear flows has resulted in a puzzling picture in which turbulence appears in a variet
226  the Mediterranean referral centers offers a puzzling picture of the capacities to deal with the emer
227                Experimental probes present a puzzling picture of the mechanistic details of the pathw
228 composed of a heterogeneous mosaic of jigsaw puzzle piece-shaped pavement cells that vary greatly in
229               Leaf epidermis contains jigsaw puzzle piece-shaped pavement cells whose shape has been
230                                              Puzzle pieces for a broader view of neutrophil homeostas
231 cts with assembly properties (fanciful ball, puzzle pieces, 3D pixels, propellers, fluidic and multic
232                    The origin of flowers has puzzled plant biologists ever since Darwin referred to t
233                               Completing the puzzle, population genetic analyses discriminated Corsic
234                                         Such puzzling properties have been interpreted either as evid
235               Among the most distinctive and puzzling properties of these compounds is their ability
236                                            A puzzling property of synaptic transmission, originally e
237 ears to be one important explanation for the puzzling question of why addicted individuals continue d
238 the host and the microbiota may help resolve puzzling questions such as how a microorganism can contr
239                            One long-standing puzzle regarding RTKs centers on how the extracellular d
240  described in terms of resonant bonding, but puzzles remain, particularly regarding different physica
241                                         Many puzzles remain, the greatest being understanding the sel
242                              A long-standing puzzle remains unsolved: why the Au surfaces with {100}
243                                   Hence, the puzzle remains: how a single-amino-acid difference betwe
244                      This explains both, the puzzling requirement of Egfr in oncogenic Ras-mediated o
245                                 Solving this puzzle requires us to identify the genes underlying intr
246              A fundamental question that has puzzled researchers for decades is how the transition fr
247    Although their structural design has long puzzled researchers, only a limited model for sesamoid b
248                                         This puzzling result was studied theoretically for the case o
249 utionary history that would account for this puzzling result, we analyzed extensive genomic data incl
250                                        These puzzling results prompted us to ask whether neuroligin-3
251      Even though their exact structures have puzzled scientists for decades, superhard transition-met
252 titative biochemical measurements, which has puzzled scientists for decades.
253 e oxic water column of marine ecosystems has puzzled scientists over the past years.
254 novel cocaine self-administration procedure [puzzle self-administration procedure (PSAP)] that requir
255 ly, we note that such breaks may explain the puzzling 'self-inflicted wounds' at the ends of the Mos1
256 used to segment a large population of jigsaw-puzzle shaped epidermal cells from Arabidopsis thaliana
257 lant species, PCs form highly complex jigsaw-puzzle-shaped cells with interlocking lobes.
258                                   The jigsaw puzzle-shaped pavement cells in the leaf epidermis colle
259                          The latter event is puzzling, since spore heat resistance is due largely to
260                          This unexpected and puzzling situation is a vexing issue in the pulmonary co
261  responsible for the oceanic anoxia that has puzzled so many researchers for so many years.
262 omputational time, programming expertise, or puzzle-solving talent has emerged as a powerful tool for
263 on-inducible M cells, provides an intriguing puzzle: some variants may augment luminal surveillance t
264                  The Galactic Centre hosts a puzzling stellar population in its inner few parsecs, wi
265 r the last decade have repeatedly revealed a puzzling strong preference towards minimally chiral (nea
266 on and that this explains to some degree the puzzling structural heterogeneity of anesthetics.
267 he NEPSY II affect recognition and geometric puzzle subtests.
268                               The scientific puzzle that fascinated me most was the metabolism of the
269  level may represent only a small piece of a puzzle that is linked to the entire picture.
270 ation, scientists get their kicks by solving puzzles that advance biomedical research.
271 es such studies have revealed and ponder the puzzles that remain to be solved.
272 ke artists who get their thrills by creating puzzles that stimulate the imagination, scientists get t
273                                     It seems puzzling that females have not evolved wider pelvises de
274                                        It is puzzling that highly evolved, crystal-poor silicic magma
275                                   Thus it is puzzling that statistics show violence and out-group con
276                                        It is puzzling that this extracellular DNA of M. tuberculosis
277 fference in sign of volume changes have been puzzling the field for the past 50 years.
278 rials with unusual properties that have been puzzling the scientific community since their discovery.
279 nd clinicians with a veritable physiological puzzle, the pieces of which--many of them unknown--are c
280                                        It is puzzling, therefore, that the sulfur isotope record of t
281 ct connects 37,000 enthusiasts to RNA design puzzles through an online interface.
282                  It has been an old unsolved puzzle to evolutionary theorists on which mechanisms wou
283 edback controls work in insects is a complex puzzle to solve.
284 catalysts coevolved remains a mystery in the puzzle to understand the origin of life.
285  in rats by requiring animals to solve daily puzzles to gain access to cocaine.
286 ce of an identical molecular defect is still puzzling to the research field.
287 lowed us to better understand the previously puzzling topographic features of plate interiors and con
288 ifferent retroviruses, including HIV-1, have puzzled virologists for over 20 years.
289                 In the midst of this genomic puzzle, viruses, especially those that infect microbial
290                                          The puzzle was resolved in OPPERA's nested case-control stud
291 er, searching a medical image diverges, in a puzzling way, from the typical search for a target featu
292                              To unravel this puzzle, we employed a poly(A) tag sequencing protocol an
293 ternative neural pathways could explain this puzzle, we investigated patients with callosal dysgenesi
294                        However, it remains a puzzle where and through which route the near-inertial e
295                               This creates a puzzle, which calls for reconceptualization of the relat
296 eral intelligence poses a major evolutionary puzzle, which has led to increased interest in its prese
297 ic neuronal subtype rather than another is a puzzle whose solution underlies the development of speci
298                         It is a longstanding puzzle why non-coding variants in the complement factor
299 ce, often called the "Axial Age," presents a puzzle: why did this emerge at the same time as distinct
300                             Reasons for this puzzling, yet important phenomenon, are not understood.

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