ライフサイエンスコーパス: pyogenes

1 el factors related to the invasiveness of S. pyogenes.

2 d by Staphylococcus aureus and Streptococcus pyogenes.

3 in response to infection with Streptococcus pyogenes.

4 tide from the mucosal pathogen Streptococcus pyogenes.

5 on proteins from the bacterium Streptococcus pyogenes.

6 ributes to the immune evasion strategy of S. pyogenes.

7 sive M3-type strain MGAS315 of Streptococcus pyogenes.

8 (SLO), a virulence factor from Streptococcus pyogenes.

9 sidues in YtgP, a homolog from Streptococcus pyogenes.

10 n by the Rgg2/3 quorum-sensing circuit in S. pyogenes.

11 lase secreted by the bacterium Streptococcus pyogenes.

12 rtant role in the virulence of Streptococcus pyogenes.

13 nd removal of read-through transcripts in S. pyogenes.

14 zed murine vaginal colonization model for S. pyogenes.

15 es contained in HIV, M. tuberculosis, and S. pyogenes.

16 also for invasion of endothelial cells by S. pyogenes.

17 ae, Staphylococcus aureus, and Streptococcus pyogenes.

18 d antigen detection assays for Streptococcus pyogenes.

19 al for the in vivo survival of Streptococcus pyogenes.

20 biological diagnosis of empyema caused by S. pyogenes.

21 e clinically relevant pathogen Streptococcus pyogenes.

22 ely, Staphylococcus aureus and Streptococcus pyogenes.

23 from Staphylococcus aureus and Streptococcus pyogenes.

24 with the riboflavin auxotroph Streptococcus pyogenes.

25 n cells and kill intracellular Streptococcus pyogenes.

26 and the function of VNTR polymorphisms in S. pyogenes.

27 43.5%] vs 4 [12.9%]; P = .02), Streptococcus pyogenes (2 [8.7%] vs 19 [61.3%]; P < .001) and Escheric

28 N-beta, which is significantly induced by S. pyogenes 23S rRNA in an Irf5-dependent manner.

29 pproach, we have identified in Streptococcus pyogenes a gene that exhibits a receptor-like function f

30 resulting from infection with Streptococcus pyogenes (a group A Streptococcus [GAS]) can be associat

31 In Streptococcus pyogenes, a common and potentially deadly pathogen, many

32 Streptococcus pyogenes, a human-restricted pathogen, accounts for subs

33 Streptococcus pyogenes activates IFN-I production in innate immune cel

34 y ADP-ribosyltransferase designated SpyA (S. pyogenes ADP-ribosyltransferase).

35 oribosyltransferase activity of NadC from S. pyogenes allows the organism to sustain growth when Qa i

36 Streptococcus pyogenes , also known as group A streptococcus (GAS), is

37 result for samples containing Streptococcus pyogenes and a negative result for those without.

38 ed an RNase III null mutant of Streptococcus pyogenes and its RNA sequencing (RNA-Seq) data were anal

39 type II CRISPR/Cas system from Streptococcus pyogenes and its simplified derivative, the Cas9/single

40 to in vitro penetration by S. aureus and S. pyogenes and partially resistant to P. aeruginosa.

41 hal soft tissue infection with Streptococcus pyogenes and prevented bacterial dissemination.

42 inst Staphylococcus aureus and Streptococcus pyogenes and protected against staphylococcal alpha-toxi

43 iagnose include Staphylococci, Streptococcus pyogenes and Pseudomonas aeruginosa in blepharitis; Stap

44 Finally, we assess comparative S. pyogenes and S. aureus Cas9 specificity using GUIDE-seq.

45 rarely, been reported for the Streptococcus pyogenes and S. bovis groups of species, even though man

46 al of clinical and laboratory isolates of S. pyogenes and S. pneumoniae as both organisms are thought

47 om those recognized by Cas9 proteins from S. pyogenes and S. thermophilus (SpCas9 and StCas9, respect

48 Both Streptococcus pyogenes and Streptococcus pneumoniae are widely thought

49 common human pathogens, e.g., Streptococcus pyogenes and Streptococcus pneumoniae.

50 y two CRISPR-Cas systems (from Streptococcus pyogenes and Streptococcus thermophilus), each with thei

51 combine the CRISPR system from Streptococcus pyogenes and synthetic antisense RNAs (asRNAs) in Escher

52 tion the toxin has to the pathogenesis of S. pyogenes and that both versions of SPN play an important

53 of patients with GP respond to Streptococcus pyogenes and whether this initial immune response is fav

54 orrhoeae, Salmonella enterica, Streptococcus pyogenes and Xenorhabdus nematophila.

55 EndoS (an endoglycosidase from Streptococcus pyogenes ) and were found to be capable of efficiently t

56 ive (Staphylococcus aureus and Streptococcus pyogenes) and gram-negative bacteria (Pseudomonas aerugi

57 ureus, Pseudomonas aeruginosa, Streptococcus pyogenes, and Candida albicans.

58 Moraxella catarrhalis, S. pyogenes, and culture-negative episodes were also signif

59 (NTHi), Moraxella catarrhalis, Streptococcus pyogenes, and culture-negative OM.

60 2) For L. plantarum, S. pyogenes, and E. faecalis, the effects of Pi are disting

61 of NadD confirmed its functional role in S. pyogenes, and its potential as an antibacterial target w

62 from Staphylococcus aureus and Streptococcus pyogenes, and recombinant Cas9 and developed protocols f

63 and Streptococcus agalactiae, Streptococcus pyogenes, and Streptococcus salivarius in 1 patient each

64 Streptococcus pyogenes, and to a lesser extent, Staphylococcus aureus,

65 in-resistant S. aureus (MRSA), Streptococcus pyogenes, and vancomycin-resistant Enterococcus faecalis

66 Streptococcus pyogenes AP1, a strain of the highly virulent M1 serotyp

67 Streptococcus pneumoniae, and Streptococcus pyogenes, are most commonly isolated.

68 h as Staphylococcus aureus and Streptococcus pyogenes, are the dominant organisms isolated early in t

69 on the tip of the T3 pilus of Streptococcus pyogenes as a fusion to the Cpa protein (LL-Gag).

70 th of the pathogenic bacterium Streptococcus pyogenes as effectively as melittin created by solid pha

71 pathogen the group A Streptococcus (GAS; S. pyogenes) as a model organism, we review the types and r

72 the need for a refined model of prolonged S. pyogenes asymptomatic mucosal colonization, we have adap

73 e FIC of >2.5 mM, while those of Bacteroides pyogenes, B. fragilis, and Akkermansia muciniphila were

74 The BC-GP detected a case of Streptococcus pyogenes bacteremia but failed to detect 2/3 clinical bl

75 allenged by HRG, sHIP was found to rescue S. pyogenes bacteria.

76 ansgenic mouse model expressing human FH (S. pyogenes binds FH in a human-specific manner).

77 peptide based on F1 adhesin of Streptococcus pyogenes, binds by anti-parallel beta-strand addition to

78 lls prevented nasopharyngeal infection by S. pyogenes, but not by Streptococcus pneumoniae, a bacteri

79 s in mastitis cases diagnosed as Trueperella pyogenes by culture, Streptococcus dysgalactiae sequence

80 r, these data show that ME contributes to S. pyogenes' carbon source repertory, that malate utilizati

81 ing modules, the nuclease-dead Streptococcus pyogenes Cas9 (dCas9) protein, which recognizes a specif

82 get effects of the widely used Streptococcus pyogenes Cas9 (SpCas9) are imperfect, possessing only pa

83 we show that the commonly used Streptococcus pyogenes Cas9 (SpCas9) can be modified to recognize alte

84 The success of Streptococcus pyogenes Cas9 (SpCas9) has led to the discovery of sever

85 The Streptococcus pyogenes Cas9 (SpCas9) nuclease can be efficiently targe

86 -cassette system expressing pieces of the S. pyogenes Cas9 (SpCas9) protein which splice together in

87 Streptococcus pyogenes Cas9 (SpCas9), a CRISPR-associated protein, has

88 is significantly smaller than Streptococcus pyogenes Cas9 (SpCas9), to facilitate efficient in vivo

89 ncy as previously reported for Streptococcus pyogenes Cas9 (SpCas9).

90 with those of the widely used Streptococcus pyogenes Cas9 (SpCas9).

91 to improve the specificity of Streptococcus pyogenes Cas9 (SpCas9).

92 , compared to 45 degrees C for Streptococcus pyogenes Cas9 (SpyCas9), which expands the temperature r

93 vity, and reaction kinetics of Streptococcus pyogenes Cas9 activity, we challenged libraries of rando

94 Structures of Streptococcus pyogenes Cas9 alone or bound to single-guide RNA (sgRNA)

95 with mutually permissive NGGRRT PAMs, the S. pyogenes Cas9 and S. aureus Cas9 yield indels at compara

96 successfully delivered a plasmid encoding S. pyogenes Cas9 and sgRNA to the corneal epithelium by int

97 Streptococcus pyogenes Cas9 cleavage of the viral genome requires the

98 Here we show that the Streptococcus pyogenes Cas9 DNA endonuclease and single guide RNAs (sg

99 pressing maize codon-optimized Streptococcus pyogenes Cas9 endonuclease and single guide RNAs were co

100 eport the crystal structure of Streptococcus pyogenes Cas9 in complex with sgRNA and its target DNA a

101 Confirmation that S. pyogenes Cas9 lacks the specificity to discriminate betw

102 tgRNA) that repeatedly directs Streptococcus pyogenes Cas9 nuclease activity toward the DNA that enco

103 the cleavage efficiency of the Streptococcus pyogenes Cas9 protein based on expression using three di

104 es of the catalytically active Streptococcus pyogenes Cas9 R-loop that show the displaced DNA strand

105 s shows that in contrast to the type II-A S. pyogenes Cas9 that is widely used for genome engineering

106 sign rules and paired S. aureus Cas9 with S. pyogenes Cas9 to achieve dual targeting in a high fracti

107 s also blocked the widely used Streptococcus pyogenes Cas9 when assayed in Escherichia coli and human

108 ning a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of

109 ng only the well-characterized Streptococcus pyogenes Cas9, by incorporating MS2 or PP7 RNA aptamers

110 M. tuberculosis, the existing Streptococcus pyogenes Cas9-based CRISPRi system is of limited utility

111 Streptococcus pyogenes Cas9-guide RNA (gRNA) was successfully applied

112 for target site recognition by Streptococcus pyogenes Cas9.

113 studies to date utilizing the Streptococcus pyogenes Cas9.

114 spacer-adjacent motif (PAM) of Streptococcus pyogenes Cas9.

115 For the Gram-positive pathogen Streptococcus pyogenes, catabolism of the amino acid arginine via the

116 Trueperella pyogenes causes tissue pathology in many mammals by secr

117 nd activity of SLO, DNase, and Streptococcus pyogenes cell envelope protease in vitro.

118 e form of the streptococcal CXC protease, S. pyogenes cell envelope proteinase, we developed a combin

119 d that the cluster was caused by a unique S. pyogenes clone.

120 Thus, human immune responses against S. pyogenes consist of a robust Th1 cellular memory respons

121 PRi system is derived from the Streptococcus pyogenes CRISPR (clustered regularly interspaced palindr

122 The Cas9 protein from the Streptococcus pyogenes CRISPR-Cas acquired immune system has been adap

123 RISPR-Cas systems, such as the Streptococcus pyogenes CRISPR-Cas9 system, can be adapted such that Ca

124 re, we demonstrate that nuclease-inactive S. pyogenes CRISPR/Cas9 can bind RNA in a nucleic-acid-prog

125 The Mga regulator of Streptococcus pyogenes directly activates the transcription of a core

126 de- and tetracycline-resistant Streptococcus pyogenes emm12 isolates represent the majority of clinic

127 bacterial endoglycosidase from Streptococcus pyogenes , EndoS, is complementary to other known endogl

128 In conclusion, we have identified a novel S. pyogenes enzyme with 5'-nucleotidase activity and immune

129 S. pyogenes expresses HSA-binding surface proteins, and HSA

130 e cocultured ex vivo in the presence of an S pyogenes extract.

131 he utility of our model for investigating S. pyogenes factors contributing to mucosal carriage was ve

132 Streptococcus pyogenes fibronectin-binding protein FbaB contains a dom

133 The "Big Papi" (paired aureus and pyogenes for interactions) approach described here will

134 ut not methicillin-resistant S. aureus or S. pyogenes from cellulitis tissue specimens.

135 of the human pathogen group A Streptococcus pyogenes (GAS) and subsequent hPg activation to the prot

136 M-proteins (M-Prt) in group A Streptococcus pyogenes (GAS) are surface-expressed virulence factors i

137 phylococcus aureus and group A Streptococcus pyogenes (GAS) express superantigen (SAg) exotoxin prote

138 A emm53 subclass of Group A Streptococcus pyogenes (GAS) interacts tightly with human plasma plasm

139 Infection by Group A Streptococcus pyogenes (GAS) is a leading cause of severe invasive dis

140 Group A Streptococcus pyogenes (GAS) strain AP53 is a primary isolate from a p

141 A skin-tropic invasive group A Streptococcus pyogenes (GAS) strain, AP53, contains a natural inactiva

142 nophagocytosis enables group A Streptococcus pyogenes (GAS) to establish infection.

143 n genomic study of the group A Streptococcus pyogenes (GAS), a human pathogen with highly recombining

144 fluorescence intensity of the Streptococcus pyogenes gave a signal that is up to 16.4 times higher t

145 that can detect intergenic regions of the S. pyogenes genome.

146 pyogenes genomes and 3407 sequence runs deposited in the

147 Genomic analyses of available S. pyogenes genomes revealed the presence of intact genes w

148 Infections caused by Streptococcus pyogenes (group A Streptococcus [GAS]) are highly preval

149 Streptococcus pyogenes (group A Streptococcus [GAS]) is a leading huma

150 (Rgg2/3) regulatory circuit of Streptococcus pyogenes (group A streptococcus [GAS]) is one of only a

151 The important human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]) produces a hyalur

152 efflux in the pathogenesis of Streptococcus pyogenes (group A Streptococcus [GAS]), a human pathogen

153 rtholog has been identified in Streptococcus pyogenes (group A streptococcus [GAS]).

154 All sequenced genomes of Streptococcus pyogenes (Group A Streptococcus, GAS) encode a protein,

155 tive human-restricted pathogen Streptococcus pyogenes (Group A Streptococcus, GAS) has long focused o

156 The human-restricted pathogen Streptococcus pyogenes (Group A Streptococcus, GAS) is responsible for

157 Streptococcus pyogenes (Group A Streptococcus; GAS) is a major cause o

158 Streptococcus pyogenes [group A Streptococcus; (GAS)] is a major etiol

159 We demonstrated that S. pyogenes has an unusually high mRNA turnover rate, with

160 editing using CRISPR/Cas9 from Streptococcus pyogenes has enabled rapid and accessible alteration of

161 atalytically, in the pili from Streptococcus pyogenes has highlighted the role that such cross-links

162 e cells, and the cellular role of GdpP in S. pyogenes has not been examined yet.

163 Hypervirulent strains of S. pyogenes have evolved a plethora of virulence factors th

164 globulin G-degrading enzyme of Streptococcus pyogenes (IdeS) followed by chemical reduction.

165 -degrading enzyme derived from Streptococcus pyogenes (IdeS), an endopeptidase, cleaves human IgG int

166 nzyme, IgG-degrading enzyme of Streptococcus pyogenes (IdeS), was shown to specifically cleave IgG mo

167 globulin G-degrading enzyme of Streptococcus pyogenes (IdeS), which is capable of digesting IgGs in o

168 gainst IgG-degrading enzyme of Streptococcus pyogenes (IdeS)- or pepsin-generated F(ab')2 fragments o

169 terial IgG degrading enzyme of Streptococcus pyogenes , IdeS.

170 ors were also able to specifically detect S. pyogenes in 50% (v/v) human saliva, with good selectivit

171 he human adaptive immune response against S. pyogenes in both children and adults.

172 e T cells activated by epidermal cells and S pyogenes in patients with GP.

173 that promoted opsonophagocytic killing of S. pyogenes in vitro and provided passive immunity in vivo.

174 We found that FH6-7/Fc alleviated S. pyogenes-induced sepsis in a transgenic mouse model expr

175 S. pyogenes-induced Th17 formation depended on TGF-beta1 fr

176 I interferons produced during Streptococcus pyogenes infection are required to prevent inflammation-

177 naling protects the host against invasive S. pyogenes infection by restricting inflammation-driven da

178 unctive treatment for clinical Streptococcus pyogenes infection however, the protein targets of the r

179 d the finding that patients with invasive S. pyogenes infection respond with antibody production agai

180 oled human immunoglobulin during invasive S. pyogenes infection, and demonstrate a potential route to

181 -deficient mice are highly susceptible to S. pyogenes infection.

182 ssociated with severe invasive Streptococcus pyogenes infections.

183 o obtain new information about Streptococcus pyogenes intrahost genetic variation during invasive inf

184 adhesive is capable of killing Streptococcus pyogenes introduced subcutaneously at the bioadhesive's

185 ny virulence factors promoting Streptococcus pyogenes invasive disease have been described, specific

186 Streptococcus pyogenes is a significant bacterial pathogen in the huma

187 protein secretion organelle in Streptococcus pyogenes is an anionic phospholipid-containing membrane

188 Streptococcus pyogenes is an important human pathogen that causes a wi

189 )-associated protein Cas9 from Streptococcus pyogenes is an RNA-guided DNA endonuclease with widespre

190 ath in the United Kingdom, and Streptococcus pyogenes is the leading pathogen.

191 tors for the survival and colonization of S. pyogenes is well established, and many of these factors

192 he group A Streptococcus (GAS, Streptococcus pyogenes) is a Gram-positive bacterial pathogen from whi

193 he Group A Streptococcus (GAS, Streptococcus pyogenes) is a Gram-positive human pathogen that must ad

194 Group A Streptococcus (GAS, Streptococcus pyogenes) is a human-restricted pathogen with a capacity

195 nd 30 S. aureus, 15 S. pneumoniae, and 15 S. pyogenes isolates by disk diffusion (DD) methods.

196 All cluster-associated S. pyogenes isolates were genotype emm1 and were initially

197 the absence of FBP, Pi is an activator of S. pyogenes LDH, E. faecalis LDH1, and L. lactis LDH1 and L

198 alis LDH1 < L. lactis LDH1 </= Streptococcus pyogenes LDH.

199 ns of people are infected with Streptococcus pyogenes, leading to an estimated 500,000 annual deaths

200 ocused experimental testing in Streptococcus pyogenes, led to a better understanding of NAD metabolis

201 rol protein modules 6 and 7) that bind to S. pyogenes, linked to the Fc region of IgG (FH6-7/Fc).

202 lly inactive Cas9 (dCas9) from Streptococcus pyogenes loaded with single guide RNAs (sgRNAs) in mouse

203 us aureus (</=0.12 microg/mL), Streptococcus pyogenes (</=0.12 microg/mL), Streptococcus agalactiae (

204 S. pyogenes MHC class II-bound peptide-specific CD4(+) T ce

205 d Northern blot analyses to determine the S. pyogenes mRNA half-life of the transcriptome and to unde

206 ld prove effective for future analyses of S. pyogenes mucosal colonization.

207 Now S. pyogenes NAATs are being used with increasing frequency.

208 and Robin Patel of the Mayo Clinic, where S. pyogenes NAATs have been used for well over a decade wit

209 The Streptococcus pyogenes NAD(+) glycohydrolase (SPN) is secreted from th

210 larger amounts of the secreted cytotoxins S. pyogenes NADase (SPN) and streptolysin O (SLO).

211 so prevented penetration by S. aureus and S. pyogenes; NeoForm was less effective in withstanding the

212 combinant S5nA acted synergistically with S. pyogenes nuclease A to generate macrophage-toxic deoxyad

213 Two postpartum deaths caused by S. pyogenes occurred within 24 h; one was characterized by

214 sis of an endoglycosidase from Streptococcus pyogenes of serotype M49 (Endo-S2) and the evaluation of

215 Streptococcus pyogenes, one of the most common human pathogens, secret

216 Streptococcus pyogenes (or group A streptococcus [GAS]) is a major hum

217 an be applied for specific agents such as S. pyogenes, or commercial multiplex NAATs for detection of

218 Streptococcus pyogenes, or group A Streptococcus (GAS), is a human bac

219 Streptococcus pyogenes, or group A Streptococcus (GAS), is a pathogen

220 h SPN and SLO contribute significantly to S. pyogenes pathogenesis in these virulence assays.

221 st sHIP suggest a role for the protein in S. pyogenes pathogenesis.

222 nding of the function of the sal locus in S. pyogenes pathogenesis.

223 infection in a mouse model of Streptococcus pyogenes peritonitis.

224 am-positive bacterial pathogen Streptococcus pyogenes produces a C3 family ADP-ribosyltransferase des

225 The human pathogen Streptococcus pyogenes produces pili that are essential for adhesion t

226 e pathogenic bacterium Group A Streptococcus pyogenes produces several extracellular DNases that have

227 , we quantitatively analyzed and compared S. pyogenes proteins in the growth medium of a strain that

228 Pyolysin (PLO) from Trueperella pyogenes provided a unique opportunity to explore cellul

229 Streptococcus pyogenes ranks among the main causes of mortality from b

230 how SAgs contribute to the life cycle of S. pyogenes remain poorly understood.

231 n, the elucidation of GAC biosynthesis in S. pyogenes reported here enhances our understanding of how

232 nducted on streptolysin O from Streptococcus pyogenes revealed that this CDC also has glycan-binding

233 Streptococcus pyogenes Rgg is a transcriptional regulator that interac

234 identify mutations in rgg2 of Streptococcus pyogenes (rgg2Sp ) that conferred pheromone-independent

235 nst most streptococcal species, including S. pyogenes, S. agalactiae, S. dysgalactiae, S. equi, S. mu

236 t the meconium SALSA, bound to Streptococcus pyogenes, S. agalactiae, S. gordonii, and Escherichia co

237 ogenic streptococci, including Streptococcus pyogenes, S. agalactiae, S. pneumoniae, and S. equi.

238 Streptococcus pyogenes secretes many toxins that facilitate human colo

239 he globally prominent pathogen Streptococcus pyogenes secretes potent immunomodulatory proteins known

240 s Streptococcus pneumoniae and Streptococcus pyogenes, SEER identifies relevant previously characteri

241 Trueperella pyogenes sequences were the second most prevalent sequen

242 t genome sequence of a group A Streptococcus pyogenes serotype M23 (emm23) strain (M23ND), isolated f

243 ntified across four contemporary invasive S. pyogenes serotypes (M1, M3, M12 and M89).

244 The well-characterized Scl1 proteins of S. pyogenes show a dichotomous switch in ligand binding bet

245 reus sortase A) or LPXTA (for Staphylococcus pyogenes sortase A), can be appended to a variety of pro

246 ociated endonuclease Cas9 from Streptococcus pyogenes (spCas9) along with a single guide RNA (sgRNA)

247 iated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) can be used to edit single or multiple

248 ided CRISPR-Cas9 nuclease from Streptococcus pyogenes (SpCas9) has been widely repurposed for genome

249 ays demonstrate that Cas9 from Streptococcus pyogenes (SpCas9) is more active in creating double-stra

250 iated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) is used to deplete VEGFR2 in vascular

251 of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for basic research

252 phage-encoded endolysin, lyses Streptococcus pyogenes (Spy) on contact.

253 ther virulent pathogens (e.g., Streptococcus pyogenes, Staphylococcus aureus, and potentially Haemoph

254 g bioinformatics analysis of the complete S. pyogenes strain SF370 genome, we have identified a novel

255 N and SLO in epidemic serotype M1 and M89 S. pyogenes strains is associated with rapid intercontinent

256 ariation, we pooled DNA of 100 Streptococcus pyogenes strains of different emm types in two pools, ea

257 atants prepared from cultures of invasive S. pyogenes strains of varying serotypes in the stationary

258 uestion, we discovered that all sequenced S. pyogenes strains possess the genes for the malic enzyme

259 S. pyogenes strains with this type of polymorphism cause hu

260 and/or systemic infections by Streptococcus pyogenes, Streptococcus pneumoniae, Listeria monocytogen

261 encoded by Bacillus subtilis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus mutans

262 canonical PAM preferences for Streptococcus pyogenes, Streptococcus thermophilus CRISPR3 (Sth3), and

263 mortality when associated with Streptococcus pyogenes superinfection.

264 The important human pathogen, Streptococcus pyogenes, synthesizes a key antigenic surface polymer, t

265 For many years, S. pyogenes testing algorithms used a rapid and specific gr

266 erized an intergenic VNTR polymorphism in S. pyogenes that affects toxin production and virulence.

267 based on a protein domain from Streptococcus pyogenes, that locks itself together via spontaneous iso

268 ion and increased virulence in Streptococcus pyogenes The nature of the polymorphism is a one-unit de

269 an exclusively human pathogen, Streptococcus pyogenes (the group A streptococcus [GAS]) has specifica

270 strains of the human pathogen Streptococcus pyogenes (the group A Streptococcus [GAS]).

271 , including the human pathogen Streptococcus pyogenes(the group A Streptococcus[GAS]), we characteriz

272 sms, Staphylococcus aureus and Streptococcus pyogenes, the activity is dependent on prior lipoylation

273 the human-pathogenic bacterium Streptococcus pyogenes, the tagatose bisphosphate aldolase LacD.1 like

274 st the Gram-positive bacterium Streptococcus pyogenes This protein is composed of two domains of comp

275 ving outbreak highlights the potential of S. pyogenes to cause a range of diseases in the puerperium

276 shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacteriu

277 linical settings, by a throat culture for S. pyogenes to increase the sensitivity of its detection.

278 The ability of Streptococcus pyogenes to infect different niches within its human hos

279 llustrating the intrinsic ability of emm1 S. pyogenes to spread while retaining virulence.

280 escued, demonstrating that the ability of S. pyogenes to utilize arginine was dispensable in the abse

281 n found that between 3.7 and 28.5% of the S. pyogenes transcripts were differentially expressed, depe

282 nd some Gram-positive pathogens including S. pyogenes use this cyclic nucleotide derivative as a seco

283 s a novel mechanism of virulence by which S. pyogenes uses its metabolism to modulate innate immunity

284 markably, these observations suggest that S. pyogenes uses SAgs to manipulate Vbeta-specific T cells

285 nslocation (CMT), performed by Streptococcus pyogenes, utilizes the cholesterol-dependent cytolysin S

286 of reports of hypervirulent SpeB-negative S. pyogenes variants present during invasive infections.

287 SF370 genome, we have identified a novel S. pyogenes virulence factor, which we termed streptococcal

288 dependent manner, suggesting a role as an S. pyogenes virulence factor.

289 rophil extracellular traps, and modulates S. pyogenes virulence.

290 reus was not found by culture or PCR, and S. pyogenes was not identified by any technique.

291 The Cas9 protein from Streptococcus pyogenes was pre-complexed with a single guide RNA targe

292 e pilus tip adhesin Spy0125 of Streptococcus pyogenes, we developed a single molecule assay to unambi

293 Biotin tagged whole antibodies against S. pyogenes were conjugated to Ptyr amine group via biotin-

294 epitope from the M protein of Streptococcus pyogenes, were designed by exchanging one amino acid at

295 t antibody complex specific to Streptococcus pyogenes, were volumetrically normalized according to th

296 IdeS (IgG-degrading enzyme of Streptococcus pyogenes), which selectively cleaves IgG antibodies to y

297 d promiscuity of epitopes from Streptococcus pyogenes, which is known to exhibit epitope diversity, a

298 bacterial pathogens, including Streptococcus pyogenes, which utilizes the cholesterol-dependent cytol

299 surface of Gram-positive bacteria such as S. pyogenes will enable professional phagocytes to eliminat

300 ed system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of