ライフサイエンスコーパス: pyridoxal

1 hosphates and plays an important role in the pyridoxal 5' phosphate salvage pathway.

2 In S. enterica, 2AA inactivates a number of pyridoxal 5'-phosephate(PLP)-dependent enzymes, some of

3 antile spasms (onset 5 months) responsive to pyridoxal 5'-phosphate (n = 1); and (iii) patients with

4 s with neonatal onset seizures responding to pyridoxal 5'-phosphate (n = 6); (ii) a patient with infa

5 sample preparation procedure for quantifying pyridoxal 5'-phosphate (PLP) and 4-pyridoxic acid (4PA)

6 In the case of the pyridoxal 5'-phosphate (PLP) and cobalamin-dependent enz

7 aeruginosa PAO1 in complex with the cofactor pyridoxal 5'-phosphate (PLP) and product UDP-GlcNAc(3NH(

8 Pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phospha

9 ian HAD phosphatase known to dephosphorylate pyridoxal 5'-phosphate (PLP) and serine/threonine-phosph

10 Low plasma concentrations of pyridoxal 5'-phosphate (PLP) are common in renal transpl

11 In this study, we characterized the pyridoxal 5'-phosphate (PLP) biosynthesis pathway in Str

12 The accumulating P6C inactivates pyridoxal 5'-phosphate (PLP) by forming a Knoevenagel co

13 CBS contains a pyridoxal 5'-phosphate (PLP) cofactor which catalyzes th

14 no longer makes a Schiff base linkage to the pyridoxal 5'-phosphate (PLP) cofactor, and instead the c

15 tion from an adenosylcobalamin (AdoCbl) to a pyridoxal 5'-phosphate (PLP) cofactor.

16 bstrate on the internal aldimine form of the pyridoxal 5'-phosphate (PLP) cofactor.

17 PNPO activity was quantified by measuring pyridoxal 5'-phosphate (PLP) concentrations in a DBS bef

18 BioA, a pyridoxal 5'-phosphate (PLP) dependent aminotransferase,

19 DDC is a pyridoxal 5'-phosphate (PLP) dependent enzyme.

20 ytically diverse but structurally homologous pyridoxal 5'-phosphate (PLP) dependent enzymes known as

21 Both of these enzymes are pyridoxal 5'-phosphate (PLP) dependent, and their three-

22 CBS uses coenzyme pyridoxal 5'-phosphate (PLP) for catalysis, and S-adenos

23 le-enzyme biosynthetic pathway that produces pyridoxal 5'-phosphate (PLP) from glutamine, ribose 5-ph

24 sma concentrations of the vitamin B-6 marker pyridoxal 5'-phosphate (PLP) have been associated with r

25 Pyridoxal 5'-phosphate (PLP) is a fundamental, multifunc

26 nic modulation in aspartate aminotransferase.Pyridoxal 5'-phosphate (PLP) is a ubiquitous co factor f

27 ine and erythrocytes, and among these plasma pyridoxal 5'-phosphate (PLP) is most commonly used.

28 Pyridoxal 5'-phosphate (PLP) is the active vitamer of vi

29 Pyridoxal 5'-phosphate (PLP) is the biologically active

30 tonation and H-bonded states of the cofactor pyridoxal 5'-phosphate (PLP) linked as an internal aldim

31 uced during the regeneration of the cofactor pyridoxal 5'-phosphate (PLP) of OAT by an unamplified mo

32 cluster, S-adenosyl-L-methionine (SAM), and pyridoxal 5'-phosphate (PLP) to isomerize L-alpha-lysine

33 semialdehyde with concomitant conversion of pyridoxal 5'-phosphate (PLP) to pyridoxamine 5'-phosphat

34 t was formed from SADTA covalently linked to pyridoxal 5'-phosphate (PLP) while the other adduct was

35 acidity of alpha-amino acids by the cofactor pyridoxal 5'-phosphate (PLP) with an unusual, unprotonat

36 The enzyme activity was dependent on pyridoxal 5'-phosphate (PLP), and C18-S-ACP was the pref

37 The most common status marker, plasma pyridoxal 5'-phosphate (PLP), decreases during inflammat

38 Pyridoxal 5'-phosphate (PLP), the active form of vitamin

39 ogy of vitamin B-6 status with use of plasma pyridoxal 5'-phosphate (PLP), the indicator of vitamin B

40 and responsible for the de novo synthesis of pyridoxal 5'-phosphate (PLP), the major active form of v

41 An insufficiency of cellular pyridoxal 5'-phosphate (PLP), which is the coenzyme form

42 lix DNA-binding domain and a long C-terminal pyridoxal 5'-phosphate (PLP)-binding putative aminotrans

43 A) accumulates and inactivates at least some pyridoxal 5'-phosphate (PLP)-containing enzymes in Salmo

44 due to mechanism-based inhibition of BioA, a pyridoxal 5'-phosphate (PLP)-dependent aminotransferase.

45 rst step in mammalian heme biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent and reversible re

46 Pyridoxal 5'-phosphate (PLP)-dependent basic amino acid

47 platinum-cysteine S-conjugate followed by a pyridoxal 5'-phosphate (PLP)-dependent cysteine S-conjug

48 eme-synthesizing organisms, results from the pyridoxal 5'-phosphate (PLP)-dependent enzymatic condens

49 Glycine decarboxylase, or P-protein, is a pyridoxal 5'-phosphate (PLP)-dependent enzyme in one-car

50 thionine beta-synthase (CBS) is an essential pyridoxal 5'-phosphate (PLP)-dependent enzyme of the tra

51 O-Acetylserine sulfhydrylase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

52 l-lyase (TPL) from Citrobacter freundii is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

53 Serine hydroxymethyltransferase (SHMT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

54 butyric acid aminotransferase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degra

55 ystathionine beta-synthase (CBS) is a unique pyridoxal 5'-phosphate (PLP)-dependent enzyme that has a

56 olevulinate synthase (EC 2.3.1.37) (ALAS), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, catalyzes

57 rine sulfydrylase (OASS), a highly conserved pyridoxal 5'-phosphate (PLP)-dependent enzyme, present i

58 biotin biosynthesis is performed by BioA, a pyridoxal 5'-phosphate (PLP)-dependent enzyme.

59 Pyridoxal 5'-phosphate (PLP)-dependent enzymes utilize t

60 ber of the alpha-oxoamine synthase family of pyridoxal 5'-phosphate (PLP)-dependent enzymes.

61 e and serine to their other chiral form in a pyridoxal 5'-phosphate (PLP)-dependent manner.

62 The pyridoxal 5'-phosphate (PLP)-dependent S-selective trans

63 re generated as mechanistic intermediates of pyridoxal 5'-phosphate (PLP)-dependent serine/threonine

64 focused on the dehydration of serine by the pyridoxal 5'-phosphate (PLP)-dependent serine/threonine

65 The pyridoxal 5'-phosphate (PLP)-dependent transaminase BioA

66 ct distribution generated upon reaction with pyridoxal 5'-phosphate (PLP).

67 sylmethionine (SAM), a [4Fe-4S] cluster, and pyridoxal 5'-phosphate (PLP).

68 ms, most notable among which is the cofactor pyridoxal 5'-phosphate (PLP).

69 e kynurenine pathway includes 2 vitamin B-6 [pyridoxal 5'-phosphate (PLP)]-dependent enzymes.

70 Enzymes dependent on pyridoxal 5'-phosphate (PLP, the active form of vitamin

71 valuated the relation between plasma folate, pyridoxal 5'-phosphate (PLP; the biologically active for

72 Pyridoxal 5'-phosphate (PLP; vitamin B(6))-catalyzed rea

73 an essential enzyme (pdxB) in production of pyridoxal 5'-phosphate (the active form of Vitamin B6),

74 ase, an enzyme involved in the catabolism of pyridoxal 5'-phosphate (vitamin B 6).

75 dc), an enzyme involved in the catabolism of pyridoxal 5'-phosphate (Vitamin B6).

76 at the minor allele is destabilized and that pyridoxal 5'-phosphate and aminooxyacetic acid binding s

77 We also examine the effect of known ligands pyridoxal 5'-phosphate and aminooxyacetic acid on stabil

78 involved in binding flavin mononucleotide or pyridoxal 5'-phosphate and many of them showed residual

79 n a novel metabolic pathway for synthesis of pyridoxal 5'-phosphate and the existing metabolic networ

80 The dependence of the enzyme on pyridoxal 5'-phosphate and the production of 3H4P with t

81 smitter gamma-aminobutyric acid (GABA) using pyridoxal 5'-phosphate as a cofactor.

82 for HMP-P biosynthesis as well as the use of pyridoxal 5'-phosphate as a substrate rather than as a c

83 The enzyme activity requires pyridoxal 5'-phosphate but not alpha-keto acid; therefor

84 formed substrate channel and solvent-exposed pyridoxal 5'-phosphate cofactor and provides a rationale

85 termediates by masking the absorption of the pyridoxal 5'-phosphate cofactor.

86 plays a role in modulating the pK(a) of the pyridoxal 5'-phosphate complexes during catalysis.

87 nobutyric acid aminotransferase (GABA-AT), a pyridoxal 5'-phosphate dependent enzyme, catalyzes the d

88 NSALP substrates inorganic pyrophosphate and pyridoxal 5'-phosphate diminished.

89 beta-synthase (CBS), a novel heme-containing pyridoxal 5'-phosphate enzyme, catalyzes the condensatio

90 the newly discovered enzyme does not require pyridoxal 5'-phosphate for its activity.

91 n the beta-site, indole and l-Ser react with pyridoxal 5'-phosphate in a two-stage reaction to give l

92 own genes involved in the salvage pathway of pyridoxal 5'-phosphate in plants.

93 own homologs of the previously characterized pyridoxal 5'-phosphate or pyruvoyl-dependent arginine de

94 Enzymes that utilize the cofactor pyridoxal 5'-phosphate play essential roles in amino aci

95 ional change that releases strain in the Lys pyridoxal 5'-phosphate Schiff base and increases the pK(

96 Along with pyridoxal 5'-phosphate synthases and aryl nitroreductase

97 gher levels of pyridoxine, pyridoxamine, and pyridoxal 5'-phosphate than the wild type, reflected in

98 C) impairs binding of the essential cofactor pyridoxal 5'-phosphate to ALAS2, resulting in destabiliz

99 Vitamin B(6) (pyridoxal 5'-phosphate) is an essential cofactor of many

100 tanx is a product containing L-methylfolate, pyridoxal 5'-phosphate, and methylcobalamin for manageme

101 cysteine, folate and vitamin B6 (active form pyridoxal 5'-phosphate, PLP), we conducted a meta-analys

102 significantly decreased levels of pyridoxal, pyridoxal 5'-phosphate, pyridoxamine, and pyridoxamine 5

103 rspermidine in CANSDC, form a Schiff base to pyridoxal 5'-phosphate, suggesting that the product comp

104 the oxidation of pyridoxine 5'-phosphate to pyridoxal 5'-phosphate, the active cofactor form of vita

105 MP) form of BCATm (PMP-BCATm) but not to the pyridoxal 5'-phosphate-BCATm and other metabolon protein

106 The enzyme is composed of a pyridoxal 5'-phosphate-binding catalytic domain, flanked

107 n the C-terminal domain, catalytic loop, and pyridoxal 5'-phosphate-binding domain that drives struct

108 two genes, At2g20340 and At4g28680, encoding pyridoxal 5'-phosphate-dependent AADCs with high homolog

109 motetrameric enzyme that belongs to group II pyridoxal 5'-phosphate-dependent amino-acid decarboxylas

110 primary sequence analysis, MppP and MppQ are pyridoxal 5'-phosphate-dependent aminotransferases; MppR

111 Escherichia coli adiA gene, which encodes a pyridoxal 5'-phosphate-dependent arginine decarboxylase,

112 5-Aminolevulinate synthase catalyzes the pyridoxal 5'-phosphate-dependent condensation of glycine

113 mammals is controlled by the activity of the pyridoxal 5'-phosphate-dependent enzyme 5-aminolevulinat

114 SelA, a member of the fold-type-I pyridoxal 5'-phosphate-dependent enzyme superfamily, has

115 Kynureninase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes t

116 O-Acetylserine sulfhydrylase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes t

117 duced expression of several glucagon-induced pyridoxal 5'-phosphate-dependent enzymes that convert am

118 s structural features with other fold-type-I pyridoxal 5'-phosphate-dependent enzymes with native dim

119 ctive enamine intermediate generated by some pyridoxal 5'-phosphate-dependent enzymes, accumulates in

120 t mutational routes between the functions of pyridoxal 5'-phosphate-dependent enzymes, regardless of

121 mix between periplasmic binding proteins and pyridoxal 5'-phosphate-dependent enzymes.

122 th (13)C-labeled precursors indicated that a pyridoxal 5'-phosphate-dependent mechanism is involved i

123 reactive enamine/imine intermediates of the pyridoxal 5'-phosphate-dependent threonine dehydratase (

124 The enzyme is pyridoxal 5'-phosphate-dependent, but unlike most of the

125 of the serine/threonine-specific protein and pyridoxal 5'-phosphate-directed HAD phosphatase chronoph

126 yjgF mutants, suggests that intermediates of pyridoxal 5'-phosphate-mediated reactions may have metab

127 all organisms, notably as the coenzyme form pyridoxal 5'-phosphate.

128 ity of seizures in response to pyridoxine or pyridoxal 5'-phosphate.

129 h pyridoxine but responded to treatment with pyridoxal 5'-phosphate.

130 g of symptoms on changing from pyridoxine to pyridoxal 5'-phosphate.

131 suramin (a general P2 receptor antagonist), pyridoxal 5'-phosphonucleotide derivative (a specific P2

132 P < 0.05) and lower plasma vitamin B-12 and pyridoxal 5-phosphate (P < 0.05) than did nonsmokers.

133 d to assess HTPO inhibition as a function of pyridoxal 5-phosphate (PLP) concentration.

134 Pyridoxal 5-phosphate (PLP), the phosphorylated and the

135 ein is dimeric and adopts the type I-fold of pyridoxal 5-phosphate (PLP)-dependent aminotransferases.

136 I reveals that it belongs to the fold-type I pyridoxal 5-phosphate (PLP)-dependent enzymes.

137 y evaluated plasma concentrations of folate, pyridoxal 5-phosphate (PLP; the principal active form of

138 This is the first instance in which one pyridoxal 5-phosphate enzyme has been crystallized with

139 Both substrates form external aldemines with pyridoxal 5-phosphate in the structures.

140 erase (GABA-AT; GabT) upon interactions with pyridoxal-5'-phosphate (PLP) and GABA, and thereby promo

141 the cofactors adenosylcobalamin (AdoCbl) and pyridoxal-5'-phosphate (PLP) and the substrate into prox

142 es of serum carotenoids, retinyl esters, and pyridoxal-5'-phosphate (PLP) by using high-pressure liqu

143 al clinical observation of isolated cases of pyridoxal-5'-phosphate (PLP) deficiency, this prospectiv

144 Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung can

145 Two routes for the de novo biosynthesis of pyridoxal-5'-phosphate (PLP) have been discovered and re

146 Pyridoxal-5'-phosphate (PLP) is introduced to a biomimet

147 Vitamin B-6 as pyridoxal-5'-phosphate (PLP) is required as the coenzyme

148 Pyridoxal-5'-phosphate (PLP) is the biologically active

149 nents of vitamin B6 i.e. pyridoxine (Py) and pyridoxal-5'-phosphate (PLP) using the same MIP format.

150 The group IV pyridoxal-5'-phosphate (PLP)-dependent decarboxylases be

151 This first step is catalyzed by the pyridoxal-5'-phosphate (PLP)-dependent enzyme serine pal

152 spartate 4-carboxylyase, E.C. 4.1.1.12) is a pyridoxal-5'-phosphate (PLP)-dependent enzyme that catal

153 Human cystathionine-gamma-lyase (CGL) is a pyridoxal-5'-phosphate (PLP)-dependent enzyme, which fun

154 acid-base chemistry that drives catalysis in pyridoxal-5'-phosphate (PLP)-dependent enzymes has been

155 transformations of amino acids performed by pyridoxal-5'-phosphate (PLP)-dependent enzymes.

156 f 5,6-LAM are 5'-deoxyadenosylcobalamin- and pyridoxal-5'-phosphate (PLP)-dependent.

157 , vitamin B6 [whose main circulating form is pyridoxal-5'-phosphate (PLP)], vitamin B12, and homocyst

158 Pyridoxal-5'-phosphate (vitamin B(6) ) is an essential c

159 Homo sapiens kynureninase is a pyridoxal-5'-phosphate dependent enzyme that catalyzes t

160 Pyrococcus horikoshii was transaminated with pyridoxal-5'-phosphate to produce a ketone-bearing prote

161 nine with the help of three cofactors, heme, pyridoxal-5'-phosphate, and S-adenosyl-l-methionine.

162 vealed this transformation is dependent upon pyridoxal-5'-phosphate, the enzyme has no activity with

163 e-6-azophenyl-2',5'-disulfonic acid (PPADS), pyridoxal-5'-phosphate-6(2'-naphthylazo-6-nitro-4',8'-di

164 on of P2 and glutamate receptor antagonists (pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic aci

165 Application of the ATP receptor antagonists pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic aci

166 ntly inhibited by the purinergic antagonists pyridoxal-5'-phosphate-6-azophenyl-2',5'-disulfonic acid

167 roton-consuming acid resistance system has a pyridoxal-5'-phosphate-dependent amino acid decarboxylas

168 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-phosphate-dependent enzyme that catalyzes t

169 f the indoline quinonoid intermediate in the pyridoxal-5'-phosphate-dependent enzyme tryptophan synth

170 In the 143 kDa pyridoxal-5'-phosphate-dependent enzyme tryptophan synth

171 It is endogenously synthesized mainly by two pyridoxal-5'-phosphate-dependent enzymes involved in L-c

172 beta-synthase (CBS) is a heme-dependent and pyridoxal-5'-phosphate-dependent protein that controls t

173 e reported low circulating concentrations of pyridoxal-5-phospate (PLP) in renal transplant recipient

174 The pyridoxal-5-phosphate (PLP) molecule bonded tightly to L

175 s PNPO variant had a low cerebrospinal fluid pyridoxal-5-phosphate level.

176 f enzyme characterization revealed that this pyridoxal-5-phosphate-dependent decarboxylase takes L-ly

177 1,3,5-naphthalenetrisulfonic acid), MRS2159 (pyridoxal-alpha5-phosphate-6-phenylazo-4'-carboxylic aci

178 , interacts with the formyl group at C-4' of pyridoxal and may also determine if residues from anothe

179 and rely on uptake of B(6) vitamers such as pyridoxal and pyridoxamine from their hosts, which are s

180 We evaluated the vitamin B-6 biomarkers PLP, pyridoxal, and pyridoxic acid (PA) and the pyridoxic aci

181 rals lowered concentrations of nicotinamide, pyridoxal, and vitamin B-12.

182 With pyridoxal as the aldehyde component, furo[2,3-c]pyridine

183 odeled; such processes may also be common to pyridoxal-catalyzed transamination and related reactions

184 ly-modified cellulosic paper strips with the pyridoxal conjugated BSA-AuNCs for detecting Hg(2+) ion

185 oxal phosphate (PLP) > pyridoxic acid (PA) > pyridoxal] differed from that of CSF (pyridoxal > PLP >

186 her endogenous small molecules (for example, pyridoxal, folinic acid, ATP, and AMP) also convert the

187 banion reacts with the iminium carbon of the pyridoxal-glycine iminium ion to form the second Claisen

188 (PA) > pyridoxal] differed from that of CSF (pyridoxal > PLP > PA > pyridoxamine).

189 oung rabbits and sharks were pretreated with pyridoxal hydrochloride and copper ions before CXL.

190 Pretreatment with pyridoxal hydrochloride resulted in significantly higher

191 d ligands, namely the aroylhydrazone (1)(4)C-pyridoxal isonicotinoyl hydrazone ((1)(4)C-PIH) and the

192 whether high-affinity iron chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class can restri

193 salicylaldehyde isonicotinoyl hydrazone and pyridoxal isonicotinoyl hydrazone and demonstrate that t

194 report on the characterization of T. brucei pyridoxal kinase (PdxK), an enzyme required for the salv

195 ts, which are subsequently phosphorylated by pyridoxal kinase (PdxK).

196 We recently identified a pyridoxal kinase (SaPLK) as a target of the natural prod

197 now report the crystal structure of E. coli pyridoxal kinase 1 (ePL kinase 1), encoded by a pdxK gen

198 y been published, including Escherichia coli pyridoxal kinase 2 (ePL kinase 2) and sheep pyridoxal ki

199 Pyridoxal kinase catalyses the phosphorylation of pyrido

200 These findings suggest that pyridoxal kinase is an essential and druggable target th

201 superfamily members reveal that B. subtilis pyridoxal kinase is more closely related in both sequenc

202 Two pyridoxal kinase structures have recently been published

203 Unlike sheep pyridoxal kinase, ePL kinase 1 may not tolerate wide var

204 pyridoxal kinase 2 (ePL kinase 2) and sheep pyridoxal kinase, products of the pdxY and pdxK genes, r

205 doxine/pyridoxamine 5'-phosphate oxidase and pyridoxal kinase, respectively, are the only known genes

206 K and pdxY genes have been found to code for pyridoxal kinases, enzymes involved in the pyridoxal pho

207 to the family of HMPP kinases than to other pyridoxal kinases, suggesting that this structure repres

208 rst for a novel family of "HMPP kinase-like" pyridoxal kinases.

209 nomutase, an adenosylcobalamin (AdoCbl)- and pyridoxal L-phosphate (PLP)-dependent enzyme that cataly

210 13 mU mg(-1) and a K(m)(app) with respect to pyridoxal of 29.6 +/- 3.9 microM.

211 conformational change upon binding of either pyridoxal or MgATP.

212 functional vitamin B-6 status, and PA:(PLP + pyridoxal) (PAr), a marker of inflammation and oxidative

213 e vitamin B-6 vitamer composition of plasma [pyridoxal phosphate (PLP) > pyridoxic acid (PA) > pyrido

214 I reflect on my research on pyridoxal phosphate (PLP) enzymes over fifty-five years

215 their cofactors (the pterins and vitamin B6 (pyridoxal phosphate (PLP))) in human cerebrospinal fluid

216 Baseline serum riboflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flav

217 CAS and the Gm-CAS K95A mutant with a linked pyridoxal phosphate (PLP)-Cys molecule in the active sit

218 Cysteine desulfurases perform pyridoxal phosphate (PLP)-dependent desulfuration of cys

219 t: (i) the bioinformatics analysis reveals a pyridoxal phosphate (PLP)-dependent domain, we termed cy

220 Pyridoxal phosphate (PLP)-dependent enzymes catalyze man

221 l therapies for inherited diseases involving pyridoxal phosphate (PLP)-dependent enzymes, including p

222 ase (PanD), the enzyme in M. jannaschii is a pyridoxal phosphate (PLP)-dependent l-aspartate decarbox

223 amin pyrimidine is formed from histidine and pyridoxal phosphate (PLP).

224 ecies (ROS) detoxification and production of pyridoxal phosphate (PLP).

225 two enzymes of the biosynthetic pathway for pyridoxal phosphate (SerC and PdxA), we have found that

226 nd the nonselective P2 receptor antagonists, pyridoxal phosphate 6-azophenyl-2',4'-disulfonic acid an

227 s of very slow biological reactions, notably pyridoxal phosphate and the ceric ion, are shown to meet

228 hould be measured, and therapeutic trials of pyridoxal phosphate as well as pyridoxine should be cons

229 DhpH is a multidomain protein, in which a pyridoxal phosphate binding domain is fused to an N-acet

230 lyzes the second step in the biosynthesis of pyridoxal phosphate by oxidizing 4-phospho-d-erythronate

231 e provides information on the binding of the pyridoxal phosphate cofactor as well as on amino acid re

232 ocated on a helix that connects the heme and pyridoxal phosphate cofactor domains.

233 ases via reactions of the compounds with the pyridoxal phosphate cofactor forming an irreversible add

234 PtaA is homodimeric and contains a pyridoxal phosphate cofactor.

235 rnal aldimine form of NtdA with the cofactor pyridoxal phosphate covalently attached to Lys-247.

236 The pyridoxal phosphate dependent alanine racemase catalyzes

237 which belong to two different fold types of pyridoxal phosphate enzymes: an aspartate aminotransfera

238 plants, the pathway for de novo synthesis of pyridoxal phosphate has been well characterized, however

239 Pyridoxal phosphate is the cofactor for the enzyme histi

240 hildren with intractable seizures respond to pyridoxal phosphate rather than pyridoxine, including a

241 and formation of the external aldimine with pyridoxal phosphate required for early steps in SufS cat

242 r pyridoxal kinases, enzymes involved in the pyridoxal phosphate salvage pathway.

243 lly thought to be due to abnormal binding of pyridoxal phosphate to glutamic acid decarboxylase resul

244 Fasting plasma concentration of pyridoxal phosphate was inversely associated with myocar

245 Plasma levels of pyridoxal phosphate were inversely associated with risk

246 Vitamin B6 (pyridoxal phosphate) is an essential cofactor in enzymat

247 en fasting plasma levels of vitamin B(6), as pyridoxal phosphate, and subsequent myocardial infarctio

248 ervation that the active form of vitamin B6 (pyridoxal phosphate, P5P) modulates the self-assembly of

249 referred to as Pat) that, in the presence of pyridoxal phosphate, transfers the primary amino group o

250 Pyridoxal phosphate, which binds at the intersubunit act

251 ythroidine and reduced by the P2X antagonist pyridoxal phosphate-6-azo (benzene-2,4-disulfonic acid (

252 r ATP, and by blocking P2 purinoceptors with pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) t

253 PPADS [pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid)],

254 Hindlimb intra-arterial infusion of pyridoxal phosphate-6-azophenyl-2,4-disulfonic acid (PPA

255 We recently discovered that the pyridoxal phosphate-containing enzyme PvdN is responsibl

256 e enzyme binds the substrate cysteine in the pyridoxal phosphate-containing site, and a persulfide is

257 ucose-6-phosphate 3-dehydrogenase, NtdA is a pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:

258 ylacetaldehyde (4-HPAA), Rhodiola contains a pyridoxal phosphate-dependent 4-HPAA synthase that direc

259 The S-signal was generated by the pyridoxal phosphate-dependent aminotransferase ScrA; sig

260 Sequence homology identified the pyridoxal phosphate-dependent decarboxylase-like protein

261 nzymological source of the amine moiety as a pyridoxal phosphate-dependent decarboxylating enzyme tha

262 The catalytic effects of perdeuterating the pyridoxal phosphate-dependent enzyme alanine racemase fr

263 S. cerevisiae FKF had been reported to be a pyridoxal phosphate-dependent enzyme encoded by BNA3.

264 Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the

265 te, which is converted to Ala(P) by a second pyridoxal phosphate-dependent enzyme, DhpD.

266 site of cystathionine beta-synthase (CBS), a pyridoxal phosphate-dependent enzyme.

267 a sugar aminotransferase that catalyzes the pyridoxal phosphate-dependent equatorial transamination

268 vivo and in vitro enzyme assays, supports a pyridoxal phosphate-dependent mechanism of Sec-tRNA(Sec)

269 y Sep-tRNA:Cys-tRNA synthase (SepCysS) via a pyridoxal phosphate-dependent mechanism.

270 steine, a toxic metabolite, with serine in a pyridoxal phosphate-dependent reaction.

271 Among them, we identified the L136 gene as a pyridoxal phosphate-dependent sugar aminotransferase.

272 by catalyzing incorporation of its cofactor, pyridoxal phosphate.

273 Unexpectedly, the double bond linking the pyridoxal-phosphate and benzoate moieties was reduced by

274 y X-rays to create a covalent linkage of the pyridoxal-phosphate moiety to lysine 120 in the binding

275 adult rats show that bilateral injections of pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS

276 blocked by P2Y receptor antagonists suramin, pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS

277 s with the broad-spectrum antagonists PPADS (pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate) or RB

278 blocked by the broad P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (

279 blocked by the broad P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (

280 ed to MA; (iii) the P2X receptor antagonist, pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (

281 e or no effect on sensitivity to suramin and pyridoxal-phosphate-6-azophenyl-2,4-disulfonate in chime

282 r, which is inhibited by NF449, suramin, and pyridoxal-phosphate-6-azophenyl-2,4-disulfonate, with re

283 e and that AGXT2L1 and AGXT2L2 catalyzed the pyridoxal-phosphate-dependent breakdown of phosphoethano

284 1 and AGXT2L2, two closely related, putative pyridoxal-phosphate-dependent enzymes encoded by vertebr

285 a salvage pathway that phosphorylates either pyridoxal (PL) or its related vitamers, pyridoxine (PN)

286 sue distribution or increased catabolism via pyridoxal (PL) to pyridoxic acid (PA).

287 pyridoxic acid (PA) and the pyridoxic acid:(pyridoxal + PLP) ratio (PAr), a proposed marker of vitam

288 ndex, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 cataboli

289 n B6, with significantly decreased levels of pyridoxal, pyridoxal 5'-phosphate, pyridoxamine, and pyr

290 yme has equivalent catalytic efficiency with pyridoxal, pyridoxamine and pyridoxine, and that ginkgot

291 PLP, pyridoxal, pyridoxic acid (PA), 3-hydroxykynurenine, and

292 ell characterized, however only two enzymes, pyridoxal (pyridoxine, pyridoxamine) kinase (SOS4) and p

293 oxal kinase catalyses the phosphorylation of pyridoxal, pyridoxine and pyridoxamine to their 5' phosp

294 A putative pyridoxal reductase (PLR1) was identified in Arabidopsis

295 oding region in a yeast mutant deficient for pyridoxal reductase confirmed that the enzyme catalyzes

296 This is the first report of a pyridoxal reductase in the vitamin B6 salvage pathway in

297 ed and binary complexes with either MgATP or pyridoxal to 2.1-, 2.6-, and 3.2-A resolutions, respecti

298 me catalyzes the NADPH-mediated reduction of pyridoxal to pyridoxine.

299 the biosynthesis of thiamin (vitamin B1) and pyridoxal (vitamin B6).

300 The vitamin B6 cofactor pyridoxal was conjugated with the luminescent BSA-AuNCs