ライフサイエンスコーパス: pyridoxal 5'-phosphate

1 natural substrate (L-alanine) and cofactor (pyridoxal 5'-phosphate).

2 tion by covalent modification of lysine with pyridoxal 5-phosphate.

3 all organisms, notably as the coenzyme form pyridoxal 5'-phosphate.

4 ached but appears to be partially present as pyridoxal 5'-phosphate.

5 hieved by the simultaneous administration of pyridoxal 5'-phosphate.

6 shown to exist as a tetramer and to contain pyridoxal 5'-phosphate.

7 ssay is linear in the 2- to 50-pmol range of pyridoxal 5'-phosphate.

8 ity of seizures in response to pyridoxine or pyridoxal 5'-phosphate.

9 h pyridoxine but responded to treatment with pyridoxal 5'-phosphate.

10 g of symptoms on changing from pyridoxine to pyridoxal 5'-phosphate.

11 sulfuration to cystathionine, which requires pyridoxal-5'-phosphate.

12 etion and the blockade of these responses by pyridoxal 5-phosphate 6-azophenyl-2',4'-disulphonic acid

13 t to their ligand preference, sensitivity to pyridoxal 5-phosphate 6-azophenyl-2',4'-disulphonic acid

14 ovel analogues of the P2 receptor antagonist pyridoxal-5'-phosphate 6-azophenyl-2',5'-disulfonate (2)

15 e-6-azophenyl-2',5'-disulfonic acid (PPADS), pyridoxal-5'-phosphate-6(2'-naphthylazo-6-nitro-4',8'-di

16 Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-

17 on of P2 and glutamate receptor antagonists (pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic aci

18 Application of the ATP receptor antagonists pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic aci

19 LM (microinjection of P2 receptor antagonist pyridoxal-5'-phosphate-6-azophenyl-2',4'-disulphonic aci

20 ntly inhibited by the purinergic antagonists pyridoxal-5'-phosphate-6-azophenyl-2',5'-disulfonic acid

21 The currents were inhibited by suramin, pyridoxal-5-phosphate-6-azo-2',4'-disulfonic acid and Br

22 e determined fasting plasma folate, B12, and pyridoxal 5'-phosphate (active vitamin B6) levels, along

23 and function of SHMT and a possible role in pyridoxal 5'-phosphate addition to the apo-enzyme.

24 When the crystals are soaked with excess pyridoxal 5'-phosphate an additional molecule of this co

25 bT promoter only in the presence of GABA and pyridoxal 5'-phosphate, an essential cofactor of aminotr

26 nase that is involved in the biosynthesis of pyridoxal-5-phosphate, an active form of vitamin B6.

27 at the minor allele is destabilized and that pyridoxal 5'-phosphate and aminooxyacetic acid binding s

28 We also examine the effect of known ligands pyridoxal 5'-phosphate and aminooxyacetic acid on stabil

29 The purified OASS contained pyridoxal 5'-phosphate and catalyzed the formation of L-

30 regulated by modulation of the synthesis of pyridoxal 5'-phosphate and failure to maintain pyridoxal

31 A similar requirement for pyridoxal 5'-phosphate and GABA for GabR-mediated transc

32 involved in binding flavin mononucleotide or pyridoxal 5'-phosphate and many of them showed residual

33 alyzes a hydride ion transfer between C4' of pyridoxal 5'-phosphate and N5 of FMN.

34 n a novel metabolic pathway for synthesis of pyridoxal 5'-phosphate and the existing metabolic networ

35 The dependence of the enzyme on pyridoxal 5'-phosphate and the production of 3H4P with t

36 sine with activated enzyme and the coenzymes pyridoxal-5'-phosphate and S-adenosylmethionine, followe

37 by pharmacological studies in animal cells, pyridoxal-5-phosphate and its derivatives are also ligan

38 mosine, pyridoxine, pyridoxamine, pyridoxal, pyridoxal-5'-phosphate) and various synthetic hydroxypyr

39 n the biosynthesis of the essential coenzyme pyridoxal 5"-phosphate, and the ksgA gene, which encodes

40 tanx is a product containing L-methylfolate, pyridoxal 5'-phosphate, and methylcobalamin for manageme

41 nine with the help of three cofactors, heme, pyridoxal-5'-phosphate, and S-adenosyl-l-methionine.

42 free to rotate and bring adenosylcobalamin, pyridoxal-5'-phosphate, and substrate into proximity.

43 The K(m) values for adenosylcobalamin and pyridoxal 5'-phosphate are 6.6 and 1.0 microM, respectiv

44 enzyme functions as a homodimer and requires pyridoxal 5'-phosphate as a cofactor.

45 smitter gamma-aminobutyric acid (GABA) using pyridoxal 5'-phosphate as a cofactor.

46 for HMP-P biosynthesis as well as the use of pyridoxal 5'-phosphate as a substrate rather than as a c

47 MP) form of BCATm (PMP-BCATm) but not to the pyridoxal 5'-phosphate-BCATm and other metabolon protein

48 e that is also predicted to be important for pyridoxal 5'-phosphate binding to Lcb2p also dominantly

49 In this mode of pyridoxal-5'-phosphate binding, the cofactor acts as an

50 The enzyme is composed of a pyridoxal 5'-phosphate-binding catalytic domain, flanked

51 n the C-terminal domain, catalytic loop, and pyridoxal 5'-phosphate-binding domain that drives struct

52 nd the other from the peptide containing the pyridoxal 5'-phosphate-binding lysine residue, are ident

53 se from E. coli with one or two molecules of pyridoxal 5'-phosphate bound to each monomer has been de

54 The enzyme activity requires pyridoxal 5'-phosphate but not alpha-keto acid; therefor

55 Other B6 vitamers are converted to pyridoxal 5'-phosphate by a preincubation with a combina

56 zes the terminal step in the biosynthesis of pyridoxal 5'-phosphate by the FMN oxidation of pyridoxin

57 tructure, a Rossmann domain covalently binds pyridoxal-5'-phosphate by means of lysine 144 and positi

58 of covalent intermediates formed between the pyridoxal 5'-phosphate coenzyme (PLP) and the reacting s

59 The enzyme contains a pyridoxal 5' phosphate cofactor and is a dimer.

60 into a structure amenable to binding of the pyridoxal 5'-phosphate cofactor and assembly of the two

61 formed substrate channel and solvent-exposed pyridoxal 5'-phosphate cofactor and provides a rationale

62 expected to form the Schiff's base with the pyridoxal 5'-phosphate cofactor.

63 synthase forms a Schiff base linkage to the pyridoxal 5'-phosphate cofactor.

64 termediates by masking the absorption of the pyridoxal 5'-phosphate cofactor.

65 plays a role in modulating the pK(a) of the pyridoxal 5'-phosphate complexes during catalysis.

66 of NADPH production with respect to original pyridoxal 5'-phosphate content.

67 Ornithine decarboxylase (ODC) is a pyridoxal 5'-phosphate dependent enzyme that catalyzes t

68 nobutyric acid aminotransferase (GABA-AT), a pyridoxal 5'-phosphate dependent enzyme, catalyzes the d

69 Homo sapiens kynureninase is a pyridoxal-5'-phosphate dependent enzyme that catalyzes t

70 two genes, At2g20340 and At4g28680, encoding pyridoxal 5'-phosphate-dependent AADCs with high homolog

71 motetrameric enzyme that belongs to group II pyridoxal 5'-phosphate-dependent amino-acid decarboxylas

72 primary sequence analysis, MppP and MppQ are pyridoxal 5'-phosphate-dependent aminotransferases; MppR

73 Escherichia coli adiA gene, which encodes a pyridoxal 5'-phosphate-dependent arginine decarboxylase,

74 5-Aminolevulinate synthase catalyzes the pyridoxal 5'-phosphate-dependent condensation of glycine

75 a tetrameric hemeprotein that catalyzes the pyridoxal 5'-phosphate-dependent condensation of serine

76 heme biosynthesis in mammals begins with the pyridoxal 5'-phosphate-dependent condensation reaction c

77 These are the pyridoxal 5'-phosphate-dependent deaminases and the deam

78 is an obligate homodimer that catalyzes the pyridoxal 5'-phosphate-dependent decarboxylation of l-or

79 mammals is controlled by the activity of the pyridoxal 5'-phosphate-dependent enzyme 5-aminolevulinat

80 allowing the elucidation of a key species of pyridoxal 5'-phosphate-dependent enzyme catalysis.

81 SelA, a member of the fold-type-I pyridoxal 5'-phosphate-dependent enzyme superfamily, has

82 Kynureninase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes t

83 O-Acetylserine sulfhydrylase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes t

84 5-Aminolevulinate synthase (ALAS), a pyridoxal 5'-phosphate-dependent enzyme, catalyzes the f

85 duced expression of several glucagon-induced pyridoxal 5'-phosphate-dependent enzymes that convert am

86 s structural features with other fold-type-I pyridoxal 5'-phosphate-dependent enzymes with native dim

87 ctive enamine intermediate generated by some pyridoxal 5'-phosphate-dependent enzymes, accumulates in

88 t mutational routes between the functions of pyridoxal 5'-phosphate-dependent enzymes, regardless of

89 similarity with aminotransferases and other pyridoxal 5'-phosphate-dependent enzymes.

90 mix between periplasmic binding proteins and pyridoxal 5'-phosphate-dependent enzymes.

91 assay based on ethanolamine (Etn) formation, pyridoxal 5'-phosphate-dependent l-serine decarboxylase

92 th (13)C-labeled precursors indicated that a pyridoxal 5'-phosphate-dependent mechanism is involved i

93 any other euryarchaeon have orthologs of the pyridoxal 5'-phosphate-dependent ornithine or arginine d

94 reactive enamine/imine intermediates of the pyridoxal 5'-phosphate-dependent threonine dehydratase (

95 The enzyme is pyridoxal 5'-phosphate-dependent, but unlike most of the

96 prefers the L-enantiomer of S-methyl-Met, is pyridoxal 5'-phosphate-dependent, generates equimolar am

97 protein representing an additional family of pyridoxal-5' phosphate-dependent enzymes in eukaryotes.

98 aldehyde-lyase (threonine aldolase, TA) is a pyridoxal-5'-phosphate-dependent (PLP) enzyme that catal

99 Ornithine decarboxylase (ODC) is a pyridoxal-5'-phosphate-dependent (PLP) enzyme that catal

100 roton-consuming acid resistance system has a pyridoxal-5'-phosphate-dependent amino acid decarboxylas

101 ystathionine beta-synthase (CBS) is a unique pyridoxal-5'-phosphate-dependent enzyme in which heme is

102 5,6-aminomutase is an adenosylcobalamin and pyridoxal-5'-phosphate-dependent enzyme that catalyzes a

103 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-phosphate-dependent enzyme that catalyzes t

104 f the indoline quinonoid intermediate in the pyridoxal-5'-phosphate-dependent enzyme tryptophan synth

105 In the 143 kDa pyridoxal-5'-phosphate-dependent enzyme tryptophan synth

106 It is endogenously synthesized mainly by two pyridoxal-5'-phosphate-dependent enzymes involved in L-c

107 beta-synthase (CBS) is a heme-dependent and pyridoxal-5'-phosphate-dependent protein that controls t

108 f enzyme characterization revealed that this pyridoxal-5-phosphate-dependent decarboxylase takes L-ly

109 In contrast to the enzymes that employ pyridoxal 5'-phosphate, detailed physical and mechanisti

110 NSALP substrates inorganic pyrophosphate and pyridoxal 5'-phosphate diminished.

111 of the serine/threonine-specific protein and pyridoxal 5'-phosphate-directed HAD phosphatase chronoph

112 beta-synthase (CBS), a novel heme-containing pyridoxal 5'-phosphate enzyme, catalyzes the condensatio

113 As a soluble, pyridoxal 5'-phosphate enzyme, SDC contrasts sharply wit

114 aminotransferase, the archetypal alpha-class pyridoxal 5'-phosphate enzyme.

115 This is the first instance in which one pyridoxal 5-phosphate enzyme has been crystallized with

116 As a member of the subfamily of pyridoxal 5'-phosphate enzymes known as the alpha-oxoami

117 the newly discovered enzyme does not require pyridoxal 5'-phosphate for its activity.

118 tunnel exists between the two sites so that pyridoxal 5'-phosphate formed at the active site may tra

119 e formation of the Michaelis complex and the pyridoxal 5'-phosphate-glycine aldimine, followed by the

120 Although pyridoxal 5'-phosphate hydrolase activity is usually att

121 c alkaline phosphatase may perform cutaneous pyridoxal 5'-phosphate hydrolase activity.

122 an skin, both of which exhibited significant pyridoxal 5'-phosphate hydrolase activity.

123 ith kinase and oxidase activity and not with pyridoxal 5'-phosphate hydrolase activity.

124 Pyridoxal 5'-phosphate hydrolase has been proposed as a

125 f both pyridoxamine 5'-phosphate oxidase and pyridoxal 5'-phosphate hydrolase was significantly incre

126 n the beta-site, indole and l-Ser react with pyridoxal 5'-phosphate in a two-stage reaction to give l

127 own genes involved in the salvage pathway of pyridoxal 5'-phosphate in plants.

128 sferase, which is a measure of the amount of pyridoxal 5'-phosphate in the original sample.

129 Both substrates form external aldemines with pyridoxal 5-phosphate in the structures.

130 GuHCl alters the equilibrium distribution of pyridoxal 5'-phosphate intermediates formed in reactions

131 notransferase-like reaction between GABA and pyridoxal 5'-phosphate is essential for GabR action as a

132 In this method pyridoxal 5'-phosphate is used to activate aposerine hyd

133 Vitamin B(6) (pyridoxal 5'-phosphate) is an essential cofactor of many

134 s PNPO variant had a low cerebrospinal fluid pyridoxal-5-phosphate level.

135 adjusted for plasma folate, vitamin B12, and pyridoxal 5'-phosphate levels, age, and gender confirmed

136 total homocysteine, folate, vitamin B12, and pyridoxal 5'-phosphate levels, along with serum cystatin

137 yjgF mutants, suggests that intermediates of pyridoxal 5'-phosphate-mediated reactions may have metab

138 One of the pyridoxal 5'-phosphate molecules is clearly bound at the

139 antile spasms (onset 5 months) responsive to pyridoxal 5'-phosphate (n = 1); and (iii) patients with

140 s with neonatal onset seizures responding to pyridoxal 5'-phosphate (n = 6); (ii) a patient with infa

141 the active site with the aldehyde at C4' of pyridoxal 5'-phosphate near N5 of the bound FMN.

142 own homologs of the previously characterized pyridoxal 5'-phosphate or pyruvoyl-dependent arginine de

143 P < 0.05) and lower plasma vitamin B-12 and pyridoxal 5-phosphate (P < 0.05) than did nonsmokers.

144 Enzymes that utilize the cofactor pyridoxal 5'-phosphate play essential roles in amino aci

145 s developed for the routine determination of pyridoxal 5'-phosphate (PLP) and 4-pyridoxic acid (4-PA)

146 sample preparation procedure for quantifying pyridoxal 5'-phosphate (PLP) and 4-pyridoxic acid (4PA)

147 The enzyme contains pyridoxal 5'-phosphate (PLP) and a [4Fe-4S] center and r

148 In the case of the pyridoxal 5'-phosphate (PLP) and cobalamin-dependent enz

149 aeruginosa PAO1 in complex with the cofactor pyridoxal 5'-phosphate (PLP) and product UDP-GlcNAc(3NH(

150 Pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phospha

151 ian HAD phosphatase known to dephosphorylate pyridoxal 5'-phosphate (PLP) and serine/threonine-phosph

152 Low plasma concentrations of pyridoxal 5'-phosphate (PLP) are common in renal transpl

153 the recombinant R. sphaeroides HemA requires pyridoxal 5'-phosphate (PLP) as a cofactor for catalysis

154 ction catalyzed by the beta-subunit requires pyridoxal 5'-phosphate (PLP) as a cofactor.

155 Pyridoxal 5'-phosphate (PLP) binds tightly to bovine low

156 In this study, we characterized the pyridoxal 5'-phosphate (PLP) biosynthesis pathway in Str

157 The enzyme is a homodimer with one pyridoxal 5'-phosphate (PLP) bound per subunit deep with

158 The accumulating P6C inactivates pyridoxal 5'-phosphate (PLP) by forming a Knoevenagel co

159 CBS contains a pyridoxal 5'-phosphate (PLP) cofactor which catalyzes th

160 no longer makes a Schiff base linkage to the pyridoxal 5'-phosphate (PLP) cofactor, and instead the c

161 tion from an adenosylcobalamin (AdoCbl) to a pyridoxal 5'-phosphate (PLP) cofactor.

162 bstrate on the internal aldimine form of the pyridoxal 5'-phosphate (PLP) cofactor.

163 PNPO activity was quantified by measuring pyridoxal 5'-phosphate (PLP) concentrations in a DBS bef

164 BioA, a pyridoxal 5'-phosphate (PLP) dependent aminotransferase,

165 ODC is a pyridoxal 5'-phosphate (PLP) dependent enzyme and an obl

166 lopropane-1-carboxylate (ACC) deaminase is a pyridoxal 5'-phosphate (PLP) dependent enzyme catalyzing

167 Ornithine decarboxylase (ODC) is a pyridoxal 5'-phosphate (PLP) dependent enzyme that catal

168 lopropane-1-carboxylate (ACC) deaminase is a pyridoxal 5'-phosphate (PLP) dependent enzyme which cata

169 Cystathionine beta-synthase (CBS), a pyridoxal 5'-phosphate (PLP) dependent enzyme, catalyzes

170 DDC is a pyridoxal 5'-phosphate (PLP) dependent enzyme.

171 ytically diverse but structurally homologous pyridoxal 5'-phosphate (PLP) dependent enzymes known as

172 Ornithine decarboxylase (ODC) is a pyridoxal 5'-phosphate (PLP) dependent homodimeric enzym

173 Both of these enzymes are pyridoxal 5'-phosphate (PLP) dependent, and their three-

174 (SGAT) from Hyphomicrobium methylovorum is a pyridoxal 5'-phosphate (PLP) enzyme that catalyzes the i

175 contains an iron-sulfur cluster and requires pyridoxal 5'-phosphate (PLP) for activity.

176 CBS uses coenzyme pyridoxal 5'-phosphate (PLP) for catalysis, and S-adenos

177 le-enzyme biosynthetic pathway that produces pyridoxal 5'-phosphate (PLP) from glutamine, ribose 5-ph

178 sma concentrations of the vitamin B-6 marker pyridoxal 5'-phosphate (PLP) have been associated with r

179 Pyridoxal 5'-phosphate (PLP) is a fundamental, multifunc

180 nic modulation in aspartate aminotransferase.Pyridoxal 5'-phosphate (PLP) is a ubiquitous co factor f

181 initiated by a transamination step in which pyridoxal 5'-phosphate (PLP) is converted to pyridoxamin

182 ine and erythrocytes, and among these plasma pyridoxal 5'-phosphate (PLP) is most commonly used.

183 Pyridoxal 5'-phosphate (PLP) is the active vitamer of vi

184 Pyridoxal 5'-phosphate (PLP) is the biologically active

185 tonation and H-bonded states of the cofactor pyridoxal 5'-phosphate (PLP) linked as an internal aldim

186 Both active sites contain a pyridoxal 5'-phosphate (PLP) molecule in aldimine linkag

187 uced during the regeneration of the cofactor pyridoxal 5'-phosphate (PLP) of OAT by an unamplified mo

188 cluster, S-adenosyl-L-methionine (SAM), and pyridoxal 5'-phosphate (PLP) to isomerize L-alpha-lysine

189 semialdehyde with concomitant conversion of pyridoxal 5'-phosphate (PLP) to pyridoxamine 5'-phosphat

190 ysis of the Schiff base linking the coenzyme pyridoxal 5'-phosphate (PLP) to the polypeptide is much

191 t was formed from SADTA covalently linked to pyridoxal 5'-phosphate (PLP) while the other adduct was

192 acidity of alpha-amino acids by the cofactor pyridoxal 5'-phosphate (PLP) with an unusual, unprotonat

193 The enzyme activity was dependent on pyridoxal 5'-phosphate (PLP), and C18-S-ACP was the pref

194 The active site contains a cofactor, pyridoxal 5'-phosphate (PLP), and the product phosphonoa

195 The most common status marker, plasma pyridoxal 5'-phosphate (PLP), decreases during inflammat

196 Pyridoxal 5'-phosphate (PLP), the active form of vitamin

197 We hypothesized a relationship between pyridoxal 5'-phosphate (PLP), the active form of vitamin

198 ogy of vitamin B-6 status with use of plasma pyridoxal 5'-phosphate (PLP), the indicator of vitamin B

199 and responsible for the de novo synthesis of pyridoxal 5'-phosphate (PLP), the major active form of v

200 An insufficiency of cellular pyridoxal 5'-phosphate (PLP), which is the coenzyme form

201 in part by alanine racemase (EC 5.1.1.1), a pyridoxal 5'-phosphate (PLP)-assisted enzyme.

202 lix DNA-binding domain and a long C-terminal pyridoxal 5'-phosphate (PLP)-binding putative aminotrans

203 A) accumulates and inactivates at least some pyridoxal 5'-phosphate (PLP)-containing enzymes in Salmo

204 ng a protein with sequence similarity to the pyridoxal 5'-phosphate (PLP)-dependent 1-aminocyclopropa

205 due to mechanism-based inhibition of BioA, a pyridoxal 5'-phosphate (PLP)-dependent aminotransferase.

206 rst step in mammalian heme biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent and reversible re

207 Pyridoxal 5'-phosphate (PLP)-dependent basic amino acid

208 the final step of cysteine biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent conversion of O-a

209 platinum-cysteine S-conjugate followed by a pyridoxal 5'-phosphate (PLP)-dependent cysteine S-conjug

210 rine dehydratase, EC 4.3.1.17) catalyzes the pyridoxal 5'-phosphate (PLP)-dependent dehydration of L-

211 eme-synthesizing organisms, results from the pyridoxal 5'-phosphate (PLP)-dependent enzymatic condens

212 The two half-reactions of the pyridoxal 5'-phosphate (PLP)-dependent enzyme dialkylgly

213 Glycine decarboxylase, or P-protein, is a pyridoxal 5'-phosphate (PLP)-dependent enzyme in one-car

214 thionine beta-synthase (CBS) is an essential pyridoxal 5'-phosphate (PLP)-dependent enzyme of the tra

215 O-Acetylserine sulfhydrylase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

216 l-lyase (TPL) from Citrobacter freundii is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

217 Ornithine decarboxylase (ODC) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

218 Serine hydroxymethyltransferase (SHMT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catal

219 butyric acid aminotransferase (GABA-AT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degra

220 ystathionine beta-synthase (CBS) is a unique pyridoxal 5'-phosphate (PLP)-dependent enzyme that has a

221 ptophan indole-lyase (Trpase) is a bacterial pyridoxal 5'-phosphate (PLP)-dependent enzyme which cata

222 olevulinate synthase (EC 2.3.1.37) (ALAS), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, catalyzes

223 rine sulfydrylase (OASS), a highly conserved pyridoxal 5'-phosphate (PLP)-dependent enzyme, present i

224 biotin biosynthesis is performed by BioA, a pyridoxal 5'-phosphate (PLP)-dependent enzyme.

225 Pyridoxal 5'-phosphate (PLP)-dependent enzymes utilize t

226 ber of the alpha-oxoamine synthase family of pyridoxal 5'-phosphate (PLP)-dependent enzymes.

227 CsdB protein is a member of the homodimeric pyridoxal 5'-phosphate (PLP)-dependent family of enzymes

228 The three-dimensional structure of the pyridoxal 5'-phosphate (PLP)-dependent L-threonine-O-3-p

229 e and serine to their other chiral form in a pyridoxal 5'-phosphate (PLP)-dependent manner.

230 The pyridoxal 5'-phosphate (PLP)-dependent S-selective trans

231 focused on the dehydration of serine by the pyridoxal 5'-phosphate (PLP)-dependent serine/threonine

232 re generated as mechanistic intermediates of pyridoxal 5'-phosphate (PLP)-dependent serine/threonine

233 The pyridoxal 5'-phosphate (PLP)-dependent transaminase BioA

234 ct distribution generated upon reaction with pyridoxal 5'-phosphate (PLP).

235 sylmethionine (SAM), a [4Fe-4S] cluster, and pyridoxal 5'-phosphate (PLP).

236 g leads including nucleotide analogs such as pyridoxal 5'-phosphate (PLP).

237 r 5,6-LAM are adenosylcobalamin (AdoCbl) and pyridoxal 5'-phosphate (PLP).

238 ms, most notable among which is the cofactor pyridoxal 5'-phosphate (PLP).

239 e kynurenine pathway includes 2 vitamin B-6 [pyridoxal 5'-phosphate (PLP)]-dependent enzymes.

240 Enzymes dependent on pyridoxal 5'-phosphate (PLP, the active form of vitamin

241 Pyridoxal 5'-phosphate (PLP, vitamin B6), a cofactor in

242 valuated the relation between plasma folate, pyridoxal 5'-phosphate (PLP; the biologically active for

243 Pyridoxal 5'-phosphate (PLP; vitamin B(6))-catalyzed rea

244 d to assess HTPO inhibition as a function of pyridoxal 5-phosphate (PLP) concentration.

245 B-6 restriction significantly reduced plasma pyridoxal 5-phosphate (PLP) concentrations (55.1 +/- 8.3

246 Pyridoxal 5-phosphate (PLP), the phosphorylated and the

247 ein is dimeric and adopts the type I-fold of pyridoxal 5-phosphate (PLP)-dependent aminotransferases.

248 I reveals that it belongs to the fold-type I pyridoxal 5-phosphate (PLP)-dependent enzymes.

249 y evaluated plasma concentrations of folate, pyridoxal 5-phosphate (PLP; the principal active form of

250 erase (GABA-AT; GabT) upon interactions with pyridoxal-5'-phosphate (PLP) and GABA, and thereby promo

251 the cofactors adenosylcobalamin (AdoCbl) and pyridoxal-5'-phosphate (PLP) and the substrate into prox

252 coli, purified to homogeneity, shown to bind pyridoxal-5'-phosphate (PLP) and to catalyze cysteine de

253 es of serum carotenoids, retinyl esters, and pyridoxal-5'-phosphate (PLP) by using high-pressure liqu

254 al clinical observation of isolated cases of pyridoxal-5'-phosphate (PLP) deficiency, this prospectiv

255 Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung can

256 Two routes for the de novo biosynthesis of pyridoxal-5'-phosphate (PLP) have been discovered and re

257 Pyridoxal-5'-phosphate (PLP) is introduced to a biomimet

258 Vitamin B-6 as pyridoxal-5'-phosphate (PLP) is required as the coenzyme

259 Pyridoxal-5'-phosphate (PLP) is the biologically active

260 nthase (ACS) in complex with either cofactor pyridoxal-5'-phosphate (PLP) or both PLP and inhibitor a

261 nents of vitamin B6 i.e. pyridoxine (Py) and pyridoxal-5'-phosphate (PLP) using the same MIP format.

262 o rapid in vivo dissociation of its cofactor pyridoxal-5'-phosphate (PLP), a surprising finding, beca

263 expressed in Pichia pastoris, contains bound pyridoxal-5'-phosphate (PLP), but does not catalyze the

264 The x-ray crystal structure of the pyridoxal-5'-phosphate (PLP), S-adenosyl-L-methionine (S

265 The group IV pyridoxal-5'-phosphate (PLP)-dependent decarboxylases be

266 This first step is catalyzed by the pyridoxal-5'-phosphate (PLP)-dependent enzyme serine pal

267 spartate 4-carboxylyase, E.C. 4.1.1.12) is a pyridoxal-5'-phosphate (PLP)-dependent enzyme that catal

268 Kynureninase [E.C. 3.7.1.3] is a pyridoxal-5'-phosphate (PLP)-dependent enzyme that catal

269 Human cystathionine-gamma-lyase (CGL) is a pyridoxal-5'-phosphate (PLP)-dependent enzyme, which fun

270 eso-diaminopimelate decarboxylase (DAPDC), a pyridoxal-5'-phosphate (PLP)-dependent enzyme.

271 acid-base chemistry that drives catalysis in pyridoxal-5'-phosphate (PLP)-dependent enzymes has been

272 Cysteine desulfurases (CDs) are pyridoxal-5'-phosphate (PLP)-dependent enzymes that clea

273 transformations of amino acids performed by pyridoxal-5'-phosphate (PLP)-dependent enzymes.

274 f 5,6-LAM are 5'-deoxyadenosylcobalamin- and pyridoxal-5'-phosphate (PLP)-dependent.

275 , vitamin B6 [whose main circulating form is pyridoxal-5'-phosphate (PLP)], vitamin B12, and homocyst

276 The pyridoxal-5-phosphate (PLP) molecule bonded tightly to L

277 cysteine, folate and vitamin B6 (active form pyridoxal 5'-phosphate, PLP), we conducted a meta-analys

278 significantly decreased levels of pyridoxal, pyridoxal 5'-phosphate, pyridoxamine, and pyridoxamine 5

279 We propose that pyridoxal-5-phosphate regulates Na(+) and K(+) homeostas

280 demonstrate that modification of Lys-1699 by pyridoxal 5'-phosphate results in a specific decrease in

281 hosphates and plays an important role in the pyridoxal 5' phosphate salvage pathway.

282 ional change that releases strain in the Lys pyridoxal 5'-phosphate Schiff base and increases the pK(

283 rspermidine in CANSDC, form a Schiff base to pyridoxal 5'-phosphate, suggesting that the product comp

284 The orientation of the bound pyridoxal 5'-phosphate suggests that the enzyme catalyze

285 Along with pyridoxal 5'-phosphate synthases and aryl nitroreductase

286 gher levels of pyridoxine, pyridoxamine, and pyridoxal 5'-phosphate than the wild type, reflected in

287 The results show that the pool of pyridoxal 5'-phosphate that is not bound to proteins is

288 f an aldimine linkage between the enzyme and pyridoxal 5'-phosphate that was not observed when HemT w

289 an essential enzyme (pdxB) in production of pyridoxal 5'-phosphate (the active form of Vitamin B6),

290 th change in serum vitamin B(12) (P=0.64) or pyridoxal 5' phosphate, the coenzyme form of vitamin B(6

291 the oxidation of pyridoxine 5'-phosphate to pyridoxal 5'-phosphate, the active cofactor form of vita

292 Bacillus subtilis synthesizes pyridoxal 5'-phosphate, the active form of vitamin B(6),

293 vealed this transformation is dependent upon pyridoxal-5'-phosphate, the enzyme has no activity with

294 ase contains a non-catalytic site that binds pyridoxal 5'-phosphate tightly.

295 C) impairs binding of the essential cofactor pyridoxal 5'-phosphate to ALAS2, resulting in destabiliz

296 Pyrococcus horikoshii was transaminated with pyridoxal-5'-phosphate to produce a ketone-bearing prote

297 ase, an enzyme involved in the catabolism of pyridoxal 5'-phosphate (vitamin B 6).

298 dc), an enzyme involved in the catabolism of pyridoxal 5'-phosphate (Vitamin B6).

299 Pyridoxal-5'-phosphate (vitamin B(6) ) is an essential c

300 partial inhibition by substrate, and excess pyridoxal 5'-phosphate was found to be inhibitory.