ライフサイエンスコーパス: pyridyl

1 aphenylporphyrin dianion), and S = 1/2 4-(4'-pyridyl)-1,2,3,5-dithiadiazolyl (py-DTDA) radical, 2.

2 [Co4(bptz)4(dbm)4].4MeCN (2) (bptz = 3,6-bis(pyridyl)-1,2,4,5-tetrazine; dbm = 1,3-diphenyl-1,3-propa

3 templated metallacycles with bptz [3,6-bis(2-pyridyl)-1,2,4,5-tetrazine] in high yields.

4 for the accessory ACh site, such as 3-[3-(3-pyridyl)-1,2,4-oxadiazol-5-yl]benzonitrile (NS9283), can

5 cid and subsequently reacted to 2,4,6-tri(2'-pyridyl)-1,3,5-triazine (TPTZ) then measured at 593 nm.

6 90 degrees Pt(II) acceptor with 2,4,6-tris(4-pyridyl)-1,3,5-triazine (TPyT) or 5,10,15,20-Tetra(4-pyr

7 ially the one using C3-symmetric 2,4,6-tri(4-pyridyl)-1,3,5-triazine as pore-partition agent in MIL-8

8 nd measured urine 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanol (a biomarker of cigarette smoke expo

9 ) (0.05 ng/L) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) (0.2 ng/L) along with the redu

10 utanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) as the targets, we first devel

11 ent nicotine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a metabolite of the powerful

12 tanone (NNK), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), NNAL-N-beta-glucuronide, and

13 inine and urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).

14 novel biomarker [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)], an established biomarker (co

15 ogenic metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol [NNAL]) and VOCs (including metabolit

16 nicotine uptake; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), a

17 olism, as well as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), an

18 lness, smokers by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol had similar severity of lung injury a

19 to patients with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol levels consistent with active smoking

20 Patients with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol levels in the active smoking range we

21 Urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol levels were consistent with active sm

22 with undetectable 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol levels.

23 red by history or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol was not associated with acute respira

24 measured by urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol was significantly associated with acu

25 ine, and the TSNA 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol were identified and quantified in aut

26 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol, a validated tobacco-specific marker,

27 with undetectable 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

28 the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) (0.05 ng/L) and 4-(methylnitro

29 on TSNAs, including (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3

30 ific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN

31 ific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonicotine (NNN) ar

32 ecific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces Ca(2+) signalling, a m

33 ornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and 4-(methylnitrosamino)-1-(

34 dducts of the NOC 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), O(6)-methyl-dG (O(6)-Me-dG) a

35 cific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

36 cco procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

37 l lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

38 obacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK); and r-1-,t-2,3,c-4-tetrahydro

39 ing agent, 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNKOAc).

40 kers of uptake of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and nicotine, respectively, in rela

41 trosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and volatiles.

42 alogs in blocking 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced short-term O(6)-methylguanin

43 1-Alkyl-1H-imidazol-2-yl, ortho pyridyl, 1-alkyl-1H-benzo[d]imidazole-2-yl, 4-bromo-1-me

44 escence spectra of a series of 5-substituted pyridyl-1,2,3-triazolato Pt(II) homoleptic complexes sho

45 Ph(CH2)3 6; Ph(CH2)4 7; Ph 8; 2-pyridyl 9; 3-pyridyl 10] with various dienes using copper-oxidation b

46 -), with examples including R = Me (1a) or 3-pyridyl (1b).

47 luorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole) also blocked clearance of axon de

48 luorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole]) of p38 MAPK.

49 meridional [Rh(IV)(pyalk)3](+) {pyalk =2-(2-pyridyl)-2-propanoate}, the first coordination complex i

50 2,2'-bipyridine, 2-phenylpyridine, or 2-(2'-pyridyl)-2-propanolate were found to be highly resistant

51 wever, the cpCN obtained by rearrangement of pyridyl-2-((13)C-carbene) 34 carries (13)C label on all

52 2)] complexes supported by tetradentate tris(pyridyl-2-methyl)amine ligands (1 and 2) by several orde

53 of iron complexes supported by the TPA (tris(pyridyl-2-methyl)amine) ligand family with H2O2/AcOH or

54 r, emission of a framework composed of bis(5-pyridyl-2-methyl-3-thienyl)cyclopentene (BPMTC) and tetr

55 t obtained from Cp*IrL(OH) precursors (L = 2-pyridyl-2-propanoate) has been difficult to characterize

56 at units (CPDT = cyclopentadithiophene, PT = pyridyl[2,1,3]thiadiazole, IDT = indacenodithiophene) an

57 cal pyridyl substituents, 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine (TPyP), was investigated using

58 -1,3,5-triazine (TPyT) or 5,10,15,20-Tetra(4-pyridyl)-21H,23H-porphine (TPyP).

59 (trpy)](mu-bpp)}(4+) (3(4+)) (bpp(-) = bis(2-pyridyl)-3,5-pyrazolate; trpy = 2,2';6':2''-terpyridine)

60 e stereoselective synthesis of indanyl-7-(3'-pyridyl)-(3R,6R,7R)-2,5-diketopiperazines oxytocin antag

61 ure-based drug design approaches, leading to pyridyl 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolones.

62 be the straightforward synthesis of a stable pyridyl(4-methoxyphenyl)iodonium salt and its [(18)F] ra

63 e simultaneous quantifications of O(6)-[4-(3-pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine (O(6)-POBdG) a

64 (O(6)-POBdG) as well as O(2)- and O(4)-[4-(3-pyridyl)-4-oxobut-1-yl]-thymidine (O(2)-POBdT and O(4)-P

65 dihydroxy-tet rahydrofuran-2-yl]-N-[2-[[1-(2-pyridyl)-4-piperidyl]carbamoylamino]ethyl]purine-2 -carb

66 romethyl)phenyl]-N-[1-[5-(trifluoromethyl)-2-pyridyl]-4-piperi-dyl]p yridin-3-amine (UDD; Protein Dat

67 da compound 101 (Cmpd101; 3-[[[4-methyl-5-(4-pyridyl)-4H-1,2,4-triazole-3-yl] methyl] amino]-N-[2-(tr

68 Ph(CH2)2 5; Ph(CH2)3 6; Ph(CH2)4 7; Ph 8; 2-pyridyl 9; 3-pyridyl 10] with various dienes using coppe

69 The pyridyl-acyl E-hydrazone acts as a hydrogen bonding temp

70 In molecular shuttles containing pyridyl-acyl hydrazone and succinic amide ester binding

71 We report on rotaxanes featuring a pyridyl-acyl hydrazone moiety on the axle as a photo/the

72 Incorporation of 3- and 4-pyridyl-alanine (3-Pal and 4-Pal) enhanced aqueous solub

73 for the cycloaddition reaction between N-(3-pyridyl)aldimines and acetylenes where 1,5-naphthyridine

74 The mechanism of reaction of N-(3-pyridyl)aldimines with olefins can be explained by an as

75 tructs (L being a tridentate or tetradentate pyridyl/alkylamino ligand), and spectroscopic and kineti

76 A 2-pyridyl alkyne, possessing a proximal nitrogen, influenc

77 ctene polymerization as catalyzed by hafnium-pyridyl amido precursors enables quantification of the a

78 talytic systems, including 'ligand free' and pyridyl amine ligand based systems, that have been appli

79 significantly more potent than the 3- and 4-pyridyl analogs.

80 -isoquinolyl)naphthalene N-oxide (2) and its pyridyl analogue 3 combine fast substrate binding with d

81 s were of the type X-Y-X, where X represents pyridyl anchors with para (p), meta (m) or ortho (o) con

82 In contrast, 2-pyridyl and 5-thiazolyl boronic acids undergo rapid prot

83 The resulting 3-pyridyl and m-hydroxyphenyl ethers have high alpha4beta2

84 ls, and how it compares with other classical pyridyl and polypyridyl based ligands, and then present

85 ds, which arise from competing influences of pyridyl and pyrazolyl ligand substituents on Fe-L sigma

86 re also attained by meta hydroxylating the 3-pyridyl and the phenyl ethers of (S)-N-methylprolinol an

87 in this paper we describe a small library of pyridyl- and imidazolylmethylchromones as potential inhi

88 We have generated two persistent pyridyl-appended radical cations: 10-(pyrid-2-yl)-10H-ph

89 bene, dipyridylamine, pyridyl-benzimidazole, pyridyl-azolate, and other aromatic ligands provides a c

90 showed that the activation by methylation of pyridyl-based alkoxyamine 1 increased with the hydrogen

91 The design of pyridyl-based fluorescent sensors for selective sensing

92 The design of pyridyl-based ligands for the separation of Am(III) from

93 of these classes of compounds we termed the pyridyl benzamides.

94 2 and 1,4-bis-(4-(3,5-dicyano-2,6-dipyridyl)pyridyl)benzene (3); the latter formed in situ from the

95 ,10-phenanthroline, carbene, dipyridylamine, pyridyl-benzimidazole, pyridyl-azolate, and other aromat

96 te the pbnHH ligand-pbnHH = 1,5-dihydro-2-(2-pyridyl)-benzo[b]-1,5-naphthyridine-to model the functio

97 situations where pore chemistry is similar (pyridyl benzoate-type linkers) or identical (in the case

98 An iron(II) pyridyl-benzohydrazonate-based complex decorated with lo

99 Problem solved: an air-stable 2-pyridyl borane that can effectively couple to a wide ran

100 very slow protodeboronation, as do 3- and 4-pyridyl boronic acids (t0.5 > 1 week, pH 12, 70 degrees

101 forms a dimethylamidoiron(II) complex and a pyridyl-bridged tetrairon(II) square.

102 se adducts, including bulky O(6)-[4-oxo-4-(3-pyridyl)but-1-yl]deoxyguanosine (O(6)-POB-dG) lesions.

103 ed hemiketal, but also to Cys269 through the pyridyl C5-substituent, thus providing an inhibitor with

104 d efficient NH insertion reaction of rhodium pyridyl carbenes derived from pyridotriazoles was develo

105 uorescence quenching effect was observed for pyridyl carrying push-pull porphyrin 4c in the presence

106 rongly coordinated with the nitrogens of the pyridyl coated electrodes, with a binding energy that is

107 e in 1,2-addition fashion to form the stable pyridyl complex (PNP)Sc(NH[DIPP])(eta(2)-NC(5)H(4)) (2).

108 in the presence of free pyridine to give the pyridyl complex [Ru(eta(5)-C(5)H(5))(C(5)H(4)N)( horizon

109 oligophenyleneethynylene (OPE)-based Pd(II) pyridyl complex has been synthesized, and its self-assem

110 enyl ring to the pyridine ring of an yttrium pyridyl complex supported by a 1,1'-ferrocene diamide li

111 The position of the nitrogen in pyridyl-containing alkyne substrates also affects the re

112 ), that the CHEF effect can be achieved with pyridyl-containing fluorophores that coordinate directly

113 vity is phenyl-linked rather than having the pyridyl core as in the peripheral cavities.

114 sponding diols 7 and 10 to the corresponding pyridyl cryptands 3 and 4 by reaction with pyridine-2,6-

115 yl)imide (PyTFSI)-templated syntheses of 2,6-pyridyl cryptands of cis(4,4')-dibenzo-30-crown-10 (3a),

116 -(2-methoxyphenyl) piperazin-1-yl]ethyl-N-(2-pyridyl) cyclohexane carboxamide ((18)F-FCWAY) PET and C

117 (2-methoxyphenyl)-1-piperazinyl)ethyl))-N-(2-pyridyl)-cyclohexanecarbo xamide ([11C]WAY-100635), a se

118 lene (TCNE) at 20-90 degrees C to yield 3-(2-pyridyl)cyclopropanetetracarbonitrile 11 and 3-(tricyano

119 u treatment of the resultant quaternary N-(2-pyridyl)-DABCO salts with nucleophiles, resulting in rin

120 PEt3)2(OSO2CF3)2, with two organic donors, a pyridyl-decorated tetraphenylethylene and one of two ben

121 ation of S355C-beta2 with the 4-(bromomethyl)pyridyl derivative of [Re] to yield the labeled species,

122 A series of air-stable, tunable, P-chiral pyridyl-dihydrobenzooxaphosphole ligands were designed a

123 stigate this difference for four different 2-pyridyl diketopyrrolopyrrole (DPP) polymer-fullerene sol

124 -benzo[d]imidazol-2-ylidene; py2-BMe2 = di(2-pyridyl)dimethylborate).

125 -deficient 2-pyrone substrate containing a 2-pyridyl directing group, which undergoes regioselective

126 yl) methacrylamide corona block with pendent pyridyl disulfide groups for reversible conjugation of t

127 e chain-end functionalities included alkyne, pyridyl disulfide, dopamine, beta-thiolactone, and bioti

128 with an iron complex of EDTA-2-aminoethyl 2-pyridyl disulfide.

129 The second component uses (ortho-pyridyl) disulfide-PEG-succinimidyl ester to couple the

130 roup that is appended to the 6-position of a pyridyl donor of a tripodal tetradentate ligand.

131 idine)s [4,4'-bis(pyridyl)ethylene, 4,4'-bis(pyridyl)ethane, and 4,4'-bipyridine].

132 (bpa)] and [Cu2(glu)2(bpp)] (bpa = 1,2-bis(4-pyridyl)ethane; bpp = 1,3-bis(4-pyridyl)propane), underg

133 (bpy-1 = 4,4'-bipyridine; bpy-2 = 1,2-bis(4-pyridyl)ethene) has been studied to assess its selectivi

134 )(2)(M'O(4))] (M = Co or Ni; bpe = 1,2-bis(4-pyridyl)ethene; M' = Mo or Cr) has been synthesized and

135 inked by one of three rigid ligands: 4-(2-(4-pyridyl)ethenyl)benzoate (1), 4-(pyridin-4-yl)benzoate (

136 -inactive spacers consisting of 1,4-bis[2-(4-pyridyl)ethenyl]benzene (BPEB) and PdCl2 of variable thi

137 both the 3-hydroxyphenyl and the 5-hydroxy-3-pyridyl ether of N-methylprolinol are alpha4beta2 full a

138 A 3-pyridyl ether scaffold bearing a cyclopropane-containing

139 this study we synthesized a novel ITC, 2-(2-pyridyl) ethyl ITC (PY-ITC), and assessed its chemopreve

140 Me(2))MoO](2+) (PY5Me(2) = 2,6-bis(1,1-bis(2-pyridyl)ethyl)pyridine).

141 s the pentadentate ligand, 2,6-bis(1,1-bis(2-pyridyl)ethyl)pyridine.

142 Crystals incorporating 4,4'-bis(pyridyl)ethylene and 4,4'-bipyridine displayed conductiv

143 and three different bis(pyridine)s [4,4'-bis(pyridyl)ethylene, 4,4'-bis(pyridyl)ethane, and 4,4'-bipy

144 ymene)4(bpe)2(donq)2][DOS]4 (bpe = 1,2-bis(4-pyridyl)ethylene, donq = 5,8-dioxydo-1,4-naphtoquinonato

145 The binding of trans-1,2-bis(4-pyridyl)-ethylene (BPE) molecules on substrates arrayed

146 The rod-like molecule bis((4-(4-pyridyl)ethynyl)bicyclo[2.2.2]oct-1-yl)buta-1,3-diyne, 1

147 ophenyl)porphinato]zinc(II) and [5,15-bis[4-(pyridyl)ethynyl]-10,20-diphenylporphinato]zinc(II), resp

148 ns are used in a second step to assemble the pyridyl-functionalized alkene into a geometry in the sol

149 via a 1D coordination polymer to generate a pyridyl-functionalized cyclobutane stereoselectively and

150 Removal of the pyridyl group affords the aldehyde-functionalized cyclob

151 roup of the dibemethin was replaced with a 2-pyridyl group and in which the 4-amino-7-chloroquinoline

152 on (not ortho or meta) of the A-ring and a m-pyridyl group as B-ring, significantly improve activity.

153 As the directing 2-pyridyl group can easily be removed at any suitable stag

154 erty analysis shows that replacing the rotor pyridyl group of our typical hydrazone switch with a phe

155 de evidence that linking hpp groups with the pyridyl group stabilizes the protonation center, thereby

156 These studies also indicated that a 3-pyridyl group was the preferred substituent at one inhib

157 ryl sulfone as a replacement for the 3-cyano pyridyl group.

158 ed with quaternarization of the peripheral 4-pyridyl groups (PhiF increases from 0.22 to 0.96) while

159 the relative affinity of ligands containing pyridyl groups for divalent and trivalent metal ions in

160 r optical activity and the important role of pyridyl groups in the self-assembly of these chiral macr

161 mainly attributed to the protonation of the pyridyl groups of 4c.

162 s a covalently attached polymer with pendent pyridyl groups that provide attachment points for assemb

163 lexes and metalloligands with four divergent pyridyl groups.

164 pling of a large array of aryl, thienyl, and pyridyl halides with cyclic nitrones, including DMPO.

165 minantly a pipi* state localized at the 1-(2-pyridyl)-imidazo[1,5-alpha]pyridine (= impy) ligand core

166 aracters and dynamics of [ReCl(CO)3(3-R-1-(2-pyridyl)-imidazo[1,5-alpha]pyridine)] complexes (abbrevi

167 aving N-heterocyclic substituents, including pyridyl, imidazolyl, pyrimdyl, and other groups.

168 here there is a clear hierarchy for zinc(II)-pyridyl interaction followed by hydrogen-bonding between

169 se of Turbo Grignard generated the metallo-2-pyridyl intermediate more reliably than alkyllithium rea

170 rough three different interactions: a strong pyridyl-iron one, and two weaker carboxamido-iron ones t

171 dional isomers of [Ir(pyalk)3] (pyalk = 2-(2-pyridyl)isopropanoate), as model complexes for a powerfu

172 Di-2-pyridyl ketone (dpk)-supported amidoarylpallada(II)cycle

173 developed a series of second-generation di-2-pyridyl ketone thiosemicarbazone (DpT) and 2-benzoylpyri

174 Migration of the pyridyl ligand (or its pyridylidene tautomer) to the alp

175 st assembly step, BCPs functionalized with a pyridyl ligand on the chain end form star-shaped polymer

176 hesized by the self-assembly of a tetratopic pyridyl ligand with a 180 degrees diplatinum(II) motif a

177 The combination of pyridyl ligands and square-planar Pd(ii) or Pt(ii) catio

178 bly of dibenzosuberone-based bis-monodentate pyridyl ligands L(1) with Pd(II) cations leads to the qu

179 Here the binding of pyridyl ligands to zinc porphyrins with thioester-linked

180 s(heteroleptic) Ir(III) compounds containing pyridyl ligands with weakly coordinating nido-carboranyl

181 porphyrins bearing either 4-aminophenyl or 4-pyridyl meso substituents were performed using methanesu

182 on at Pd(IV) centers supported by the tris(2-pyridyl)methane (Py3CH) ligand.

183 (5) and (dpms)Pd(II)Me(OH2) (8) (dpms = di(2-pyridyl)methanesulfonate) in water in the pH range of 6-

184 ) and (dpms)Pt(II)Me(OH)(-) (2) [dpms = di(2-pyridyl)methanesulfonate] in water in the pH range of 4-

185 u-OH)2}(OTf)2 (L = Me2TMPA = bis((6-methyl-2-pyridyl)methyl)(2-pyridylmethyl)amine) in which water ox

186 H4)CH3)DPFN]NTf2 (DPFN = 2,7-bis(fluoro-di(2-pyridyl)methyl)-1,8-naphthyridine; NTf2(-) = N(SO2CF3)2(

187 )2C6H3, and C6F5; DPFN = 2,7-bis(fluoro-di(2-pyridyl)methyl)-1,8-naphthyridine; X = BAr4(-) and NTf2(

188 ate ligand (6-Ph(2)TPA = N,N-bis((6-phenyl-2-pyridyl)methyl)-N-(2-pyridylmethyl)amine) and containing

189 sence of the capping ligand tris((6-methyl-2-pyridyl)methyl)amine (Me3TPyA) affords the dinuclear com

190 onane (L1) or 1,4,7-tris[(5-amino-6-methyl-2-pyridyl)methyl]-1,4,7-triazacyclononane (L2).

191 O)](2+) (N4Py: N,N-bis(2-pyridylmethyl)bis(2-pyridyl)methylamine), is the least basic oxidant.

192 tate ligand N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine, has been proposed to attack C-H bon

193 pump inhibitors having the core structure, 2-pyridyl-methylsulfinyl-benzimidazole.

194 ian cones and horizontal cells showed that 2-pyridyl-methylsulfinyl-benzimidazoles blocked the negati

195 onal prismatic primary MBBs decorated by six pyridyl moieties (tp-PMBB-1).

196 ovel Ir(III) luminophores containing pendant pyridyl moieties that allow for adsorption onto metal su

197 as oxidation or amine quaternization, of the pyridyl moiety carried by the alkyl fragment was suitabl

198 functionalizing every primary CH2OH with a 4-pyridyl moiety.

199 ecules that differ only in the position of a pyridyl N-atom within an acceptor fragment are compared

200 tly organized PT orientations, such that the pyridyl N-atoms point toward the CPDT fragment.

201 single crystals reveals that positioning the pyridyl N-atoms proximal to the molecules center changes

202 binding salicylaldehyde unit and an adjacent pyridyl N-oxide fluorophore undergoes rapid condensation

203 into spin adducts of the spin trap alpha-(4-pyridyl N-oxide)-N-tert-butylnitrone (POBN).

204 The N-(2-pyridyl)-N'-ethylpiperazines are important structural mo

205 -[4-(2-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(trans-4-(18)F-fluoro methylcyclohexane)carbo

206 [Ru(tpy)(Mebim-py)(OH(2))](2+) (Mebim-py = 2-pyridyl-N-methylbenzimidazole), catalyze water oxidation

207 inhibitors were designed leading to the 2-(3-pyridyl)naphthalenes 10 and 11 with strong inhibition of

208 qdpq; bpy = 2,2'-bipyridine; qdpq = 2,3-di(2-pyridyl)naphtho[2,3-f]quinoxaline-7,12-quinone) possesse

209 The four pyridyl nitrogen atoms define a perfectly planar rectang

210 nitrogen photoelectron peak associated with pyridyl nitrogen atoms residing on bridging sites.

211 ll defined by electron density maps with its pyridyl nitrogen bound to the heme iron.

212 ting the N-alkyl substituent attached to the pyridyl nitrogen from ortho to meta and para positions.

213 oach involves the preferential attack of the pyridyl nitrogen over aryl ring and leads to the formati

214 ue to the positive charge centralized on the pyridyl nitrogen, N-H(+).

215 nofingers through the lone pair electrons of pyridyl nitrogens, not through delocalized pi electrons.

216 ovide a toolset for the predictive design of pyridyl nitroxides.

217 3,6-Substituted tetrazines 2 (a: R(2) = 2-pyridyl or b: CO(2)Me) react with 2,3,9,10-(R(1))(4)-dih

218 h oxalamide host molecules containing either pyridyl or nitrile side groups, in which halogen bonds a

219 This approach provides rapid access to pyridyl (or pyridone)-substituted 1,3,5-triazines with h

220 itives (e.g., Cu, Zn salts) can attenuate (2-pyridyl) or accelerate (5-thiazolyl and 5-pyrazolyl) fra

221 A series of novel pyridyl- or isoquinolinyl-substituted indolines and indo

222 beta-stereocenters was developed using a new pyridyl-oxazoline ligand.

223 bond-formation occurs from (PtBu(3))Pd(Ar)(2-pyridyl oxide).

224 OAr-Py, and HOAr-CH(2)Py, respectively; Py = pyridyl; Ph = phenyl).

225 hips demonstrated the importance of the di-2-pyridyl pharmacophore in their activity.

226 , forming a stable Rh(II) radical Cp*Rh(2-(2-pyridyl)phenyl)* (14a) that can activate H2 at room temp

227 e high energy of the Rh(I) anion [Cp*Rh(2-(2-pyridyl)phenyl)](-).

228 d for the Rh(III) hydride complex Cp*Rh(2-(2-pyridyl)phenyl)H (1a).

229 ination-driven self-assembly of hexakis[4-(4-pyridyl)phenyl]benzene, cis-(PEt(3))(2)Pt(II)(OTf)(2), a

230 spontaneous hydrolysis of the anion of di-2-pyridyl phosphate (DPP) is thousands of times faster (ca

231 (2) in the presence of meso-tetra(N-methyl-4-pyridyl)porphine tetratosylate (TMPyP) afforded porph@MO

232 meso-Tetra(N-methyl-4-pyridyl)porphine tetratosylate (TMPyP) templates the syn

233 Mn(III) Tetrakis (1-methyl-4-pyridyl) porphyrin (MnTMPyP), an antioxidant, reduced su

234 ionic porphyrin (5,10,15,20-tetra(N-methyl-4-pyridyl) porphyrin (TMPyP4)), which can bind some G-quad

235 ionic porphyrin, 5,10,15,20-tetra(N-methyl-4-pyridyl)porphyrin (TMPyP4), using differential scanning

236 With water-soluble iron tetrakis(N-methyl-4-pyridyl)porphyrin as an example, procedures are describe

237 eous catalysis with iron tetrakis(N-methyl-4-pyridyl)porphyrin has been overlooked in previous studie

238 -) scavenger, iron-(III)-tetrakis(N-methyl-4'pyridyl)porphyrin-pentachloride, or uric acid, whereas e

239 cavenger MnTMPyP [Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin].

240 hniques on monomeric cobalt(II) tetra(meso-4-pyridyl)porphyrinate (CoTPyP) and its cofacial analogue

241 A CF3-thiazole substituent at the 4-pyridyl position improved inhibitory potency due to a fa

242 nd acid isosteres were incorporated at the 5-pyridyl position of this fragment, bridging to a key asp

243 d the neutral N-donor spacer ligand 1,3-di(4-pyridyl)propane (dpp) lead in a single reaction vial to

244 = 1,2-bis(4-pyridyl)ethane; bpp = 1,3-bis(4-pyridyl)propane), undergo spontaneous phase changes upon

245 a N-pyridinio aryl group (Ar) phenyl (Ph), 4-pyridyl (Py), and 4-pyridylium (qPy) and their bulky 3,5

246 having four different anchoring groups (SH, pyridyl (PY), NH(2), and CN) at a solid/liquid interface

247 p cyano (CN), amino (NH2), thiol (SH), and 4-pyridyl (PY).

248 te in an ethanol-water system with 2,3-bis(2-pyridyl)pyrazine yielded basic bismuth nitrate Reuleaux

249 ) (bpy = 2,2'-bipyridine and dpp = 2,3-bis(2-pyridyl)pyrazine) catalyze the photochemical reduction o

250 l2 ](5+) (bpy=2,2'-bipyridine, dpp=2,3-bis(2-pyridyl)pyrazine).

251 +) (3) (bipy = 2,2'-bipyridine; CppH = 2-(2'-pyridyl)pyrimidine-4-carboxylic acid; Cpp-NH-Hex-COOH =

252 halides on aniline derivatives as well as on pyridyl-, pyrimidyl-, and pyrazolyl-substituted arenes.

253 isiae to copper is overcome by 2-(6-benzyl-2-pyridyl)quinazoline (BPQ), providing a chemical-biology

254 The potent oral activity of 2-pyridyl quinolones underlines the potential of this temp

255 n intrinsic clearance gave 2',6'-dimethyl-3'-pyridyl R-sec-butyl morpholine amide Epelsiban (69), a h

256 dicated by the presence of the corresponding pyridyl radical and pyridyne diradical species, but thes

257 al and pyridyne diradical species, but these pyridyl radicals are less stable and subject to further

258 oline can be synthesized through reaction of pyridyl radicals with 1,3-butadiene or sequentially with

259 chors that form only S-Au or N-Au bonds, the pyridyl ring also forms a highly-conductive cofacial lin

260 involving mono- and disubstitution in the 3'-pyridyl ring and variation of the 3-isobutyl group gave

261 Substitution of the pyridyl ring in the 3-, 4-, and 5-positions was used to

262 ting electrophiles at the C5 position of the pyridyl ring of 2 (OL-135) and related compounds were pr

263 sing a glycol chain at the 4-position of the pyridyl ring, and 1 and 2, which lack such a chain, and

264 ds through the stronger interaction with the pyridyl ring, which enables reversible unfolding and ref

265 nding between uranium cations and the eta(5)-pyridyl ring.

266 ituents, and donors, such as C(sp2)-H of the pyridyl rings or C(sp3)-H at various positions of the bi

267 pair, spiro[2.3]hex-1-ene (Sph) and 3,6-di(2-pyridyl)-s-tetrazine (DpTz), for the strain-promoted inv

268 The FRAP reagent contains 2,4,6-tris(2-pyridyl)-s-triazine, which forms a blue-violet complex i

269 i) (6a), Ga(Pytsi) (6b); Pytsi = [dimethyl(2-pyridyl)silyl]bis(trimethylsilyl)methyl) and [1]ruthenoc

270 The regioselectivity is guided by the pyridyl substituent attached to the nitrogen center of t

271 The strict regioselectivity is guided by the pyridyl substituent attached to the nitrogen of the pyri

272 aced electrophiles at the C5 position of the pyridyl substituent of 2 (OL-135) were prepared and exam

273 cytochrome P450 enzymes, probably due to a 4-pyridyl substituent.

274 f ditopic perylenediimide 16, containing two pyridyl substituents at its imido positions, enabled sel

275 transport in a porphyrin with four identical pyridyl substituents, 5,10,15,20-tetra(4-pyridyl)-21H,23

276 Pyridyl substituted arylsulfonyltetrahydroquinolines wer

277 NAP, a 6beta-N-4'-pyridyl substituted naltrexamine derivative, was identif

278 Pyridyl-substituted 1,3,5-triazines were synthesized in

279 An array of six pyridyl-substituted fused bicyclic piperidines was prepa

280 kappa(2)-N-eta(2)-BC Pt complexes of a boron-pyridyl-substituted monobenzofused-1,4-azaborine.

281 n be increased with the incorporation of a 2-pyridyl substitution on the boratriazaroles, and the str

282 of terminal and internal alkynes bearing a 2-pyridyl sulfonyl group (SO2Py) at the propargylic positi

283 nding on the presence or absence of the N-(2-pyridyl)sulfonyl group.

284 lation reaction taking advantage of the N-(2-pyridyl)sulfonyl group.

285 ntaining ligand L, composed of two bidentate pyridyl-thiazole moieties linked by a 1,3-diaminophenyle

286 terestingly, the substituted groups (phenyl, pyridyl, thienyl) in the 1,4-positions did affect their

287 e molecules with different anchoring groups (pyridyl, thiol, amine, nitrile and dihydrobenzothiophene

288 mine bond formation is employed to install a pyridyl to the alkene trans-cinnamaldehyde while Ag(I) i

289 hich forms a phosphate diester only when a 2-pyridyl TPG is applied.

290 was prepared by C-(11)C-methylation of the 3-pyridyl trifluoroborate precursor with (11)C-methyl iodi

291 II) metalloporphyrin backbone bearing both a pyridyl unit and a terpyridyl unit acting as coordinatin

292 parallel arene moieties of the wheel and the pyridyl unit of axle are operative in addition to metal

293 ched at the 5- or 6-position of the terminal pyridyl unit were synthesized.

294 ended tetrathiafulvalene ligand bearing four pyridyl units and cis-M(dppf)(OTf)2 (M = Pd or Pt; dppf

295 (BPTTF)-based tetratopic ligand bearing four pyridyl units is described.

296 ed conformation of the urea bond between two pyridyl units.

297 430 (1-(2,6-dibromo-4-isopropyl-phenyl)-3-(3-pyridyl)urea, molecular weight = 413), with antagonist p

298 A fragment molecule, 1-ethyl-3-(2-pyridyl)urea, provided sufficiently potent enzyme inhibi

299 luences the regioselectivity relative to a 4-pyridyl variant quite dramatically, favoring the beta-po

300 omplex is stabilized by electron-withdrawing pyridyl ("X") substituents, but also by electron-donatin