ライフサイエンスコーパス: pyrin domain

1 t, similar to FMF patients, retains the full PYRIN domain.

2 Their N termini vary, but most have a pyrin domain.

3 90-amino-acid N-terminal sequence called the PYRIN domain.

4 pha2-alpha3 loop is not a general feature of pyrin domains.

5 two zebrafish caspases containing N-terminal pyrin domains.

6 nod-like receptor family member containing a pyrin domain 3 (NLRP3) inflammasome in a protracted mann

7 diated by the NOD-like receptor containing a pyrin domain 3 (NLRP3) inflammasome, although exactly ho

8 and leucine-rich repeat receptor containing pyrin domain 3 (NLRP3) inflammasome.

9 gomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasomes and induces the rel

10 he absence of Nod-like receptor containing a pyrin domain 3 and absent in melanoma 2.

11 elanoma 2 and Nod-like receptor containing a pyrin domain 3 are partially required for caspase-1 acti

12 otide-binding domain and leucine-rich repeat pyrin domain 3 are simultaneously present in the same in

13 lood leukocytes and encodes a protein with a pyrin domain, a nucleotide-binding site (NBS, NACHT subf

14 BRCA1 (aa 502-802) interacted with the IFI16 Pyrin domain (aa 1-130).

15 sist of three functional domains including a pyrin domain, an NACHT domain, and a leucine-rich repeat

16 amily member that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/olig

17 N-terminal region that contains a predicted pyrin domain and a putative nuclear localization signal.

18 ein containing a caspase recruitment domain) pyrin domain and the IFI16-double stranded DNA complex h

19 unexpected auto-inhibitory function for the pyrin domain, and provide the first genetic evidence lin

20 Pyrin, a protein of 781 aa with pyrin domain at the N-terminal, negatively regulates inf

21 this response by interacting with the IFI16 pyrin domain, blocking its oligomerization upon DNA sens

22 200 domain of AIM2 binds to DNA, whereas the pyrin domain (but not that of the other PYHIN family mem

23 ing dsDNA, only the Aim2 protein through its pyrin domain can form an inflammasome to activate caspas

24 gomerization domain, leucine rich repeat and pyrin domain containing 1 (NLRP1), NLRP3, and nucleotide

25 these sensors, including NLRP1 (NLR family, pyrin domain containing 1), are described to form an inf

26 ng the NOD-like receptor NLRP10 (NLR family, pyrin domain containing 10); however, the mechanism by w

27 merization domain (NOD)-like receptor family pyrin domain containing 12 (NLRP12) plays a protective r

28 One NLR gene, NLRP12 (NLR family, pyrin domain containing 12)/Monarch-1, has emerged as an

29 ucine-rich repeat containing protein family, pyrin domain containing 3 (NLRP3) (cryopyrin or NALP3) a

30 uble deficiency of Nod like receptor family, pyrin domain containing 3 (NLRP3) and caspase 8 inPstpip

31 In this context, NLR family pyrin domain containing 3 (NLRP3) inflammasome activatio

32 n and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome as an ess

33 ding domain, leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome complex a

34 cell sensor leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome controls

35 NLR family pyrin domain containing 3 (NLRP3) inflammasome has been

36 is a key to induce NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in macrop

37 itin, activate the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in primed

38 Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is involv

39 leucine-rich repeat containing gene family, pyrin domain containing 3 (NLRP3) inflammasome to induce

40 The NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, a multip

41 oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-dependent

42 of Tat in priming and activating NLR family pyrin domain containing 3 (NLRP3) inflammasomes in micro

43 ammasome system, mediated by the NLR family, pyrin domain containing 3 (NLRP3) initiating protein, wa

44 leotide-binding domain, leucine-rich repeat, pyrin domain containing 3 (NLRP3) is a key component of

45 NOD-like receptor family, pyrin domain containing 3 (NLRP3) protein is a key compo

46 rm depended on the NOD-like receptor family, pyrin domain containing 3 (NLRP3) sensor and the apoptos

47 components of the NOD-like receptor family, pyrin domain containing 3 (NLRP3), and absent in melanom

48 n and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3).

49 Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1 inflammasome

50 gomerization domain, leucine-rich repeat and pyrin domain containing 3 (NRLP3) inflammasome members (

51 erization domain (NOD)-like receptor family, pyrin domain containing 3 activation in the inflammasome

52 tightly regulating NOD-like receptor family, pyrin domain containing 3 activation.

53 rich repeat-containing-like receptor family, pyrin domain containing 3 and autophagosome-associated m

54 rvention targeting NOD-like receptor family, pyrin domain containing 3 inflammasome activity induces

55 he key role of the NOD-like receptor family, pyrin domain containing 3 inflammasome during acute pneu

56 n regulate hepatic steatosis; the NLR family pyrin domain containing 3 inflammasome is critically inv

57 he activity of the NOD-like receptor family, pyrin domain containing 3 inflammasome when compared wit

58 ypoxia activate the NOD-like receptor family pyrin domain containing 3 inflammasome.

59 IL-1beta-producing NOD-like receptor family pyrin domain containing 3 inflammasome.

60 otide-binding domain and leucine-rich repeat pyrin domain containing 3 inflammasome.

61 innate immune-sensing complex known as "NLR-Pyrin domain containing 3" (NLRP3) inflammasome, also kn

62 omain leucine-rich repeat containing family, pyrin domain containing 3) inflammasome complex, assembl

63 The NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome is a multiprotei

64 flammasomes, and that the NLRP3 (NLR family, pyrin domain containing 3) inflammasome is not involved

65 OD2 target, NLRP3 (NOD-like receptor family, pyrin domain containing 3) is of importance in the patho

66 e-recruitment domain) and NLRP3 (NLR family, pyrin domain containing 3), which are essential for casp

67 spase-1, and NLRP3 (NOD-Like Receptor family Pyrin domain containing 3).

68 eased expression of inflammatory (NLR family pyrin domain containing 3, interleukins 1beta and 6, and

69 rich repeat-containing-like receptor family, pyrin domain containing 3-associated inflammasomes and i

70 e-1/Caspase-4- and NOD-like receptor family, pyrin domain containing 3-dependent inflammatory cell de

71 ce deficient in the NOD-like receptor family pyrin domain containing 6 (NLRP6) inflammasome feature e

72 g oligomerization domain (NOD)-like receptor pyrin domain containing family of gene 12 (Nlrp12) are a

73 salivary levels of nod-like receptor family pyrin domain containing protein (NLRP) 3, apoptosis-asso

74 tide-binding domain, leucine-rich repeat and pyrin domain containing protein (NLRP) family, which for

75 leotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) inflammasome.

76 te the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome.

77 (ATG5), ATG7 and ATG16L1 but not NLR family, pyrin domain containing-3 (NALP3).We show that NOD2-medi

78 tly demonstrated that the NOD-like receptor, pyrin domain containing-3 (NLRP3) contributes to renal i

79 nding domain leucine-rich repeat containing, Pyrin domain containing-3 and for absent in melanoma 2 i

80 nding domain leucine-rich repeat containing, Pyrin domain containing-3 inflammasome, and caspase-4 ph

81 ting a role for the NOD-like receptor family pyrin domain containing-3 inflammasome.

82 e nucleotide oligomerization domain receptor pyrin-domain containing protein 3 (NLRP3) by Salmonella

83 NLRP1 (NLR family, pyrin domain-containing 1) is a contributor to innate im

84 me components, we found that both NLR family pyrin domain-containing 3 (Nlrp3) and apoptosis-associat

85 -1beta dependent on NOD-like receptor family pyrin domain-containing 3 (NLRP3) and ASC due to the sec

86 mutations in NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) cause neonatal-onset m

87 oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome and conco

88 main, leucine-rich repeat-containing family, pyrin domain-containing 3 (NLRP3) inflammasome as well a

89 oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome drives ma

90 The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been

91 The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is a casp

92 omain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is now no

93 g oligomerization domain-like receptor (NLR) pyrin domain-containing 3 (Nlrp3) inflammasome is though

94 leucine-rich repeat containing family (NLR), pyrin domain-containing 3 (NLRP3) inflammasome plays a k

95 cleotide-binding domain, leucine-rich repeat pyrin domain-containing 3 (NLRP3) inflammasome.

96 oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome.

97 In this study, we showed that NLR family pyrin domain-containing 3 (Nlrp3) is required to induce

98 n (ASC) inflammasomes, including NLR family, pyrin domain-containing 3 (NLRP3), but not NLR family, c

99 ts, including NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3), NLRP1, NLR family CAR

100 ng and oligomerization, leucine-rich repeat, pyrin domain-containing 3 (NLRP3), simultaneously and di

101 otide-binding oligomerization domain family, pyrin domain-containing 3 inflammasome activation upon H

102 is detected by the NOD-like receptor family, pyrin domain-containing 3 inflammasome and can trigger a

103 and activates the NOD-like receptor family, pyrin domain-containing 3 inflammasome.

104 oligomerization domain-like receptor family, pyrin domain-containing 3 inflammasome.

105 main, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome mediates product

106 cleotide-binding domain, leucine-rich repeat/pyrin domain-containing 3.

107 cruitment domain-containing 4 or NLR family, pyrin domain-containing 6, are required for triggering t

108 rodent NLRP1B (NACHT leucine-rich repeat and pyrin domain-containing protein 1B).

109 erization domain (NOD)-like receptor family, pyrin domain-containing protein 3 (Nlrp3) expression was

110 The NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome i

111 The NACHT, LRR, and pyrin domain-containing protein 3 (NLRP3) inflammasome i

112 osolic contact, and activation of NLR family pyrin domain-containing protein 3 (NLRP3) inflammasomes

113 binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasomes

114 inding oligomerization-like receptor family, pyrin domain-containing protein 3) activation, either by

115 flammasome components Nalp3 (NACHT, LRR, and pyrin domain-containing protein 3), ASC (apoptosis-assoc

116 The SREBP-induced NOD-like receptor family pyrin domain-containing protein inflammasome and its ins

117 e activation of the NOD-like receptor family pyrin domain-containing protein inflammasome in macropha

118 The myxoma virus (MYXV)-encoded pyrin domain-containing protein M013 coregulates inflamm

119 t nucleotide-binding leucine-rich repeat and pyrin domain-containing receptor 12 (NLRP12) impedes alt

120 ding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome controls

121 ding domain, leucine-rich-containing family, pyrin domain-containing-3 (Nlrp3, but also known as Nalp

122 ucine-rich-repeat-containing receptor (NLR), pyrin-domain-containing 3 (NLRP3) inflammasome in human

123 merization drug AP20187, suggesting that the PYRIN domain functions as an oligomerization domain, whe

124 gy include the elucidation of the N-terminal PYRIN domain in protein-protein interactions, the descri

125 8), and Glu(16), believed critical for Pyrin/Pyrin domain interaction, are important for inflammasome

126 LP1, is unlikely to be a common attribute of pyrin domain interactions.

127 The PYRIN domain is a recently identified protein-protein in

128 We show here that the pyrin domain of AIM2 (AIM2(PYD)) drives both filament fo

129 VHHASC leaves the Pyrin domain of ASC functional and stabilizes a filament

130 on the recent near-atomic structures of the PYRIN domain of ASC in the protein filament of inflammas

131 Substitution of the PYRIN domain of ASC with an inducible FKBP12 oligomeriza

132 and leucine-rich repeat regions, but not the pyrin domain of CIAS1, are responsible for this inhibiti

133 weak affinity, and it is the non-DNA-binding pyrin domain of IFI16 that drives the cooperative filame

134 the structure and dynamics of the N-terminal pyrin domain of NLRP12 (NLRP12 PYD) determined using NMR

135 the structure and dynamics of the N-terminal pyrin domain of NLRP7 (NLRP7 PYD) obtained by NMR spectr

136 protein that interacts selectively with the PYRIN domain of PYPAF1.

137 The pyrin domains of both Caspy and zAsc were required for t

138 ty, de Almeida et al. (2015) report that the PYRIN domain-only protein (POP1) efficiently inhibits in

139 cent developments in elucidating the role of PYRIN domain-only proteins (POPs) and the related CARD-o

140 Pyrin domain-only proteins (POPs) are recently evolved,

141 Mutations in another PYRIN domain protein, termed cryopyrin, are responsible

142 It is composed of an N-terminal pyrin domain (PYD) and a C-terminal caspase recruitment

143 omain structure, consisting of an N-terminal pyrin domain (PYD) and a C-terminal caspase-recruitment

144 e to intramolecular interactions between its pyrin domain (PYD) and B-box.

145 hich consists of two domains, the N-terminal pyrin domain (PYD) and the C-terminal CARD.

146 izing double-stranded DNA and its N-terminal pyrin domain (PYD) for eliciting downstream effects thro

147 ary inflammasome complexes, achieved through pyrin domain (PYD) interactions between sensors and ASC

148 otein ASC and initiate polymerization of its pyrin domain (PYD) into filaments.

149 on dsDNA engagement, the AIM2 amino-terminal pyrin domain (PYD) is responsible for downstream signali

150 rk of highly intercrossed filaments, whereas pyrin domain (PYD) or caspase activation and recruitment

151 Pyrin domain (PYD) proteins have recently emerged as imp

152 Many pyrin domain (PYD) proteins modulate NF-kappaB activity

153 recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domai

154 ng studies on human growth hormone (hGH) and pyrin domain (PYD), and the results show how mutations a

155 uman NLRP1, mouse NLRP1b lacks an N-terminal pyrin domain (PYD), indicating that the assembly of the

156 Inflammasome assembly requires the PYRIN domain (PYD)-containing adaptor ASC, and depends o

157 Pyrin domain (PYD)-containing proteins are key component

158 Here we identified the PYRIN domain (PYD)-only protein POP3, which competes wit

159 tion is controlled by phosphorylation of its pyrin domain (PYD).

160 RD (caspase activation and recruitment), and pyrin domains (PyD).

161 or domains, caspase recruitment domains, and pyrin domains (PYD).

162 Inflammasome assembly is mediated by pyrin domains (PYDs) and caspase recruitment domains, wh

163 ntain caspase recruitment domains (CARDs) or pyrin domains (PYDs).

164 ns of caspase recruitment domains (CARDs) or PYRIN domains (PYDs).

165 , which harbor essential N-terminal CARD and PYRIN domains, respectively.

166 MNDA and related proteins contain the pyrin domain that functions in signaling associated with

167 The surface residues on the pyrin domain that mediate the cooperative DNA binding ar

168 -like protein containing a CARD) through its pyrin domain to activate caspase-1.

169 We also show here that PAN1 binds via its PYRIN domain to ASC, an adapter protein involved in casp

170 The pyrin domain was identified recently in multiple protein

171 ull-length ASC, but not its isolated CARD or PYRIN domain, with procaspase-1 induced activation of pr