ライフサイエンスコーパス: pyrophosphate

1 by the synthetic phosphoantigen bromohydrin pyrophosphate.

2 ct can be rescued by addition of isopentenyl pyrophosphate.

3 es intracellular accumulation of isopentenyl pyrophosphate.

4 hyl-but-2-enyl pyrophosphate and isopentenyl pyrophosphate.

5 complex with novel ANPs and one with GMP and pyrophosphate.

6 paper strips for easy, low-cost detection of pyrophosphate.

7 oid moiety and an oligosaccharide, linked by pyrophosphate.

8 , lysine, serine, glutamate, cadaverine, and pyrophosphate.

9 PA2 or inhibition of LPA3, by diacylglycerol pyrophosphate.

10 lyzes the mineralization inhibitor inorganic pyrophosphate.

11 n through accumulation of the TNAP substrate pyrophosphate.

12 s farnesyl diphosphate (FDP) and isopentenyl pyrophosphate.

13 refers inorganic polyphosphate over inositol pyrophosphates.

14 the principal enzymes that generate inositol pyrophosphates.

15 /CD277 Ig superfamily proteins mimics prenyl pyrophosphates.

16 However, a separate inositol pyrophosphate, 1,5-bisdiphosphoinositol 2,3,4,6-tetrakis

17 that synthesizes the intracellular inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pentakisphos

18 The inositol pyrophosphates 5-InsP7 (diphosphoinositol pentakisphosph

19 idated the discriminatory ability of (99m)Tc-pyrophosphate ((99m)Tc-PYP) scintigraphy in AL versus AT

20 re, adenosine triphosphate is converted into pyrophosphate, a major inhibitor of ectopic calcificatio

21 production and extracellular accumulation of pyrophosphate, a major inhibitor of vascular calcificati

22 romotes mineralization by reducing inorganic pyrophosphate, a mineralization inhibitor.

23 Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalona

24 tion of two commercially available products, pyrophosphate, a TK cofactor analog and d-arabinose-5-ph

25 It is currently unknown how the release of pyrophosphate affects transcription.

26 y an initial stage that was resistant to the pyrophosphate analog phosphonoformic acid (PFA) followed

27 iously shown to reduce susceptibility to the pyrophosphate analog phosphonoformic acid.

28 umulation of the phosphoantigens isopentenyl pyrophosphate and ApppI.

29 We found that pyrophosphate and ATP compete with BODIPY-ATP for bindin

30 nal engagement of nisin with lipid II at the pyrophosphate and C-terminus of the pentapeptide chain.

31 ogically involved in generation of inorganic pyrophosphate and inorganic phosphate, and the findings

32 s, such as (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and isopentenyl pyrophosphate.

33 ural model of PtDXS in complex with thiamine pyrophosphate and Mg(2+) was built by homology modeling

34 Fe(3+) pyrophosphate, protein-coated Fe(3+) pyrophosphate and mixed-metal pyrophosphates containing

35 Additionally, orthophosphate, pyrophosphate and phosphonates were also detected.

36 polyphosphates, whereas increased amounts of pyrophosphate and short-chain polyphosphates formed afte

37 MraYAA, including how it avoids the need for pyrophosphate and sugar moieties, which are essential fe

38 exposure to select dianionic species (e.g., pyrophosphate and terephthalate salts), altering the vis

39 esponse to (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and the aminobisphosphonate drug zoledrona

40 The position of the pyrophosphate and the unusual phosphodiester linkage bet

41 producing (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and vitamin B2, respectively.

42 ic activity, and lower free fetuin-A, plasma pyrophosphate, and albumin concentrations, which account

43 This enzyme reversibly converts AMP, pyrophosphate, and phosphoenolpyruvate to ATP, orthophos

44 owed a three-fold enhancement of isopentenyl pyrophosphate, and targeting AACPR, DBR2, and CYP71AV1 t

45 chieve the selective binding of the hydrogen pyrophosphate anion, a conclusion supported by computati

46 he selective fluorescent sensing of hydrogen pyrophosphate anion.

47 ound capable of accommodating two trianionic pyrophosphate anions in the cavity.

48 Quantification of intracellular isopentenyl pyrophosphate/ApppI following ZOL treatment showed that

49 Inositol pyrophosphates are high energy signaling molecules invol

50 Inositol pyrophosphates are novel signaling molecules possessing

51 ss in knock-out MEFs, implying that inositol pyrophosphates are required for HR-mediated repair.

52 Inositol pyrophosphates are unique cellular signaling molecules w

53 polyphosphates, also referred to as inositol pyrophosphates, are important signaling molecules that r

54 allyl transferase utilizes 3,3-dimethylallyl pyrophosphate as a prenyl donor and prenylates resveratr

55 Our study therefore highlights inositol pyrophosphates as novel small molecule regulators of HR

56 tch is controlled by hydroxymethylpyrimidine pyrophosphate, as well as TPP, but with an identical alt

57 translocated initiation complex that traps a pyrophosphate at the active site that remains closed.

58 e is a functional interplay between inositol pyrophosphates, ATP, and polyP.

59 hibits a greater maximal initial velocity of pyrophosphate:ATP exchange than its human homolog, sugge

60 ased ratiometric sensor for Fe(III) ions and pyrophosphate based on Fe(III)-induced aggregation of th

61 evance (fluoride, chloride, iodide, cyanide, pyrophosphate, bicarbonate, hydrosulphide, peroxynitrite

62 strated to increase the strength of hydrogen pyrophosphate binding, as compared to the hydrogen-bonde

63 metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate binds to the intracellular B30.2 domain of

64 muM, whereas the endogenous pAg isopentenyl pyrophosphate binds with an affinity of 627 muM.

65 ugh the inositol kinases underlying inositol pyrophosphate biosynthesis are well characterized, the p

66 tion of the kinases involved in the inositol pyrophosphate biosynthetic pathway in Trypanosoma brucei

67 sitol polyphosphates containing an energetic pyrophosphate bond are formed primarily by a family of t

68 ily of metalloenzymes; however, it cleaves a pyrophosphate bond instead of a phosphoester bond, and i

69 molecular messengers containing an energetic pyrophosphate bond, impact a wide range of biologic proc

70 l signaling molecules possessing high-energy pyrophosphate bonds and involved in a number of biologic

71 5'-triphosphate (ATP) and ALP can hydrolysis pyrophosphate, both reactions produce phosphate ions, an

72 on of humic components from XAD-8 resin with pyrophosphate buffers including: 1) the carboxylic-rich

73 echnique coupled with stepwise elution using pyrophosphate buffers with initial pH values of 3, 5, 7,

74 be as small as 2-5 nm, are extracted with Na-pyrophosphate but not with Na-bicarbonate, except for on

75 BTN3A1 is required for stimulation by prenyl pyrophosphates but does not bind the intermediates with

76 ings support intracellular sensing of prenyl pyrophosphates by BTN3A1 rather than extracellular prese

77 agricultural soils by Na-bicarbonate and Na-pyrophosphate, by two complementary analytical technique

78 ex between DrrA, adenylylated Rab1b, and the pyrophosphate byproduct was resolved, allowing us to ana

79 noid carbon skeletons vary widely from neryl pyrophosphate (C10) to natural rubber (C>10,000).

80 racin, an antibiotic that binds undecaprenyl pyrophosphate (C55 -PP), a key intermediate in cell wall

81 tio and/or protonation states of the Mn(III)-pyrophosphate complexes.

82 roduction, and mineralization, and decreased pyrophosphate concentration in Hyp-derived osteocyte-lik

83 Here, we report that the pyrophosphate concentration is increased in Hyp bones, a

84 uppressed Tnap mRNA expression and increased pyrophosphate concentrations in the culture medium and i

85 m tuberculosis, through recognition of small pyrophosphate containing organic molecules known as phos

86 -coated Fe(3+) pyrophosphate and mixed-metal pyrophosphates containing Fe(3+) and a second cation M.

87 tors of Vgamma9Vdelta2 activation are small, pyrophosphate-containing molecules called phosphoantigen

88 hat NAI-107 forms complexes with bactoprenol-pyrophosphate-coupled precursors of the bacterial cell w

89 udy tested the effect of adding tetra-sodium pyrophosphate, cystine and lysine as surimi gelation enh

90 oinflammatory condition triggered by calcium pyrophosphate dehydrate (CPPD) crystal deposition in the

91 mine uptake and/or inhibition of the thiamin pyrophosphate-dependent enzymes using thiamine antagonis

92 In the case of the thiamin pyrophosphate-dependent thiM riboswitch, we find that Rh

93 ), spondyloarthropathy (n = 15), and calcium pyrophosphate deposition disease (CPPD) (n = 15), from t

94 lline arthropathies, including gout, calcium pyrophosphate deposition, and hydroxyapatite deposition

95 pophilic monophosphates to give lipid-linked pyrophosphate derivatives, which are lipid II mimetics e

96 anoscale silicon dioxide (NanoSiO2), calcium pyrophosphate dihydrate (CPPD) crystals, and muramyl tri

97 f calcium oxalate, monosodium urate, calcium pyrophosphate dihydrate and cystine trigger caspase-inde

98 isphosphate-1 (IP6K1) generates the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP7),

99 ntenyl pyrophosphate (IPP) to dimethyl allyl pyrophosphate (DMAPP) and vice versa.

100 Bloodstream forms unable to produce inositol pyrophosphates, due to downregulation of TbIPMK expressi

101 cturally and biochemically characterized FAD pyrophosphate enzyme in bacteria.

102 (ADCs) beyond oncology indications, a novel pyrophosphate ester linker was discovered to enable the

103 fset by an increase of both ATP and inositol pyrophosphates, evidence for a model in which there is a

104 Ferric pyrophosphate (FePP) is a widely used iron source in foo

105 ice is consumed as intact grains, and ferric pyrophosphate (FePP), which is usually used for rice for

106 d ferrous sulfate (FeSO4; study 1) or ferric pyrophosphate (FePP; study 2).

107 able plants to produce thiamine and thiamine pyrophosphate for growth and development.

108 [PSI+] prion variants require inositol poly-/pyrophosphates for their propagation, and at least IP6 o

109 al metal ion (product metal) associated with pyrophosphate formation, leading to the suggestion of it

110 sis of the wound-healing inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucoc

111 ting mevalonate pathway metabolites farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GG

112 We apply this approach to regulate farnesyl pyrophosphate (FPP) production in the isoprenoid biosynt

113 lene and ergosterol, as well as the farnesyl pyrophosphate (FPP)-derived side products farnesol and n

114 biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate (FPP).

115 losis Rel (RelMtb) enzyme, which transfers a pyrophosphate from ATP to GDP or GTP to synthesize ppGpp

116 ) family synthesize (p)ppGpp by transferring pyrophosphate from ATP to GDP or GTP.

117 riggers this degradation pathway by removing pyrophosphate from the triphosphorylated RNA 5' terminus

118 The Kcs1-catalyzed production of inositol pyrophosphates from inositol pentakisphosphate but not i

119 uranyl peroxide nanoclusters is reported for pyrophosphate-functionalized Na44K6[(UO2)24(O2)24(P2O7)1

120 ontaining protein-1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K2 We previou

121 nesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), which are used for protein prenyla

122 rly pathway-derived isoprene gernanylgeranyl pyrophosphate (GGPP).

123 presence of ligands (i.e., oxalate, citrate, pyrophosphate) greatly retards the oxidation of As(III),

124 f lipid A biosynthesis, i.e. cleavage of the pyrophosphate group of UDP-2,3-diacyl-GlcN, is carried o

125 The pyrophosphate group stays in the bilayer head group regi

126 dimethylorsellinic acid (DMOA) and farnesyl pyrophosphate have attracted much biosynthetic attention

127 Derivatives of ribosyl pyrophosphate have been synthesized, and examined with m

128 -dimethylorsellinic acid (DMOA) and farnesyl pyrophosphate have not been reported despite heavy biosy

129 Inositol pyrophosphates have not been the subject of investigatio

130 eing inhibited by ruthenium red, isopentenyl pyrophosphate, HC-030031, A967079 or TRPA1 knockout.

131 microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) or endogenous pyrophosphates (isop

132 Pyrophosphate homeostasis is crucial for normal phloem f

133 activity is critical for the maintenance of pyrophosphate homeostasis required for phloem function.

134 een demonstrated to dephosphorylate inositol pyrophosphates; however, theSaccharomyces cerevisiaehomo

135 ciation rate, and increased the affinity for pyrophosphate in the pre-translocation state.

136 other biologically important anions such as pyrophosphate in the presence of interferent sodium chlo

137 and highly selective fluorescent sensor for pyrophosphate in water at physiological pH.

138 incipal kinase responsible for generation of pyrophosphates in synchronously progressing cells.

139 ter mutants have elevated levels of inositol pyrophosphates in their seed, providing unequivocal iden

140 ither mevalonate 5-phosphate or mevalonate 5-pyrophosphate, in which a single enzyme carries out two

141 es, including InsP(5), InsP(6), and inositol pyrophosphates, in mediating the action of Plc.

142 l C10, C20, C30, and C40 polyisoprenol sugar pyrophosphates, including those bearing repeating cis-pr

143 regions of the B30.2 domain abrogated prenyl pyrophosphate-induced proliferation.

144 ization factor, and an appropriate inorganic pyrophosphate/inorganic phosphate ratio is critical for

145 pathomechanism relating to reduced inorganic pyrophosphate/inorganic phosphate ratio.

146 We show a specific induction of inositol pyrophosphate InsP8 by jasmonate and demonstrate that st

147 incorporations in the presence of inorganic pyrophosphate intended to equilibrate forward (polymeriz

148 s are stimulated by self- and foreign prenyl pyrophosphate intermediates in isoprenoid synthesis.

149 step being the conversion of geranylgeranyl pyrophosphate into casbene.

150 pyrophosphatase, which hydrolyzes inorganic pyrophosphate into two phosphates.

151 Pyrophosphate ion (PPi) release during transcription elo

152 adds nucleotides to the 3'-end of the RNA, a pyrophosphate ion is generated after each nucleotide inc

153 In the presence of pyrophosphate ions the solubility of FePP strongly incre

154 mation a soluble complex between Fe(III) and pyrophosphate ions, which leads to an 8-10-fold increase

155 ty of FePP as a function of pH and excess of pyrophosphate ions.

156 esponsible for the synthesis of the inositol pyrophosphates IP7 and IP8, reach abnormally high cell d

157 or the synthesis of the high-energy inositol pyrophosphates (IP7), is associated with chromatin and i

158 ant truncated AaIPPI1 isomerized isopentenyl pyrophosphate (IPP) to dimethyl allyl pyrophosphate (DMA

159 a subset of the phosphoantigen {isopentenyl pyrophosphate [IPP] and (E)-4-hydroxy-3-methyl-but-2-eny

160 P) or endogenous pyrophosphates (isopentenyl pyrophosphate [IPP]).

161 Thiamine pyrophosphate is a required coenzyme that contains a mec

162 Ferric pyrophosphate is a widely used material in the area of m

163 By improving the reaction, pyrophosphate is produced via DNA polymerization and che

164 main viable and resume growth if accumulated pyrophosphate is removed.

165 raphosphate dimers in which ATP, rather than pyrophosphate, is the leaving group.

166 In this study, we cloned an isopentenyl pyrophosphate isomerase (IPPI) cDNA, AaIPPI1, from Artem

167 t-2-enyl pyrophosphate (HMBPP) or endogenous pyrophosphates (isopentenyl pyrophosphate [IPP]).

168 ate kinases mediate biosynthesis of inositol pyrophosphates: Kcs1/IP6K- and Vip1/PPIP5K-like proteins

169 Both the inositol pyrophosphate kinase and the basic leucine zipper domain

170 we show that KCS1, which encodes an inositol pyrophosphate kinase, is a regulator of inositol metabol

171 extracellular BTN3A1 IgV domain binds prenyl pyrophosphates, leading to the proposal that the Vgamma2

172 cidate how the methylene substitution in the pyrophosphate leaving group affects cognate and non-cogn

173 and associated metal complex and orients the pyrophosphate leaving group for in-line catalysis with s

174 and associated metal complex and orient the pyrophosphate leaving group for in-line catalysis.

175 imeric dinucleotide (DIAL) that replaces the pyrophosphate leaving group of the native substrate with

176 Bisphosphonates can mimic the pyrophosphate leaving group of the nucleotidyl transfer

177 control CBS-PPase activity and hence affect pyrophosphate level and biosynthetic activity in bacteri

178 ABCC6 mutations thus lead to reduced plasma pyrophosphate levels, resulting in the calcification dis

179 he price of embedding a ribonucleotide and a pyrophosphate linkage in the repaired strand.

180 causes the accumulation of the undecaprenyl pyrophosphate-linked intermediate ECA-lipid II.

181 synthesis by templated polymerases embeds a pyrophosphate-linked ribonucleotide in DNA.

182 ed for activity and that the utility for the pyrophosphate linker may be general for internalizing AD

183 e that a Plc1- and Kcs1-mediated increase in pyrophosphates may have in progression through S phase.

184 te factor, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate, may increase both the attractiveness of i

185 imilation is coupled with a highly efficient pyrophosphate-mediated glycolytic pathway, which under o

186 sis, including a connection between inositol pyrophosphate metabolism and complex sphingolipid homeos

187 ological phosphatase that modulates inositol pyrophosphate metabolism by dephosphorylating the IP7iso

188 olving the local regulation of phosphate and pyrophosphate metabolism; and 4) approaches directed at

189 The pyrophosphate mimic and broad spectrum antiviral phospho

190 ons of residues making hydrogen bonds to the pyrophosphate moiety also abrogated TNF-alpha secretion,

191 role for Glu-486 in the interaction with the pyrophosphate moiety of the dNTP.

192 and platinum(IV) complexes coordinated to a pyrophosphate moiety, exhibit excellent antitumor activi

193 The inositol pyrophosphates, molecular messengers containing an energ

194 Vdelta2 T cells recognize pyrophosphate molecules derived from microbes or tumor c

195 e kinases (IP6Ks) that generate the inositol pyrophosphates, most notably 5-diphosphoinositol pentaki

196 ing partners are the C-terminus of LtnA1 and pyrophosphate of lipid II.

197 the affinity for anions, especially hydrogen pyrophosphate, of the new receptors.

198 ng lines in media containing either thiamine pyrophosphate or thiamine.

199 de) ligand HL with Cu(2+) in the presence of pyrophosphate (P2O7)(4-) affords the complex [LCu(II)2(P

200 and characterisation of colloidal iron(III) pyrophosphate particles with potential for application a

201 Our study links the inositol pyrophosphate pathway to the synthesis of polyphosphate

202 Undecaprenyl pyrophosphate phosphatase (UppP), an integral membrane p

203 osphatase family as a physiological inositol pyrophosphate phosphatase.

204 In the presence of pyrophosphate, phosphate, and imidodiphosphate, the numb

205 ns have suggested that the reduced inorganic pyrophosphate/phosphate ratio is the cause of soft conne

206 dissolution by soluble Mn(III) stabilized by pyrophosphate (PP) and desferrioxamine B (DFOB).

207 re we study the second oxidation step, using pyrophosphate (PP) as a Mn(III) trap.

208 The inositol pyrophosphates (PP-InsPs) are a unique group of intracel

209 inositol polyphosphates (InsPs) and inositol pyrophosphates (PP-InsPs).

210 catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virule

211 tion of stress alarmone guanosine-3', 5'-bis pyrophosphate (ppGpp) is increased.

212 protein have significantly higher levels of pyrophosphate (PPi ) and short-chain polyphosphate (poly

213 n the pH and cofactors, can hydrolyse either pyrophosphate (PPi ) or polyphosphate (polyP).

214 s have a well-documented role in hydrolyzing pyrophosphate (PPi) and capturing the released energy to

215 chemosensor for highly selective sensing of pyrophosphate (PPi) anion in physiological medium.

216 phate release with DNA templates showed that pyrophosphate (PPi) dissociation was fast after nucleoti

217 dered binding with Ufm1 and ATP, and its ATP-pyrophosphate (PPi) exchange activity was inhibited by b

218 ble nanocomposite probe for the detection of pyrophosphate (PPi) in physiological conditions and in i

219 Plasma inorganic pyrophosphate (PPi) level was reduced (<30%) in the Abcc

220 er and consequently reduced plasma inorganic pyrophosphate (PPi) levels underlie PXE.

221 gene, resulting in reduced plasma inorganic pyrophosphate (PPi) levels.

222 rtantly, during processive primer extension, pyrophosphate (PPi) release was rate-limiting so that th

223 Using the binding of pyrophosphate (PPi) to Bacillus subtilis RNase P protein

224 The approach combines the use of inorganic pyrophosphate (PPi) to control the onset and rate of ena

225 It is thought that the release of pyrophosphate (PPi) triggers reverse conformational chan

226 flux of ATP, which is rapidly converted into pyrophosphate (PPi), a major calcification inhibitor.

227 ls leads to supraphysiologic accumulation of pyrophosphate (PPi), a strong inhibitor of hydroxyapatit

228 With the natural substrates, NMN and pyrophosphate (PPi), the intrinsic KIEs of [1'-(14)C], [

229 decreased concentrations of plasma inorganic pyrophosphate (PPi).

230 such as adenosine-5'-triphosphate (ATP) and pyrophosphate (PPi).

231 f extracellular inorganic phosphate (Pi) and pyrophosphate (PPi).

232 Entamoeba histolytica ACK (EhACK) which uses pyrophosphate (PPi)/inorganic phosphate (Pi) (acetyl pho

233 dal stability and reactivity studied: Fe(3+) pyrophosphate, protein-coated Fe(3+) pyrophosphate and m

234 [4Fe-4S] iron-sulfur clusters and a thiamine pyrophosphate radical upon reduction by pyruvate.

235 d significant decreases in the monoester and pyrophosphate regions, with a corresponding increase in

236 ase that catalyzes the synthesis of inositol pyrophosphate, regulates inositol synthesis in mammalian

237 Pyrophosphate release completes the nucleotide addition

238 in single turnover kinetic studies show that pyrophosphate release is faster than the chemistry step,

239 surements of the rates of polymerization and pyrophosphate release with DNA templates showed that pyr

240 (NTP) binding followed by NTP incorporation/pyrophosphate release, quantitatively accounts for these

241 ogical function was previously assumed to be pyrophosphate removal from triphosphorylated transcripts

242 e two metabolites, chlorophyllide and phytyl pyrophosphate, required for the final step in chlorophyl

243 cellular B30.2 domain of BTN3A1 binds prenyl pyrophosphates, resulting in a change in the extracellul

244 abidopsis, the THIC promoter and the thiamin-pyrophosphate riboswitch act simultaneously to tightly r

245 biosynthesis and the consequences of thiamin pyrophosphate riboswitch deficiency on metabolism in Ara

246 in the structure of the eukaryotic thiamine pyrophosphate riboswitch in the context of a hexanucleot

247 well-defined PS repeating unit undecaprenyl pyrophosphate (RU-PP-Und), the key building block in thi

248 n contained within insoluble colloidal metal-pyrophosphate salts was determined and compared to the r

249 omography and such specialized techniques as pyrophosphate scanning.

250 Herein, we adapt a pyrophosphate sensor assay to monitor PBP1b-catalyzed gl

251 thesis is based on the notion that inorganic pyrophosphate serves as a powerful inhibitor of minerali

252 Our findings demonstrate that inositol pyrophosphate signaling influences nuclear functions by

253 at can contribute to specificity in inositol pyrophosphate signaling, regulating InsP8 turnover indep

254 proteins for their ability to mediate prenyl pyrophosphate stimulation of Vgamma2Vdelta2 T cells to p

255 (BTN)3A1 was shown to be required for prenyl pyrophosphate stimulation.

256 Glycosyltransferases that act on polyprenol pyrophosphate substrates are challenging to study becaus

257 The inositol pyrophosphates, such as 5-diphosphoinositol pentakisphos

258 Inositol pyrophosphates, such as diphospho-myo-inositol pentakisp

259 Inositol pyrophosphates, such as diphosphoinositol pentakisphosph

260 fects through the modulation of the farnesyl pyrophosphate synthase (FPPS) activity.

261 firmly established cellular target, farnesyl pyrophosphate synthase (FPPS).

262 Human farnesyl pyrophosphate synthase (hFPPS) is the gate-keeper of mam

263 The human farnesyl pyrophosphate synthase (hFPPS), a key regulatory enzyme

264 Undecaprenyl pyrophosphate synthase (UppS) is an essential enzyme in

265 and expressed much lower levels of farnesyl pyrophosphate synthase.

266 pse-specific mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1), which encodes a

267 single rate-limiting enzyme, phosphoribosyl-pyrophosphate synthetase 2 (PRPS2), promotes increased n

268 Phosphoribosyl pyrophosphate synthetase-1 (PRPS1) is a key enzyme in nu

269 In single-center studies, technetium 99m pyrophosphate (Tc 99m PYP) cardiac imaging noninvasively

270 sed by reduced extracellular accumulation of pyrophosphate that results from increased tissue-nonspec

271 Thiamin pyrophosphate (ThDP), the active form of thiamin (vitami

272 ine amperometric biosensor based on thiamine pyrophosphate (ThDP)-dependent transketolase (TK)-cataly

273 in a strained conformation, and transfer of pyrophosphate through a nucleophilic substitution (SN2)

274 doles from cis-indole isonitrile and geranyl pyrophosphate through a presumed biosynthetic Cope rearr

275 in Hyp osteocytes drives the accumulation of pyrophosphate through auto-/paracrine suppression of TNA

276 chemical evidence that synthesis of inositol pyrophosphates through activation of Plc1 and Kcs1 plays

277 were supplemented with thiamine or thiamine pyrophosphate throughout the life cycle, they grew norma

278 atalyze the hydrolysis of dUTP into dUMP and pyrophosphate to maintain the proper nucleotide pool for

279 oxidizing UO2 was higher at lower ratios of pyrophosphate to Mn(III) and lower pH, which is probably

280 short energy supply is to use the by-product pyrophosphate to support cation gradients in membranes.

281 alyzes the dephosphorylation of undecaprenyl pyrophosphate to undecaprenyl phosphate, which is an ess

282 ssays show high-affinity binding of inositol pyrophosphates to the F-box protein COI1-JAZ jasmonate c

283 In the case of the thiamine 5'-pyrophosphate (TPP) riboswitch from the Escherichia coli

284 The thiamine pyrophosphate (TPP) riboswitch is a cis-regulatory eleme

285 Thiamin pyrophosphate (TPP) riboswitches are found in organisms

286 nt mechanism for this control is via thiamin-pyrophosphate (TPP) riboswitches, regions of the mRNA to

287 Thiamine pyrophosphate (TPP)-dependent oxalate oxidoreductase (OO

288 e amount of thiamine in the form of thiamine pyrophosphate (TPP).

289 ons instead of its modern catalyst, thiamine pyrophosphate (TPP).

290 pression of the human mitochondrial thiamine pyrophosphate transporter (the product of the SLC25A19 g

291 iamin transporters and mitochondrial thiamin pyrophosphate transporter expression levels were suppres

292 min transporter-2, and mitochondrial thiamin pyrophosphate transporter proteins and messenger RNA wer

293 iamin transporters and mitochondrial thiamin pyrophosphate transporter, leading to adenosine triphosp

294 in transporter-2), and mitochondrial thiamin pyrophosphate transporter.

295 eagent type (water, NaNO3, KNO3, tetrasodium pyrophosphate (TSPP), tetramethylammonium hydroxide (TMA

296 iameter, contains 24 uranyl moieties, and 12 pyrophosphate units.

297 rmation, hPolbeta reopened its conformation, pyrophosphate was released, and the newly incorporated p

298 s resulted in the precipitation of magnesium pyrophosphate, which caused a change in turbidity that c

299 tol phosphate pathway to produce isopentenyl pyrophosphate with more favorable thermodynamics than th

300 Here, we show that Zn-pyrophosphate (ZnP) nanoparticles loaded with the photos