ライフサイエンスコーパス: pyrrolidinyl

1 A series of diastereomeric 2-(2-pyrrolidinyl)-1,4-benzodioxanes bearing a small, hydroge

2 st (5alpha,7alpha,8alpha)-(+)-N-methyl-N-[7-(pyrrolidinyl)-1-oxaspiro [4,5]dec-8-yl]-benzeneacetamide

3 [(+)-(5alpha,7alpha, 8beta)-N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4, 5)dec-8-yl)-benzeneacetamide

4 t (5alpha,7alpha,8beta)-(-)-N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4,5)de c-8-yl) benzeneacetamide

5 d (+)-(5alpha,7alpha,8beta)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]de c-8-yl]benzeneacetamide

6 [(+)-(5alpha,7alpha,8beta)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl ]benzeneacetamide;

7 [(+)-(5alpha,7alpha,8beta)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl ]benzeneacetamide]

8 t (+)-(5alpha,7alpha,8beta)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl] -benzeneacetamide

9 +)-(5 alpha,7 alpha,8 beta)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneaceta mide

10 orine methiodide N,N,N,-trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide] were insensitiv

11 A series of (5-substituted pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidine (C5-Pro-Pro)

12 he TAAR1 antagonist, N-(3-ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl) benzamide.

13 nichiral analogues of 2R,2'S-2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane, a potent and s

14 antioenriched gem-difluoromethylenated spiro-pyrrolidinyl and spiro-piperidinyl oxindoles is describe

15 forded chiral gem-difluoromethylenated spiro-pyrrolidinyl and spiro-piperidinyl oxindoles.

16 Bu(pyrr)(2)](-); (t)Bu = C(CH(3))(3); pyrr = pyrrolidinyl) and [Pu(3+)(NPC)(4)][K(2.2.2.-cryptand)],

17 dyads the chromophoric electron donors 4-(N-pyrrolidinyl)- and 4-(N-piperidinyl)naphthalene-1,8-dica

18 g in the eventual formation of the reduced m-pyrrolidinyl-aniline as the predominant stable photoprod

19 ne-pot process to (2S)-cis-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]amino]benzoic acid monohydrochlori

20 n the oxidative coupling of lithium (n-Bu)(2-pyrrolidinyl)cuprate.

21 agonist (trans)-3,4-dichloro-N-methyl-N-[2-1-pyrrolidinyl)-cyclo-hexyl] benzeneacetamide (U50488) int

22 88H (trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(pyrrolidinyl)cyclohexyl] benzeneacetamide methanesulfona

23 trans-(1S,2S)-3,4-dichloro-N-mathyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benze neacetamide hydrochloride

24 8 [(+/-)-trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetam ide] (0.3 mg/kg,

25 agonist trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide (U50488) and t

26 nd trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]ben zeneacetamide methanesulfona

27 gonist (trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl] benzeneacetamide methanesulfon

28 rom) and trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetam ide methanesulfon

29 ), trans-(+/-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl) benzene-acetamide methanesulfon

30 The pyrrolidinyl derivative (S)-12 in most cases showed grea

31 , along with a series of derivatives bearing pyrrolidinyl electron-releasing groups on the ancillary

32 ane-1,4,7,10-tetraacetic acid 1-(2,5-dioxo-1-pyrrolidinyl) ester (DOTA-NHS) to the surface of a water

33 nin norepinephrine reuptake inhibitor (SNRI) pyrrolidinyl ether 2 was synthesized by employing a dyna

34 yl)-N-methyl-N-[1-(3- or 4-aminophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide (10 and 14) were prepared e

35 SIB-1553A ((+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol HCl) is a neuronal nicoti

36 SIB-1553A ((+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thiophenol HCl) is a neuronal nicotin

37 -[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine (2).

38 [2-(3, 4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine) > 4-IPBS > haloperidol > (+)-pe

39 Its propyl pyrrolidinyl group interacts with the 23S ribosomal RNA

40 which consist of a phenothiazine ring and a pyrrolidinyl group joined by a four-carbon alkyl bridge.

41 ups, including morpholinyl, piperazinyl, and pyrrolidinyl heterocycles, are compatible under the reac

42 enylpiperazinium, (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole, and (+/-)-epibatidine, resulted

43 efficient tandem multicatalytic synthesis of pyrrolidinyl ketones.

44 gand for nAChRs, 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl) pyridine,

45 (-)-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl) methyl]benzamide ([123I]IBZM).

46 h yl-5-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-[1,1'-biph enyl]-2-sulfonamide, BMS

47 raclopride (S-(-)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)]methyl-2-hydroxy-6-methoxy benzamide) (533

48 Bu(pyrr)(2)](-); (t)Bu = C(CH(3))(3); pyrr = pyrrolidinyl (N(C(2)H(4))(2)); B(ArF(5))(4) = tetrakis(2

49 mercially available and recyclable (1S,2R)-N-pyrrolidinyl norephedrine as a ligand to promote the hig

50 , N(CH2CH3)2, NCH3(CH(CH3)2), and either the pyrrolidinyl or the piperidinyl analogues.

51 Modification of aromatic 39 with a pyrrolidinyl para substituent (compound 60) enhanced the

52 ased on an immobilized anthraquinone-labeled pyrrolidinyl peptide nucleic acid (acpcPNA) probe was su

53 itive DNA detection system using immobilized pyrrolidinyl peptide nucleic acid (acpcPNA) probes.

54 olorimetric assay for DNA detection based on pyrrolidinyl peptide nucleic acid (acpcPNA)-induced nano

55 cal miRNA biosensor was developed based on a pyrrolidinyl peptide nucleic acid (acpcPNA)/polypyrrole

56 enrichment of the zein gene from maize using pyrrolidinyl peptide nucleic acid (PNA) immobilized on a

57 Furthermore, a pyrrolidinyl peptide nucleic acid (so-called "acpcPNA")

58 detection by leveraging the highly specific pyrrolidinyl peptide nucleic acids (PNAs) as probes for

59 In this work, m-pyrrolidinyl-phenyl hydrazine hydrochloride (1) is synth

60 photochemically generate the corresponding m-pyrrolidinyl-phenyl nitrenium ion (2), which is computed

61 synthesized with NH2, N-alkyl, N,N-dialkyl, pyrrolidinyl, piperidinyl, and piperazinyl substituents

62 (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), is a

63 be replaced by other aromatic rings and the pyrrolidinyl ring is not required for CB1 allosteric mod

64 obalt catalyst was obtained by introducing a pyrrolidinyl substituent into the 4-position of the bis(

65 Compound 19 containing a pyrrolidinyl substituent on the phenyl ring provided pot

66 Terpyridyl pyrrolidinyl substituents can be utilized to destabilize

67 donating and sterically blocking methyl and pyrrolidinyl substituents that exhibited increased activ

68 5-Pyrrolidinyl substituted perhydroquinoxalines were desig

69 ro-4-hydroxybutyl)-5-[1-(2(S)-(methoxymethyl)pyrrolidinyl)sulf onyl]isatin were synthesized in 140 mi

70 zeniumdiolate ion (R2N[N(O)NO]-, where R2N = pyrrolidinyl) that spontaneously decomposes to NO with a

71 S,5S)-5-[[(3-Carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl ]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-o

72 ging the ribose-pocket binding moiety from a pyrrolidinyl to an azetidinyl ring system.

73 ligand (NPC=[N=P(t) Bu(pyrr)(2) ](-) ; pyrr=pyrrolidinyl) to tetrahomoleptic NPC complexes of neptun