ライフサイエンスコーパス: pyruvate

1 tic flux that led to deficiencies in ATP and pyruvate.

2 lfhydrase that degrades Cys to H2S, NH3, and pyruvate.

3 glyceric acid 3-phosphate, phosphoserine and pyruvate.

4 bance interference from compounds other than pyruvate.

5 ogical pyruvate (0.1 mm) but not with 1.0 mm pyruvate.

6 for more than 90% of the over-estimation of pyruvate.

7 s a high-affinity receptor for extracellular pyruvate.

8 eration through oxidative decarboxylation of pyruvate.

9 widespread methodology for estimating onion pyruvate.

10 c conversion of phosphoenolpyruvate (PEP) to pyruvate.

11 abolism and re-conversion of lactate back to pyruvate.

12 0.1 mmol/kg dose of hyperpolarized [1-(13)C]pyruvate.

13 h export of metabolites, such as lactate and pyruvate.

14 glucose was essential for the generation of pyruvate.

15 ogenation of alpha-keto esters such as ethyl pyruvate.

16 ic enzyme support the formation of plastidic pyruvate.

17 cid rich media and responds to extracellular pyruvate.

18 use pyruvate dehydrogenase to decarboxylate pyruvate.

19 mal (state 3) respiration with physiological pyruvate (0.1 mm) but not with 1.0 mm pyruvate.

20 CMV increased diaphragmatic pyruvate (40 vs. 146 mumol L(-1) after 5:20 hrs between

21 mage signal:noise ratio was 115 for [1-(13)C]pyruvate, 56 for (13)C-bicarbonate, and 53 for [1-(13)C]

22 (13)C MRSI of hyperpolarized (HP) [1-(13)C] pyruvate, a non-invasive metabolic imaging method, could

23 dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, mitochondrial reactive o

24 these spectrophotometry-based procedures for pyruvate analysis using a diverse collection of onion cu

25 ce spectroscopic imaging approach with (13)C-pyruvate and (13)C-urea to investigate differences in pe

26 Pyruvate and 2-oxoglutarate dehydrogenases are substitut

27 Here a protocol using HP [1-(13)C]pyruvate and [1-(13)C]butyrate is used to measure carboh

28 PKM2 directs the synthesis of pyruvate and acetyl-CoA, the latter of which is transpor

29 cytosolic glucose carbon flow via OAA-malate-pyruvate and acetyl-CoA-fatty acid pathways in TRCs.

30 y purified proteins, we demonstrate that the pyruvate and alpha-ketoglutarate dehydrogenase complexes

31 s are substituted by 'ancient' CoA-dependent pyruvate and alpha-ketoglutarate ferredoxin oxidoreducta

32 es that catalyse the conversion of malate to pyruvate and are essential for NADPH regeneration and re

33 succinate, fumarate, L-malate, oxaloacetate, pyruvate and D- and L-2HG support the kinetic studies sh

34 These involved altered rates of pyruvate and fatty acid beta-oxidation and the likely re

35 Lactate, pyruvate and glucose levels were measured continuously u

36 be involved in regulation by the 2-oxo acids pyruvate and glyoxylate) and propose that this is the ma

37 Interestingly, the sigL mutant produced less pyruvate and H2S than the wild-type strain.

38 te but not on the key C3 compounds L-serine, pyruvate and L-lactate, showing that CanB is crucial in

39 In particular, the dynamic (13)C-labeling of pyruvate and lactate formed from (13)C-glucose was obser

40 f short-carbon-chain energy metabolites like pyruvate and lactate to neurons.

41 urnished metabolic products, [(13)C]-labeled pyruvate and lactate, originating from glycolysis.

42 enzyme that catalyses the interconversion of pyruvate and lactate, promotes cancer cell invasion, ano

43 version of phosphoenolpyruvate and Mg-ADP to pyruvate and Mg-ATP.

44 sphoenolpyruvate to ATP, orthophosphate, and pyruvate and provides diverse functions in plants.

45 -independent lipophilic methyl-conjugates of pyruvate and tricarboxylic acid cycle metabolites bypass

46 ensive substrates (3-hydroxybenzaldehyde and pyruvate), and involves a carboligation step, a subseque

47 extracellular metabolites (glucose, lactate, pyruvate), and oxygen consumption rate (OCR).

48 g, dynamic MR spectroscopy of hyperpolarized pyruvate, and (18)F-FDG PET/computed tomographic (CT) im

49 ll treatment and dose groups, while glucose, pyruvate, and alanine varied.

50 They are involved in the methane, pyruvate, and glyoxylate and dicarboxylate metabolic pat

51 rt of monocarboxylate fuels such as lactate, pyruvate, and ketone bodies across brain endothelial cel

52 sing acetyl-CoA as a substrate and generates pyruvate, and pyruvate-formate lyase (PFL) converting py

53 ource inside the cell based on studies using pyruvate as a cellular redox modulator.

54 AD-dependent transhydrogenase activity using pyruvate as a hydrogen acceptor.

55 te a potential for (13)C MRSI of HP [1-(13)C]pyruvate as a neuroimaging method for assessment of infl

56 panosoma brucei, using hyperpolarized (13)C1 pyruvate as a substrate and compare the parasite metabol

57 pha-HBCD group with significant increases in pyruvate at the same treatment and dose group.

58 in Listeria monocytogenes by inhibiting its pyruvate carboxylase (LmPC), a biotin-dependent enzyme w

59 egmatis for biotin auxotrophs and identified pyruvate carboxylase (Pyc) as required for biotin biosyn

60 mutations in the acetyl-CoA binding site of pyruvate carboxylase (PycA) rescued cefuroxime resistanc

61 found that the otherwise integrative enzyme pyruvate carboxylase (TgPyC) is dispensable not only in

62 tochondrial citrate synthase flux (V CS) and pyruvate carboxylase flux (V PC) in vivo.

63 ative pyruvate dehydrogenase and anaplerotic pyruvate carboxylase fluxes.

64 Pyruvate carboxylase, which catalyzes the first step of

65 CanB is crucial in bicarbonate provision for pyruvate carboxylase-mediated oxaloacetate synthesis.

66 hat chemical inhibition of the mitochondrial pyruvate carrier (MPC) protects primary cortical neurons

67 Recent studies have shown that mitochondrial pyruvate carrier 1 (MPC1), a crucial player in pyruvate

68 nhibitory interaction with the mitochondrial pyruvate carrier 2 (MPC2), which was recently identified

69 I inhibitor metformin and the mitochondrial pyruvate carrier inhibitor UK5099.

70 to pyruvate influx through the mitochondrial pyruvate carrier) was calculated to be 21, close to uppe

71 hondria but no decrease in the mitochondrial pyruvate carriers 1 and 2 (MPC1 and MPC2).

72 impaired hepatic glucose production after a pyruvate challenge, an effect accentuated by an iron-def

73 sed hepatic gluconeogenesis in response to a pyruvate challenge.

74 ity for the aldol reaction of erythrose with pyruvate compared with the wild-type enzyme.

75 Onion pyruvate concentration is used as a predictor of flavor

76 is significantly decreased regardless of the pyruvate concentration.

77 ts of both glycolytic rate and mitochondrial pyruvate consumption revealed significant effects even a

78 However, how pyruvate controls the transcriptional responses underlyi

79 ed progressive sperm motility generated more pyruvate conversion to lactate and bicarbonate.

80 nge of physiological conditions with minimal pyruvate cycling and detects increased hepatic V CS foll

81 rometry (LC-MS/MS) method to directly assess pyruvate cycling relative to mitochondrial pyruvate meta

82 Citric acid cycle fluxes, pyruvate cycling, anaplerosis, and cataplerosis were als

83 has been made possible by the evolution of a pyruvate decarboxylase, analogous to that in brewer's ye

84 multienzyme complex that have evolved into a pyruvate decarboxylase, while other copies retained the

85 e E2 subunit of the metabolic enzyme complex pyruvate dehydrogenase (E2-PDH) with a fatty acid deriva

86 Phosphorylated pyruvate dehydrogenase (PDH) (Ser-293) and PDH kinase 4

87 s network of genes also causes inhibition of pyruvate dehydrogenase (PDH) activity resulting in dimin

88 points after injury, in line with decreased pyruvate dehydrogenase (PDH) activity, suggesting impair

89 Mechanistically, silencing MICU1 activates pyruvate dehydrogenase (PDH) by stimulating the PDPhosph

90 untington's disease (HD) by showing that the pyruvate dehydrogenase (PDH) complex is a promising ther

91 Resveratrol targets the pyruvate dehydrogenase (PDH) complex, a key mitochondria

92 encoding the E2 subunit of the mitochondrial pyruvate dehydrogenase (PDH) complex.

93 es in mitochondrial bioenergetics, including pyruvate dehydrogenase (PDH) dysfunction, have been desc

94 Pyruvate dehydrogenase (PDH) is the main regulator of th

95 Pyruvate dehydrogenase (PDH) plays a well-known metaboli

96 and phosphorylation-dependent inhibition of pyruvate dehydrogenase (PDH) within a single day of feed

97 elta is synthetically lethal with mutants in pyruvate dehydrogenase (PDH), which catalyzes the conver

98 chondrial calcium ([Ca(2+)]mito), inhibiting pyruvate dehydrogenase activity and glucose oxidation, w

99 lycolysis, tricarboxylic acid metabolism and pyruvate dehydrogenase activity for ATP-dependent thermo

100 In contrast, pyruvate dehydrogenase activity is significantly decreas

101 ative function, increases in ATP content and pyruvate dehydrogenase activity, and marked inhibition o

102 the disruption of two key TCA cycle enzymes, pyruvate dehydrogenase and alpha-ketoglutarate dehydroge

103 itochondrial metabolism, enhancing oxidative pyruvate dehydrogenase and anaplerotic pyruvate carboxyl

104 The human pyruvate dehydrogenase complex (PDC) comprises four mult

105 The pyruvate dehydrogenase complex (PDC) is a critical mitoc

106 The pyruvate dehydrogenase complex (PDC) is the primary meta

107 AT5A bound the E1beta and E2 subunits of the pyruvate dehydrogenase complex (PDC).

108 ecular mimicry between the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), the major mitoc

109 At baseline, IMTG, muscle pyruvate dehydrogenase complex activity and the protein

110 ese novel genetic interactions involving the pyruvate dehydrogenase complex suggested a new role for

111 e that loss of PDHK4, a key regulator of the pyruvate dehydrogenase complex, caused a profound cell g

112 sion of pyruvate to acetyl-coenzyme A by the pyruvate dehydrogenase complex.

113 However, induction of the expressions of the pyruvate dehydrogenase E1 component subunit beta (PDHB)

114 nase 1 (PDK1) protein levels and a decreased pyruvate dehydrogenase enzyme activity.

115 the key molecular substitution in duplicated pyruvate dehydrogenase genes that underpins one of the m

116 es new support for the presence of an active pyruvate dehydrogenase in this stage.

117 tion in activated MPs, resulting in regional pyruvate dehydrogenase inhibition.

118 In humans, the enzyme pyruvate dehydrogenase is transiently nuclear at the 4/8

119 (off-rate, kd) for compounds binding to the pyruvate dehydrogenase kinase (PDHK) enzyme.

120 Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in br

121 ycolysis, which were paralleled by increased pyruvate dehydrogenase kinase 1 (PDK1) protein levels an

122 n HP [1-(13)C]lactate was likely mediated by pyruvate dehydrogenase kinase 1 up-regulation in activat

123 ibility is driven by robust up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) and phosphorylati

124 the downregulation of a miR-211 target gene, pyruvate dehydrogenase kinase 4 (PDK4).

125 protein and glycogen content, and increased pyruvate dehydrogenase kinase 4 mRNA abundance in the he

126 pregnancy hormone progesterone induces PDK4 (pyruvate dehydrogenase kinase 4) in cardiomyocytes and t

127 HIF-1alpha increased glycolytic enzymes and pyruvate dehydrogenase kinase-1 (PDK-1), which reduces m

128 vates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and

129 have provided additional gene copies of the pyruvate dehydrogenase multienzyme complex that have evo

130 nt ones, such as Streptococcus gordonii, use pyruvate dehydrogenase to decarboxylate pyruvate.

131 in late pregnancy lead to inhibition of PDH (pyruvate dehydrogenase) and pyruvate flux into the trica

132 tric acid cycle (as inferred by flux through pyruvate dehydrogenase), were down-regulated by beta-lap

133 -ketoacid dehydrogenase complexes, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenas

134 bited hyperphosphorylation and inhibition of pyruvate dehydrogenase, the key Ca(2+)-sensitive gatekee

135 regulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in py

136 dent regulation of the key metabolic enzyme, pyruvate dehydrogenase.

137 expression and inhibitory phosphorylation of pyruvate dehydrogenase.

138 human and mouse LLPCs could robustly engage pyruvate-dependent respiration, whereas their short-live

139 hence the tricarboxylic acid cycle influx of pyruvate-derived acetyl-CoA relative to beta-oxidation-d

140 Pyruvate determinations according to AB significantly re

141 We report Psyr_1625, encoding a functional pyruvate deydrogenase-E1 subunit PdhQ, is required to pr

142 Here, we report that this pyruvate effect involves heme.

143 aminolysis, de novo fatty acid synthesis and pyruvate entry into the tricarboxylic acid cycle.

144 al OCR in EDL fibre bundles when compared to pyruvate exposure, suggesting that fatty acids might be

145 partial Wood-Ljungdahl and complete reversed pyruvate ferredoxin oxidoreductase / pyruvate-formate-ly

146 M. girerdii encodes pyruvate-ferredoxin oxidoreductase and may be sensitive

147 a novel therapeutic, amixicile, that targets pyruvate:ferredoxin oxidoreductase (PFOR), a major metab

148 via two biochemical reactions: the reversed pyruvate:ferredoxin oxidoreductase (rPFOR), which incorp

149 bon fixation routes (Wood-Ljungdahl pathway, pyruvate:ferredoxin oxidoreductase reaction and anaplero

150 hibition of PDH (pyruvate dehydrogenase) and pyruvate flux into the tricarboxylic acid cycle.

151 Pyruvate flux through PDC is regulated via phosphorylati

152 tion, while administration of fatty acids or pyruvate for mitochondrial respiration rescued different

153 lyase activating enzyme (coded by pflA) and pyruvate formate lyase (coded by pflB).

154 Pyruvate formate lyase (PFL) is a crucial enzyme for mix

155 PFL requires the activities of two enzymes: pyruvate formate lyase activating enzyme (coded by pflA)

156 Pyruvate formate-lyase activating enzyme (PFL-AE) is a r

157 a catalytically essential glycyl radical on pyruvate formate-lyase.

158 A as a substrate and generates pyruvate, and pyruvate-formate lyase (PFL) converting pyruvate to form

159 eversed pyruvate ferredoxin oxidoreductase / pyruvate-formate-lyase-dependent (rPFOR/Pfl) pathways.

160 fficient and robust synthesis of phosphoenol pyruvate from prebiotic nucleotide precursors, glycolald

161 Notably, pyruvate fully rescues the impaired insulin secretion of

162 izing specific substrates, namely glutamine, pyruvate, glucose, or palmitate, in mitochondria.

163 r, our results demonstrate that HP [1-(13)C] pyruvate has great potential for in vivo non-invasive de

164 d central carbon metabolism genes, including pyruvate hub enzymes and fermentation pathways and virul

165 sm that requires transport and metabolism of pyruvate in mitochondria.

166 , is required to prevent the accumulation of pyruvate in rich media.

167 primarily on the PDH-catalyzed conversion of pyruvate in the mitochondria and on the PDH bypass in th

168 sed liver PEPCK1 protein level and prevented pyruvate-induced blood glucose from increasing.

169 ect (the ratio of lactate production flux to pyruvate influx through the mitochondrial pyruvate carri

170 Furthermore, phosphoenol pyruvate is derived within an alpha-phosphorylation cont

171 Pyruvate is essential for development beyond this stage,

172 Pyruvate is essential for this nuclear localization, and

173 Glucose-derived pyruvate is oxidized via PDH to generate citrate in the

174 Phosphoenol pyruvate is the highest-energy phosphate found in living

175 m glyceraldehyde 3-phosphate via phosphoenol pyruvate) is among the most central and highly conserved

176 ase responsible for the conversion of PEP to pyruvate, is responsible for a significant in vivo flux

177 -opts the cellular glycolytic ATP-generating pyruvate kinase (PK) directly into the viral replicase c

178 of the low-activity (dimeric) M2 isoform of pyruvate kinase (PK) over its constitutively active spli

179 duct generates the PKM1 and PKM2 isoforms of pyruvate kinase (PK), and PKM2 expression is closely lin

180 ted Sites (BORIS) at the alternative exon of Pyruvate Kinase (PKM) is associated with cancer-specific

181 mely, the rate-limiting enzyme of glycolysis pyruvate kinase (PKM), which plays a critical role in ca

182 active tetramer and inactive dimer forms of pyruvate kinase (PKM2) in cancer cells, similar to the t

183 Pyruvate kinase (PYK) is an essential glycolytic enzyme

184 olysis and theMtbgenome harbors one putative pyruvate kinase (pykA, Rv1617).

185 t allosteric regulation of the activities of pyruvate kinase (PykF, but not PykA), phosphofructokinas

186 ibility of this approach using rabbit muscle pyruvate kinase (rM1-PK) which catalyzes the conversion

187 its BC cell survival in a dose-dependent but pyruvate kinase activity-independent manner.

188 Pyruvate kinase catalyzes the last and rate-limiting ste

189 y a SiLAD proteomics analysis, we identified pyruvate kinase isoenzyme M2 (PKM2), a critical regulato

190 ate-responsive element-binding protein-beta, pyruvate kinase L, SCD-1, and DGAT1, key transcriptional

191 romote dimerization of the glycolytic enzyme pyruvate kinase M2 (PKM2) and enable its nuclear translo

192 In particular, pyruvate kinase M2 (PKM2) expression and activity were u

193 The tumor form of pyruvate kinase M2 (PKM2) undergoes tyrosine phosphoryla

194 Recent data indicate that pyruvate kinase M2 (PKM2), a glycolytic enzyme for Warbu

195 ylation at Y59, which interacts with nuclear pyruvate kinase M2 (PKM2).

196 lycolytic pathway, 6-phosphofructokinase and pyruvate kinase M2.

197 xpression to control alternative splicing of pyruvate kinase muscle (PKM) isoforms 1 and 2, resulting

198 Moreover, we show that the metabolic enzyme, pyruvate kinase muscle (PKM), interacts with sub-pools o

199 y in nucleus pulposus (NP) cells through the pyruvate kinase muscle (PKM)-2-Jumonji domain--containin

200 otein), resulting in alternative splicing of pyruvate kinase muscle isoforms 1 and 2 (PKM1 and 2) and

201 Pyruvate kinase muscle isozyme 2 (PKM2) is a key regulat

202 our cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), which is upregulated and

203 versible aggregation of the metabolic enzyme pyruvate kinase under environmental stress and propose a

204 hosphate isomerase was up-regulated, whereas pyruvate kinase was down-regulated.

205 We quantified gene copy numbers of the pyruvate kinase, liver, and red blood cell (PKLR) gene a

206 Here, we assessed whether disrupting pyruvate kinase-M (Pkm), an enzyme that acts in the term

207 acetylation and lysosomal degradation of the pyruvate kinase-M2 isoform (PKM2).

208 synthase, SREBP1c, chREBP, glucokinase, and pyruvate kinase.

209 [(13)C]Pyruvate labeling was performed to compare metabolism th

210 gher pyruvate-to-lactate conversion (lactate/pyruvate + lactate ratio) was found 2 days after treatme

211 e SW method always led to over-estimation of pyruvate levels in colored, but not in white onions, by

212 ATP(lo)pyruvate(lo) conditions triggered fatty acid biosynthesi

213 y (PET) and hyperpolarized carbon 13 ((13)C)-pyruvate magnetic resonance (MR) spectroscopy, can serve

214 We used hyperpolarized [1-(13)C]pyruvate magnetic resonance spectroscopy to determine th

215 s pyruvate cycling relative to mitochondrial pyruvate metabolism (VPyr-Cyc/VMito) in vivo using [3-(1

216 sis, but also possessing hydrogenosomal-type pyruvate metabolism and substrate-level phosphorylation.

217 Our data demonstrate a novel role for apc in pyruvate metabolism and that pyruvate metabolism dictate

218 role for apc in pyruvate metabolism and that pyruvate metabolism dictates intestinal cell fate and di

219 we define the requirement for mitochondrial pyruvate metabolism during development with a progressiv

220 ts of metformin treatment on heart and liver pyruvate metabolism in rats in vivo.

221 This shows that assessment of pyruvate metabolism in vivo in humans is feasible using

222 The finding links mitochondrial pyruvate metabolism to glutamatergic neurotransmission a

223 ruvate carrier 1 (MPC1), a crucial player in pyruvate metabolism, is downregulated in colon adenocarc

224 sults suggest an impairment in mitochondrial pyruvate metabolism, resulting in a decrease in aerobic

225 ge activation by reprogramming mitochondrial pyruvate metabolism.

226 metabolic pathways, including glycolysis and pyruvate metabolism.

227 is coordinated with suppressed mitochondrial pyruvate metabolism.

228 e findings suggest that hyperpolarized (13)C-pyruvate MR spectroscopy may serve as an early indicator

229 c-di-AMP modulates central metabolism at the pyruvate node to moderate citrate production and indeed,

230 Finally, we showed that the effect of pyruvate on toxin gene expression is mediated at least i

231 s directly catalyze phenazine reduction with pyruvate or alpha-ketoglutarate as electron donors.

232 OX1A by glutamate mimicked its activation by pyruvate or glyoxylate, but not in AOX1C and AOX1D.

233 ternative electron donors (lactate, formate, pyruvate, or hydrogen) was found to be significant.

234 nine and employs alanine transaminase (ALT), pyruvate oxidase (POx), and horseradish peroxidase (HRP)

235 nes encoding lactate dehydrogenase (ldh) and pyruvate oxidase (poxB) were deleted to block the synthe

236 acteristic slow rate of FAD reduction by the pyruvate oxidase side reaction of the enzyme.

237 rved attributes from its predicted ancestor, pyruvate oxidase, such as a ubiquinone-binding site and

238 tion, we observed that a mutant deficient in pyruvate oxidase, which converts pyruvate to acetyl-phos

239 etermined that pneumolysin and streptococcal pyruvate oxidase-derived H2O2 production were required f

240 mechanisms of ATP synthesis, fatty acid, and pyruvate oxidation in EC.

241 Therefore, it has been speculated that pyruvate oxidation through PDH is decreased in pro-infla

242 Yeast metabolites such as acetaldehyde and pyruvate participate in the formation of stable pigments

243 ded by o2 include pdk1 and pdk2 that specify pyruvate phosphate dikinase (PPDK).

244 l of [O] consumed) are 2.73 for oxidation of pyruvate plus malate and 1.64 for oxidation of succinate

245 uding metabolic imaging using hyperpolarized pyruvate, points to reduced oxidative flux due to NAD(+)

246 s the resolution to distinguish the starting pyruvate precursor from the carbonyl resonances in the r

247 Restoration of pyruvate production or inhibition of fatty acid synthesi

248 d metabolic deficits as evidenced by lactate/pyruvate ratio (LPR) elevation (a clinically-established

249 Despite CCI, the HP [1-(13)C] lactate-to-pyruvate ratio at the injury cortex of microglia-deplete

250 V and STIM; p < 0.0001), but not the lactate/pyruvate ratio.

251 ur results show that HP [1-(13)C] lactate-to-pyruvate ratios were increased in the injured cortex at

252 that modulations of HP [1-(13)C] lactate-to-pyruvate ratios were linked to microglial activation.

253 Pyruvate release was also decelerated and in Y215F, it w

254 ifferent temperatures for the stability; the pyruvate remained stable at all temperatures except at 2

255 bstrates, glutamine, N-acetylglucosamine, or pyruvate) revealed contrasting capacity of bacterioplank

256 critical mitochondrial enzyme that catalyzes pyruvate's conversion to acetyl coenzyme A (AcCoA), ther

257 The [1-(13)C]pyruvate signal appeared within the chambers but not wit

258 RP)- and (SP)-[(16)O,(17)O,(18)O]phosphoenol pyruvate starting from enantiomerically pure (R)-2-chlor

259 line PC3M assessed by hyperpolarized in vivo pyruvate studies, nuclear magnetic resonance spectroscop

260 cetic anhydride inhibits pyruvate uptake and pyruvate-supported respiration in a similar manner to th

261 ), seawater-naphthalene (SW-N), and seawater-pyruvate (SW-P).

262 jungdahl pathway, right branch of TCA cycle, pyruvate synthesis, and sugar phosphate pathways, but th

263 e; tidal flat-naphthalene (TF-N), tidal flat-pyruvate (TF-P), seawater-naphthalene (SW-N), and seawat

264 In yeast cells that do not readily take up pyruvate, the addition of the electroporation pulse to t

265 llowing injection of hyperpolarized [1-(13)C]pyruvate, the resulting (13)C-bicarbonate signal was fou

266 se habitats that either added naphthalene or pyruvate; tidal flat-naphthalene (TF-N), tidal flat-pyru

267 ase (PDH), which catalyzes the conversion of pyruvate to acetyl-CoA.

268 n the mitochondrial matrix where it converts pyruvate to acetyl-CoA.

269 gnaling complex stimulates the conversion of pyruvate to acetyl-coenzyme A by the pyruvate dehydrogen

270 eficient in pyruvate oxidase, which converts pyruvate to acetyl-phosphate under non-CCR-inducing grow

271 Conversion of pyruvate to CO2 in the T. brucei bloodstream form provid

272 The observed conversion rate from pyruvate to CO2 normalized for cell density was found to

273 nvolves both hydride and proton transfers to pyruvate to form l-lactate, using reduced nicotinamide a

274 and pyruvate-formate lyase (PFL) converting pyruvate to formate and acetyl-CoA.

275 time to show the rapid conversion of (13)C1-pyruvate to lactate and bicarbonate, indicating active g

276 tic enzyme responsible for the conversion of pyruvate to lactate coupled with oxidation of NADH to NA

277 modeled to provide quantitative measures of pyruvate to lactate flux (kPL ) and urea perfusion (urea

278 d the potential of (13)C MRSI of HP [1-(13)C]pyruvate to monitor the presence of neuroinflammatory le

279 icant in vivo flux in the reverse direction (pyruvate to PEP) during both gluconeogenic and glycolyti

280 ed, which corresponded to elevated flux from pyruvate to phosphoenolpyruvate.

281 Significantly higher pyruvate-to-lactate conversion (lactate/pyruvate + lacta

282 detect a significant increase in HP [1-(13)C]pyruvate-to-lactate conversion, which was associated wit

283 hrough MR detection of increased HP [1-(13)C]pyruvate-to-lactate conversion.

284 nes encoding glycerate kinase (glxK), valine-pyruvate transaminase (avtA), superoxide dismutase (sodB

285 study supports the conclusion that deficient pyruvate transport activity, mediated in part by acetyla

286 that there is a 70% decrease in the rate of pyruvate transport in Akita heart mitochondria but no de

287 e foundational for understanding the role of pyruvate transport in health and disease.

288 orted respiration in a similar manner to the pyruvate transport inhibitor alpha-cyano-4-hydroxycinnam

289 Pyruvate treatment did not generate the same effects in

290 acetylating agent acetic anhydride inhibits pyruvate uptake and pyruvate-supported respiration in a

291 Reductions in mitochondrial pyruvate uptake do not compromise cellular energy metabo

292 developed a 96-well scaled method of [(14)C]pyruvate uptake that markedly decreases sample requireme

293 hyperacetylation in mediating this impaired pyruvate uptake was examined.

294 lyzes in vitro the oxidation of d-lactate to pyruvate using flavin adenine dinucleotide as a cofactor

295 This reduces mitochondrial pyruvate utilization, suppresses reactive oxygen species

296 ic conditions, with a moderate increase when pyruvate was added.

297 Binding of radiolabeled pyruvate was found for full-length YehU in right-side-ou

298 High levels of sulfide and pyruvate were produced in the presence of 10 mM cysteine

299 Two protected-[(16)O,(17)O,(18)O]phosphoenol pyruvates were formed and finally globally deprotected.

300 -infected cells produce more glucose-derived pyruvate, which can be converted to acetate through a no