ライフサイエンスコーパス: pyruvate carboxylase

1 lso contain a biotinylated protein, probably pyruvate carboxylase.

2 yl-CoA and propionyl-CoA carboxylases and of pyruvate carboxylase.

3 on of glutamine into lipids does not involve pyruvate carboxylase.

4 Furthermore, enzyme activity of pyruvate carboxylase, a key regulator of pyruvate cyclin

5 -body lipolysis, hepatic acetyl CoA content, pyruvate carboxylase activity and hepatic glucose produc

6 spartate indicated high rates of anaplerotic pyruvate carboxylase activity and incomplete equilibrati

7 ese two carboxylases in the islet and of low pyruvate carboxylase activity in the islet in NIDDM.

8 arbamoylphosphate synthetase 1 (urea cycle), pyruvate carboxylase (anaplerosis, gluconeogenesis), pro

9 ficial miRNAs for simultaneous repression of pyruvate carboxylase and glutaminase by selecting all se

10 f mRNAs encoding two malate-forming enzymes, pyruvate carboxylase and malic enzyme, are observed in t

11 termediates and bicarbonate is diagnostic of pyruvate carboxylase and PEPCK flux in the liver.

12 esses two oxaloacetate-synthesizing enzymes, pyruvate carboxylase and phosphoenolpyruvate carboxylase

13 glucose oxidation partially occurred through pyruvate carboxylase and rendered NNT knockdown cells mo

14 ts differentiation-dependent expression like pyruvate carboxylase and the cytosolic isozymes CA II an

15 ndrial glycerol phosphate dehydrogenase, and pyruvate carboxylase), and ion channels/pumps (Kir6.2, V

16 non-neuronal SNAP25-like protein homolog 1, pyruvate carboxylase, and BCKDC kinase.

17 , phosphoenolpyruvate carboxykinase (PEPCK), pyruvate carboxylase, and glucose-6-phosphatase, and the

18 ic acetyl-CoA content, a potent activator of pyruvate carboxylase, and increased glycerol conversion

19 rial carboxylases propionyl-CoA carboxylase, pyruvate carboxylase, and methylcrotonoyl-CoA carboxylas

20 C]pyruvate into the hepatic TCA cycle is via pyruvate carboxylase, and that cataplerotic flux through

21 lipogenesis involves an inhibitory effect on pyruvate carboxylase as opposed to acetyl CoA carboxylas

22 Interestingly, pyruvate carboxylase ASO also reduced adiposity, plasma

23 Pyruvate carboxylase ASO did not alter de novo fatty aci

24 Pyruvate carboxylase ASO had similar effects in Zucker D

25 Pyruvate carboxylase ASO reduced plasma glucose concentr

26 Here we report the complete structure of pyruvate carboxylase at 2.0 angstroms resolution, which

27 Chicken liver pyruvate carboxylase catalyzes a nonclassical ping-pong

28 o urea cycle defects, organic acidurias, and pyruvate carboxylase deficiency as a treatable condition

29 and pyruvate conversion to oxaloacetate via pyruvate carboxylase (DET0119-0120).

30 In addition, C. elegans homologues of pyruvate carboxylase, DNA gyrase, beta-adrenergic recept

31 tochondrial citrate synthase flux (V CS) and pyruvate carboxylase flux (V PC) in vivo.

32 ted mitochondrial TCA cycle flux and induced pyruvate carboxylase flux and gluconeogenesis in lean ra

33 gnal generated by anaplerosis from increased pyruvate carboxylase flux is essential for glucose-stimu

34 Hepatic pyruvate carboxylase flux was impaired with ChREBP delet

35 tricarboxylic acid (TCA) cycle activity and pyruvate carboxylase flux were normal in newly diabetic

36 dipose tissue (WAT) leading to reductions in pyruvate carboxylase flux.

37 hepatic acetyl-CoA allosteric activation of pyruvate carboxylase flux.

38 ative pyruvate dehydrogenase and anaplerotic pyruvate carboxylase fluxes.

39 In addition, SNPs in the pyruvate carboxylase gene showed evidence of association

40 arboxyl transferase domain of Rhizobium etli pyruvate carboxylase have been determined for the forwar

41 ondrial enzyme that provides bicarbonate for pyruvate carboxylase in liver and kidney.

42 We assessed the role of pyruvate carboxylase in regulating glucose and lipid met

43 We conclude that the decreased mGPD and pyruvate carboxylase in the pancreatic islet of the GK r

44 Tissue-specific inhibition of pyruvate carboxylase is a potential therapeutic approach

45 In particular, we demonstrate that pyruvate carboxylase is essential to re-supply the deple

46 ty fits the suggestion that in M. smegmatis, pyruvate carboxylase is not anaplerotic but rather gluco

47 gh C. reinhardtii has a single gene encoding pyruvate carboxylase, it has six genes encoding putative

48 in Listeria monocytogenes by inhibiting its pyruvate carboxylase (LmPC), a biotin-dependent enzyme w

49 tors, including the central metabolic enzyme pyruvate carboxylase (LmPC).

50 This decrease in pyruvate carboxylase-mediated [14C] carbon fixation was

51 CanB is crucial in bicarbonate provision for pyruvate carboxylase-mediated oxaloacetate synthesis.

52 demonstrate a potentially important role for pyruvate carboxylase-mediated pyruvate cycling pathways

53 Moreover, the result is a function of pyruvate-carboxylase, mitochondrial pyruvate transporter

54 flux through three anaplerotic pathways: 1) pyruvate carboxylase of pyruvate derived from glycolytic

55 pyruvate derived from glycolytic sources; 2) pyruvate carboxylase of pyruvate derived from nonglycoly

56 phate dehydrogenase (mGPD) (EC 1.1.99.5) and pyruvate carboxylase (PC) (EC 6.4.1.1) have been reporte

57 ited apparent correlation with gluconeogenic pyruvate carboxylase (PC) activity in hepatocytes.

58 and glutamine, which require the activity of pyruvate carboxylase (PC) and glutaminase 1 (GLS1), resp

59 The reason was increased flux through pyruvate carboxylase (PC) and the malate-pyruvate and ci

60 correlation of insulin secretion rates with pyruvate carboxylase (PC) flux suggest that a pyruvate-m

61 Pyruvate carboxylase (PC) has important roles in metabol

62 observed in the structure of the tetrameric pyruvate carboxylase (PC) holoenzyme.

63 ive mRNA level of the key anaplerotic enzyme pyruvate carboxylase (PC) were 80-90% lower in human pan

64 Pyruvate carboxylase (PC), a multifunctional biotin-depe

65 pensatory anaplerotic mechanism catalyzed by pyruvate carboxylase (PC), allowing the cells to use glu

66 5S and human pyruvate carboxylase (PC), an enzyme crucial to gluconeo

67 s the expression of the mitochondrial enzyme pyruvate carboxylase (PC), resulting in diminished produ

68 nsulin secretion, we lowered the activity of pyruvate carboxylase (PC), the major enzyme of anapleros

69 secretion (GSIS) is tightly correlated with pyruvate carboxylase (PC)-catalyzed anaplerotic flux int

70 cetate in the carboxyl transferase domain of pyruvate carboxylase (PC).

71 plets was suggested by the identification of pyruvate carboxylase, prohibitin, and a subunit of ATP s

72 biopsy specimens and found that only hepatic pyruvate carboxylase protein levels related strongly wit

73 The assayable activity and amount of pyruvate carboxylase protein were decreased approximatel

74 egmatis for biotin auxotrophs and identified pyruvate carboxylase (Pyc) as required for biotin biosyn

75 thermoautotrophicum strain DeltaH possessed pyruvate carboxylase (PYC), and this biotin prototroph r

76 4)beta(4)-type acetyl coenzyme A-independent pyruvate carboxylase (PYC), composed of 64.2-kDa biotiny

77 ted under low CO2 , including both PEPCs and pyruvate carboxylase (PYC), whereas ME abundance did not

78 mutations in the acetyl-CoA binding site of pyruvate carboxylase (PycA) rescued cefuroxime resistanc

79 A high pyruvate carboxylase rate (V(PC), approximately 0.14-0.1

80 found that the otherwise integrative enzyme pyruvate carboxylase (TgPyC) is dispensable not only in

81 sulinotropic polypeptide (GIP) receptor, and pyruvate carboxylase) that are important regulators of b

82 With the exception of pyruvate carboxylase, the activities of other enzymes we

83 ing a conversion of lactate to pyruvate, via pyruvate carboxylase to oxaloacetate, and via PCK2 to ph

84 d the biotin carrying polypeptide from yeast pyruvate carboxylase to the carboxyl terminus of Cin8p.

85 ate-malate shuttle is suggested by unchanged pyruvate carboxylase Vmax and a fourfold higher release

86 The activity of pyruvate carboxylase was low in muscle, and no PEP carbo

87 propionyl-CoA carboxylase and mitochondrial pyruvate carboxylase, was inhibited.

88 The activities of both mGPD and pyruvate carboxylase were also normalized by insulin tre

89 Pyruvate carboxylase, which catalyzes the first step of

90 Inactivation studies of pyruvate carboxylase, which has an analogous mode of act

91 nzyme of the glycerol phosphate shuttle, and pyruvate carboxylase, which is the key component of the

92 Pyruvate carboxylation catalyzed by pyruvate carboxylase will supply oxaloacetate to mitocho