ライフサイエンスコーパス: pyruvate dehydrogenase

1 of other lipoic acid requiring enzymes (e.g. pyruvate dehydrogenase).

2 , MCAT (malonylCoA:ACP transferase) and PDH (pyruvate dehydrogenase).

3 buted to inhibition of the regulatory enzyme pyruvate dehydrogenase.

4 and acrylate pathways as well as a role for pyruvate dehydrogenase.

5 hyl acetylphosphonate, a potent inhibitor of pyruvate dehydrogenase.

6 iety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase.

7 se, thereby inhibiting glucose oxidation via pyruvate dehydrogenase.

8 eavy chain (MHC)-PDK4 mice), an inhibitor of pyruvate dehydrogenase.

9 increased phosphorylation and inhibition of pyruvate dehydrogenase.

10 rtionate reductions in catalytic subunits of pyruvate dehydrogenase.

11 dent regulation of the key metabolic enzyme, pyruvate dehydrogenase.

12 expression and inhibitory phosphorylation of pyruvate dehydrogenase.

13 r growth in PMN included the upregulation of pyruvate dehydrogenase.

14 he p.E379K variant also has a de novo VUS in pyruvate dehydrogenase 1 (PDHA1) affecting the same amin

15 omplexes carrying lipoic acid as a cofactor (pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and

16 In addition, pyruvate dehydrogenase, 2-oxoxglutarate dehydrogenase, a

17 chondrial calcium ([Ca(2+)]mito), inhibiting pyruvate dehydrogenase activity and glucose oxidation, w

18 lycolysis, tricarboxylic acid metabolism and pyruvate dehydrogenase activity for ATP-dependent thermo

19 In contrast, pyruvate dehydrogenase activity is significantly decreas

20 These results were consistent with the lower pyruvate dehydrogenase activity observed in children wit

21 hydrogenase phosphatase 1 (Pdp1) expression, pyruvate dehydrogenase activity, and glucose flux to the

22 ative function, increases in ATP content and pyruvate dehydrogenase activity, and marked inhibition o

23 e gastrocnemius muscle, oxfenicine increased pyruvate dehydrogenase activity, membrane GLUT4 content,

24 iated attenuation was sufficient to increase pyruvate dehydrogenase activity, oxidative phosphorylati

25 palmitate oxidation and increased indices of pyruvate dehydrogenase activity, TCA cycle flux, and hep

26 g II and PE, resulting in a reduction in the pyruvate dehydrogenase activity, the rate-limiting step

27 results in inhibitory phosphorylation of the pyruvate dehydrogenase alpha (PDHalpha) subunit.

28 -ketoacid dehydrogenase complexes, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenas

29 nsfer results in enhanced phosphorylation of pyruvate dehydrogenase and activation of AMPK, which act

30 the disruption of two key TCA cycle enzymes, pyruvate dehydrogenase and alpha-ketoglutarate dehydroge

31 dative damage to the lipoic acid cofactor of pyruvate dehydrogenase and alpha-ketoglutarate dehydroge

32 ell characterized as the E3 component of the pyruvate dehydrogenase and alpha-ketoglutarate dehydroge

33 Lat1 and Kgd2, the respective E2 subunits of pyruvate dehydrogenase and alpha-ketoglutarate dehydroge

34 itochondrial metabolism, enhancing oxidative pyruvate dehydrogenase and anaplerotic pyruvate carboxyl

35 n of two other genes isolated in the screen, pyruvate dehydrogenase and citrate synthase.

36 ntially druggable microbial factors, such as pyruvate dehydrogenase and ClpB, to help combat this ant

37 he ductal smooth muscle cells that activates pyruvate dehydrogenase and increases mitochondrial H2O2

38 te dehydrogenase kinase 1, which interrupted pyruvate dehydrogenase and reduced mitochondrial glucose

39 in late pregnancy lead to inhibition of PDH (pyruvate dehydrogenase) and pyruvate flux into the trica

40 r heat shock protein (HSP)-27, vimentin, and pyruvate dehydrogenase beta (PDHB), with a statistical s

41 Pharmacological inhibition of pyruvate dehydrogenase by triphenylbismuthdichloride was

42 This suggests that the pyruvate dehydrogenase bypass provided by the aerobic fe

43 ct of its activity, the inactive form of the pyruvate dehydrogenase complex (P-Pdc), both of which ar

44 increasing CHO oxidation in vivo, using the pyruvate dehydrogenase complex (PDC) activator, dichloro

45 uscle protein: DNA ratio, a 56% reduction in pyruvate dehydrogenase complex (PDC) activity (P < 0.05)

46 Here we show that inhibition of pyruvate dehydrogenase complex (PDC) activity contribute

47 w that all the subunits of the mitochondrial pyruvate dehydrogenase complex (PDC) are also present an

48 yl-CoA acetyltransferase 1 (ACAT1) regulates pyruvate dehydrogenase complex (PDC) by acetylating pyru

49 The pyruvate dehydrogenase complex (PDC) catalyzes the conve

50 The human pyruvate dehydrogenase complex (PDC) comprises four mult

51 ogenase (PDH) and consequently inhibition of pyruvate dehydrogenase complex (PDC) in cancer cells.

52 any putative (causative) association between pyruvate dehydrogenase complex (PDC) inhibition and lact

53 The human pyruvate dehydrogenase complex (PDC) is a 9.5-megadalton

54 The pyruvate dehydrogenase complex (PDC) is a critical mitoc

55 Mammalian pyruvate dehydrogenase complex (PDC) is a key multi-enzy

56 Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for gluc

57 The mitochondrial pyruvate dehydrogenase complex (PDC) is down-regulated b

58 Human pyruvate dehydrogenase complex (PDC) is down-regulated b

59 The pyruvate dehydrogenase complex (PDC) is the primary meta

60 The mitochondrial pyruvate dehydrogenase complex (PDC) plays a crucial rol

61 High-fat feeding inhibits pyruvate dehydrogenase complex (PDC)-controlled carbohyd

62 ized that PDK4 up-regulation, which inhibits pyruvate dehydrogenase complex (PDC)-dependent carbohydr

63 AT5A bound the E1beta and E2 subunits of the pyruvate dehydrogenase complex (PDC).

64 etyl-CoA in mitochondria is catalyzed by the pyruvate dehydrogenase complex (PDC).

65 activates mitochondrial PDH and consequently pyruvate dehydrogenase complex (PDC).

66 gh the phosphorylation and inhibition of the pyruvate dehydrogenase complex (PDC).

67 poylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC-E2) are targets for

68 hondrial response to the E2 component of the pyruvate dehydrogenase complex (PDC-E2), has unique feat

69 ecular mimicry between the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), the major mitoc

70 ondrial autoantigen, the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

71 (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

72 The pyruvate dehydrogenase complex (PDH) has been hypothesiz

73 as a cellular lipoamidase that regulates the pyruvate dehydrogenase complex (PDH).

74 xidative decarboxylation of pyruvate via the pyruvate dehydrogenase complex (PDH).

75 In Escherichia coli, the pyruvate dehydrogenase complex (PDHC) and pyruvate forma

76 The Escherichia coli pyruvate dehydrogenase complex (PDHc) catalyzing convers

77 cherichia coli and report that disruption of pyruvate dehydrogenase complex (PDHc), which converts py

78 f oxidative phosphorylation by targeting the pyruvate dehydrogenase complex (PDHC).

79 tabolic fuel selection as a component of the pyruvate dehydrogenase complex (PDHc).

80 At baseline, IMTG, muscle pyruvate dehydrogenase complex activity and the protein

81 et-induced obese mice significantly augments pyruvate dehydrogenase complex activity with reduced pho

82 45 and 392 on PDHK2 and results in increased pyruvate dehydrogenase complex activity.

83 ase-specific loss of immune tolerance to the pyruvate dehydrogenase complex and subsequent developmen

84 rotein complexes identified in our analysis, pyruvate dehydrogenase complex and succinate dehydrogena

85 e of oxythiamine, which can inhibit both the pyruvate dehydrogenase complex and transketolase, result

86 l analysis showing that the lipoyl moiety of pyruvate dehydrogenase complex appears to be involved in

87 ively regulate activity of the mitochondrial pyruvate dehydrogenase complex by reversible phosphoryla

88 Both pyruvate-formate lyase and the pyruvate dehydrogenase complex contributed to acetyl-coe

89 e two active centers of the Escherichia coli pyruvate dehydrogenase complex E1 component provides a s

90 The PKCdelta/retinol complex signaled the pyruvate dehydrogenase complex for enhanced flux of pyru

91 s (HiBECs) translocate the E2 subunit of the pyruvate dehydrogenase complex immunologically intact in

92 without increased glucose oxidation through pyruvate dehydrogenase complex in the energy-poor, hyper

93 ainst a complex set of proteins, among which pyruvate dehydrogenase complex is considered the main au

94 t indicates that inhibition of the bacterial pyruvate dehydrogenase complex may represent a promising

95 drogenase kinase 4 (PDK4) is upregulated and pyruvate dehydrogenase complex phosphorylation is increa

96 he E3-binding domain (E3BD) of the mammalian pyruvate dehydrogenase complex show that hSBDb has an ar

97 ese novel genetic interactions involving the pyruvate dehydrogenase complex suggested a new role for

98 umor activity is its ability to activate the pyruvate dehydrogenase complex through inhibition of pyr

99 CCase subunits; (2) four subunits to plastid pyruvate dehydrogenase complex were 25% to 70% down-regu

100 e that loss of PDHK4, a key regulator of the pyruvate dehydrogenase complex, caused a profound cell g

101 fferential expression of glycolysis, plastid pyruvate dehydrogenase complex, fatty acid, and lipid sy

102 f pdhD, putatively encoding a subunit of the pyruvate dehydrogenase complex, impairs survival of both

103 e investigated whether the E2 subunit of the pyruvate dehydrogenase complex, the E2 subunit of the br

104 chondrial protein kinase that phosphorylates pyruvate dehydrogenase complex, thereby down-regulating

105 dehydrogenase kinase 2 (PDHK2) inhibits the pyruvate dehydrogenase complex, thereby regulating entry

106 at may catalyze the dephosphorylation of the pyruvate dehydrogenase complex.

107 nt, uncompetitive inhibitor of the bacterial pyruvate dehydrogenase complex.

108 ologic phenotypes, or PDHX, a subunit of the pyruvate dehydrogenase complex.

109 sion of pyruvate to acetyl-coenzyme A by the pyruvate dehydrogenase complex.

110 kinase 1 (PDK1) on Thr346 to inactivate the pyruvate dehydrogenase complex.

111 PDH2, which encodes a subunit of the plastid pyruvate dehydrogenase complex.

112 The pyruvate dehydrogenase complexes (PDCs) from all known l

113 Most bacterial pyruvate dehydrogenase complexes from either gram-positi

114 component of this entire class of bacterial pyruvate dehydrogenase complexes is responsible for bind

115 A key target of MGF appears to be pyruvate dehydrogenase, determined to be activated by MG

116 However, induction of the expressions of the pyruvate dehydrogenase E1 component subunit beta (PDHB)

117 ing protein C), glucose metabolism proteins (pyruvate dehydrogenase E1, PYGB, Pgm2), and antioxidant

118 bstrate YHGH(292)SMSDPGSTYR derived from the pyruvate dehydrogenase E1alpha subunit sequence.

119 inducible inhibitory phosphorylations on the pyruvate dehydrogenase E1alpha subunit.

120 membrane protein MgPa, elongation factor Tu, pyruvate dehydrogenase E1alpha, and DnaK (Hsp70), indica

121 novel alleles of the putative mitochondrial pyruvate dehydrogenase E1alpha-subunit, IAA-Alanine Resi

122 hat employs three catalytic components, i.e. pyruvate dehydrogenase (E1p), dihydrolipoyl transacetyla

123 e E2 subunit of the metabolic enzyme complex pyruvate dehydrogenase (E2-PDH) with a fatty acid deriva

124 They had low pyruvate dehydrogenase enzyme activity but most did not

125 nase 1 (PDK1) protein levels and a decreased pyruvate dehydrogenase enzyme activity.

126 Reversible phosphorylation of the pyruvate dehydrogenase enzyme is a critical regulatory m

127 vestigate the rate and regulation of in vivo pyruvate dehydrogenase flux in the hyperthyroid heart an

128 , (2) rats in which dichloroacetate enhanced pyruvate dehydrogenase flux, and (3) rats in which dobut

129 In vivo pyruvate dehydrogenase flux, assessed with hyperpolarize

130 By 22 weeks, alterations were also seen in pyruvate dehydrogenase flux, which decreased at lower ej

131 e changes were independent of alterations in pyruvate dehydrogenase flux.

132 Krebs cycle activity precede a reduction in pyruvate dehydrogenase flux.

133 (13)CO2:[1-(13)C]pyruvate ratio, an index of pyruvate dehydrogenase flux.

134 his hypothesis we assessed relative rates of pyruvate dehydrogenase flux/mitochondrial oxidative flux

135 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacill

136 the key molecular substitution in duplicated pyruvate dehydrogenase genes that underpins one of the m

137 es new support for the presence of an active pyruvate dehydrogenase in this stage.

138 tion in activated MPs, resulting in regional pyruvate dehydrogenase inhibition.

139 that metabolism of pyruvate by both LDH and pyruvate dehydrogenase is subject to the acute effects o

140 In humans, the enzyme pyruvate dehydrogenase is transiently nuclear at the 4/8

141 (off-rate, kd) for compounds binding to the pyruvate dehydrogenase kinase (PDHK) enzyme.

142 ylation activates and inhibits mitochondrial pyruvate dehydrogenase kinase (PDK) and phosphatase (PDP

143 od development, we used the dedicated kinase pyruvate dehydrogenase kinase (PDK) for the in vitro ass

144 f increased transcription of muscle-specific pyruvate dehydrogenase kinase (PDK) isoenzymes.

145 wn-regulated by phosphorylation catalyzed by pyruvate dehydrogenase kinase (PDK) isoforms 1-4.

146 drogenase complex (PDC) is down-regulated by pyruvate dehydrogenase kinase (PDK) isoforms 1-4.

147 acetic acids are developed for inhibition of pyruvate dehydrogenase kinase (PDK), an enzyme responsib

148 by inhibiting a key enzyme in cancer cells, pyruvate dehydrogenase kinase (PDK), that is required fo

149 report that hypoxia drives expression of the pyruvate dehydrogenase kinase (PDK1) and EGFR along with

150 We observed increased expression of pyruvate dehydrogenase kinase 1 (a HIF gene target), whi

151 K1 acts as a protein kinase to phosphorylate pyruvate dehydrogenase kinase 1 (PDHK1) at T338, which a

152 lysis in part due to increased expression of pyruvate dehydrogenase kinase 1 (PDK1) and lactate dehyd

153 We identify pyruvate dehydrogenase kinase 1 (PDK1) as an important d

154 Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in br

155 tochondria during hypoxia and phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) on Thr346 to inac

156 ycolysis, which were paralleled by increased pyruvate dehydrogenase kinase 1 (PDK1) protein levels an

157 result in the induction of the gene encoding pyruvate dehydrogenase kinase 1 (PDK1), which inhibits p

158 gulation of key glycolytic enzymes including pyruvate dehydrogenase kinase 1 (PDK1).

159 ascular endothelial growth factor (VEGF) and pyruvate dehydrogenase kinase 1 (PDK1).

160 n HP [1-(13)C]lactate was likely mediated by pyruvate dehydrogenase kinase 1 up-regulation in activat

161 nsporter Glut1, phospho-fructose kinase, and pyruvate dehydrogenase kinase 1, which interrupted pyruv

162 Pyruvate dehydrogenase kinase 2 (PDHK2) inhibits the pyr

163 Mitochondrial pyruvate dehydrogenase kinase 2 (PDHK2) phosphorylates t

164 Compared with CD, HFD increased resting pyruvate dehydrogenase kinase 2 (PDK2), PDK4, forkhead b

165 f PKCdelta leads to the dephosphorylation of pyruvate dehydrogenase kinase 2 (PDK2), thereby decreasi

166 cle glucose metabolism in awake mice lacking pyruvate dehydrogenase kinase 2 and 4 [double knockout (

167 mice with cardiac-specific overexpression of pyruvate dehydrogenase kinase 4 (myosin heavy chain (MHC

168 ibility is driven by robust up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) and phosphorylati

169 In this study, we have observed that pyruvate dehydrogenase kinase 4 (PDK4) is upregulated an

170 Furthermore, Dex suppressed LPS-induced pyruvate dehydrogenase kinase 4 (PDK4) mRNA upregulation

171 for carnitine palmitoyltransferase (cpt1a), pyruvate dehydrogenase kinase 4 (pdk4), and phosphoenolp

172 e palmitoyltransferase (CPT1a and CPT1c) and pyruvate dehydrogenase kinase 4 (PDK4), effects that wou

173 the downregulation of a miR-211 target gene, pyruvate dehydrogenase kinase 4 (PDK4).

174 thalamic expression of four genes, including pyruvate dehydrogenase kinase 4 and glycerol 3-phosphate

175 activated receptor-gamma coactivator-1alpha, pyruvate dehydrogenase kinase 4 and mitochondrial transc

176 Cardiac pyruvate dehydrogenase kinase 4 expression was upregulat

177 ose oxidation was mediated by a reduction in pyruvate dehydrogenase kinase 4 expression, enabling pyr

178 on an ERRalpha-responsive element within the pyruvate dehydrogenase kinase 4 gene promoter in cardiac

179 d protein (2-fold, P < 0.05) expression, and pyruvate dehydrogenase kinase 4 mRNA (15-fold, P < 0.001

180 protein and glycogen content, and increased pyruvate dehydrogenase kinase 4 mRNA abundance in the he

181 Pyruvate dehydrogenase kinase 4 upregulation correlated

182 pregnancy hormone progesterone induces PDK4 (pyruvate dehydrogenase kinase 4) in cardiomyocytes and t

183 PDK4 (pyruvate dehydrogenase kinase 4) regulates pyruvate oxid

184 1 directly regulates the gene encoding PDK4 (pyruvate dehydrogenase kinase 4), a key nutrient sensor

185 blastoma protein-E2F-induced upregulation of pyruvate dehydrogenase kinase 4, and targeting these pat

186 ctivity still remains its ability to inhibit pyruvate dehydrogenase kinase and force mitochondrial ox

187 calization of the aerobic glycolysis enzymes pyruvate dehydrogenase kinase and lactate dehydrogenase

188 id not activate the classic hypoxia targets (pyruvate dehydrogenase kinase and vascular endothelial g

189 roduction, as glycolytic inhibition with the pyruvate dehydrogenase kinase inhibitor dichloroacetate

190 long-term delivery of dichloroacetic acid, a pyruvate dehydrogenase kinase inhibitor.

191 e complete absence of K+ and phosphate (Pi), pyruvate dehydrogenase kinase isoform 2 (PDHK2) was cata

192 Deltaex3/Bnip3FL isoform ratio by inhibiting pyruvate dehydrogenase kinase isoform 2 (PDK2) in Panc-1

193 Pyruvate dehydrogenase kinase isoform 2 (PDK2) was ident

194 Pyruvate dehydrogenase kinase isoforms (PDKs 1-4) negati

195 ivation of phosphoinositide 3-kinase (PI3K), pyruvate dehydrogenase kinase isozyme 1 (PDK1), and mamm

196 gulation of the gene expression response for pyruvate dehydrogenase kinase to pressure overload.

197 s to glucose oxidation, via an inhibition of pyruvate dehydrogenase kinase was used.

198 O1-mediated transcriptional upregulation of pyruvate dehydrogenase kinase), and glutaminolysis (refl

199 es PDHc activity by altering the affinity of pyruvate dehydrogenase kinase, an inhibitor of the enzym

200 enzyme biosynthesis and iron metabolism, the pyruvate dehydrogenase kinase, and a type 2C protein pho

201 tal RVH and can be achieved by inhibition of pyruvate dehydrogenase kinase, fatty acid oxidation, or

202 thyroidism increases the ex vivo activity of pyruvate dehydrogenase kinase, thereby inhibiting glucos

203 HIF-1alpha increased glycolytic enzymes and pyruvate dehydrogenase kinase-1 (PDK-1), which reduces m

204 inhibition occurs via enhanced expression of pyruvate dehydrogenase kinase-1 (PDK-1), which results i

205 lucose transporters, glycolytic enzymes, and pyruvate dehydrogenase kinase-1 were increased in their

206 ctivity, because specific inhibition of Akt, pyruvate dehydrogenase kinase-1, or its downstream targe

207 led to the upregulation of the HIF1 target, pyruvate dehydrogenase kinase-1, which inhibits PDH acti

208 th factor (VEGF), glucose transporter-1, and pyruvate dehydrogenase kinase-1.

209 Wild-type p53 expression decreased levels of pyruvate dehydrogenase kinase-2 (Pdk2) and the product o

210 vates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and

211 via specific reduction in the expression of pyruvate dehydrogenase kinase-3 (PDK3).

212 DH inhibitory phosphorylation, expression of pyruvate dehydrogenase kinase-3, and levels of hypoxia i

213 array were shown to induce the expression of pyruvate dehydrogenase kinase-4 (PDK4) and uncoupling pr

214 protein O1 (FOXO1) mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) gene transcriptio

215 f these antibodies to PDH activity using the pyruvate dehydrogenase kinase-specific inhibitor dichlor

216 he hyperthyroid heart in vivo is mediated by pyruvate dehydrogenase kinase.

217 dehydrogenase complex through inhibition of pyruvate dehydrogenase kinase.

218 PDC is inhibited by phosphorylation via the pyruvate dehydrogenase kinases (PDKs).

219 2 released specifically from mitochondria by pyruvate dehydrogenase-mediated metabolism of hyperpolar

220 phenyl)-1,1-dimethylurea and antimycin A, of pyruvate dehydrogenase, moniliformin, of calmodulins, N-

221 Reductions in pyruvate dehydrogenase mRNA and activity resulting from

222 rogenase kinase 2 (PDHK2) phosphorylates the pyruvate dehydrogenase multienzyme complex (PDC) and the

223 The pyruvate dehydrogenase multienzyme complex (PDC) is a ke

224 and E1 components from the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDHc), as a

225 The Escherichia coli pyruvate dehydrogenase multienzyme complex (PDHc), consi

226 nter of the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex are essential

227 The Escherichia coli pyruvate dehydrogenase multienzyme complex contains mult

228 tion cycle of the BBL-equivalent domain in a pyruvate dehydrogenase multienzyme complex in which the

229 in the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex is an outcome

230 have provided additional gene copies of the pyruvate dehydrogenase multienzyme complex that have evo

231 E.g. pyruvate dehydrogenase mutants accumulated large amounts

232 o-ADP ratio) by hypoxia, or by inhibitors of pyruvate dehydrogenase or electron transport chain compl

233 ainst the lipoyl domain of the E2 subunit of pyruvate dehydrogenase (PDC-E2) are detected in 95% of p

234 ly restricted peptide of the E2 component of pyruvate dehydrogenase (PDC-E2) involving autoantibody a

235 ainst the lipoyl domain of the E2 subunit of pyruvate dehydrogenase (PDC-E2).

236 of pyruvate dehydrogenase, the E2 subunit of pyruvate dehydrogenase (PDC-E2).

237 Phosphorylated pyruvate dehydrogenase (PDH) (Ser-293) and PDH kinase 4

238 As pyruvate dehydrogenase (PDH) activity appears central to

239 Levels of both glutamate and pyruvate dehydrogenase (PDH) activity have been shown to

240 s network of genes also causes inhibition of pyruvate dehydrogenase (PDH) activity resulting in dimin

241 muscle, which was associated with decreased pyruvate dehydrogenase (PDH) activity, accumulation of p

242 points after injury, in line with decreased pyruvate dehydrogenase (PDH) activity, suggesting impair

243 nhanced inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) and consequently inhibition

244 e dehydrogenase complex (PDC) by acetylating pyruvate dehydrogenase (PDH) and PDH phosphatase.

245 e on glutaminolysis through malic enzyme and pyruvate dehydrogenase (PDH) as well as fatty acid and b

246 A Pyruvate dehydrogenase (PDH) assay mechanistically confi

247 nvolves inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) by PDH kinase (PDK), wherea

248 Mechanistically, silencing MICU1 activates pyruvate dehydrogenase (PDH) by stimulating the PDPhosph

249 The mitochondrial pyruvate dehydrogenase (PDH) complex (PDC) acts as a cen

250 The pyruvate dehydrogenase (PDH) complex connects the glycol

251 untington's disease (HD) by showing that the pyruvate dehydrogenase (PDH) complex is a promising ther

252 P. falciparum possesses a pyruvate dehydrogenase (PDH) complex that is localized t

253 Resveratrol targets the pyruvate dehydrogenase (PDH) complex, a key mitochondria

254 encoding the E2 subunit of the mitochondrial pyruvate dehydrogenase (PDH) complex.

255 vates PDHK1 to phosphorylate and inhibit the pyruvate dehydrogenase (PDH) complex.

256 d-chain 2-oxoacid dehydrogenase (BCKDH), and pyruvate dehydrogenase (PDH) complexes are also capable

257 es in mitochondrial bioenergetics, including pyruvate dehydrogenase (PDH) dysfunction, have been desc

258 ation in skeletal muscle is due to decreased pyruvate dehydrogenase (PDH) enzyme activity related, in

259 ummary Plasmodium parasites possess a single pyruvate dehydrogenase (PDH) enzyme complex that is loca

260 Plasmodium parasites possess a single pyruvate dehydrogenase (PDH) enzyme complex that is loca

261 se to acute hypoglycemia: controls decreased pyruvate dehydrogenase (PDH) flux in astrocytes by 64 +/

262 Metabolic profiling revealed that pyruvate dehydrogenase (PDH) is a key bifurcation point

263 However, flux through pyruvate dehydrogenase (PDH) is disproportionally decrea

264 Under anaerobic growth conditions, an active pyruvate dehydrogenase (PDH) is expected to create a red

265 Pyruvate dehydrogenase (PDH) is the main regulator of th

266 by, in part, upregulating gene expression of pyruvate dehydrogenase (PDH) kinase 1 (PDHK1), which pho

267 bolic reprogramming by markedly upregulating pyruvate dehydrogenase (PDH) kinase 4 (PDK4) through est

268 a-oxidation-derived NADH, which can activate pyruvate dehydrogenase (PDH) kinase isoforms that inhibi

269 Intralipid enhanced pyruvate dehydrogenase (PDH) phosphorylation and lactate

270 Pyruvate dehydrogenase (PDH) plays a well-known metaboli

271 ased mitochondrial respiration and decreased pyruvate dehydrogenase (PDH) protein level and activity

272 ehydrogenase kinase 1 (PDK1), which inhibits pyruvate dehydrogenase (PDH) via phosphorylation.

273 ochondrial biogenesis and phosphorylation of pyruvate dehydrogenase (PDH) were observed in kidneys fr

274 and phosphorylation-dependent inhibition of pyruvate dehydrogenase (PDH) within a single day of feed

275 ral essential multienzyme complexes, such as pyruvate dehydrogenase (PDH), alpha-ketoglutarate dehydr

276 outes for carbohydrate oxidation, other than pyruvate dehydrogenase (PDH), in hypertrophied heart.

277 Inactivation of aceE, a subunit of pyruvate dehydrogenase (PDH), was found to increase leve

278 elta is synthetically lethal with mutants in pyruvate dehydrogenase (PDH), which catalyzes the conver

279 In muscle, adropin activates pyruvate dehydrogenase (PDH), which is rate limiting for

280 ivity of the most important enzyme component pyruvate dehydrogenase (PDH).

281 r determinants (glycolysis, gluconeogenesis, pyruvate dehydrogenase [PDH], and H2O2 levels) in mice s

282 te decarboxylase (AceE), the E1 component of pyruvate dehydrogenase (PDHC), can participate in AceE/D

283 phorylation sites on the E1 alpha subunit of pyruvate dehydrogenase (PDHE1alpha).

284 Representatively, the bacterial pyruvate dehydrogenase (PdhR), trehalose (TreR), and l-a

285 mponents and by NOTCH-dependent induction of pyruvate dehydrogenase phosphatase 1 (Pdp1) expression,

286 5, glucose transporter GLUT2, phosphorylated pyruvate dehydrogenase pPDH and PDH-kinase.

287 [(13)C]O3(-) appearance reflects activity of pyruvate dehydrogenase rather than pyruvate carboxylatio

288 glyceraldehyde 3-phosphate dehydrogenase and pyruvate dehydrogenase subunit e1alpha.

289 mic functions, include GroEL, DnaK, enolase, pyruvate dehydrogenase subunits PdhB and PdhD, and SodA.

290 re directed against a very conserved site of pyruvate dehydrogenase, the E2 subunit of pyruvate dehyd

291 bited hyperphosphorylation and inhibition of pyruvate dehydrogenase, the key Ca(2+)-sensitive gatekee

292 channeling of mitochondrial acetyl-CoA from pyruvate dehydrogenase to carnitine acetyltransferase.

293 dehydrogenase kinase 4 expression, enabling pyruvate dehydrogenase to compete against anaplerotic en

294 nt ones, such as Streptococcus gordonii, use pyruvate dehydrogenase to decarboxylate pyruvate.

295 basal and insulin-stimulated rates of muscle pyruvate dehydrogenase (VPDH) flux relative to citrate s

296 tric acid cycle (as inferred by flux through pyruvate dehydrogenase), were down-regulated by beta-lap

297 duction, which is needed for the activity of pyruvate dehydrogenase, which feeds acetyl-coenzyme A in

298 The complex control of pyruvate dehydrogenase, which links glycolysis to the TC

299 regulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in py

300 establish whether modulation of flux through pyruvate dehydrogenase would alter cardiac hypertrophy.