ライフサイエンスコーパス: pyruvate dehydrogenase complex

1 kinase 1 (PDK1) on Thr346 to inactivate the pyruvate dehydrogenase complex.

2 of the lipoyl-bearing subunit (E(2)) of the pyruvate dehydrogenase complex.

3 gluconeogenic substrates by inactivating the pyruvate dehydrogenase complex.

4 PDH2, which encodes a subunit of the plastid pyruvate dehydrogenase complex.

5 ld-type kinase toward the protein substrate, pyruvate dehydrogenase complex.

6 lipoamide dehydrogenase associated with the pyruvate dehydrogenase complex.

7 at may catalyze the dephosphorylation of the pyruvate dehydrogenase complex.

8 nt, uncompetitive inhibitor of the bacterial pyruvate dehydrogenase complex.

9 ologic phenotypes, or PDHX, a subunit of the pyruvate dehydrogenase complex.

10 sion of pyruvate to acetyl-coenzyme A by the pyruvate dehydrogenase complex.

11 in kinase that regulates the activity of the pyruvate dehydrogenase complex.

12 edium, likely because of the activity of the pyruvate dehydrogenase complex.

13 the tricarboxylic acid (TCA) cycle enzymes, pyruvate dehydrogenase complex, 2-oxoglutarate dehydroge

14 decreases occurred in the activities of the pyruvate dehydrogenase complex (-41%), isocitrate dehydr

15 ia, in the absence (control) and presence of pyruvate dehydrogenase complex activation by dichloroace

16 No increase in pyruvate dehydrogenase complex activation or acetyl grou

17 Dichloroacetate increased resting pyruvate dehydrogenase complex activation, acetyl-CoA an

18 At baseline, IMTG, muscle pyruvate dehydrogenase complex activity and the protein

19 Greater pyruvate dehydrogenase complex activity caused a stimula

20 Thus, pyruvate dehydrogenase complex activity is increased by

21 et-induced obese mice significantly augments pyruvate dehydrogenase complex activity with reduced pho

22 45 and 392 on PDHK2 and results in increased pyruvate dehydrogenase complex activity.

23 yruvate dehydrogenase kinases (PDK) inhibits pyruvate dehydrogenase complex activity.

24 The assembled core structure of mammalian pyruvate dehydrogenase complex also includes the dihydro

25 es were tested by ELISA for E2 components of pyruvate dehydrogenase complex and 2-oxoglutarate dehydr

26 or entry points to oxidative metabolism (eg, pyruvate dehydrogenase complex and Acyl-CoA dehydrogenas

27 ferase (tE2) of the Saccharomyces cerevisiae pyruvate dehydrogenase complex and complexes of the tE2

28 Activities of the pyruvate dehydrogenase complex and E3 from patient were

29 phosphate (HEThDP) with the Escherichia coli pyruvate dehydrogenase complex and its E1 subunit (PDHc-

30 on of its use in miniaturized assays for the pyruvate dehydrogenase complex and its kinase.

31 rifies the essential nature of the plastidic pyruvate dehydrogenase complex and its role in embryo fo

32 utomers coexist on the E1 component of human pyruvate dehydrogenase complex and pyruvate oxidase.

33 ase-specific loss of immune tolerance to the pyruvate dehydrogenase complex and subsequent developmen

34 rotein complexes identified in our analysis, pyruvate dehydrogenase complex and succinate dehydrogena

35 e of oxythiamine, which can inhibit both the pyruvate dehydrogenase complex and transketolase, result

36 was determined by measuring the activity of pyruvate dehydrogenase complex, and cellular metabolic s

37 LUT4, hexokinase II, the E1 component of the pyruvate dehydrogenase complex, and subunits of all four

38 erase (LipB), respectively, to lipoylate apo-pyruvate dehydrogenase complex (apo-PDC).

39 l analysis showing that the lipoyl moiety of pyruvate dehydrogenase complex appears to be involved in

40 uced protein sequences for E3BP of the human pyruvate dehydrogenase complex are reported here.

41 and kinetic parameters as determined by the pyruvate dehydrogenase complex assay; (ii) in thermostab

42 However, a pyruvate dehydrogenase complex assembled in vitro with c

43 of the E1 component of the Escherichia coli pyruvate dehydrogenase complex become organized only on

44 enase kinase (PDK) inhibit the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the

45 enzyme form the structural core of the human pyruvate dehydrogenase complex by providing the binding

46 ively regulate activity of the mitochondrial pyruvate dehydrogenase complex by reversible phosphoryla

47 cetyltransferase (E2) component of mammalian pyruvate dehydrogenase complex can form a 60-mer via ass

48 The pyruvate dehydrogenase complex catalyzes the conversion

49 e that loss of PDHK4, a key regulator of the pyruvate dehydrogenase complex, caused a profound cell g

50 ites of the E1 (EC 1.2.4.1) component of the pyruvate dehydrogenase complex communicate over a distan

51 Both pyruvate-formate lyase and the pyruvate dehydrogenase complex contributed to acetyl-coe

52 Glucose oxidation via pyruvate dehydrogenase complex did not compensate for re

53 s (R1-2) as containing the E2 subunit of the pyruvate dehydrogenase complex, dihydrolipoamide acetylt

54 e two active centers of the Escherichia coli pyruvate dehydrogenase complex E1 component provides a s

55 (ThDP) binding site of the Escherichia coli pyruvate dehydrogenase complex E1 subunit (PDHc-E1), and

56 een in the structure of the Escherichia coli pyruvate dehydrogenase complex E1 subunit (PDHc-E1), mas

57 hondrial matrix-located citrate synthase and pyruvate dehydrogenase complex E1alpha-subunit polypepti

58 y biliary cirrhosis (PBC) is the presence of pyruvate dehydrogenase complex E2 subunit (PDC-E2) antim

59 e S-acetyltransferase subunit of the plastid pyruvate dehydrogenase complex (E2) was isolated from a

60 lecule in BEC, we examined the expression of pyruvate dehydrogenase complex-E2 (PDC-E2) messenger RNA

61 fferential expression of glycolysis, plastid pyruvate dehydrogenase complex, fatty acid, and lipid sy

62 The PKCdelta/retinol complex signaled the pyruvate dehydrogenase complex for enhanced flux of pyru

63 lpd and odp (encode enzymes involved in the pyruvate dehydrogenase complex formation).

64 acetyltransferase (E2) catalytic core of the pyruvate dehydrogenase complex from Bacillus stearotherm

65 Most bacterial pyruvate dehydrogenase complexes from either gram-positi

66 The activity of the pyruvate dehydrogenase complex has long been determined

67 nase (PDH), the first component of the human pyruvate dehydrogenase complex, has two isoenzymes, soma

68 s (HiBECs) translocate the E2 subunit of the pyruvate dehydrogenase complex immunologically intact in

69 f pdhD, putatively encoding a subunit of the pyruvate dehydrogenase complex, impairs survival of both

70 ute to the tissue-specific regulation of the pyruvate dehydrogenase complex in normal and pathophysio

71 Regulation of the activity of the pyruvate dehydrogenase complex in skeletal muscle plays

72 without increased glucose oxidation through pyruvate dehydrogenase complex in the energy-poor, hyper

73 complex that spontaneously reconstituted the pyruvate dehydrogenase complex in the presence of native

74 hyperphosphorylation and inactivation of the pyruvate dehydrogenase complex in these metabolic condit

75 ly resembles that of the lipoyl domains from pyruvate dehydrogenase complexes, in accord with the exi

76 ainst a complex set of proteins, among which pyruvate dehydrogenase complex is considered the main au

77 Activity of the mammalian pyruvate dehydrogenase complex is regulated by phosphory

78 component of this entire class of bacterial pyruvate dehydrogenase complexes is responsible for bind

79 rase), the E2 component of the mitochondrial pyruvate dehydrogenase complex, is a novel metabolic lon

80 E1 (pyruvate dehydrogenase) component of the pyruvate dehydrogenase complex, it has not proved possib

81 ensional reconstruction of the bovine kidney pyruvate dehydrogenase complex (M(r) approximately 7.8 x

82 t indicates that inhibition of the bacterial pyruvate dehydrogenase complex may represent a promising

83 The pyruvate dehydrogenase complex (mPDC) from potato (Solan

84 f light on the activity of the mitochondrial pyruvate dehydrogenase complex (mt-PDC) by using intact

85 E1 component (pyruvate decarboxylase) of the pyruvate dehydrogenase complex of Bacillus stearothermop

86 poyl acetyltransferase (E2) component of the pyruvate dehydrogenase complex of Bacillus stearothermop

87 drolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes.

88 ct of its activity, the inactive form of the pyruvate dehydrogenase complex (P-Pdc), both of which ar

89 mportance of muscle pyruvate availability to pyruvate dehydrogenase complex (PDC) activation during i

90 increasing CHO oxidation in vivo, using the pyruvate dehydrogenase complex (PDC) activator, dichloro

91 uscle protein: DNA ratio, a 56% reduction in pyruvate dehydrogenase complex (PDC) activity (P < 0.05)

92 By increasing muscle pyruvate dehydrogenase complex (PDC) activity and acetyl

93 Here we show that inhibition of pyruvate dehydrogenase complex (PDC) activity contribute

94 ion status of glycogen phosphorylase and the pyruvate dehydrogenase complex (PDC) and on the accumula

95 or dephosphorylation and reactivation of the pyruvate dehydrogenase complex (PDC) and, by this means,

96 w that all the subunits of the mitochondrial pyruvate dehydrogenase complex (PDC) are also present an

97 Autoantibodies to the pyruvate dehydrogenase complex (PDC) are present in the

98 and, in particular, the E2 component of the pyruvate dehydrogenase complex (PDC) are the target of a

99 yl-CoA acetyltransferase 1 (ACAT1) regulates pyruvate dehydrogenase complex (PDC) by acetylating pyru

100 The pyruvate dehydrogenase complex (PDC) catalyzes the conve

101 The pyruvate dehydrogenase complex (PDC) catalyzes the conve

102 The human pyruvate dehydrogenase complex (PDC) comprises four mult

103 cetyltransferase (E2) component of mammalian pyruvate dehydrogenase complex (PDC) consists of 60 COOH

104 oantibodies to the assumed major autoantigen pyruvate dehydrogenase complex (PDC) dihydrolipoamide ac

105 The pyruvate dehydrogenase complex (PDC) has a pivotal role

106 ogenase (PDH) and consequently inhibition of pyruvate dehydrogenase complex (PDC) in cancer cells.

107 structural diversity of the E2 component of pyruvate dehydrogenase complex (PDC) in normal and disea

108 any putative (causative) association between pyruvate dehydrogenase complex (PDC) inhibition and lact

109 The human pyruvate dehydrogenase complex (PDC) is a 9.5-megadalton

110 The pyruvate dehydrogenase complex (PDC) is a critical mitoc

111 Mammalian pyruvate dehydrogenase complex (PDC) is a key multi-enzy

112 Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for gluc

113 The mitochondrial pyruvate dehydrogenase complex (PDC) is down-regulated b

114 Human pyruvate dehydrogenase complex (PDC) is down-regulated b

115 The pyruvate dehydrogenase complex (PDC) is inactivated in m

116 Pyruvate dehydrogenase complex (PDC) is one of the large

117 Activity of the mammalian pyruvate dehydrogenase complex (PDC) is regulated by pho

118 The human pyruvate dehydrogenase complex (PDC) is regulated by rev

119 The pyruvate dehydrogenase complex (PDC) is subjected to mul

120 The pyruvate dehydrogenase complex (PDC) is the primary meta

121 cterized by serum autoantibodies against the pyruvate dehydrogenase complex (PDC) located in the inne

122 e carbohydrate reserves, the reaction of the pyruvate dehydrogenase complex (PDC) must be down-regula

123 poyl domain, p45, has been identified in the pyruvate dehydrogenase complex (PDC) of the adult parasi

124 The mitochondrial pyruvate dehydrogenase complex (PDC) plays a crucial rol

125 ion in adjusting the activation state of the pyruvate dehydrogenase complex (PDC) through determining

126 ogenase kinase (PDHK) is an integral part of pyruvate dehydrogenase complex (PDC) to which it is anch

127 rase (E2) subunit of the maize mitochondrial pyruvate dehydrogenase complex (PDC) was postulated to c

128 wing 2-oxo acid dehydrogenase complexes: the pyruvate dehydrogenase complex (PDC), the branched chain

129 pyruvate dehydrogenase (E1) in the mammalian pyruvate dehydrogenase complex (PDC), whose activity is

130 High-fat feeding inhibits pyruvate dehydrogenase complex (PDC)-controlled carbohyd

131 ized that PDK4 up-regulation, which inhibits pyruvate dehydrogenase complex (PDC)-dependent carbohydr

132 immunized rabbits develop high-titer Abs to pyruvate dehydrogenase complex (PDC)-E2, the major autoa

133 AT5A bound the E1beta and E2 subunits of the pyruvate dehydrogenase complex (PDC).

134 E2 components of the purified KDC and (0)the pyruvate dehydrogenase complex (PDC).

135 breakdown of normal immune self tolerance to pyruvate dehydrogenase complex (PDC).

136 ional states of the Saccharomyces cerevisiae pyruvate dehydrogenase complex (PDC).

137 yzes phosphorylation and inactivation of the pyruvate dehydrogenase complex (PDC).

138 regulator of flux through the mitochondrial pyruvate dehydrogenase complex (PDC).

139 esponses to a highly conserved self-antigen, pyruvate dehydrogenase complex (PDC).

140 etyl-CoA in mitochondria is catalyzed by the pyruvate dehydrogenase complex (PDC).

141 activates mitochondrial PDH and consequently pyruvate dehydrogenase complex (PDC).

142 gh the phosphorylation and inhibition of the pyruvate dehydrogenase complex (PDC).

143 sis is breakdown of T-cell self-tolerance to pyruvate dehydrogenase complex (PDC).

144 oligodeoxynucleotides (ODN) on responses to pyruvate dehydrogenase complex (PDC, the autoantigen in

145 49 (92%), with specificity directed against pyruvate dehydrogenase complex (PDC-E2) alone in 22 of 4

146 poylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC-E2) are targets for

147 they were specifically directed against the pyruvate dehydrogenase complex (PDC-E2) in 15 of 19 pati

148 The E2 component of mitochondrial pyruvate dehydrogenase complex (PDC-E2) is the immunodom

149 The E2 subunit of pyruvate dehydrogenase complex (PDC-E2) is the major aut

150 hondrial response to the E2 component of the pyruvate dehydrogenase complex (PDC-E2), has unique feat

151 e acetyltransferase, the E2 component of the pyruvate dehydrogenase complex (PDC-E2), is the autoanti

152 cognized by AMA are the E2 components of the pyruvate dehydrogenase complex (PDC-E2), the branched ch

153 oantigens including the E2 components of the pyruvate dehydrogenase complex (PDC-E2), the branched-ch

154 ecular mimicry between the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), the major mitoc

155 In this study, we produced recombinant pyruvate dehydrogenase complex (PDC-E2)-specific dimeric

156 s have homology with the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

157 is directed against the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

158 ondrial autoantigen, the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

159 (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

160 ic autoantibodies to the E2 component of the pyruvate dehydrogenase complex (PDC-E2).

161 ry biliary cirrhosis (PBC), E2 components of pyruvate dehydrogenase complexes (PDC-E2), has a lipoate

162 , amino acids 159 to 167 on E2 components of pyruvate dehydrogenase complexes (PDC-E2), the major mit

163 peptides encoded by the E2 components of the pyruvate dehydrogenase complexes (PDC-E2).

164 e, amino acid 159-167 of the E2 component of pyruvate dehydrogenase complexes (PDC-E2).

165 nodominant mitochondrial autoantigen of PBC (pyruvate dehydrogenase complex [PDC-E2]) was addressed.

166 The pyruvate dehydrogenase complexes (PDCs) from all known l

167 The pyruvate dehydrogenase complex (PDH) has been hypothesiz

168 as a cellular lipoamidase that regulates the pyruvate dehydrogenase complex (PDH).

169 xidative decarboxylation of pyruvate via the pyruvate dehydrogenase complex (PDH).

170 Dichloroacetate (DCA) stimulates pyruvate dehydrogenase complex (PDHC) activity and lower

171 In Escherichia coli, the pyruvate dehydrogenase complex (PDHC) and pyruvate forma

172 The Escherichia coli pyruvate dehydrogenase complex (PDHc) catalyzing convers

173 cherichia coli and report that disruption of pyruvate dehydrogenase complex (PDHc), which converts py

174 f oxidative phosphorylation by targeting the pyruvate dehydrogenase complex (PDHC).

175 tabolic fuel selection as a component of the pyruvate dehydrogenase complex (PDHc).

176 oxylase variant, or to the E1 subunit of the pyruvate dehydrogenase complex (PDHc-E1) from Escherichi

177 nd on the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex (PDHc-E1).

178 fpr promoter region as the E1 subunit of the pyruvate dehydrogenase complex (PDHE1), a central enzyme

179 drogenase kinase 4 (PDK4) is upregulated and pyruvate dehydrogenase complex phosphorylation is increa

180 s to be a common feature in the phylogeny of pyruvate dehydrogenase complexes, protein dynamics is an

181 The highest correlation was with pyruvate dehydrogenase complex (r = 0.77, r2= 0.59).

182 e acetyltransferase (tE(2)) component of the pyruvate dehydrogenase complex reveal an extraordinary e

183 he E3-binding domain (E3BD) of the mammalian pyruvate dehydrogenase complex show that hSBDb has an ar

184 ese novel genetic interactions involving the pyruvate dehydrogenase complex suggested a new role for

185 mitochondrial antibodies that react with the pyruvate dehydrogenase complex, targeting the inner lipo

186 boxylate pyruvate: the E1 component of human pyruvate dehydrogenase complex, the E1 subunit of Escher

187 e investigated whether the E2 subunit of the pyruvate dehydrogenase complex, the E2 subunit of the br

188 chondrial protein kinase that phosphorylates pyruvate dehydrogenase complex, thereby down-regulating

189 dehydrogenase kinase 2 (PDHK2) inhibits the pyruvate dehydrogenase complex, thereby regulating entry

190 umor activity is its ability to activate the pyruvate dehydrogenase complex through inhibition of pyr

191 ch that down-regulates activity of the human pyruvate dehydrogenase complex through reversible phosph

192 t binding of the lipoyl domain 2 (L2) of the pyruvate dehydrogenase complex to PDK3 induces a "cross-

193 n exposure of LThDP to the E1 subunit of the pyruvate dehydrogenase complex was 0.4 s(-1), still more

194 The pyruvate dehydrogenase complex was considerably more act

195 KGDH enzymatic activity, whereas the related pyruvate dehydrogenase complex was unmodified by TFEC an

196 CCase subunits; (2) four subunits to plastid pyruvate dehydrogenase complex were 25% to 70% down-regu

197 stearothermophilus and Enterococcus faecalis pyruvate dehydrogenase complexes were determined and rev

198 g protein, inactivated kinase-depleted maize pyruvate dehydrogenase complex when incubated with MgATP

199 apicoplast LipDH is an integral part of the pyruvate dehydrogenase complex which occurs only in the

200 ion that was required to elicit a 50% active pyruvate dehydrogenase complex, which indicates a marked

201 complex, the E1 subunit of Escherichia coli pyruvate dehydrogenase complex, yeast pyruvate decarboxy