コーパス検索結果 (１語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 he hyperthyroid heart in vivo is mediated by pyruvate dehydrogenase kinase.
2 dehydrogenase complex through inhibition of pyruvate dehydrogenase kinase.
3 imately 37% amino acid identity to mammalian pyruvate dehydrogenase kinases.
4 d motifs that are proposed to be specific to pyruvate dehydrogenase kinases.
6 K1 acts as a protein kinase to phosphorylate pyruvate dehydrogenase kinase 1 (PDHK1) at T338, which a
7 lysis in part due to increased expression of pyruvate dehydrogenase kinase 1 (PDK1) and lactate dehyd
10 tochondria during hypoxia and phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) on Thr346 to inac
11 ycolysis, which were paralleled by increased pyruvate dehydrogenase kinase 1 (PDK1) protein levels an
12 result in the induction of the gene encoding pyruvate dehydrogenase kinase 1 (PDK1), which inhibits p
16 n HP [1-(13)C]lactate was likely mediated by pyruvate dehydrogenase kinase 1 up-regulation in activat
17 catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruv
18 nsporter Glut1, phospho-fructose kinase, and pyruvate dehydrogenase kinase 1, which interrupted pyruv
19 HIF-1alpha increased glycolytic enzymes and pyruvate dehydrogenase kinase-1 (PDK-1), which reduces m
20 inhibition occurs via enhanced expression of pyruvate dehydrogenase kinase-1 (PDK-1), which results i
21 lucose transporters, glycolytic enzymes, and pyruvate dehydrogenase kinase-1 were increased in their
22 ctivity, because specific inhibition of Akt, pyruvate dehydrogenase kinase-1, or its downstream targe
23 led to the upregulation of the HIF1 target, pyruvate dehydrogenase kinase-1, which inhibits PDH acti
32 f PKCdelta leads to the dephosphorylation of pyruvate dehydrogenase kinase 2 (PDK2), thereby decreasi
33 cle glucose metabolism in awake mice lacking pyruvate dehydrogenase kinase 2 and 4 [double knockout (
34 Wild-type p53 expression decreased levels of pyruvate dehydrogenase kinase-2 (Pdk2) and the product o
35 vates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and
37 DH inhibitory phosphorylation, expression of pyruvate dehydrogenase kinase-3, and levels of hypoxia i
38 mice with cardiac-specific overexpression of pyruvate dehydrogenase kinase 4 (myosin heavy chain (MHC
39 ibility is driven by robust up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) and phosphorylati
42 d 2.5- and 5-fold, respectively, whereas the pyruvate dehydrogenase kinase 4 (PDK4) was upregulated 4
43 le coordinately upregulate the expression of pyruvate dehydrogenase kinase 4 (PDK4), a negative regul
44 for carnitine palmitoyltransferase (cpt1a), pyruvate dehydrogenase kinase 4 (pdk4), and phosphoenolp
45 e palmitoyltransferase (CPT1a and CPT1c) and pyruvate dehydrogenase kinase 4 (PDK4), effects that wou
47 ubunits, and dramatic increases in mRNAs for pyruvate dehydrogenase kinase 4 and glutamine synthase,
48 thalamic expression of four genes, including pyruvate dehydrogenase kinase 4 and glycerol 3-phosphate
49 HLpL0 hearts had decreased expression of pyruvate dehydrogenase kinase 4 and increased cardiomyoc
50 ceptor substrate 2 was increased and that of pyruvate dehydrogenase kinase 4 and insulin receptor sub
51 activated receptor-gamma coactivator-1alpha, pyruvate dehydrogenase kinase 4 and mitochondrial transc
53 ose oxidation was mediated by a reduction in pyruvate dehydrogenase kinase 4 expression, enabling pyr
54 on an ERRalpha-responsive element within the pyruvate dehydrogenase kinase 4 gene promoter in cardiac
56 d protein (2-fold, P < 0.05) expression, and pyruvate dehydrogenase kinase 4 mRNA (15-fold, P < 0.001
57 protein and glycogen content, and increased pyruvate dehydrogenase kinase 4 mRNA abundance in the he
59 pregnancy hormone progesterone induces PDK4 (pyruvate dehydrogenase kinase 4) in cardiomyocytes and t
61 1 directly regulates the gene encoding PDK4 (pyruvate dehydrogenase kinase 4), a key nutrient sensor
62 nes (medium chain acyl-CoA dehydrogenase and pyruvate dehydrogenase kinase 4), and caused substrate s
63 blastoma protein-E2F-induced upregulation of pyruvate dehydrogenase kinase 4, and targeting these pat
64 lucose transporter 1, glucose transporter 4, pyruvate dehydrogenase kinase 4, peroxisome proliferator
65 ulation and starvation-induced regulation of pyruvate-dehydrogenase kinase 4 and uncoupling protein 3
66 of several lipid regulatory genes, including pyruvate-dehydrogenase kinase 4 and uncoupling protein 3
67 array were shown to induce the expression of pyruvate dehydrogenase kinase-4 (PDK4) and uncoupling pr
69 protein O1 (FOXO1) mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) gene transcriptio
70 as CD36, Ly-6D, Rbp7, monoglyceride lipase, pyruvate dehydrogenase kinase-4, and C3f, that have been
71 insulin treatment of diabetic rats decreased pyruvate dehydrogenase kinase activity and also reversed
72 ti-PDK1 antibodies immunoprecipitated 75% of pyruvate dehydrogenase kinase activity from a maize mito
73 ion and diabetes induce a stable increase in pyruvate dehydrogenase kinase activity in skeletal muscl
74 PPAR-alpha), also induced large increases in pyruvate dehydrogenase kinase activity, PDK4 protein, an
76 es PDHc activity by altering the affinity of pyruvate dehydrogenase kinase, an inhibitor of the enzym
77 ctivity still remains its ability to inhibit pyruvate dehydrogenase kinase and force mitochondrial ox
78 calization of the aerobic glycolysis enzymes pyruvate dehydrogenase kinase and lactate dehydrogenase
80 id not activate the classic hypoxia targets (pyruvate dehydrogenase kinase and vascular endothelial g
82 O1-mediated transcriptional upregulation of pyruvate dehydrogenase kinase), and glutaminolysis (refl
83 enzyme biosynthesis and iron metabolism, the pyruvate dehydrogenase kinase, and a type 2C protein pho
84 ied housekeeping genes include Pdk, encoding pyruvate dehydrogenase kinase, and GdcH, encoding glycin
85 tal RVH and can be achieved by inhibition of pyruvate dehydrogenase kinase, fatty acid oxidation, or
87 ry subsequent to postischemic, intracoronary pyruvate dehydrogenase kinase inhibition with dichloroac
88 roduction, as glycolytic inhibition with the pyruvate dehydrogenase kinase inhibitor dichloroacetate
90 rease in the expression of PDK4, one of four pyruvate dehydrogenase kinase isoenzymes expressed in ma
91 e complete absence of K+ and phosphate (Pi), pyruvate dehydrogenase kinase isoform 2 (PDHK2) was cata
92 Deltaex3/Bnip3FL isoform ratio by inhibiting pyruvate dehydrogenase kinase isoform 2 (PDK2) in Panc-1
96 ivation of phosphoinositide 3-kinase (PI3K), pyruvate dehydrogenase kinase isozyme 1 (PDK1), and mamm
97 crystal structure reported here reveals that pyruvate dehydrogenase kinase isozyme 2 has two domains
99 report that genes for pancreatic lipase and pyruvate dehydrogenase kinase isozyme 4 are up-regulated
101 This is in contrast to the related mammalian pyruvate dehydrogenase kinase isozymes that occur as hom
102 esults indicate that BCKD kinase, similar to pyruvate dehydrogenase kinase isozymes, belongs to the s
103 y oxidative mitochondrial enzymes, including pyruvate dehydrogenase kinase, medium-chain length fatty
106 roxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that s
108 at insulin has a profound effect to suppress pyruvate dehydrogenase kinase (PDK) 4 expression in rat
109 phosphorylation caused in part by increased pyruvate dehydrogenase kinase (PDK) activity due to incr
110 ylation activates and inhibits mitochondrial pyruvate dehydrogenase kinase (PDK) and phosphatase (PDP
111 acilitates markedly enhanced function of the pyruvate dehydrogenase kinase (PDK) and pyruvate dehydro
113 od development, we used the dedicated kinase pyruvate dehydrogenase kinase (PDK) for the in vitro ass
121 s with antibodies raised against recombinant pyruvate dehydrogenase kinase (PDK) isoforms PDK2 and PD
122 yltransferase (E2) has an enormous impact on pyruvate dehydrogenase kinase (PDK) phosphorylation of t
123 acetic acids are developed for inhibition of pyruvate dehydrogenase kinase (PDK), an enzyme responsib
124 by inhibiting a key enzyme in cancer cells, pyruvate dehydrogenase kinase (PDK), that is required fo
127 rpose of this study was to determine whether pyruvate dehydrogenase kinase (PDK)4 was expressed in ad
128 phorylation of pyruvate dehydrogenase by the pyruvate dehydrogenase kinases (PDK) inhibits pyruvate d
129 report that hypoxia drives expression of the pyruvate dehydrogenase kinase (PDK1) and EGFR along with
133 f these antibodies to PDH activity using the pyruvate dehydrogenase kinase-specific inhibitor dichlor
134 thyroidism increases the ex vivo activity of pyruvate dehydrogenase kinase, thereby inhibiting glucos
135 gulation of the gene expression response for pyruvate dehydrogenase kinase to pressure overload.
WebLSDに未収録の専門用語（用法）は "新規対訳" から投稿できます。