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1 nd 21 years, during which lung volume nearly quadruples.
3 1 undergoes constitutive degradation in pp2c quadruple abi1/abi2/hab1/pp2ca mutant plants, revealing
4 everal mutants possessed double, triple, and quadruple amino acid substitutions with a total of seven
6 ndem mass spectrometry analysis using triple quadruple analyser and operated in the multiple reaction
8 performance liquid chromatography coupled to quadruple and time-of-flight mass spectrometers (UPLC-QT
9 tra high pressure chromatography (UPLC) with quadruple and time-of-flight mass spectrometry (Q/TOF, T
12 Concurrent mutation of the four genes in a quadruple Arabidopsis mutant resulted in increased defen
16 ly opposite barrels of a laser-pulled quartz quadruple-barreled pipet and filling the open channels w
19 ANP, E5R, and Nac1 (BEN) domain 3 (BEND3), a quadruple BEN domain-containing protein, localizes in nu
20 pyrenes were synthesized through a double or quadruple benzannulation reaction of alkynes promoted by
22 1 and 3 that lack the quadruply bonded M(A)[quadruple bond]M(A) groups, though the magnitude of the
23 tal atom positions such that the linear M(A)[quadruple bond]M(A)...M(B) array for a given molecule in
25 xcited states of the compounds containing MM quadruple bonds trans-M(2)(T(i)PB)(2)(O(2)CC(6)H(4)-4-CN
26 s study that modification of Gs within the G quadruple by 7-deaza-guanine or 7-deaza-2'-O-methyl-guan
27 imated to be 1245 million and is expected to quadruple by the end of the century, necessitating the b
28 in response to increases in [Ca(2+)](i), the quadruple Ca(2+)-ligand mutant does not bind Ca(2+) but
29 ty of Ca(V)2.3 was nearly abolished with the quadruple Ca(V)beta3 Leu mutant L200G/L303G/L337G/L342G.
30 A-containing phases in double-, triple-, and quadruple-cation lead halides in bulk and in a thin film
31 quadrastable, which enables direct study of quadruple cell fate determination on an engineered lands
35 ted physical mixtures of double, triple, and quadruple combinations of neutralizing MAbs targeting fo
36 mine whether a 5-day levofloxacin-containing quadruple concomitant regimen was as safe and effective
46 he annual number of KAH recipients more than quadrupled during the study period from 24 in 1995 to 99
48 a mutant set of single, double, triple, and quadruple ECF sigma factor deletions in the undomesticat
53 GPa and 165 degrees C (where it exists in a quadruple equilibrium, together with an aqueous fluid an
54 s the "4X cell", for signal detection at the quadruple frequency multiple was implemented and charact
55 e-adjusted prevalence of atrial fibrillation quadrupled from 20.4 to 96.2 cases per 1000 person-years
58 nnot be constructed, we demonstrate that the quadruple groEL1 groESL3 groEL4 groESL5 and groEL2 groES
59 ESL5 mutant acts like the wild type, but the quadruple groEL1 groESL3 groEL4 groESL5 mutant acts like
63 f restoring some HR elicitation to the hrpK1 quadruple harpin gene polymutant, which suggests that a
65 with a risk of graft loss that was more than quadrupled (hazard ratio, 4.78; 95% confidence interval
66 Q, IRT1H156Q, IRT1H158Q, IRT1H160Q, IRT14HQ (quadruple His mutant), IRT1K146R, IRT1K171R, and a doubl
68 showed growth defects similar to that of the quadruple hli deletion mutant under different light cond
71 midinones have been reported to dimerize via quadruple hydrogen bonding systems with dimerization con
72 on regarding their association via triple or quadruple hydrogen bonding, which is controlled by the c
73 , we describe a readily accessible AAAA-DDDD quadruple hydrogen-bonding array that exhibits exception
76 agents based on high-affinity, high-fidelity quadruple hydrogen-bonding units (e.g., DAN.DeUG, Kassoc
77 hondrial protein levels, we have developed a quadruple immunofluorescence method to accurately quanti
79 bnormalities in disease, we have developed a quadruple immunofluorescent technique enabling the quant
80 ed in primary rat hippocampal neurons, using quadruple immunolocalization against endogenous proteins
83 atric donors after cardiac death (PDCD) have quadrupled in the past 9 years, but little data exist on
87 to 2g, effectively doubling body weight and quadrupling induced power requirements; (2) increase fla
91 ll (RF) and throughfall (TF) together with a quadruple isotope approach, which combines delta(18) O,
97 2 construct into hsfa1a/hsfa1b/hsfa1d/hsfa1e quadruple knockout (QK) and wild-type (Wt) backgrounds t
99 enerated two independent pal1 pal2 pal3 pal4 quadruple knockout mutants, which are stunted and steril
102 DTs and used to generate double, triple, and quadruple knockouts (KOs) in different combinations.
103 ants was reduced approximately 10-fold, with quadruple knockouts showing morphological abnormalities.
105 atography (LC) electrospray ionization (ESI)-quadruple linear ion trap (Q-LIT) mass spectrometry (MS)
106 this study, we generated double, triple, and quadruple loss-of-function mutants of all four members o
107 ralizing activities of double-, triple-, and quadruple-MAb combinations targeting four distinct epito
109 tion by gas chromatography coupled to single quadruple mass spectrometers (GC-SQ/MS) was used for the
110 hy coupled to electrospray ionization triple quadruple mass spectrometry (LC-ESI-MS/MS) was developed
111 r to liquid chromatography coupled to triple quadruple mass spectrometry (LC-MS/MS) analysis of targe
113 s localized to the apicoplast, a specialized quadruple membrane organelle, suggesting that separate a
114 s in FcgammaRI/II/III/IV-deficient (FcgammaR quadruple(-/-)) mice, and the cross-presentation ability
115 ases that can extend single, double and even quadruple mismatches, process non-canonical primer-templ
120 l 12 mismatches using an engineered RB69 pol quadruple mutant (qm, L415A/L561A/S565G/Y567A) that enab
122 a previous study, direct administration of a quadruple mutant albumin-fused butyrylcholinesterase tha
124 k and round prey peptidoglycan, results in a quadruple mutant Bdellovibrio which leaves prey-shaped g
126 function-based purification of wild-type and quadruple mutant capsid proteins, which relies on the in
128 ation in vitro; however, specific triple and quadruple mutant combinations were constructed that prom
130 ry high drug dosages that the most resistant quadruple mutant DHFR allele is favored by selection.
132 s generate severely dwarfed plants, with the quadruple mutant displaying reproductive lethality.
133 he mouse Mesp2 mutant, in the zebrafish Mesp quadruple mutant embryos the positions of somite boundar
135 copper ligands, including H46R, H48Q, and a quadruple mutant H46R/H48Q/H63G/H120G, also diminish the
137 ed in a phytochrome interacting factor (pif) quadruple mutant in the dark and increased in a phytochr
141 In a dga1Deltalro1Deltaare1Deltaare2Delta quadruple mutant lacking all four triacylglycerol- and s
143 ng a human fH binding region on PorB2 of the quadruple mutant of strain 4243 with a chimeric protein
144 he five-residue H chimera with the CDV F-ODP quadruple mutant partially restores activity, indicating
145 hogenic phenotypes of cop1-6 pif1 and of the quadruple mutant pifq both in the dark and in far-red li
146 he PYR/PYLs, we analysed pyr1/pyl1/pyl2/pyl4 quadruple mutant plants and found strong insensitivities
149 type, and histochemical analysis of the rwa quadruple mutant stem indicates defects in cell differen
152 verall degree of wall acetylation in the rwa quadruple mutant was reduced by 63% compared with the wi
154 sruption of auxin influx carrier AUX1 in the quadruple mutant yuc1 yuc2 yuc4 yuc6, but not in wild-ty
159 , yfnI, yqgS and yvgJ single, triple and the quadruple mutant, showed that LTA production was only ab
160 loss of ATS activity in the ats cna phb phv quadruple mutant, showing that CNA/PHB/PHV act in concer
161 defects could only be observed in the family quadruple mutant, which also showed the strongest change
168 ion of the gas was detected in a hydrogenase quadruple-mutant strain containing deletions in the hya,
169 ed in its virulence characteristics, and the quadruple-mutant strain had the same (greatly attenuated
170 ess, selected pme single, double, triple and quadruple mutants allowed significantly more growth of P
175 Genetic analysis of double, triple, and quadruple mutants confirmed that XLGs and Gbg functional
178 of gibberellin (GA) or by introducing della quadruple mutants in the nfl background, suggesting that
180 r, yuc1yuc4, yuc2yuc6, all of the triple and quadruple mutants of the four YUC genes, display severe
182 polymerase chain reaction data performed in quadruple mutants revealed altered phosphoinositide leve
184 eleration of flowering is seen in triple and quadruple mutants under both inductive and non-inductive
185 d all four of the above-mentioned molecules (quadruple mutants), we recently identified a role for Po
191 ebilitate Nef MHC-I downregulation, but this quadruple mutation also impairs the ability of Nef to re
192 f monomeric IgG for C1q by introduction of a quadruple mutation at the C1q binding site or via genera
195 the histidine-aspartate acid (HD) domain (a quadruple mutation) or in the GGDD motif of the Cmr-2alp
198 monly use 193 nm excimer or 266 nm frequency-quadrupled Nd:YAG lasers to ablate and ionize particles
199 re of a previously reported extremely strong quadruple NH...N AAAA-DDDD hydrogen-bond array [5.4] (K(
200 a yeast Saccharomyces cerevisiae gsk-3Delta quadruple-null mutant, in which all four genes encoding
204 stigate this question by comparing a typical quadrupling-of-CO2 experiment with a simulation driven b
205 and NFH with and without alpha-internexin in quadruple- or quintuple-transfected SW13vim(-) cells.
206 erformance liquid chromatography-linear trap quadruple-Orbitrap-mass spectrometry (HPLC LTQ-Orbitrap
211 Here we show that an A- and B-site-ordered quadruple perovskite oxide, CaCu3Fe2Re2O12, has spin-pol
212 Optimization of CaCu3Fe2Re2O12 and related quadruple perovskite phases is expected to produce a new
216 AP share unique purine-binding geometry with quadruple pi-stacking interactions between adjacent aden
218 factor genes act downstream of SFPS, as the quadruple pif mutant pifq suppresses defects of sfps mut
222 plasmepsins (pfpm4, pfpm1, pfpm2 and pfhap; quadruple-PM KO), were prepared by double cross-over int
223 ar bodies resembling ceroid in the DV of the quadruple-PM KO, and intermediates of the autophagic pat
224 The sensitivity of both the triple- and quadruple-PM KOs to six different HIV aspartic proteinas
227 ndles multiple junctions, triple points, and quadruple points in two dimensions, as well as triple li
228 SnRK1 repression is abrogated in double and quadruple pp2c knockout mutants, provoking, similarly to
230 However, compared with wild-type triple and quadruple pten knockouts, caulonemal cells grew faster,
231 aba1-6 mutant, or in ABA signaling, like the quadruple pyr/pyl mutant (pyr1pyl1pyl2pyl4), were more r
234 etrahydrocyclohepta[b]indoles, and a one-pot quadruple reaction sequence of the enynols generates dih
236 efficacy of 2 different optimized nonbismuth quadruple regimens in areas of high resistance to antimi
239 ks 6 days of gestation) and second-trimester quadruple screening (measurement of alpha-fetoprotein, t
242 ition, exhibits dual-, triple-, and at least quadruple-shape memory effects, all highly tunable witho
244 of data available for querying has more than quadrupled since it went into production and OLS functio
246 ic core, an intraprotein hydrogen bond and a quadruple stacking interaction between U1A and U1hpII.
248 est pair will form a bound binary, while the quadruple stellar system itself is bound but unstable on
250 Guanine-rich oligonucleotides can fold into quadruple-stranded helical structures known as G-quadrup
253 tion (greater than 1,000 astronomical units) quadruple system composed of a young protostar and three
255 plified by polymerase chain reaction using a quadruple-tagging set of primers specific for E. coli ea
257 they had a second trimester screening test (Quadruple test) and treated as positive only if this wer
259 The maternal mortality ratio in Ragh was quadruple that in Kabul (713 per 100 000 livebirths, 95%
261 nce interval [CI]: 16% to 28%) was more than quadruple the 5% average worldwide background rate of PE
264 s study in African Americans, XPEB more than quadrupled the discoveries from the conventional approac
265 ) and time-dependent exposure to carbapenems quadrupled the hazard (hazard ratio, 4.087; 95% CI, 1.87
267 S613 with the liaF allele from isolate R712 quadrupled the MIC of daptomycin, whereas replacement of
268 of 150 mum ATP into female rat sciatic nerve quadrupled the number of axons growing into a lesion epi
269 Although the Haber-Bosch process more than quadrupled the productivity of agricultural crops, chemi
271 otagmin, inclusion of both Munc13 and Munc18 quadruples the Ca(2+)-triggered amplitude and achieves C
273 cytic glutamate uptake using TFB-TBOA nearly quadruples the duration of SD in layers 2-3 of visual co
274 analysis was constructed that suggested that quadrupling the rate of severe hypoglycemia and doubling
275 identifies nearly 300 novel EBV transcripts, quadrupling the size of the annotated viral transcriptom
276 hyroid hormone-dependent glycolytic rate and quadrupling the transcription of thyroid hormone target
277 an macrophages to TSE for 20 hours more than quadrupled their production of MMP14-positive MVs (contr
278 ithromycin and Levofloxacin-based sequential quadruple therapies as first-line treatment options and
280 arithromycin [PAMC]) and traditional bismuth quadruple therapy (PPI + bismuth + metronidazole + tetra
281 ne strategies include concomitant nonbismuth quadruple therapy (proton pump inhibitor [PPI] + amoxici
284 xcitation at 197 nm from a tunable frequency-quadrupled Ti:sapphire laser provided high-quality UVRR
286 matography (LC) nano electrospray ionization quadruple time-of-flight (nano-ESI-Q-TOF) mass spectrome
288 sing ultra-performance liquid chromatography-quadruple time-of-flight high-sensitivity mass spectrome
289 uid chromatography coupled with electrospray quadruple time-of-flight mass spectrometry (IPRP-UPLC ES
290 detector and an ultrahigh resolution hybrid quadruple-time-of-flight mass spectrometer with ESI sour
298 time illustrates the relevance of the larger quadruple VirB6 paralogs by demonstrating the protein ex
299 sults suggest that E. chaffeensis VirB9, the quadruple VirB6 proteins, and the VirB6-2 80-kDa fragmen
300 doubled with multiple 3 min air breaks, and quadrupled with 10 min air breaks compared with continuo
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