ライフサイエンスコーパス: quadruplex

1 e of forming four-stranded DNA structures (G-quadruplexes).

2 ing selectivity for human telomeric hybrid G-quadruplex.

3 central pore on the folding topology of the quadruplex.

4 via the formation of a K(+)-ion-stabilized G-quadruplex.

5 nal features, including an unknown form of G-quadruplex.

6 ecifically to human telomeric antiparallel G-quadruplex.

7 ytosine across from a replication-stalling G-quadruplex.

8 high degree of selectivity for a particular quadruplex.

9 ng enzymes, FANCJ partially stabilizes the G-quadruplex.

10 rm two secondary structures, a hairpin and a quadruplex.

11 distribute between a monomeric and dimeric G-quadruplex.

12 es interaction of TRF2 with a p21 promoter G-quadruplex.

13 analogous to (but different from) that for G-quadruplexes.

14 determined preference for most investigated quadruplexes.

15 on of various secondary structures such as G-quadruplexes.

16 m stable four-stranded structures known as G-quadruplexes.

17 ves that can be used as optical probes for G-quadruplexes.

18 This article surveys the chemical biology of quadruplexes.

19 ghly stable secondary structures including G-quadruplexes.

20 property of individual human telomeric DNA G-quadruplexes.

21 blies, such as G-ribbons, G4-quartets, and G-quadruplexes.

22 o into non-canonical DNA structures called G-quadruplexes.

23 in concentrated solutions of various model G-quadruplexes.

24 elomeric G-quadruplex from other telomeric G-quadruplexes.

25 antiparallel htel-22 into hybrid or parallel quadruplexes.

26 ompound stabilizes the three existing KRAS G-quadruplexes.

27 broadening the definition of irregular RNA G-quadruplexes, a bioinformatic search was performed to fi

28 determining the biochemical specificity of G-quadruplex activity.

29 nstrate the formation of a parallel folded G-quadruplex and a B-form duplex DNA stacked coaxially.

30 egnanol derivatives that recognize the MYC G-quadruplex and BCL2 i-motif promoter DNA structures lowe

31 sis-specific DSBs fold into intramolecular G-quadruplex and i-motif structures, both in vitro and in

32 nstrate mutual exclusivity between the MYC G-quadruplex and i-motif, providing a rationale for a mole

33 ect of these G-rich sequences is caused by G-quadruplex and is dose dependent.

34 e diverse DNA structures (duplex, hairpin, G-quadruplex and single-stranded), ligand types (ion, smal

35 lectively stabilize human telomeric hybrid G-quadruplex and strongly inhibit telomerase activity with

36 These studies show that T-oligo can form a G-quadruplex and that the antitumor effects of T-oligo may

37 formed between putative parallel stranded G-quadruplexes and a duplex DNA sequence constructed from

38 ructures including interstrand crosslinks, G quadruplexes and DNA triplexes.

39 be the mechanism by which FANCJ recognizes G-quadruplexes and mediates their stepwise unfolding, but

40 srupt the topology and stability of the htel quadruplexes and restrict their conformational space.

41 method in different structural contexts of G-quadruplexes and their complexes.

42 SB) in Saccharomyces cerevisiae folds into G-quadruplex, and the C-rich sequence complementary to the

43 FNAs mainly include DNAzymes, G-quadruplexes, and mismatched base pairs and nanomaterial

44 insight into the sequence requirements of G-quadruplexes, and should facilitate the analysis of such

45 Using an anti-G-quadruplex antibody, we showed that T-oligo can form G4

46 P1G4 and previously identified Pu39 G-quadruplexes appear to form independently in adjacent re

47 Using NMR spectroscopy, the P1G4 G-quadruplex appears to be a novel dynamic equilibrium of

48 The results demonstrated that each G-quadruplex aptamer can capture two adenosine molecules.

49 lecule targeted selectivity for a particular quadruplex are discussed in relation to the potential of

50 A-binding protein footprints revealed that G quadruplexes are enriched in heterogeneous nuclear ribon

51 Because low stability G-quadruplexes are hardly detectable by mass spectrometry,

52 G-quadruplexes are nucleic acids structures stabilized by

53 vidence suggests that different types of DNA quadruplexes are widely present in the genome of all org

54 inine to L-citrulline by a series of hemin/G-quadruplex-arginine aptamer conjugated nucleoapzymes.

55 ex at the 5'-end, followed by the stronger G-quadruplex at the 3'-end via various intermediates.

56 en proceeded through disrupting the weaker G-quadruplex at the 5'-end, followed by the stronger G-qua

57 o guanine electron donors into crystalline G-quadruplex-based organic frameworks, wherein the electro

58 d at the surface or alternative sites of the quadruplex because the ion specificity of the central po

59 n termination due to formation of a hybrid G-quadruplex between the nascent RNA and the nontemplate D

60 ompounds were synthesized and evaluated as G-quadruplex binders.

61 G-Quadruplex-binding compounds are currently perceived as

62 anistic insight, we studied the effects of G-quadruplex-binding ligands on hTERT expression and obser

63 The in vitro G-quadruplex-binding properties of the synthesized compoun

64 It critically examines the major classes of quadruplex-binding small molecules that have been develo

65 Using the GMP-quadruplex, built by the stacking of G-quartets with no

66 G-quadruplex can readily form in the P1G4 sequence under p

67 ermal, pH (i-motif), K(+) ion/crown ether (G-quadruplexes), chemical (pH-doped polyaniline), or bioca

68 least 6 cycling times by heat to transfer G-quadruplex conformation to single strand of DNA sequence

69 with no modification of the physiological G-quadruplex conformation.

70 of an NMS construct and that of truncated G-quadruplex constructs revealed a quadruplex-quadruplex i

71 00 to bind and exert regulatory functions at quadruplex-containing RNA or DNA sequences.

72 ermore, an interaction between BC200 and the quadruplex-containing telomerase RNA was confirmed by pu

73 (EMT)-associated CD44 isoform switch in a G-quadruplex-dependent manner, which results in inhibition

74 screen for small molecules able to induce G-quadruplex-dependent transcriptional reprogramming.

75 guanine-rich sequences that can fold into G-quadruplex DNA (G4DNA).

76 stoichiometry was more complex for telomeric quadruplex DNA and a double-stranded DNA control.

77 the first example of a reduction-activated G-quadruplex DNA binder.

78 G-quadruplex DNA folds into different topologies that are

79 Moreover, G-quadruplex DNA has been implicated in the alignment of f

80 o 10-fold and on bimolecular anti-parallel G-quadruplex DNA structures and three-stranded D-loop appr

81 all molecules that can selectively bind to G-quadruplex DNA structures.

82 etains limited accessibility, of telomeric G-quadruplex DNA to complementary single stranded DNA and

83 ince then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapidly

84 eral elements, exhibits strong affinity to G-quadruplex DNA, it displays a much weaker affinity for t

85 undreds of ligands which can interact with G-quadruplex DNA, yet very few which target i-motif.

86 platinum(II) complex has good affinity for G-quadruplex DNA.

87 n, the assembly of antibody and alkylthiol/G-quadruplex DNA/hemin on gold nanoparticles was used as b

88 Targeting G-quadruplex DNAs for cancer treatment is a very promising

89 G-quadruplex DNAs form four-stranded helical structures an

90 cles (MNPs) as supporting matrix and hemin/G-quadruplex DNAzyme as signal amplifier for determination

91 colorimetric determination system based on G-quadruplex DNAzyme integrated with a smartphone was deve

92 A present in a sample, by exposing a hemin/G-quadruplex DNAzyme, which then catalyzes the generation

93 he presence of hemin, form catalytic hemin/G-quadruplex DNAzymes with peroxidase activity.

94 ine to aminochrome using a series of hemin/G-quadruplex-dopamine aptamer nucleoapzymes.

95 We successfully generated a series of G-quadruplex-duplex containing crystals, both alone and in

96 interface occludes ligand binding at the 3' quadruplex-duplex interface, in agreement with in silico

97 ovides a detailed snapshot of a telomeric 3' quadruplex-duplex junction: a junction that appears to h

98 ister chromatids by forming parallel guanine quadruplexes during meiosis; however, the underlying mec

99 zole rings shows higher affinity for c-MYC G-quadruplex, exhibits fluorescence "turn-on" response wit

100 present a general overview of the helicase/G-quadruplex field.

101 f the duplex to unmask the PQS, adopting a G-quadruplex fold in which apurinic/apyrimidinic endonucle

102 is framework clarifies the driving forces of quadruplex folding and interconversion processes over a

103 have been performed on two different common quadruplex folding topologies.

104 e methodological tools for understanding DNA quadruplex folding, notably at low cation concentrations

105 bits substantially reduced perturbation of G-quadruplex folding.

106 further importance was the finding that the quadruplex formation disrupts CTCF protein binding, whic

107 te footprinting revealed some evidence for G-quadruplex formation in (G3T)n sequences, this was not a

108 Our results not only identify quadruplex formation in the first exon promoted by CpG d

109 Quadruplex formation must therefore first require local

110 ent along with their C-rich complements, and quadruplex formation will be in competition with the cor

111 ative DNA structures, we have investigated G-quadruplex formation within negatively supercoiled DNA p

112 ercoiling alone is not sufficient to drive G-quadruplex formation.

113 : (i) the intramolecular parallel-stranded G-quadruplex formed by the 22-mer four-repeat human telome

114 (ii) the intermolecular parallel-stranded G-quadruplex formed by the TG4T oligonucleotides.

115 tection of naturally occurring extracellular quadruplexes formed by cyclic dimeric guanosine monophos

116 Our investigation has been performed for G-quadruplexes formed by folding of GGG(TTAGGG)3 single st

117 denines (A/AP) and tetrad guanines (G/AP) in quadruplexes formed by the human telomere d[AG3(TTAG3)3]

118 ibe not only the basic structural motif of G-quadruplexes formed by, e.g., telomeric DNA sequences, b

119 -folding topologies have been reported for Q-quadruplexes formed from telomeric repeats depending on

120 high-affinity compounds that bind putative G-quadruplex forming sequences only rarely have a high deg

121 Here we demonstrate that RNA elements with G-quadruplex-forming capacity promote exon inclusion.

122 Destroying G-quadruplex-forming capacity while keeping G tracts intac

123 sequences but can also be found for other G-quadruplex-forming motifs, arguing for widespread applic

124 ions were assembled using different putative quadruplex-forming scaffolds linked at the 3' end to a t

125 We found a new 28-mer G-quadruplex-forming sequence, P1G4, immediately upstream

126 en OG is formed in guanine-rich, potential G-quadruplex-forming sequences (PQS) in promoter-coding st

127 nstead undergone evolutionary depletion of G-quadruplex-forming sequences.

128 Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here

129 The G-quadruplex frameworks also demonstrate potential as cath

130 o the P1G4 sequence and distinguish the P1G4 quadruplex from other parallel structures.

131 t Delta1a can discriminate human telomeric G-quadruplex from other telomeric G-quadruplexes.

132 ll-molecule optical probe (DAOTA-M2) and a G-quadruplex from the promoter region of the c-myc oncogen

133 ch DNA element, identified several potential Quadruplex G-Rich Sequences (QGRS).

134 G-quadruplexes/G-quadruplex-ligand complexes were also cor

135 We find that PARP3 regulates G quadruplex (G4) DNA in response to DNA damage, which sup

136 RN RECQ helicase protein binds and unwinds G-quadruplex (G4) DNA substrates in vitro, and we identifi

137 fficiently to both double-stranded DNA and G-quadruplex (G4) DNA.

138 e-based computational model to predict DNA G-quadruplex (G4) formation.

139 presence of a stable secondary structure, G-quadruplex (G4) in the 5' UTR of P1-HNF4A, the predomina

140 G-quadruplex (G4) is a higher-order nucleic acid structure

141 at transcriptional start sites and contain G-quadruplex (G4) motifs.

142 Quadruplex (G4) nucleic acids, a family of secondary str

143 G-quadruplex (G4) structural motifs have been linked to tr

144 The guanine quadruplex (G4) structure in DNA is a secondary structur

145 C's promoter is governed by a higher order G-quadruplex (G4) structure in the NHE III1 region.

146 A and has a high affinity for folded guanine quadruplex (G4) structures but little binding to duplex

147 RPA is able to unfold G-quadruplex (G4) structures formed by telomeric DNA seque

148 This motif can form G-quadruplex (G4) structures in vitro.

149 sical properties typically associated with G-quadruplex (G4) structures render them a significant blo

150 anine rich nucleic acid sequences can form G-quadruplex (G4) structures that interfere with DNA repli

151 strate that spiroketal does not affect the G-quadruplex (G4) thermal stability.

152 ondary, four-stranded DNA structure termed G-quadruplex (G4), which has been implicated in genomic in

153 G-quadruplex (G4)-containing substrates mimicking the mamm

154 G-quadruplex (G4)-forming genomic sequences, including tel

155 whose stacking leads to the formation of a G-quadruplex (G4).

156 G-quadruplexes (G4) are polymorphic four-stranded structur

157 G-quadruplexes (G4) within oncogene promoters are consider

158 Guanine-rich oligonucleotides can form G-quadruplexes (G4), which are stabilized by the hydrogen

159 complex (Pt-DA) has been incorporated into G-quadruplex G4K(+) borate hydrogels by using borate ester

160 G-quadruplexes (G4s) are extremely stable DNA or RNA secon

161 G-quadruplexes (G4s) are higher-order DNA structures typic

162 G quadruplexes (G4s) can present potent blocks to DNA repl

163 lar complexes containing both i-motifs and G-quadruplexes (G4s) is demonstrated.

164 G-quadruplexes (G4s), DNA secondary structures displaying

165 anosines strongly tend to fold into stable G-quadruplexes (G4s).

166 G-quadruplex (GQ) is a four stranded DNA secondary structu

167 G-quadruplex (GQ) is a four-stranded DNA structure that ca

168 The potential use of G-quadruplex (GQ) stabilizing small molecules as anti-canc

169 oth WRN and BLM have been shown to resolve G-quadruplex (GQ) structures.

170 ic acid) (ABTS)-H2O2 reaction catalyzed by G-quadruplex halves.

171 or non-canonical DNA structures including G-quadruplexes has been proposed as the major underlying c

172 owledge about the structural properties of G-quadruplexes has helped to design and develop a repertoi

173 he structural and topological diversity of G-quadruplexes have attracted great attention for decades.

174 Although RNA G-quadruplexes have been implicated in posttranscriptional

175 While the G-quadruplexes have been well characterized, the i-motifs

176 Since quadruplexes have the tendency to obstruct DNA replicati

177 lline phase behaviors of two other related G-quadruplexes: (i) the intramolecular parallel-stranded G

178 revealed transition dynamics of the targeted quadruplex in a native environment, which is named as na

179 stable species (parallel and antiparallel G-quadruplex in K+ and Na+, respectively).

180 ith strong G/C skew and propensity to form G-quadruplex in non-template DNA, corroborating with all b

181 governed by the EF1a interaction with the G-quadruplex in the NRF2 5' UTR during oxidative stress.

182 he potential functions and applications of G-quadruplexes in basic and applied biosciences.

183 ed active genes suggests a potential role of quadruplexes in expression regulation.

184 These data suggest a critical role for RNA G quadruplexes in regulating alternative splicing.

185 from enhanced eIF4A-dependent unwinding of G-quadruplexes in the 5' untranslated region of GW182 mRNA

186 order DNA structures into two constituting G-quadruplexes in the promoter of the human telomerase rev

187 f mammalian RNA regions that can fold into G-quadruplexes in vitro, but in contrast to previous assum

188 the identification and characterization of G-quadruplexes in vivo as well as in vitro, and at a much

189 l pH, these sequences fold into i-motif like quadruplexes in which every two repeats a globular struc

190 The current belief is that RNA G-quadruplexes include loops of l to 7 nucleotides in leng

191 of the new supramolecular squares to guanine quadruplexes, including oncogene and telomere-associated

192 nical and thermodynamic stabilities of the G-quadruplex inside the nanocage increase with decreasing

193 molecularly crowded buffer solutions, the G-quadruplex inside the nanocage is significantly more sta

194 icational or co-transcriptional folding of G-quadruplex inside the polymerase machinery in cells.

195 a quadruplex structure and does not bind the quadruplex-interacting motif of RHAU, it has direct affi

196 This dual i-motif/G-quadruplex-interactive compound presents a new mechanism

197 learly demonstrate that what defines a RNA G-quadruplex is much broader than what we previously belie

198 Even if the composition of a RNA G-quadruplex is not quite completely understood, the resul

199 compound on the Mid-region i-motif and the G-quadruplexes leads to downregulation of KRAS gene expres

200 G-quadruplexes/G-quadruplex-ligand complexes were also correctly detected

201 ty to perform high-throughput screening of G-quadruplex ligands for the development of drug molecules

202 The first prototypes of twice-as-smart quadruplex ligands were designed to exploit the self-ass

203 of DNA secondary structures, specifically G-quadruplex-like DNA, within the CTD coding region.

204 oguanine motifs at their 5'-ends, assemble G-quadruplex-like structures and interact with the transla

205 tic search was performed to find potential G-quadruplexes located in the untranslated regions of huma

206 Interestingly, a G-quadruplex motif at the hTERT promoter was essential for

207 for a continuous stack of bases to link the quadruplex motif with the duplex region.

208 y small-molecule-mediated stabilization of G-quadruplex nucleic acid secondary structures triggers lo

209 ses occurring at specific locations within G-quadruplex nucleic acids, providing valuable probes for

210 tional dynamics of guanine amino groups in G-quadruplex nucleic acids.

211 ia hnRNPA1-mediated destabilization of the G-quadruplex on the KRAS promoter.

212 p to form unique DNA secondary structures: G-quadruplexes on the G-rich strand and i-motifs on the C-

213 G-quadruplex or G4 DNA is a non-B secondary DNA structure

214 The presence of G-quadruplex or i-motif structures upstream of the green f

215 ectopic oncogenic expression of cyclin E, G-quadruplexes, or R-loop formation facilitate the ALT pat

216 y study the relative affinity of the central quadruplex pore for different cation types and the assoc

217 sm of hTERT epigenetic control involving a G-quadruplex promoter motif, which potentially can be targ

218 truncated G-quadruplex constructs revealed a quadruplex-quadruplex interaction with 2 kcal/mol stabil

219 The residues responsible for G-quadruplex recognition also participate in interaction w

220 structural basis for tight gold(I) complex/G-quadruplex recognition and its selectivity are described

221 While their quadruplex recognition capability has been thoroughly do

222 ria, transcription termination events at a G-quadruplex region near the replication origin are though

223 encing (rG4-seq), a transcriptome-wide RNA G-quadruplex (rG4) profiling method that couples rG4-media

224 RNA G-quadruplex (RG4) structures are involved in multiple bio

225 RNA G-quadruplex (rG4) structures are of fundamental importanc

226 veral G4 motifs capable to form stable RNA G-quadruplex (RG4) structures that can serve as targets fo

227 To elucidate the significance of these quadruplex-RHAU interactions, we have performed RNA co-i

228 Preferential binding of G-quadruplex RNA is conserved, surprisingly using differen

229 fluoroisopropanol mixture highly increased G-quadruplex sensitivity with no modification of the physi

230 1 alpha (EF1a) as a protein binding to the G-quadruplex sequence.

231 differentiates many widely accepted putative quadruplex sequences that do not actually form stable ge

232 We introduce RNA G-quadruplex sequencing (rG4-seq), a transcriptome-wide RN

233 Thus, the G-quadruplex serves as an effective conduit for positive c

234 ar tetramers, which we term supramolecular G-quadruplexes (SGQs).

235 ore, we demonstrated that mutating PIF1, a G-quadruplex-specific helicase, results in increased CTD r

236 Here, we show that CX-5461 is a G-quadruplex stabilizer, with specific toxicity against BR

237 lines in vitro and behaves as a selective G-quadruplex stabilizer.

238 G-quadruplex stabilizers are an established opportunity in

239 These results suggest a potential role for G-quadruplex stabilizers in the treatment of KSHV-associat

240 gation led to the identification of potent G-quadruplex stabilizers with high selectivity over duplex

241 Overall, these data show that G-quadruplex stabilizing compounds retard the progression

242 dency to obstruct DNA replication, we used G-quadruplex stabilizing compounds to examine their effect

243 Modulation of G-quadruplex structural integrity may control cellular pro

244 Although BC200 does not adopt a quadruplex structure and does not bind the quadruplex-in

245 atly expanded our current understanding of G-quadruplex structure and function.

246 Hemin/G-quadruplex structure as HRP mimicking-DNAzyme significan

247 Here we demonstrate the presence of a G-quadruplex structure in the 5' untranslated region (UTR)

248 Additionally, we have identified a G-quadruplex structure in the 5' untranslated region of Ga

249 it channel to prevent formation of the RNA G-quadruplex structure required for termination and thus s

250 The sequences that adopted a G-quadruplex structure were cloned into a luciferase dual

251 Although different ions can stabilize a G-quadruplex structure, the preferred bound ions are typic

252 aqueous-media, which first implements the G-quadruplex structure-switching biosensing principle in g

253 rify the signaling principle competency of G-quadruplex structure-switching in graphene electronic bi

254 ludes a G-rich portion that likely forms a G-quadruplex structure.

255 quilibrium from the hairpin structure to the quadruplex structure.

256 Indeed, stabilization of G-quadruplex structures activates PARP1 and leads to accel

257 d on different triggers, provided that their quadruplex structures and stability display a high depen

258 anine-rich oligonucleotides, non-canonical G-quadruplex structures are based on G-quartets formed by

259 The results for the quadruplex structures are compared with those for the co

260 G-quadruplex structures are composed of coplanar guanines

261 Small molecules that can stabilize quadruplex structures augment these effects and produce

262 s the conversion of alternative antiparallel quadruplex structures binding only one cation, formed in

263 The first indication of how G-quadruplex structures could be unfolded enzymatically ca

264 ys reveal that the POT1-TPP1 complex binds G-quadruplex structures formed in buffers containing Na(+)

265 affinity that is fivefold higher than for G-quadruplex structures formed in the presence of K(+).

266 helicase that demonstrates high affinity for quadruplex structures in DNA and RNA.

267 lected derivatives have been shown to trap G-quadruplex structures in the nucleus of cancer cells.

268 epeats of the sequence d(TTAGGG) that form G-quadruplex structures made of stacked guanines with mono

269 Evidence suggests that G-quadruplex structures may act as 'knots' within genomic

270 iether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by means

271 quences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by

272 telomere DNA fragments fold into different G-quadruplex structures with parallel, hybrid, and antipar

273 neuroblastoma cell line, in particular at G-quadruplex structures, and recombinant CSB can melt G-qu

274 d by the ordered rylene diimide arrays and G-quadruplex structures, respectively.

275 We also show that CST unfolds G-quadruplex structures, thus providing a mechanism for CS

276 interact with Pb(2+) ions and switch into G-quadruplex structures.

277 ro by in-line probing for the formation of G-quadruplex structures.

278 x structures, and recombinant CSB can melt G-quadruplex structures.

279 TG(Br)GG(Br)GAC7) that self-assemble to form quadruplex supramolecules under certain conditions.

280 investigate the sequence requirements of a G-quadruplex that can both bind GTP and promote peroxidase

281 were recently developed to track and label G-quadruplexes: these higher-order nucleic acid structures

282 After mechanically targeting the two G-quadruplexes together, the same interaction was observed

283 dary structure is substantially faster for G-quadruplex topologies formed in the presence of Na(+) io

284 ity over duplex DNA and preference for one G-quadruplex topology over others.

285 Finally, we compare the mesophases of the G-quadruplexes, under PEG-induced crowding conditions, wit

286 ty of BC200 to act as an acceptor of unwound quadruplexes via a cytosine-rich region near the 3'-end

287 d state is slower but more efficient for the quadruplex vs duplex structures.

288 hylcaffein-8-ylidene)2 ](+) and Tel 23 DNA G-quadruplex was solved.

289 Introducing the term 'clustered damage to G-quadruplexes' we report here on the structural effects o

290 late translation in cellulo Some irregular G-quadruplexes were observed to either promote or repress

291 robust machinery that globally unfolds RNA G-quadruplexes, whereas some bacteria have instead undergo

292 re can result in the unfolding of existing G-quadruplexes which can lead to telomere shortening.

293 licases in cancer cells are unable to unwind quadruplexes, which are impediments to transcription, tr

294 nduce targeted mechanical unfolding of the G-quadruplex while leaving the nanocage unperturbed.

295 d(TG(Br)GG(Br)GAC7) forms long linear quadruplex wires under acidic conditions in the presence

296 lick-chemistry coupling, we sandwiched one G-quadruplex with two dsDNA handles while leaving the othe

297 3' (G3T) sequence folds into a monomolecular quadruplex with unusually high thermal stability and uni

298 both human telomeric and oncogene promoter G-quadruplexes with different folding topologies as target

299 revealed multiple motifs predicted to form G-quadruplexes, with the greatest potential detected for t

300 tudy on oxidative damage of human telomere G-quadruplexes without mediation of external molecules.