ライフサイエンスコーパス: quadruplex DNA

1 nteractions between TOTA and duplex DNA or G-quadruplex DNA.

2 aluate the binding of TMPyP4 and Se2SAP to G-quadruplex DNA.

3 ased selectivity of Tel01 interaction with G-quadruplex DNA.

4 es in their ability to efficiently disrupt G-quadruplex DNA.

5 ity of the perylene-EDTA*metal complex for G-quadruplex DNA.

6 probes have been synthesized and targeted to quadruplex DNA.

7 that are potent and selective ligands for G-quadruplex DNA.

8 complexation of TMPyP4 with human telomeric quadruplex DNA.

9 the presence of 6SG blocks the formation of quadruplex DNA.

10 platinum(II) complex has good affinity for G-quadruplex DNA.

11 during unfolding of intramolecular parallel quadruplex DNA.

12 with correct linkage chemistry relative to G-quadruplex DNA.

13 regulation via removal of damaged bases from quadruplex DNA.

14 lymerase REV1 are defective in replicating G-quadruplex DNA.

15 eously binds TERRA and telomeric duplex or G-quadruplex DNA.

16 on at increasing excess over human telomeric quadruplex DNA.

17 l molecules that selectively interact with G-quadruplex DNA.

18 ty in both the Na(+) and K(+) forms of the G-quadruplex DNA.

19 c metal ion binding to DNA, particularly for quadruplex DNA.

20 molecules that bind to different features of quadruplex DNA.

21 ing class of anticancer agents that target G-quadruplex DNA.

22 or nucleic acids and specific preference for quadruplex DNAs.

23 the manganese in the narrow grooves of these quadruplex DNAs.

24 conformational dynamics of 6mG residues in G-quadruplex DNAs.

25 mpounds with selectivity for human telomeric quadruplex DNAs.

26 oth unwind a variety of different forms of G-quadruplex DNA, a structure that can form at guanine-ric

27 at ligands imparted higher stabilization for quadruplex DNA (an increase in the T(m) of up to 21 degr

28 of up to 21 degrees C for human telomeric G-quadruplex DNA and >25 degrees C for promoter G-quadrupl

29 stoichiometry was more complex for telomeric quadruplex DNA and a double-stranded DNA control.

30 in the level of binding of the helicase to G-quadruplex DNA and a reduction in the degree to which th

31 ublished model for PIPER bound to the same G-quadruplex DNA and failed to provide a structural basis

32 methyl-4-pyridyl)porphyrin (TMPyP4) binds to quadruplex DNA and is thereby an inhibitor of human telo

33 ase activity by stabilization of telomeric G-quadruplex DNA and point to a polymerase arrest assay as

34 cation as a probe for interactions between G-quadruplex DNA and potential anticancer therapeutical bi

35 t only mNeil3 had excision activity on Tg in quadruplex DNA and that the glycosylase exhibited a stro

36 ive agents (QIAs) that stabilize telomeric G-quadruplex DNA and thereby inhibit human telomerase; 50%

37 CG)n repeats which can, respectively, form G-quadruplex DNA and Z-DNA.

38 here are many different folding patterns for quadruplex DNAs and the loops exhibit much more variatio

39 ple of an engineered protein that binds to G-quadruplex DNA, and represents a new type of binding int

40 d using thrombin aptamer (TBA), one of the G-quadruplex DNA aptamers, without expensive nanoparticles

41 research, we expect that various types of G-quadruplex DNA aptasensors capable of specifically sensi

42 the discrimination between duplex DNA and G-quadruplex DNA are necessary to unravel the biological f

43 opper(II) salphen metal complexes bound to a quadruplex DNA are presented.

44 G-Quadruplex DNAs are folded, non-Watson-Crick structures

45 Thus, a minimal synthetic model of G-quadruplex DNA, as in that associated with human gene pr

46 -C70 terminal three-helix bundle binds the G-quadruplex DNA at the interface between helices H1 and H

47 to study binding kinetics of ligands with G-quadruplex DNA at the single molecule level.

48 nium ligands bind tightly and selectively to quadruplex DNAs at low ligand concentration ( approximat

49 the first example of a reduction-activated G-quadruplex DNA binder.

50 tion (R(2) = 0.81) across the series between quadruplex DNA binding affinity and TRAP inhibition pote

51 Selectivity for quadruplex DNA binding and stabilization by compounds we

52 and evaluation for telomerase-inhibitory and quadruplex DNA binding properties of three related serie

53 ic acid diimide], have different levels of G-quadruplex DNA binding selectivity at pH 7 as determined

54 mM KCl, 1 mM EDTA buffer also demonstrated G-quadruplex DNA binding selectivity under these buffer co

55 pH 6.4, where it demonstrates only modest G-quadruplex DNA binding selectivity, and PIPER in pH 8.5

56 that ligand aggregation is correlated with G-quadruplex DNA binding selectivity.

57 n resonance and fluorescence spectroscopic G-quadruplex DNA binding studies of these T-ag G-quadruple

58 unds retain high affinity to human telomeric quadruplex DNA but are 10-fold more potent against the M

59 PER specifically prevents the unwinding of G-quadruplex DNA but not duplex DNA by Sgs1.

60 istamycin A, and DTC all form complexes with quadruplex DNA, but only Tel01 is completely selective f

61 duplex DNA can be effectively converted to G-quadruplex DNA by a small molecular weight ligand.

62 etal) indicates that the compound binds to G-quadruplex DNA by stacking externally on the 3' G-tetrad

63 druplex and the antiparallel hairpin dimer G-quadruplex DNA by yeast Sgs1 helicase (Sgs1p).

64 and a reduction in the degree to which the G-quadruplex DNA can support DNA-dependent ATPase activity

65 mics simulations has been undertaken on four quadruplex-DNA complexes.

66 L1, none of the glycosylases had activity on quadruplex DNA containing 8-oxoG.

67 Because G-quadruplex DNA exhibits structural polymorphism, differe

68 G-quadruplex DNA folds into different topologies that are

69 Targeting G-quadruplex DNAs for cancer treatment is a very promising

70 G-quadruplex DNAs form four-stranded helical structures an

71 .62 A crystal structure of an intramolecular quadruplex DNA formed from a sequence in the promoter re

72 s the possibility that insulin may bind to G-quadruplex DNA formed in the ILPR in vivo and thereby pl

73 is required for successful replication of G-quadruplex DNA (G4 DNA) in higher eukaryotes.

74 ecific DNA helicase that dissociates guanine quadruplex DNA (G4 DNA) in vitro.

75 particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucle

76 e-bis(piperazinyl benzimidazole) unit with G-quadruplex DNA (G4DNA) formed by human telomeric repeat

77 guanine-rich sequences that can fold into G-quadruplex DNA (G4DNA).

78 ) based on Troger's base skeleton with the G-quadruplex DNA (G4DNA).

79 Moreover, G-quadruplex DNA has been implicated in the alignment of f

80 G-quadruplex DNA has been suggested to regulate DNA replic

81 oth potent and selective inhibitors of the G-quadruplex DNA helicase activity of T-ag.

82 n, the assembly of antibody and alkylthiol/G-quadruplex DNA/hemin on gold nanoparticles was used as b

83 tro experiments support the involvement of G-quadruplex DNA in the binding interaction.

84 ilino side chains as telomeric and genomic G-quadruplex DNA interacting agents are described.

85 Quadruplex DNA interaction was further characterized thr

86 formation about the details of the potassium-quadruplex DNA interactions are of interest.

87 me of these ligands among the most selective quadruplex DNA interactive agents reported to date.

88 derivative, is a very potent and selective G-quadruplex DNA-interactive agent.

89 The study of ligand interaction with G-quadruplex DNA is an active research area, because many

90 esion at the site most prone to oxidation in quadruplex DNA is not efficiently removed by NEIL1 or NE

91 The binding of actinomycin D to the G-quadruplex DNAs is characterized by intrinsic associatio

92 eral elements, exhibits strong affinity to G-quadruplex DNA, it displays a much weaker affinity for t

93 ngs on the selectivity of other classes of G-quadruplex DNA ligands is discussed.

94 perylenetetracarboxylic acid diimide-based G-quadruplex DNA ligands, PIPER [N,N'-bis(2-(1-piperidino)

95 As quadruplex DNAs may be important in the structure of tel

96 kinase Aurora A to a greater extent than the quadruplex DNA of a human telomeric sequence.

97 Insulin capture by a G-quadruplex DNA oligonucleotide containing a two-repeat s

98 s significantly more effective in disrupting quadruplex DNA on long telomeric tails than an antisense

99 ingle-chain antibody that is selective for G-quadruplex DNA over double-stranded DNA, and here show t

100 G-quadruplex DNA presents a potential target for the desig

101 clease assay confirmed the ligand mediated G-quadruplex DNA protection.

102 eviously identified the major tetramolecular quadruplex DNA resolving activity in HeLa cell lysates a

103 Four-stranded G-quadruplex DNA secondary structures have recently been v

104 Here we report that the less G-quadruplex DNA selective ligand PIPER can unwind double-

105 H 8.5 buffer is both aggregated and highly G-quadruplex DNA-selective.

106 in the development of compounds that bind G-quadruplex DNA selectively has been sparked by the disco

107 This water-soluble complex cleaves G-quadruplex DNA selectively in the presence of dithiothre

108 se conditions display much lower levels of G-quadruplex DNA selectivity.

109 this telomerase inhibitor bound to telomeric quadruplex DNA should help in the design of new anticanc

110 dinium side chains form a promising class of quadruplex DNA stabilizing agents having high selectivit

111 Ligand-induced stabilization of the G-quadruplex DNA structure derived from the single-strande

112 odel for the interaction of Tel01 with the G-quadruplex DNA structure formed by d(TAGGGTTA) was deter

113 oxoguanine, on the transition from duplex to quadruplex DNA structure occurring at nuclease hypersens

114 ons of a number of compounds with a parallel quadruplex DNA structure were simulated by molecular mod

115 abilize the formation of chair- or edge-type quadruplex DNA structures and appears to be the only nat

116 o 10-fold and on bimolecular anti-parallel G-quadruplex DNA structures and three-stranded D-loop appr

117 Ligands that bind to and stabilize these G-quadruplex DNA structures are potential inhibitors of th

118 cell-cycle progression and that endogenous G-quadruplex DNA structures can be stabilized by a small-m

119 On the basis of growing evidence for G-quadruplex DNA structures in genomic DNA and the presume

120 of d(TTAGGG)n tandem repeats, which can form quadruplex DNA structures in vitro and likely in vivo.

121 Several ILPR variants form G-quadruplex DNA structures in vitro that exhibit affinity

122 (Gh), or spiroiminodihydantoin (Sp) can form quadruplex DNA structures in vitro.

123 gies to explore the therapeutic potential of quadruplex DNA structures is by stabilizing them with sm

124 Various biologically relevant G-quadruplex DNA structures offer a platform for therapeut

125 abilizing agents having high selectivity for quadruplex DNA structures over duplex DNA structures.

126 -oxodG may have a greater tendency to form G-quadruplex DNA structures than telomeric DNA lacking 8-o

127 87) has a higher selectivity for triplex and quadruplex DNA structures than the 3,6,8,11,13-pentameth

128 all molecules that can selectively bind to G-quadruplex DNA structures.

129 TAGGG) repeats that are capable of forming G-quadruplex DNA structures.

130 reakpoints prevalent in human disease form G-quadruplex DNA structures.

131 Pif1 readily unfolds a parallel quadruplex DNA substrate in a multiturnover reaction and

132 of yeast Pif1 to bind and unfold a parallel quadruplex DNA substrate.

133 ase activity to unwinding forked duplex or G-quadruplex DNA substrates or disrupting protein-DNA comp

134 cterized intermolecular and intramolecular G-quadruplex DNA substrates, as well as a unimolecular G4

135 e conjugate reacts significantly faster with quadruplex DNA (t1/2 = 1.2 h) than with double-stranded

136 that Pif1 binds more tightly to the parallel quadruplex DNA than single-stranded DNA or tailed duplex

137 druplex DNA and >25 degrees C for promoter G-quadruplex DNAs) than duplex DNA (DeltaT(m) </= 1.6 degr

138 ibutes in addition to binding affinity for G-quadruplex DNA that may be important for inhibition.

139 and displacement-driven cyclic assembly of G-quadruplex DNA, the development of an enzyme-free and no

140 In promoter G-quadruplex DNA, the NEIL glycosylases primarily remove G

141 etains limited accessibility, of telomeric G-quadruplex DNA to complementary single stranded DNA and

142 found that the exposure of (Br)dU-bearing G-quadruplex DNA to UVA light could also give rise to the

143 er substrates such as replication fork and G-quadruplex DNA, triplex DNA was a preferred substrate fo

144 y offer a route to the specific detection of quadruplex DNA under biologically important conditions.

145 ince then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapidly

146 these structures for DNA replication, the G-quadruplex DNA unwinding ability of a prototypical repli

147 quadruplex-interactive agents inhibits the G-quadruplex DNA unwinding activity of T-ag, relative to t

148 -ag, relative to those reported to inhibit G-quadruplex DNA unwinding by RecQ-family helicases.

149 elicase family whose members include other G-quadruplex DNA unwinding helicases, such as human Bloom'

150 targeting ligands is their selectivity for G-quadruplex DNA versus double-stranded DNA structures.

151 eract with and stabilize an intramolecular G-quadruplex DNA was evaluated by surface plasmon resonanc

152 nal effects and dynamics of ion binding to G-quadruplex DNA, we compare results from further experime

153 Although Sp and Gh in quadruplex DNA were good substrates for mNeil3 and NEIL1

154 through end-stacking with guanine tetrads of quadruplex DNA, while distamycin A interacts by binding

155 ibit exquisite selectivity for stabilizing G-quadruplex DNA with no stabilization of duplex DNA or RN

156 undreds of ligands which can interact with G-quadruplex DNA, yet very few which target i-motif.