ライフサイエンスコーパス: quality control mechanism

1 nd trafficking and is at the center of their quality control mechanism.

2 ter extent than wild-type Mot1, suggesting a quality control mechanism.

3 suggesting a previously unrecognized kinetic quality control mechanism.

4 that Pma1-7 is a substrate for a Golgibased quality control mechanism.

5 pparent monomers by a putative Cx43-specific quality control mechanism.

6 crucial component of the mRNA 5'-end capping quality control mechanism.

7 suppressed by inhibition of a competing RNA quality control mechanism.

8 ucidates a conserved cotranslational protein quality control mechanism.

9 oteasome pathway serves as a general protein quality-control mechanism.

10 mics, indicating compromise of mitochondrial quality control mechanisms.

11 occur after failure of the cellular protein quality control mechanisms.

12 associations are not required to satisfy ER quality control mechanisms.

13 aggregates, cells are equipped with protein quality control mechanisms.

14 tants, seeking to identify relevant cellular quality control mechanisms.

15 misfolding, revealing in vivo limitations on quality control mechanisms.

16 degeneration and (2) activate mitochondrial quality control mechanisms.

17 ng to MHCI proteins are degraded by cellular quality control mechanisms.

18 bly due to undescribed endoplasmic reticulum quality control mechanisms.

19 ablishing a molecular link between these two quality control mechanisms.

20 omain, suggesting evolutionary divergence of quality-control mechanisms.

21 dity-eggs-would be subject to more stringent quality-control mechanisms.

22 ly arising from the action of possible mtDNA quality-control mechanisms.

23 most of the cellular ATP and requires strict quality-control mechanisms.

24 of this protein to the endoplasmic reticulum quality control mechanisms, affecting its trafficking to

25 erged as an excellent system for identifying quality control mechanisms along the pathway.

26 ed with a different kinetics by different ER quality control mechanisms; although C300stop is rapidly

27 processing mutants that engage the cellular quality control mechanism and show a strong interaction

28 the endoplasmic reticulum are identified by quality control mechanisms and dislocated to the cytosol

29 Development of quality control mechanisms and introduction of peer revi

30 ication-mediated regulation of intracellular quality control mechanisms and its known involvement in

31 ian hsf genes, but specifically hsf1, in the quality control mechanisms and maintenance of CNS homeos

32 wo genomes for protein biogenesis, efficient quality control mechanisms, and appropriate distribution

33 alled ribosome into subunits.Several protein quality control mechanisms are in place to trigger the r

34 Both quality control mechanisms are key to prevent proteotoxi

35 e Clp proteolytic core, can confer a protein quality control mechanism at the envelope.

36 lasmic domains, the signal provides a common quality control mechanism at the Golgi for Kir channels.

37 be expressed in JNCL patients since cellular quality control mechanisms at the RNA and protein levels

38 arity of translocation reveals an unforeseen quality-control mechanism at the origin.

39 Interfering with common protein quality control mechanisms by mutating and inhibiting th

40 Failures of the quality control mechanisms by the heat shock proteins (H

41 Our results reveal that the Tat quality control mechanism can be harnessed for molecular

42 Here we provide evidence that a peripheral quality control mechanism can contribute to development

43 ses due to age-related impairment of protein quality control mechanisms can promote the transcellular

44 and retrieval, suggest a difference in their quality control mechanism compared with that of misfolde

45 building of filaments may act as a stringent quality control mechanism during HR.

46 Quality control mechanisms during protein synthesis are

47 Protein quality control mechanisms eliminate defective polypepti

48 e ability to perform a previously unexpected quality control mechanism for CCA synthesis.

49 ne where it possibly confers a novel protein quality control mechanism for chloroplast preprotein imp

50 face, and favor a role for p24 proteins in a quality control mechanism for endoplasmic reticulum-Golg

51 We recently described a non-canonical ER quality control mechanism for folding of thrombospondin

52 Thus, Kud acts as a quality control mechanism for LINC-mediated nucleocytosk

53 her, these modifications appear to provide a quality control mechanism for punctin-1 secretion.

54 it has been suggested that this represents a quality control mechanism for subunit functionality.

55 t this pathway also functions as an inherent quality control mechanism for the process of pre-mRNA sp

56 contrast, very little is known about post-ER quality control mechanisms for damaged or misfolded inte

57 osomes and suggest the possible existence of quality control mechanisms for disposal of aggregated pr

58 ence of translation on mRNA decay provides a quality-control mechanism for minimizing the use of poor

59 the endoplasmic reticulum (ER), reflecting a quality control mechanism found in many complex multisub

60 rt and support a broader conservation of RNA quality control mechanisms from yeast to humans.

61 We conclude that a quality control mechanism has been conserved from yeast

62 confinement, which, together with biological quality control mechanisms, helps proteins remain solubl

63 mainly when interference with mitochondrial quality control mechanisms impedes their roles in mainte

64 liferation and the p53 pathway as a powerful quality control mechanism in erythropoiesis.

65 Our data reveal a pre-mRNA 5' end capping quality control mechanism in mammalian cells, indicating

66 e transport to the GA, thus overwhelming the quality control mechanism in the ER.

67 We investigated the role of protein quality control mechanisms in cell wall integrity and fo

68 The physiological necessity of these quality control mechanisms in different environments rem

69 l substrates to interrogate cellular protein quality control mechanisms in mammalian cells using a fo

70 studies highlight the importance of protein quality control mechanisms in regulating polyglutamine-i

71 understanding of the organization of protein quality control mechanisms in the cytosol and nucleus.

72 Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibiti

73 lar senescence and implicates CHIP-dependent quality control mechanisms in the regulation of mammalia

74 Selection and/or quality-control mechanisms, including DNA repair and apo

75 otein stability that is based on the folding quality control mechanism inherent to the twin-arginine

76 Quality control mechanisms intervene appropriately when

77 One of the most fascinating quality-control mechanisms involves tmRNA, also known as

78 stalled ribosomes are rescued by a conserved quality-control mechanism involving transfer-messenger R

79 We show that this quality control mechanism is specific to G interface mut

80 Tat translocator, indicating that a folding quality-control mechanism is intrinsic to the export pro

81 misfolded proteins that escape the cellular quality-control mechanisms is a common feature of a wide

82 As a quality control mechanism, KPAF3 binding ensures that mR

83 d intervention of the "endoplasmic reticulum quality control" mechanism leading to degradation of the

84 olding defect, in conjunction with normal ER quality control mechanisms, leads to defective Tg export

85 Yet protein quality control mechanisms may also deliberately cluster

86 We propose that different quality control mechanisms may assess discrete domains o

87 Endoplasmic reticulum (ER) quality control mechanisms monitor the folding of nascen

88 ed that Saccharomyces cerevisiae possesses a quality control mechanism, nonfunctional rRNA decay (NRD

89 Thus, eukaryotes possess a quality-control mechanism, nonfunctional rRNA decay (NRD

90 Here, we provide an overview of three quality control mechanisms--nonsense-mediated mRNA decay

91 508 CFTR and associates with key elements in quality control mechanism of CFTR.

92 involve A chain unfolding in the ER and the quality control mechanism of ER-associated degradation (

93 s the cytosol by a process that involves the quality control mechanism of ER-associated degradation (

94 rigger its export to the cytosol through the quality control mechanism of ER-associated degradation (

95 s the cytosol in a process that involves the quality control mechanism of ER-associated degradation.

96 to-cytosol translocation of CTA1 through the quality control mechanism of ER-associated degradation.

97 of misfolded glycoproteins as a part of the quality control mechanism of the endoplasmic reticulum (

98 nexin, a component of what is considered the quality control mechanism of the ER.

99 ssociated degradation (ERAD) is an essential quality control mechanism of the folding state of protei

100 ed forms of hemagglutinin were bypassing the quality control mechanism of the secretory pathway.

101 d enzymes are unable to efficiently pass the quality control mechanisms of the endoplasmic reticulum,

102 stence of polyadenylated rRNAs may reflect a quality-control mechanism of rRNA biogenesis.

103 to support these divisions, which lack many quality control mechanisms operating in somatic cells un

104 several levels and by multiple mitochondrial quality control mechanisms present in the intermembrane

105 the endoplasmic reticulum (ER) is one of the quality control mechanisms present in the protein secret

106 genetic suppressors that inactivate the Tat quality-control mechanism provides direct evidence for t

107 mitophagy, and lysosomal function affect the quality control mechanisms required for neuronal surviva

108 Nonsense-mediated mRNA decay (NMD) is a quality control mechanism responsible for "surveying" mR

109 This finding suggests that quality control mechanisms sensitive to an absence of N-

110 However, whether RNA quality control mechanisms, such as nonsense-mediated mR

111 Endoplasmic reticulum (ER) quality control mechanisms target terminally misfolded p

112 s the best-characterized posttranscriptional quality control mechanism that cells have evolved in the

113 for monitoring tRNA stability in a cellular quality control mechanism that degrades structurally dam

114 Cell competition is a quality control mechanism that eliminates unfit cells.

115 m-associated degradation (ERAD) is a protein quality control mechanism that eliminates unwanted prote

116 ng the unique involvement of the Tat folding quality control mechanism that ensures only native-like

117 of excess unassembled Alg13p is an important quality control mechanism that ensures proper protein co

118 st time that the translation-like cycle is a quality control mechanism that ensures the fidelity of t

119 No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with tran

120 t are components of a unified and integrated quality control mechanism that exerts different effects

121 A system is a highly conserved translational quality control mechanism that helps maintain the transl

122 pC suggests the presence of a CtpA-dependent quality control mechanism that may sense proper transloc

123 A postthymic quality control mechanism that purges these cells from t

124 orted from folded proteins and degraded by a quality control mechanism that requires ER-to-Golgi tran

125 ly B cell development: SL chain is part of a quality control mechanism that tests a mu-chain for its

126 Eukaryotic mRNAs are subject to quality control mechanisms that degrade defective mRNAs.

127 Ribosomes stalled on aberrant mRNAs engage quality control mechanisms that degrade the partially tr

128 Protein homeostasis is maintained by quality control mechanisms that detect and eliminate def

129 Therefore, cells evolved cotranslational quality control mechanisms that eliminate these transcri

130 The current report identifies quality control mechanisms that exclude the improper pol

131 rescued DeltaF508CFTR remains susceptible to quality control mechanisms that lead to accelerated endo

132 n function and implicate homeostatic protein quality control mechanisms that may go awry in NvAMD.

133 The quality control mechanisms that oversee these processes

134 sembly on XPD and highlight the existence of quality control mechanisms that prevent the incorporatio

135 nd Mmr1p, which favors bulk inheritance; and quality control mechanisms that promote segregation of f

136 en avidly studied, little is known about the quality control mechanisms that resolve faulty transloca

137 In addition, numerous quality control mechanisms that target aberrant RNAs hav

138 se-mediated mRNA decay (NMD) is a eukaryotic quality-control mechanism that detects and degrades aber

139 Autophagy is a quality-control mechanism that helps to maintain cellula

140 ense-mediated mRNA decay (NMD) is a cellular quality-control mechanism that is thought to exacerbate

141 This response is thought to be a quality-control mechanism that protects cells from trunc

142 POFUT2 and B3GLCT mediate a noncanonical ER quality-control mechanism that recognizes folded TSRs an

143 Processing is subject to a quality-control mechanism that retains improperly proces

144 We suggest that the quality-control mechanism that retains receptors in post

145 Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively degrades mRNA

146 ole in DNA replication or replication-linked quality-control mechanisms that are especially important

147 rase II is built in the cytoplasm and reveal quality-control mechanisms that link HSP90 to the nuclea

148 These data show that a single quality-control mechanism, the editing of misacylated am

149 The pathway maintains a quality control mechanism to assure that aberrantly proc

150 yeast proteins, Rai1 and Dxo1, function in a quality control mechanism to clear cells of incompletely

151 -associated degradation (ERAD) is a cellular quality control mechanism to dispose of misfolded protei

152 egradation of mature miRNAs and siRNAs, as a quality control mechanism to eliminate dysfunctional or

153 ormally control S phase entry, possibly as a quality control mechanism to ensure adequate stem cell p

154 lta264 CFTR, binds to key elements in the ER quality control mechanism to increase the amounts of the

155 greement that proteolytic pathways provide a quality control mechanism to limit accumulation of damag

156 amine the contribution of the UGT1-regulated quality control mechanism to MHC I antigen presentation.

157 homotetramerization of apo-SiRHP serves as a quality control mechanism to prevent formation of inacti

158 long the aging process, suggesting a lack of quality control mechanism to remove defective mitochondr

159 rial cell and that FtsH acts as an important quality control mechanism to remove it.

160 We propose that nicalin/NRA-2 functions in a quality control mechanism to retain mutant channels in t

161 the FcepsilonRI alpha-chain activates the ER quality control mechanism to retain this subunit in the

162 gest that mitochondrial division serves as a quality control mechanism to suppress oxidative damage a

163 There are multiple quality control mechanisms to ensure that nascent polype

164 ryotic cells have evolved numerous layers of quality control mechanisms to ensure that the tRNAs are

165 The use of quality control mechanisms to stall developmental pathwa

166 ing mRNA maturation and lacks the need for a quality-control mechanism to ensure its fidelity.

167 to the extensively studied tapasin-mediated quality control mechanism, UGT1 adds a new level of cont

168 Collectively, these data uncover a novel quality control mechanism used by the cell to maintain p

169 chondrial fission is thought to be part of a quality-control mechanism whereby damaged mitochondrial

170 folding sensor subunit enables a stochastic quality control mechanism, which marks with increasing p

171 ine supplementation induces distinct protein quality control mechanisms, which may allow therapeutic

172 afforded by the twin-arginine translocation quality control mechanism with a function-based screen,

173 ltransferase (GT), an essential regulator of quality control mechanisms within the endoplasmic reticu