ライフサイエンスコーパス: quaternary

1 mained relatively stable in space across the Quaternary.

2 ratically to climate changes during the Late Quaternary.

3 anges of forest distribution during the Late Quaternary.

4 ly proposed by Abeles, is now available in a quaternary AA context for the first time.

5 Institute-designated cancer center within a quaternary academic medical center.

6 The versatility of the alpha-quaternary aldehyde products is demonstrated through the

7 e central pyrrolidine moiety incorporating a quaternary, all-carbon-substituted stereocenter was cons

8 Here, synthesis of quaternary alloys Mox W1-x S2y Se2(1-y) is reported usin

9 PLP enzyme inactivators; namely, a family of quaternary, alpha-(1'-fluoro)vinyl amino acids, bearing

10 ently strict restraints on their tertiary or quaternary amine and their distance to an ester or relat

11 lycan identification, and reporter ions from quaternary amine containing isobaric tag for glycan (QUA

12 ically encumbered and densely functionalized quaternary amino acids.

13 ed to yield hydantoins and unsaturated alpha-quaternary amino acids.

14 between this benzene ring and the agonist's quaternary ammonium (QA) and (2) AChRs respond strongly

15 make E. coli cells more susceptible to other quaternary ammonium based antimicrobials.

16 rbons, phthalates), fracturing fluids (e.g., quaternary ammonium biocides, 2-butoxyethanol) and downh

17 Some studies used large quaternary ammonium blocker molecules to examine the eff

18 rk demonstrates two approaches for modifying quaternary ammonium cationic polymers, which may enable

19 solute in T. erythraeum strain IMS101 as the quaternary ammonium compound N,N,N-trimethyl homoserine

20 Since quaternary ammonium compounds (QACs) are exuded by germi

21 transformation over 180 days of two cationic quaternary ammonium compounds (QACs) with perfluoroalkyl

22 ter and a quaternary nitrogen (N) of natural quaternary ammonium compounds such as stachydrine, carni

23 C difficile, for which bleach was used); UV (quaternary ammonium disinfectant and disinfecting ultrav

24 cted with one of four strategies: reference (quaternary ammonium disinfectant except for C difficile,

25 CO2 reduction were determined with different quaternary ammonium electrolytes.

26 Exemplar compounds feature a tertiary or quaternary ammonium group.

27 ct bacteria to model surfaces decorated with quaternary ammonium groups (known to kill bacteria that

28 a dissipative ion exchange process, converts quaternary ammonium groups in the hydrogel from hydrophi

29 of polymers bearing less chloramine-reactive quaternary ammonium groups with dipropylamino (DPA) subs

30 ariety of organic solvents stabilized with a quaternary ammonium halide salt.

31 Primary or quaternary ammonium ion looping strategies lead to large

32 he synthesis and properties of N-spirocyclic quaternary ammonium ionenes (spiro-ionenes) containing 5

33 efects interact with the structure-directing quaternary ammonium ions preferably close to the charge

34 bonding agents, and other resins containing quaternary ammonium methacrylates to suppress plaque bui

35 l mechanisms for chlorhexidine, nano-silver, quaternary ammonium methacrylates, and protein-repellent

36 he biotransformation of perfluorooctaneamido quaternary ammonium salt (PFOAAmS) was characterized by

37 the methylation of azatriquinacene to give a quaternary ammonium salt, followed by oxidation to the t

38 minal peripheral modification, introducing a quaternary ammonium salt, is reported and was found to p

39 Quaternary ammonium salts (QUATS), such as cetylpyridini

40 ynyl water-soluble Mannich bases and related quaternary ammonium salts were synthesized and investiga

41 Sequentially, the quaternary ammonium salts were treated with different nu

42 ion intermediates were investigated, and the quaternary ammonium salts, derived from alkyl halides an

43 alyzed borylation of two classes of aromatic quaternary ammonium salts, leading to versatile meta-bor

44 ratios to form mono- and bis-functionalized quaternary ammonium salts.

45 acidic sites and the conversion of amines to quaternary ammonium sites.

46 describe a bioreversible linkage based on a quaternary ammonium that can be used to connect a broad

47 sitive optodes based on an adsorbed layer of quaternary ammonium type anion exchanger and a phenolic

48 nts with functionalities such as betaine and quaternary ammonium was improved with the MeOH/NaOH base

49 the study highlights that surfactants, i.e., quaternary ammoniums in the positive ionization mode and

50 tidine scaffolds containing vicinal tertiary-quaternary and even quaternary-quaternary stereocenters.

51 ced glacial-interglacial cycles early in the Quaternary and for the change in their frequency about o

52 tudy the amyloid formation mechanism and the quaternary and secondary structure of soluble NFGAIL oli

53 nd isotope composition of alpha-HCH from the Quaternary and Tertiary aquifers were analyzed.

54 ed aldehydes and alkynes to generate vicinal quaternary and tertiary carbon stereocenters.

55 ia (Csy) surveillance complex leads to large quaternary and tertiary structural changes in the comple

56 rm from which sequential quaternary, one-pot quaternary, and sequential senary thiol-Michael reaction

57 five stereogenic centres-three of which are quaternary-and a decorated [3.2.2]-bridged bicycle.

58 nes into highly valuable glycosides having a quaternary anomeric position substituted by an allyl cha

59 hts into the HIV trimer, the target of these quaternary antibodies, has created invaluable new opport

60 iates in the biosynthesis of magnoflorine, a quaternary aporphine alkaloid common in plants.

61 Here we report the quaternary architecture of multi-domain retinoic acid re

62 lapI and helix alpha1c particularly modulate quaternary architecture, as well as ligand binding and k

63 nd coactivator peptides, which shows that NR quaternary architectures are variable.

64 ate show significant variations within their quaternary architectures, rather than a common architect

65 all 180 E protein copies, altering the virus quaternary arrangement and surface curvature.

66 e insight toward the development of foldamer quaternary assemblies with improved (bio)physical proper

67 ologically relevant scaffolds, such as alpha-quaternary beta-homo prolines and beta-lactams, are also

68 we identify sequence-dependent differential quaternary binding modes of the p53 tetramer interfacing

69 The quaternary binding preference of these antibodies sugges

70 beta-Ketonitriles bearing a quaternary carbon at the 2-position were prepared throug

71 tes of esters, to form products containing a quaternary carbon atom at the nucleophile moiety and a t

72 t contain two or more contiguous stereogenic quaternary carbon atoms in their intricate structures ar

73 ludes examples containing a bridgehead sp(3) quaternary carbon center as well as the cycloisomerizati

74 r the stereoselective generation of a chiral quaternary carbon center in the alkaloid scaffold is int

75 n of aldehydes along with the formation of a quaternary carbon center.

76 crylate, which enables the introduction of a quaternary carbon center.

77 1,4-dicarbonyl constitution together with a quaternary carbon center.

78 hly substituted cyclobutenes with contiguous quaternary carbon centers can be synthesized easily and

79 for altered reactivity and the formation of quaternary carbon centers.

80 transformations forming tetrasubstituted and quaternary carbon centers.

81 s containing alpha-tertiary as well as alpha-quaternary carbon centers.

82 ubstrates containing alpha-tertiary or alpha-quaternary carbon centers.

83 barbituric acid derivatives with an in-ring quaternary carbon in unprecedented enantioselectivity, o

84 omplex target structure is disconnected at a quaternary carbon stereocenter to fragments of comparabl

85 nophosphonates and to phosphonates bearing a quaternary carbon stereocenter.

86 tive methods for the construction of acyclic quaternary carbon stereocenters from achiral or chiral r

87 numerous asymmetric methods for formation of quaternary carbon stereocenters in cyclic systems have b

88 ubstituted hydroxylamines, the generation of quaternary carbon stereocenters through carbon-carbon co

89 been documented, the construction of acyclic quaternary carbon stereocenters with control of absolute

90 ketones to the enantioselective synthesis of quaternary carbon stereocenters would be highly valuable

91 olecular frameworks containing newly created quaternary carbon stereocenters.

92 Moreover, the introduction of a quaternary carbon was achieved by alkylation with ethyl

93 le to undergo nucleophilic ring opening at a quaternary carbon with complete inversion of the configu

94 ve configuration of spiroepoxides or related quaternary carbon-containing oxiranes can be troublesome

95 Its tetracyclic skeleton contains three quaternary carbons and is marked by several syn-pentane

96 rds tricyclic indolizidines that incorporate quaternary carbons and up to five stereocenters with goo

97 Alkenes bearing quaternary carbons at the allylic or homoallylic positio

98 d densely substituted tropanes incorporating quaternary carbons in good yields and with high regio- a

99 ss beta,gamma-unsaturated ketones containing quaternary carbons in the alpha-position.

100 multiple stereocenters, including contiguous quaternary carbons.

101 ich enables the one-pot preparation of alpha-quaternary carboxylic acids, esters, and amides with a h

102 polycystic kidney disease was referred to a quaternary care center due to significantly increased ab

103 ase in infectious disease consultations at a quaternary care children's hospital.

104 l transfers from community-based ICUs to the quaternary care hospital at Mayo Clinic, Rochester, MN.

105 Massachusetts General Hospital, an academic quaternary care hospital.

106 Patients from a large metropolitan quaternary care medical center with a diagnostic code of

107 Surgical suites at three academic quaternary-care hospitals were studied over a 1-year per

108 series of analogues bearing a C3' all-carbon quaternary center along with a C2'-F atom have also been

109 ring and the construction of the all-carbon quaternary center at the junction of the "BC" ring, resp

110 tion affords a variety of 2-oxindoles having quaternary center at the pseudobenzylic position in an o

111 l cascade process for installation of the C5 quaternary center common to the natural product class.

112 ates, sulfamides, and benzosultams bearing a quaternary center.

113 gement to control the stereochemistry at the quaternary center.

114 allows for the construction of tertiary and quaternary centers from simple alkene starting materials

115 The construction of quaternary centers is a common challenge in the synthesi

116 f bicyclic frameworks, generating all-carbon quaternary centers via multiple C-C bond formations in a

117 n a regioselective manner to form all-carbon quaternary centers with excellent levels of enantioselec

118 ed carbon atoms (i.e., tertiary alcohols and quaternary centers) are often not accessible in a direct

119 ed enones, including many bearing all-carbon quaternary centers, are available through a simple proto

120 rapid access to diverse sterically hindered quaternary centers.

121 stituted olefins to give products containing quaternary centers.

122 Differences between the genetic impacts of Quaternary climate cycles across continents suggest refi

123 ropean species to test for common impacts of Quaternary climate swings on genetic diversity across di

124 These events have been associated with Quaternary climatic cycles, leading to the hypothesis th

125 -binding protein, TFIIB and TFIIF can form a quaternary complex in the absence of promoter DNA, indic

126 Therefore, a 2:2 quaternary complex model grants a greater understanding

127 the cryo-electron microscopy structure of a quaternary complex of human CPSF-160, WDR33, CPSF-30, an

128 scopy, we have determined the structure of a quaternary complex of the translating Escherichia coli r

129 stal structure of the GAPDH1 holoenzyme in a quaternary complex providing the basis for the molecular

130 These surfaces allow ASF1A to form a quaternary complex with both sNASP and H3-H4.

131 1:1 binary complexes, are verified to be 2:2 quaternary complexes by a combination of isothermal titr

132 Formation of 2:2 quaternary complexes is favored by electron-donating sub

133 ed, trimeric, and it retains its native-like quaternary conformation exposing mostly broadly neutrali

134 troscopic studies reveal large Mg(2+)-driven quaternary conformational changes.

135 between amino acids, primary structures, and quaternary conformations of effector proteins and TPT we

136 o yield the corresponding 5,5-disubstituted (quaternary) derivatives remains essentially unsolved.

137 Some of the most potent bnAbs target a quaternary epitope at the apex of the surface HIV envelo

138 b 5J7 binds to a complex, 3-monomer spanning quaternary epitope in the DENV3 envelope (E) protein, bu

139 de that the hinge-spanning region of the 5J7 quaternary epitope is a target for serotype-specific neu

140 lementarity-determining regions to bind to a quaternary epitope on each side of the dimeric capsid sp

141 s revealed that ZIKV-117 recognized a unique quaternary epitope on the E protein dimer-dimer interfac

142 ding VRC01, VRC03, VRC-PG04, PGT128, and the quaternary epitope-specific bNAbs PGT145 and PGDM1400.

143 Quaternary epitopes at the apex of the spike are recogni

144 develop neutralizing antibodies that bind to quaternary epitopes formed by the viral envelope (E) pro

145 ies were ZIKV-specific and targeted EDIII or quaternary epitopes on infectious virus.

146 in is mainly a monomer that does not display quaternary epitopes, which may explain the modest succes

147 in vitro E-protein homo-dimers that display quaternary epitopes.

148 The late-Quaternary extinctions were natural experiments in large

149 coprolites has been used to reconstruct late-Quaternary floras.

150 s the Bahamas, surrounded by shallow oceans, Quaternary glacial-interglacial changes in climate and s

151 The driving force behind Quaternary glacial-interglacial cycles and much associat

152 ian icehouse, comparable in magnitude to the Quaternary glaciations.

153 merization domain to stabilize V1V2-mediated quaternary interactions, showed the highest homogeneity

154 ines containing a tertiary amine and forming quaternary intermediates destined for phthalideisoquinol

155 apply U-Pb geochronology to zircon from the Quaternary Kurobegawa Granite and Takidani Granodiorite

156 Quaternary megafaunal extinctions have been attributed t

157 Thus Pliocene-Quaternary melting of crustal rocks occurred at depths o

158 le and can be applied to produce ternary and quaternary metal oxide onions with tunable size and comp

159 ron-produced (18)F-fluoride was trapped on a quaternary methyl ammonium anion exchange cartridge, the

160 mplex in MeCN and purified using alumina and quaternary methyl ammonium solid-phase extraction cartri

161 aqueous multiphase systems (MuPSs) formed by quaternary mixtures composed of cholinium-based ionic li

162 oform solvents and their binary, ternary and quaternary mixtures.

163 ramelemorphian taxon that inhabited a latest Quaternary mosaic savannah-riparian forest ecosystem on

164 two highly conjugated diarylviologens in one quaternary motif affords the complexes enhanced conducta

165 e the cleavage of saturated alkyl chain from quaternary N via N-dealkylation reaction.

166 llowed by in situ treatment of the resultant quaternary N-(2-pyridyl)-DABCO salts with nucleophiles,

167 al exchange and alkylation rapidly assembles quaternary nitriles by three alkylations, only one of wh

168 tercept a variety of electrophiles to afford quaternary nitriles.

169 d between either methyl or alkyl ester and a quaternary nitrogen (N) of natural quaternary ammonium c

170 th (between mannose-mimicking headgroups and quaternary nitrogen centers) in modulating the DC-transf

171 While MAbs with specificity for quaternary NL trimer epitopes have provided one approach

172 ons provide a platform from which sequential quaternary, one-pot quaternary, and sequential senary th

173 osed of a Lewis base (amidine, guanidine, or quaternary onium salts) and a Lewis acid (triethyl boran

174 changes such as climatic oscillations in the Quaternary or by intrinsic biological interactions like

175 Finally, screening the quaternary organization of 60 native proteins identified

176 hat the dynamics of ligand regulation of the quaternary organization of G protein-coupled receptors i

177 come the stoichiometric imbalance, including quaternary organization of P450 and diffusion-limited mo

178 n tailoring reactions, yielding tertiary and quaternary pathway intermediates and products.

179 ng of glacial-interglacial cycles during the Quaternary period (the past 2.6 million years) is attrib

180 n the Eocene was similar to that of the late Quaternary period, this CO2 decline was sufficient to dr

181 ose substantially from the Ordovician to the Quaternary period, whereas the size of drilled prey rema

182 rties of BhCBM56, we propose that it binds a quaternary polysaccharide structure, most likely the tri

183 H followed by addition of an aldehyde led to quaternary protected 2-amino-2-vinyl-1,3-diols in high y

184 ave developed a novel methodology, QuartPAC (Quaternary Protein Amino acid Clustering), that identifi

185 re all mediated through nucleation of a core quaternary protein complex (SCL:E-protein:LMO1/2 [LIM do

186 iderable progress in using sequence data for quaternary protein structure prediction; they require, h

187 sequences but not on secondary, tertiary or quaternary protein structure.

188 taining vicinal tertiary-quaternary and even quaternary-quaternary stereocenters.

189 showing large-scale secondary, tertiary, and quaternary rearrangements compared with the prefusion tr

190 Mayo Clinic serves as quaternary referral care center for hospitals in the reg

191 included in the clinical database of a large quaternary referral center for genomic medicine in the N

192 evere droughts and heat waves could threaten quaternary relict tree refugia such as Circum-Mediterran

193 methane (CH4) varied with climate during the Quaternary, rising from a concentration of 375 p.p.b.v.

194 w small molecules can interact with specific quaternary RNA structures.

195 Late Quaternary separation of Britain from mainland Europe is

196 cally active gamma-lactam of protected alpha-quaternary serine derivative.

197 Spontaneous quaternary SNARE complex assembly is very slow.

198 , tertiary (three-dimensional structure) and quaternary (specific protein-protein interactions).

199 mouse tissues and cell lines to identify the quaternary state(s) of TBCD and ARL2.

200 e(gem-difluorocyclopropanes) incorporating a quaternary stereocenter and a protected glycolic acid mo

201 Fused azabicycloalkane scaffolds, carrying a quaternary stereocenter at C3 position of the lactam rin

202 ighly convergent assembly at the challenging quaternary stereocenter of these dimeric alkaloids.

203 ion with an N-acyliminium ion to set the C10 quaternary stereocenter, a mild dissolving-metal cleavag

204 two stereocenters, including one all-carbon quaternary stereocenter, generally with excellent diaste

205 advanced intermediate that introduces the C5-quaternary stereocenter.

206 tereochemical configuration of an all-carbon quaternary stereocenter.

207 s at challenging linkages and the associated quaternary stereocenters as illustrated in our synthesis

208 we describe the generation of remote allylic quaternary stereocenters beta, gamma, and delta relative

209 The vicinal all-carbon quaternary stereocenters having trans relative stereoche

210 to deliver products with diaryl and triaryl quaternary stereocenters in high yields and ee's.

211 formation of acyclic CF3-bearing all-carbon quaternary stereocenters in the absence of stoichiometri

212 I) substrates were used to construct the C20-quaternary stereocenters of multiple monoterpene indole

213 ycyclic architectures containing one or more quaternary stereocenters render these alkaloids syntheti

214 or the construction of adjacent tertiary and quaternary stereocenters with excellent diastereocontrol

215 rocess, which provides a direct way to forge quaternary stereocenters with high fidelity, relies on t

216 to five contiguous stereocenters (including quaternary stereocenters).

217 olycyclic core containing vicinal all-carbon quaternary stereocenters.

218 viable enantioenriched 2-oxindoles with C-3 quaternary stereocenters.

219 o generate diastereopure products containing quaternary stereocenters.

220 substituted cyclopropanes bearing all-carbon quaternary stereocenters.

221 ive stereochemistry of the two newly created quaternary stereocenters.

222 ducts bearing difluoromethylated tertiary or quaternary stereocenters.

223 install the seven-membered ring and vicinal quaternary stereocentres of the natural product.

224 newly formed vicinal tertiary and all-carbon quaternary stereodyad.

225 ss to products bearing an allylic all-carbon quaternary stereogenic center has been developed.

226 of prochiral enolates to form an all-carbon quaternary stereogenic center with an aliphatic-substitu

227 o completely controlled introduction of four quaternary stereogenic centers and guided the assembly o

228 access to key new functionalities, including quaternary stereogenic centers bearing moieties such as

229 ' carbon-carbon bonds and all the associated quaternary stereogenic centers.

230 in order to create mechanical strain on the quaternary structural level.

231 sting and drug transport states, revealing a quaternary structural switch that allosterically couples

232 cture ofSdGluc5_26A adopts a stable trimeric quaternary structure also observable in solution.

233 Quaternary structure analysis of other members of the st

234 to 10 A, HAP18 caused only minor changes in quaternary structure and actually decreased the capsid d

235 xplored the impact of phosphorylation on the quaternary structure and dynamics of Hsp27.

236 The quaternary structure and dynamics of the human small hea

237 The rod adopts a helical quaternary structure and is thought to play essential ro

238 The SAXS data capture the enzyme's quaternary structure and suggest a conformational rearra

239 t in subunit orientation leads to a peculiar quaternary structure compared with that of its ortholog

240 triphosphate, MnCl2, and tartrate, but their quaternary structure did not conform to the canonical pa

241 neutralize ZIKV and DENVs recognize complex quaternary structure epitopes displayed on E-homo-dimers

242 duce recombinant E protein dimers displaying quaternary structure epitopes is an important advance wi

243 Both antibodies bound to quaternary structure epitopes near the hinge region betw

244 ind that hemoglobin must be in the T (tense) quaternary structure for nucleation, but the presence of

245 oteins in any case when cofactor assembly or quaternary structure formation occurs after transport.

246 dification are well established, controlling quaternary structure formation remains a significant cha

247 ional clustering while utilizing the protein quaternary structure in 3D space.

248 , and in vivo data support the importance of quaternary structure in RNA-mediated regulation of targe

249 However, difficulties in engineering protein quaternary structure into stable and well-ordered shapes

250 the AQP family, the signature homotetrameric quaternary structure is conserved.

251 bits nucleus formation even when the correct quaternary structure is present.

252 AP-2 in the BiFC assay, indicating that Nef quaternary structure is required for CD4 and AP-2 recrui

253 with its analogous epitope, a discontinuous quaternary structure located at the surface of the viral

254 Thus, the quaternary structure of BRAF complexes is shaped by its

255 Because the quaternary structure of ENaC is yet undetermined, the ba

256 ial role in modulating both the tertiary and quaternary structure of Hsp27, which is pivotal to its f

257 design of novel GR ligands and redefine the quaternary structure of steroid receptors.

258 In this work, we have characterized the quaternary structure of the ABCD1 and ABCD2 proteins in

259 g site, the DNA-binding domain of GR and the quaternary structure of the dimeric complex.

260 although they have major differences in the quaternary structure of the ligand-binding domain.

261 SPOUT enzymes, Trm10 does not share the same quaternary structure or key sequences with other members

262 The different quaternary structure results in an incompletely formed s

263 small-molecule inhibitor (JNJ525) induces a quaternary structure switch of TNFalpha that inhibits th

264 operidol, resulted in re-organization of D3R quaternary structure to promote monomerization.

265 hexameric ring destabilization, and discrete quaternary structure transitions.

266 of B. thailandensis DNase II shows a dimeric quaternary structure which appears capable of binding do

267 nal analysis of E1E2 secondary, tertiary and quaternary structure with functional and immunological m

268 n domain architecture, oligomeric state, and quaternary structure, and these variations represent dif

269 ges were correlated with changes in the GMPR quaternary structure, induced by the binding of GMP, GTP

270 nd KNH1144 T162A, did not present the glycan/quaternary structure-dependent epitope for PGT145 bindin

271 ities, including targeting of polysaccharide quaternary structure.

272 o probe internal chromophores as a marker of quaternary structure.

273 well as for predicting protein function and quaternary structure.

274 uence to secondary, tertiary, and ultimately quaternary structure.

275 e accounting for the complete folded protein quaternary structure.

276 led me to propose a structural model for its quaternary structure.

277 rs to be separable from the alteration in gB quaternary structure.

278 sidues that are critical for stabilizing the quaternary structure.

279 nterface rather than generating all putative quaternary structures as accomplished by PISA or EPPIC,

280 c disulfide bonds to impart defined tertiary/quaternary structures for the formation of binding pocke

281 rotein dimers, existing in several different quaternary structures in infected hepatocytes, participa

282 The H-tube's highly repetitive primary and quaternary structures made it amenable to a genetic anal

283 nding on their interaction with the distinct quaternary structures of core protein.

284 nanes, knots, and cages, have shown that the quaternary structures of proteins are a prerequisite for

285 The secondary, tertiary, and quaternary structures of squid hemocyanin (Hc) were char

286 c proteins fold and assemble into functional quaternary structures remains unclear.

287 dumbbell-shaped, zipper-like and multi-loop quaternary structures were formed selectively.

288 ear is whether XEEL and hIntL-1 have similar quaternary structures, as XEEL lacks the corresponding c

289 n implemented, including SALIGN, modeling of quaternary structures, DOPE scores, disulfide bond model

290 rotein misfolding and toxicity via different quaternary structures, suggesting a means to generate mo

291 h to the creation of complex abiotic peptide quaternary structures.

292 principles involving secondary, tertiary and quaternary structures.

293 t lie next to bulky domains or are masked by quaternary structures.Importin alpha3 facilitates the nu

294 f an efficient enantioselective synthesis of quaternary-substituted thiazolines through the organo-ca

295 The formation of a quaternary supramolecular assembly [GH2 (2+) BB(4+) (CB7

296 of the structural ordering in such a complex quaternary system has been a great challenge, especially

297 Our proposed Quaternary test statistic incorporates all available evi

298 Most studies focus on a Quaternary timeframe, but the Neogene is well represente

299 res, which then form tetrahedral and diamond quaternary topologies with unprecedented complexity.

300 o the corresponding isoxazolidines bearing a quaternary trifluoromethyl moiety.