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1 ng the possible preservation of the original quaternary structure.
2 idase to chaperone involves changes in their quaternary structure.
3 sidues that are critical for stabilizing the quaternary structure.
4 ed without impact on secondary, tertiary, or quaternary structure.
5 oth regarding ligand binding and the protein quaternary structure.
6 e the same functional properties within each quaternary structure.
7 the equilibrium toward an amyloid-resistant quaternary structure.
8 C, slow chromophore formation and obligatory quaternary structure.
9 tive manner, which most likely is due to its quaternary structure.
10 guous domain assignments and reveal a linear quaternary structure.
11 ities, including targeting of polysaccharide quaternary structure.
12 s a-g), which combine to form a 24-mer (4x6) quaternary structure.
13 However, SInv displays an unusual quaternary structure.
14 transcriptional regulation by regulating its quaternary structure.
15 dence for assembly blockade of the RRM1-RRM2 quaternary structure.
16 change in tertiary but not net secondary or quaternary structure.
17 Da) and which constitute the doughnut-shaped quaternary structure.
18 bling the polypeptide chains into the native quaternary structure.
19 this superfamily (CAX(CK31)) and analyze its quaternary structure.
20 wo days, and is therefore uncoupled from the quaternary structure.
21 e bond results in a loss of peptide fold and quaternary structure.
22 ne residues enriched with (13)C to probe its quaternary structure.
23 ese sera mainly recognize native molecule or quaternary structure.
24 oligomerization to form a highly intertwined quaternary structure.
25 TR-Abeta interaction strongly depends on TTR quaternary structure.
26 o probe internal chromophores as a marker of quaternary structure.
27 e E1 components with an alpha(2) homodimeric quaternary structure.
28 well as for predicting protein function and quaternary structure.
29 led me to propose a structural model for its quaternary structure.
30 uence to secondary, tertiary, and ultimately quaternary structure.
31 e accounting for the complete folded protein quaternary structure.
32 rs to be separable from the alteration in gB quaternary structure.
33 ion while retaining overall protein fold and quaternary structure.
34 , to address key questions regarding laminin quaternary structure.
35 revealing its unique integrated tertiary and quaternary structure.
36 ignificantly different void volumes in their quaternary structure.
37 Both classes exhibit a dimeric quaternary structure.
38 een proteins constitute the basis of protein quaternary structures.
39 h native dimer or tetramer (dimer-of-dimers) quaternary structures.
40 mbling into 2D lattices and other prescribed quaternary structures.
41 the same fast and slow rates in both R and T quaternary structures.
42 nce in hemoglobin oxygen affinity of the two quaternary structures.
43 ween more reactive (R) and less reactive (T) quaternary structures.
44 n contacts, indicating similar secondary and quaternary structures.
45 stable signaling machines with well-defined quaternary structures.
46 q reflects the equilibrium between different quaternary structures.
47 by unique interactions with distinct ligand quaternary structures.
48 crystallized, capable of taking on multiple quaternary structures.
49 tantially different secondary, tertiary, and quaternary structures.
50 ptides display undistorted four-helix bundle quaternary structures.
51 f protein interfaces to predict most dimeric quaternary structures.
52 h to the creation of complex abiotic peptide quaternary structures.
53 principles involving secondary, tertiary and quaternary structures.
54 roteins assemble into complexes with diverse quaternary structures.
55 y of the D3 receptor and possibly other GPCR quaternary structures.
61 to 10 A, HAP18 caused only minor changes in quaternary structure and actually decreased the capsid d
64 s, we generated alpha-syn standards of known quaternary structure and conformational properties and c
65 ) unfavorably alter the heme environment and quaternary structure and destabilize the alpha1beta2 int
68 ategies, however, are limited by adiponectin quaternary structure and effective concentrations in cir
69 guingly, one subfamily retained a multimeric quaternary structure and has small insertions and deleti
70 ential to test the hypothesized link between quaternary structure and heme heterogeneity in wild-type
71 l role in promoting the stability of protein quaternary structure and in the assembly of large macrom
73 resentative structures revealed that loss of quaternary structure and large deletions or insertions a
74 According to the proposed model, spectrin's quaternary structure and mechanism of extension is simil
75 y identified protein-DNA contacts within the quaternary structure and reveal hitherto unknown roles f
78 TET2 dodecameric particle displayed the same quaternary structure and thermal stability as the wild-t
79 oth kinds of homodimers adopt a head-to-tail quaternary structure and thus do not contain direct knob
80 studying the relationship between chemokine quaternary structure and various aspects of function.
81 two sHsps are strikingly different in their quaternary structures and chaperone properties, defining
82 crete protein-like bundles possessing unique quaternary structures and exceptional thermodynamic stab
83 The recent achievements concerning tertiary/quaternary structures and the self-assembling foldameric
84 timate relationships among protein assembly, quaternary structure, and evolution and demonstrate on a
85 n domain architecture, oligomeric state, and quaternary structure, and these variations represent dif
86 ity, RNA substrate preference, processivity, quaternary structures, and auxiliary domains vary signif
87 f flavin-binding proteins with a dodecameric quaternary structure, are able to incorporate two flavin
88 s that DnaB adopts a closed spiral staircase quaternary structure around an A-form ssDNA with each C-
90 nterface rather than generating all putative quaternary structures as accomplished by PISA or EPPIC,
91 nalysis of primary, secondary, tertiary, and quaternary structures as well as the dynamics that accom
93 ear is whether XEEL and hIntL-1 have similar quaternary structures, as XEEL lacks the corresponding c
95 ed changes in protein higher order (tertiary/quaternary) structure at the picogram level, which is un
96 receptor-induced conformational changes, and quaternary structure-based strategies for immune evasion
97 transcarbamoylase exists in an intermediate quaternary structure between the canonical T and R struc
98 generally well-accommodated in helix-bundle quaternary structure, but that such replacements can be
99 e of Escherichia coli ATCase locked in the R quaternary structure by specific introduction of disulfi
100 pportive evidences that the space of protein quaternary structures can be represented by the combinat
102 hysical characterization indicates that this quaternary structure change is not accompanied by substa
105 Archaeal DHNA shows a unique secondary and quaternary structure compared with bacterial and plant D
106 t in subunit orientation leads to a peculiar quaternary structure compared with that of its ortholog
107 mn using the bNAb PGT145, which recognizes a quaternary structure-dependent epitope at the trimer ape
108 nd KNH1144 T162A, did not present the glycan/quaternary structure-dependent epitope for PGT145 bindin
109 s; cleaved, SOSIP-stabilized trimers express quaternary structure-dependent epitopes, whereas uncleav
110 at the intra-dimer interface, and the virus quaternary structure-dependent inter-dimer and inter-raf
111 triphosphate, MnCl2, and tartrate, but their quaternary structure did not conform to the canonical pa
112 acetate decarboxylase, though the respective quaternary structures differ markedly and structural dif
113 of a class I terpenoid cyclase, its dimeric quaternary structure differs from that previously observ
115 n implemented, including SALIGN, modeling of quaternary structures, DOPE scores, disulfide bond model
116 hese results indicate that aberrant myocilin quaternary structure drives Grp94 recognition, rather th
117 y, suggesting the formation of an asymmetric quaternary structure during sequential ligation of subst
118 topes, whereas alloimmunogens lacking native quaternary structure elicited antibodies to shared alpha
119 temperature, concentration, and primary and quaternary structure, employing an instrument of our own
120 proteolysis at different rates, dependent on quaternary structure environment, while particle stabili
121 tralize DENV infection by binding a complex, quaternary structure epitope that is expressed only when
122 neutralize ZIKV and DENVs recognize complex quaternary structure epitopes displayed on E-homo-dimers
123 duce recombinant E protein dimers displaying quaternary structure epitopes is an important advance wi
125 to further evaluation of their effect on the quaternary structure equilibrium and enzymatic activity.
126 is associated with human PBGS variants whose quaternary structure equilibrium is shifted toward the h
127 oteins is found to be useful for identifying quaternary-structure errors in published crystal structu
128 t these mutants retain the same tertiary and quaternary structures, establishing that the reduced act
129 of holoenzyme complexes can create distinct quaternary structures even though the R(1):C(1) heterodi
130 show that SAA1.1 and SAA2.2 differ in their quaternary structure, fibrillation kinetics, prefibrilla
131 ind that hemoglobin must be in the T (tense) quaternary structure for nucleation, but the presence of
133 that relying solely on previously determined quaternary structures for homologous proteins may not be
134 oligomers, although the significance of such quaternary structures for signaling or receptor traffick
135 c disulfide bonds to impart defined tertiary/quaternary structures for the formation of binding pocke
136 oteins in any case when cofactor assembly or quaternary structure formation occurs after transport.
137 dification are well established, controlling quaternary structure formation remains a significant cha
141 but the atomic details of TRIM tertiary and quaternary structure have not been fully understood.
143 -ssDNA complex reported here shows a compact quaternary structure held together by a four-way interfa
144 t lie next to bulky domains or are masked by quaternary structures.Importin alpha3 facilitates the nu
149 , and in vivo data support the importance of quaternary structure in RNA-mediated regulation of targe
151 d to retain the ability to form a tetrameric quaternary structure in which the individual molecules a
152 sistent with the D3 receptor also assuming a quaternary structure in which two transmembrane domain I
153 rotein dimers, existing in several different quaternary structures in infected hepatocytes, participa
155 epresentations to include dynamic aspects of quaternary structure, including conformational changes u
156 comprise a protein family that forms diverse quaternary structures, including pentamers and 60-subuni
157 /T19C and N21C/A22C) converged onto the same quaternary structure, indicating that the disulphide-cro
158 ges were correlated with changes in the GMPR quaternary structure, induced by the binding of GMP, GTP
159 However, difficulties in engineering protein quaternary structure into stable and well-ordered shapes
162 proteins assemble into dodecamers and their quaternary structure is entirely critical to their funct
164 y are generally dimers or tetramers, and the quaternary structure is linked to substrate affinity.
166 AP-2 in the BiFC assay, indicating that Nef quaternary structure is required for CD4 and AP-2 recrui
167 it has been found that the space of protein quaternary structures is highly degenerate due to the pa
168 ly determined database of all representative quaternary structures is not likely in the near future.
169 a ds-DNA-binding protein functioning at the quaternary structure level and regulated by Ca(2+) ions.
171 with its analogous epitope, a discontinuous quaternary structure located at the surface of the viral
172 The H-tube's highly repetitive primary and quaternary structures made it amenable to a genetic anal
174 and dimers, morin affected the tertiary and quaternary structure of Abeta, even at low concentration
175 observations suggest that disruption of the quaternary structure of alpha1A/B-AR:CXCR4 heteromeric c
178 ectron microscopy (cryo-EM) to determine the quaternary structure of an active complex of DNA-bound E
182 The new QUAFIT method for determining the quaternary structure of biological macromolecular assemb
185 ethods for determining the stoichiometry and quaternary structure of complexes of macromolecules in l
193 incorporate additional flexibility into the quaternary structure of highly populated multienzyme com
195 ial role in modulating both the tertiary and quaternary structure of Hsp27, which is pivotal to its f
201 of potential differences in the tertiary and quaternary structure of protein reference standards is a
205 er are distinct, supporting a model in which quaternary structure of the 2:2 ChpT-CtrA complex enforc
206 the role of Ca(2+) in the modulation of the quaternary structure of the A(2A)-D(2) receptor heterome
208 meropathy" that involves perturbation of the quaternary structure of the alpha345NC1 hexamer, inducin
209 utational approaches to not only address the quaternary structure of the beta subunits within the PhK
212 and TM6, which also selectively modified the quaternary structure of the D1R-D3R heteromer, as demons
215 at unique positions required to maintain the quaternary structure of the gp160 trimer, as well as con
216 stal structure of TDO shows a dimer of dimer quaternary structure of the homotetrameric protein.
219 , our data suggest how tetramers, the native quaternary structure of the mammalian CBS enzymes, are f
222 PLM phosphomimetic mutations altered the quaternary structure of the regulatory complex and reduc
224 of immunoediting, in which modulation of the quaternary structure of the secreted tumor-specific anti
225 terminus is an important determinant of the quaternary structure of the SERCA regulatory complex.
227 derive a detailed, experimentally-supported quaternary structure of the spectrin heterotetramer.
228 a liposomal preparation strongly support the quaternary structure of the transmembrane helical bundle
230 tional changes in gp120 and gp41, changes in quaternary structure of the trimer have only recently be
236 cate that while the secondary, tertiary, and quaternary structures of CsoR and RcnR are quite similar
238 Here we determine the oligomeric states and quaternary structures of four bacterial P5CDHs using a c
240 s the potential of utilizing IM-SID to study quaternary structures of protein complexes and provides
241 nanes, knots, and cages, have shown that the quaternary structures of proteins are a prerequisite for
243 ciation pathway that we link directly to the quaternary structures of the precursor ions selected.
244 ans by which alterations in the tertiary and quaternary structures of the WCC can lead to its distinc
245 he protomers within protein complexes (i.e., quaternary structure) of membrane receptors and transpor
246 SPOUT enzymes, Trm10 does not share the same quaternary structure or key sequences with other members
247 osteric mechanisms, including changes to the quaternary structure or large, rigid-body conformational
248 tanding of the general principles underlying quaternary structure organization in protein complexes.
250 hese results have important implications for quaternary structure prediction, modeling, and engineeri
251 ent protein interactions in terms of protein quaternary structure, protein-protein and protein-ligand
252 ns among beta-sheets occur widely in protein quaternary structure, protein-protein interaction, and p
253 f gnathostomes and cyclostomes, multisubunit quaternary structures provide the basis for cooperative
255 and suggests the possibility of dissociating quaternary structures regulating novel functions of othe
259 vestigate the very different explorations of quaternary structure space that have occurred in differe
265 zymes are known to have similar tertiary and quaternary structure, subtle differences in structure, a
266 rotein misfolding and toxicity via different quaternary structures, suggesting a means to generate mo
267 f receptors and also have markedly different quaternary structures, suggesting that the CXC/CC motif
268 small-molecule inhibitor (JNJ525) induces a quaternary structure switch of TNFalpha that inhibits th
270 n solution adopts a stable tertiary fold and quaternary structure that is consistent with previously
271 is consistent with a dimer of dimer protein quaternary structure that now extends to the electronic
272 se of P. denitrificans by a hitherto unknown quaternary structure that was first modeled here by stru
273 ein characterized by a variety of infectious quaternary structures that can propagate stably and fait
274 an important feature of protein tertiary and quaternary structures that has been associated with prot
276 ral and functional properties, including the quaternary structure, the tertiary structure, and the li
277 ubunits, intermolecular interactions lead to quaternary structure--the ordered aggregation of separat
278 at they resemble LigD POL in their monomeric quaternary structures, their ability to add templated an
280 ein monooxygenase and is similar in fold and quaternary structure to MtmOIV and OxyS, which are enzym
282 ructure, and the Polyomino model for protein quaternary structure-to a simple random null model that
284 curately predict the expected frequencies of quaternary structure topologies, including those not yet
291 processes ranging from acquisition of native quaternary structure (where the association is tightly c
292 HA, have disparate secondary, tertiary, and quaternary structures, where some regions are displaced
293 of B. thailandensis DNase II shows a dimeric quaternary structure which appears capable of binding do
295 therefore appear to be a consequence of its quaternary structure, which is required for increased th
296 uperfamily, has an exceptional homodecameric quaternary structure with a molecular mass of about 500k
297 nal analysis of E1E2 secondary, tertiary and quaternary structure with functional and immunological m
299 The tetrameric enzyme assumes an unusual quaternary structure with the dinucleotides positioned q
300 we study the formation of preferred protein quaternary structures within such rapidly evaporating na
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