ライフサイエンスコーパス: quencher

1 two aniline derivatives as electron donors (quenchers).

2 leading to separation of the fluorophore and quencher.

3 s as an energy quencher and a singlet oxygen quencher.

4 this mechanism as a light sensor and energy quencher.

5 acts both as the photosensor and the energy quencher.

6 3 is quenched by both AuNP and the molecular quencher.

7 ted by cations deposited by the hydride hole quencher.

8 ature results obtained with EtOH as the hole quencher.

9 ry DNA oligomers labeled with a fluorescence quencher.

10 i SL was tagged with a 5' fluorophore and 3' quencher.

11 arnosic acid, rather than carnosol, is a ROS quencher.

12 d 2,4-dinitrophenyl-lysine (Lys(DNP)) as the quencher.

13 antisense oligonucleotide strand carrying a quencher.

14 the pigment acting as the non-photochemical quencher.

15 hairpin 8-17 DNAzyme sequence labeled with a quencher.

16 beta-clamp was labeled with a nonfluorescent quencher.

17 osure of reaction intermediates to a dynamic quencher.

18 acII, and is attached to a fluorophore and a quencher.

19 of complementary sequence 3'-labeled with a quencher.

20 using AuNPs/graphene oxide nanocomposite as quencher.

21 e-BHQ2 conjugates were employed as the guest/quencher.

22 reasing the distance between the dye and the quencher.

23 ce of Cs(+) used as an excited singlet state quencher.

24 ed with a near-infrared (NIR) dye and a dark-quencher.

25 ridine complex that acts as a photoremovable quencher.

26 in vitro, OCP is a very good singlet oxygen quencher.

27 egradation of Trp acting as a sensitizer and quencher.

28 ensemble assays, validating the use of dark quenchers.

29 acellular photocleavage of the 2-nitrobenzyl quenchers.

30 he presence of either oxidative or reductive quenchers.

31 itative diffusion coefficients for the amine quenchers.

32 ing a series of amines of different sizes as quenchers.

33 sulfoxides do not always act as fluorescence quenchers.

34 und fluorescence through the use of selected quenchers.

35 site in the protein interior, shielded from quenchers.

36 um 2-naphthalenesulfonate (2-NPS) as triplet quenchers.

37 lso contain gold nanoparticles that serve as quenchers.

38 idues into close contact with intramolecular quenchers.

39 polar side-chains that act as intramolecular quenchers.

40 d they proved to be very good singlet oxygen quenchers.

41 (MB) probes labeled with one or two pyrenes/quenchers.

42 3) were shown to be very good singlet oxygen quenchers.

43 lacks carotenoids and other known accessory quenchers.

44 noparticle, MMP2-recognized polypeptides and quenchers.

45 nching was achieved with either an oxidative quencher (1,4-benzoquinone) or a reductive quencher (N,N

46 A membrane impermeant quencher, 2,4,6-trinitrobenzene sulfonic acid, or lipid-

47 generation Raman probe, based on BlackBerry Quencher 650 compound, which provides unprecedentedly hi

48 ingle-population models; rather, a two-state quencher accessibility algorithm was required to model a

49 uorophore was used to map the diffusion of a quencher across the microchannel.

50 is turned on by rapid removal of the quinone quencher, an event that immediately occurs only after hi

51 Dual fluorescence quencher analysis showed that both helices 6 and 7 adopt

52 or consists of a DNA enzyme strand with a 3' quencher and a DNA substrate with a ribonucleotide adeno

53 ntary photoprotective functions as an energy quencher and a singlet oxygen quencher.

54 mogeneous assays utilizing fluorogenic donor/quencher and AlphaScreen chemiluminescence strategies.

55 proach allowed taking the best advantages of QUENCHER and confirmed this method as ideal for industri

56 ties such as catalytic activity, fluorescent quencher and electrochemical, high surface area, and oxy

57 eled oligonucleotides are employed, with the quencher and fluorophore placed on separate complementar

58 d probe is terminated at the 5' end with the quencher and the complement is terminated at its 3' end

59 nding on the separation distance between the quencher and the enhancer.

60 First, hydrophobic interactions between the quencher and the MGB bring the ends of the probe and, th

61 of QDs was quenched quickly upon addition of quencher and the reaction reached equilibrium within 2 m

62 iggered a release of the DNA strand with the quencher and thus relief of the contact quenching, resul

63 e much larger for the neutral versus anionic quenchers and close to predicted values.

64 by UA was significantly reduced by both ROS quenchers and JNK inhibitor.

65 resence of target receptors able to bind the quenchers and prevent electron transfer, however, the lu

66 t additives, including excited-triplet-state quenchers and scavengers of singlet oxygen as well as gr

67 nism of indirect photolysis was probed using quenchers and sensitizers, and results suggest that daid

68 lting in release of the fluorophore from its quenchers and thus a significant increase in fluorescenc

69 s in fluorescence emission, accessibility to quencher, and cleavage by either trypsin or V8 proteases

70 labeled with a fluorophore, 3'-tagged with a quencher, and designed to form a hairpin that mimics rad

71 t <nmax> depends on the identity of the hole quencher, and is thus not an intrinsic property of the m

72 wavelength, bimane exposure to fluorescence quenchers, and antibody binding to BODIPY groups.

73 de complementary to this tail, carrying a 3'-quencher ("anti-primer"), is included in the PCR along w

74 uring the process of transglycosylation, the quencher-appended polyprenol is released and the fluores

75 owdered RWPSs were used directly as samples (QUENCHER approach).

76 iguration in which the fluorophore and the G quenchers are apart.

77 Dark quenchers are chromophores that primarily relax from the

78 Dark quenchers are extensively used in many biomolecular anal

79 ization step, no external radical sources or quenchers are needed to provide the products.

80 Dark fluorescence quenchers are nonfluorescent dyes that can modulate the

81 Singlet oxygen and free radical quenchers as well as the removal of oxygen inhibited CAL

82 e donor and acceptor at the loop ends, and a quencher at an alpha-helical element involved in the nod

83 r Na(+) by labeling the enzyme strand with a quencher at the 3' end, and the DNA substrate strand wit

84 y3 fluorophore at the 5' end and a molecular quencher at the 3' end.

85 orophore at the 5'-end and a non-fluorescent quencher at the 3'-end of the DNA sequence.

86 ses, a fluorophore unit at the 5'-end, and a quencher at the 3'-end.

87 e (rA) in the middle and a fluorophore and a quencher at the 5' and 3' ends, respectively.

88 NA substrate strand with a fluorophore and a quencher at the 5' and 3' ends, respectively.

89 onucleotide probe contains a non-fluorescent quencher at the 5' end and fluorophore attached to the 3

90 cytoplasmic domain of CLS and the nitroxide quencher attached to the lipid bilayer, we showed that t

91 e intramolecular DNA hybridization, move the quencher away from the fluorophore, and, in effect, swit

92 modified with a spectrally paired black-hole quencher (BHQ).

93 use of a nonfluorescent quencher (Black Hole Quencher, BHQ) as an acceptor for smFRET.

94 oustic signal arose from the least absorbing quenchers, BHQ3 and QXL 680.

95 Here we report the use of a nonfluorescent quencher (Black Hole Quencher, BHQ) as an acceptor for s

96 igonucleotide having a 5'fluorophore and a 3'quencher brought in close proximity by the secondary str

97 d enhanced S/B window over particles without quenchers but that continued to show the essential prope

98 that the proximity of a fluorophore and dark quencher can be monitored using the stoichiometry ratio

99 Thioamide quenchers can be paired with compact fluorophores to des

100 ction--suggesting dynamic replacement of the quencher-complementary strand by IFN-gamma molecules.

101 new family of trinuclear CuRe(2) chromophore-quencher complexes having the general form [Cu(pyacac)(2

102 Use of selective probe and quencher compounds suggest hydroxyl radical and triplet

103 much larger than the diffusion limit at low quencher concentration in RTILs originate from a neglect

104 probe without quencher conjugation, the dye/quencher-conjugated activatable monolithic peptide probe

105 out that fluorescence activation of the dye/quencher-conjugated monolithic peptide probe requires du

106 ways fluorescent' iRGD control probe without quencher conjugation, the dye/quencher-conjugated activa

107 rared (NIR) fluorochrome IRDye 800CW, with a quencher connected through the lactam ring that is hydro

108 rease in fluorescence intensity as cytosolic quenchers contacted dye-labeled substrates.

109 During PCR, a quencher coupled to isoguanine (isoG) is site-specifical

110 ounds identified previously as triplet state quenchers, cyclooctatetraene, and Trolox, as well as 4-n

111 ng 1-4 pyrene monomers on the 5' end and the quencher DABCYL on the 3' end, were engineered and emplo

112 A fluorescent donor (Edans) and quencher (Dabcyl) pair was added to the C- and N-termini

113 strands with a fluorophore (fluorescein) and quencher (dabcyl).

114 Triplet quenchers did not affect the photochemical transformatio

115 nation of Hg(2+) to GSH/Cys, the fluorophore/quencher distance increases concomitantly with the dehyb

116 e aptamer/analyte complex, which induced the quencher dye close to the DNAzyme structure.

117 A quencher dye was modified at the 3' end of the aptamer s

118 design, a probe is partially blocked with a quencher dye-labeled oligonucleotide, and target hybridi

119 stem was used to test the performance of the quencher dye.

120 catalyzed chemiluminescence reaction and the quencher dye.

121 vity is determined using a channel-permeable quencher (e.g., thallium, Tl(+)) of a water-soluble fluo

122 rds labeled with two fluorophores and a dark quencher (either QSY7 or QSY21), we show that the proxim

123 , viscosity, and/or presence of fluorescence quenchers/energy acceptors within several nanometers of

124 -sn-glycero-3-phosphocholine as fluorescence quenchers, evidence has been obtained for a membrane-bou

125 anoparticles (Fe3O4 NPs) act as an efficient quencher for boron dipyrromethene-conjugated adenosine 5

126 ligand for the folate receptor as well as a quencher for doxorubicin's fluorescence.

127 o prepared gold nanoparticle (GNP) acts as a quencher for fluorescein isothiocyanate (FITC).

128 This suggests that DOM is an especially good quencher for HO(*), reacting at rates close to the diffu

129 ng a sensor containing inorganic oxides as a quencher for Nile Red dye.

130 e-stranded DNA and an efficient fluorescence quencher for reducing the background signal.

131 een helices I and II, and a Cys residue as a quencher for the acceptor.

132 terferometer, acting as both the fluorescent quencher for the FRET and the sensitive cladding for opt

133 fluorophores and demonstrate the use of dark quenchers for monitoring multiple interactions and dista

134 By generalization, additional candidate quenchers for Nile Red were identified based on Lewis ac

135 uced copolymers conjugated with fluorescence quenchers (FQs).

136 The method relies upon quencher-free DNA forced intercalation (FIT)-probes, in

137 nding between messenger RNA and multilabeled quencher-free MBs based on Glowing LNA monomers is demon

138 ration of efficient hybridization probes and quencher-free MBs.

139 s via a phosphorylation-induced release of a quencher from a peptide-based substrate, producing a 150

140 rescence signal due to the separation of the quencher from the fluorophore.

141 tide leads to separation of fluorophore from quencher, giving a proportional increase in fluorescence

142 acceptor-labeled protein and quenching with quencher gold nanoparticles and fluorescently labeled pr

143 native ligand and an analogue tagged with a quencher group to both populate and discriminate the exc

144 l)ethylenediamine (EDDnp) as fluorophore and quencher groups, respectively, have been widely used to

145 and separation of the fluorescent donor and quencher groups.

146 A singlet oxygen quencher had no effect on the rate of formation of the e

147 no systematic single-molecule study of dark quenchers has been performed, and little is known about

148 yield, but the role of potential side-chain quenchers has not yet been elucidated.

149 When the same quenchers have access to both leaflets, they quench 70-8

150 Although the advantages of dark quenchers have been exploited for ensemble bioassays, no

151 A short, complementary quencher hybridizes to unincorporated primer upon coolin

152 ith the aptamer, keeping the fluorophore and quencher in close proximity, thus switching off the fluo

153 robe and, therefore, the fluorophore and the quencher in close proximity.

154 T8-MB-T8 placed the fluorophore unit and the quencher in proximity to each other and caused collision

155 gues with a dimethylamino-azobenzenesulfonyl quencher in the lipid chain and a coumarin fluorophore i

156 e been proposed: energy transfer to a lutein quencher in trimers, formation of a zeaxanthin radical c

157 enoids are considered to be the main (1)O(2) quenchers in chloroplasts, and we show here that light s

158 rst systematic single-molecule study of dark quenchers in conjunction with fluorophores and demonstra

159 lose proximity to side chains of natural Trp quenchers in either the inward- or outward-facing confor

160 s illustrate the potential of nonfluorescent quenchers in single-molecule correlation studies.

161 se product (pNC) acts as "plate fluorescence quencher" in white solid-bottom plates.

162 proximately 355 nm and accessible to aqueous quenchers, indicating free exposure to the aqueous milie

163 rget sequence due to a disruption in the MGB-quencher interaction and concealment of the MGB moiety i

164 are connected using poly T, which brings the quencher into close proximity with the fluorophore in th

165 a noninterfering, nondiffusable fluorescence quencher into previously described cosonicate particles,

166 In microinjection experiments, delivery of quenchers into the cytosol efficiently quenched the fluo

167 labeled with the fluorophore IRDye 800CW and quencher IRDye QC-1 to yield the biomolecular probe Pan8

168 substrates were prepared by conjugating the quencher, IRDye QC-1, to a GDEVDGAK peptide in combinati

169 with the fluorophore and independent of the quencher is able to provide a modest (2-4-fold) quenchin

170 A very popular dark fluorescence quencher is dabcyl, which is a hydrophobic azobenzene de

171 Joint action of the MGB and the quencher is the basis for the unique quenching mechanism

172 rease of the pyrene emission, induced by the quencher, is hardly reflected in the pyrene excimer emis

173 Using Fc as a quencher label on a complementary DNA sequence, an intra

174 Because dark-quencher-labeled biomolecules can be used in total-inter

175 nalyte, a single-stranded DNA (ssDNA), and a quencher-labeled ssDNA competed for hybridization with a

176 ent from a tripartite substrate containing a quencher-labeled template strand, an unlabeled primer an

177 ynthesized with 5'-TYE 665 and 3'-Iowa Black quencher labels for comparison of fluorescence levels as

178 Se NCs in the presence of a borohydride hole quencher, Li[Et3BH], yields colloidal n-type CdSe NCs po

179 con (MB) is comprised of a fluorophore and a quencher linked by a DNA hairpin.

180 ing increased susceptibility to quenching by quenchers located in the lipid milieu, indicative of lip

181 In addition to molecular quenchers, many nanomaterials such as graphene oxide (GO

182 d compared to a classical single-fluorophore/quencher MB system.

183 The QUENCHER method is a time and cost-saving extraction-fre

184 DNAzyme-catalyzed cleavage of a fluorophore/quencher-modified substrate leads to a fluorescence read

185 ting assembled DNAzyme cleaves a fluorophore/quencher-modified substrate to yield fluorescence.

186 The cleavage of two different fluorophore/quencher-modified substrates by the respective DNAzymes

187 -labeled oligonucleotides, containing both a quencher moiety and a fluorophore, were attached to the

188 n, which separated the pyrene label from the quencher molecule and generated an excimer emission sign

189 ons, owing to the addition of a pH-sensitive quencher molecule paired with a static fluorophore.

190 ing can become an issue after cleavage since quencher molecules can quench cleaved fluorophore molecu

191 actions between the MOF surface and cationic quencher molecules coupled with rapid energy transfer th

192 le in providing access by electron deficient quencher molecules to the excited states within the fibe

193 n frequency between the fluorophores and the quencher molecules.

194 fter postsynthetically modified with dye and quencher molecules.

195 e quencher (1,4-benzoquinone) or a reductive quencher (N,N,N',N'-tetramethylbenzidine), as a result o

196 mer-functionalized quantum dots blocked by a quencher nucleic acid (detection limit 1 nM).

197 nd FpC) have been synthesized along with the quencher nucleosides possessing 6-{4-[(4-dimethylamino)a

198 a tunable electrophile and an intramolecular quencher of an attached dansyl fluorophore.

199 )2]4+ and show this dimer to be an effective quencher of device luminescence.

200 Oxygen is an efficient quencher of emission of many phosphorescent compounds, t

201 .OH formation upon addition of catalase as a quencher of endogenous H(2)O(2).

202 naquinone-8(H(2))], which probably acts as a quencher of energy transfer under oxic conditions, was a

203 ion limited, scavenger of singlet oxygen and quencher of excited photosensitizers.

204 9.0 as well as in the presence of Cs(+) as a quencher of excited singlet 4-Cl-aniline at pH 7.0 and 9

205 acterial dodecin a comparably less efficient quencher of flavins.

206 suggesting that carnosic acid is a chemical quencher of ROS.

207 Sodium azide, a collision quencher of singlet oxygen, reduced the magnitude of FAL

208 triplet state so it can act as an effective quencher of singlet oxygen.

209 idazole and hydroxide ion are also effective quenchers of p-cyanophenylalanine fluorescence with Ster

210 Quenchers of triplet excited states are thus required to

211 Experiments with s-BQ quenchers of two different sizes reveal that the degree

212 5'-labeled with a fluorophore and a shorter quencher oligo of complementary sequence 3'-labeled with

213 h of hybridization probe, (ii) the length of quencher oligo, (iii) the molar ratio between the two st

214 The relative lengths of the fluor-oligo and quencher-oligo, and their relative concentrations were o

215 otide with a fluorophore on the 5' end and a quencher on the 3' end, and processing of this substrate

216 is designed by labeling a fluorophore and a quencher on the DNAzyme.

217 c probe systems, placing the fluorophore and quencher on the same nucleobase facilitates the design o

218 Understanding the impact of specific quenchers on DOM could be a key to understanding the tru

219 on the electrostatic adsorption of cationic quenchers on the surface of anionic quantum dots.

220 nsfer (FRET) between conjugate and graphene (quencher) only in 10 min.

221 by culturing cells in the presence of a ROS quencher or in an anaerobic environment.

222 ds conjugated to a near-infrared fluorophore/quencher pair (IRDye 800CW/IRDye QC-1) with efficient co

223 resent results obtained with the fluorophore-quencher pair 9,10-dimethylanthracene/N,N-dimethylanilin

224 probes composed of a stem, with fluorophore/quencher pair and a loop region complementary to the des

225 DNA structure and with attached fluorophore-quencher pair at the ends of the strand has been applied

226 endent optical properties of the fluorophore/quencher pair attached to the ends of the molecular beac

227 DNA NanoBeacons labeled with the fluorophore/quencher pair Cyanine 5/BHQ2.

228 Snap-to-it probes labeled with a fluorophore-quencher pair exhibited target-dependent fluorescence en

229 an inverted repeat containing a fluorophore-quencher pair into a plasmid to enable real-time monitor

230 The selection of a suitable fluorophore and quencher pair permits the generation of substrates that

231 pendent membrane leakage assay using the dye/quencher pair, 8-aminonapthalene-1,3,6 trisulfonic acid

232 ensor is designed by attaching a fluorophore/quencher pair, detecting Nd(3+) down to 0.4 nM (72 parts

233 DNA substrates labeled by a fluorophore and quencher pair, the UNG activity was measured based on UN

234 es ranged from 40 to 83 depending on the dye/quencher pair.

235 rformed with a voltage-dependent fluorophore/quencher pair.

236 cing the emission of an attached fluorophore/quencher pair.

237 applying it to the isotopologous fluorophore-quencher pairs pyrene/DMA and pyrene-d10/DMA.

238 Each cleavage event separates fluorophore quencher pairs resulting in an increase in fluorescence.

239 st of DNA hairpins conjugated to fluorophore-quencher pairs that unfold and fluoresce when subjected

240 Here we use two donor-quencher pairs to observe and correlate both the conform

241 es are calculated as 41 to 65A for these dye/quencher pairs.

242 sequences that are modified with fluorophore-quencher pairs.

243 ential quenching for the various fluorophore/quencher partners.

244 ent quenching of ECL compared with the known quenchers phenol and 1,1-dimethyl-4,4'-bipyridine dicati

245 riments allowed characterization of the dark-quencher photophysical properties at the single-molecule

246 Antioxidant capacities were determined using QUENCHER procedure.

247 quenching of five fluorophores ("F") by six quenchers ("Q"; electron donors) are reported in acetoni

248 uorescent dye, Alexa Fluor 647, and the dark quenchers, QSY9 and QSY35, respectively, to generate For

249 Reduction of the phenoxyl radical by the quencher radical was examined as the analogue of the red

250 High concentrations of triplet quenchers relative to that of dioxygen produced only sma

251 The beneficial properties of the reductive quencher release design make these probes promising cand

252 its 5' and 3' ends with QDs and a black hole quencher, respectively.

253 eavage of the peptide removed the N-terminal quencher, resulting in fluorescent beads, which were iso

254 of energy trapping by the non-photochemical quencher(s) is lower than the efficiency of energy captu

255 ng a significant background, the use of dark quenchers should permit single-molecule Forster resonanc

256 sic fluorescence by DNA and external dynamic quenchers shows that the observed tyrosine fluorescence

257 combination with vitamin C as singlet oxygen quencher significantly improved survival of 3T3 fibrobla

258 and chemical transformation of this internal quencher site by reaction with CN(-) elicits a rapid (k

259 duction was suppressed by the singlet oxygen quencher sodium azide, and as mRNA expression of LMNA wa

260 to identify the (3)dd state as intermediate quencher state of the (3)MLCT luminescence in the non-lu

261 of light-harvesting antennas with accessory quenchers such as carotenoids.

262 trizoate in the presence of specific radical quenchers (tert-butanol and methanol) had a similar effe

263 CP is not more efficient as a singlet oxygen quencher than a protein without carotenoid.

264 groups are much more effective fluorescence quenchers than protonated amino groups.

265 We used 3.5-nm gold nanoparticles as a quencher that absorbed emission from UCNPs at a waveleng

266 rinitrobenzene sulfonic acid, or lipid-based quenchers that are restricted to the exofacial leaflet o

267 These are triplet-state quenchers that operate via photoinduced electron transfe

268 The specific action of TDP1 removes the quencher, thereby enabling optical detection of the fluo

269 An ROS quencher, thiourea, protected cells from antibiotics pre

270 irradiated regions where it escapes a strong quencher, thus visualizing the edge of a mask.

271 ed using a gA channel-permeable fluorescence quencher (Tl(+)).

272 MMP2 and then be unravelled by the attached quencher to emit visible light.

273 rhodium enolate complex acts as a reductive quencher to initiate a radical process with the aryl azi

274 gest that the 4-formylphenyl group acts as a quencher to suppress the fluorescence of the 6-methoxy-2

275 internalizing sequence (CendR motif), and a quencher to the opposite C-terminal.

276 Our results showed that SWNTs are great quenchers to singlet oxygen generation (SOG).

277 We also use dark-quenchers to study the affinity and kinetics of binding

278 range effects limit the accessibility of the quenchers to the Trp side chains in the proteins; and 6)

279 n with the membrane-impermeable fluorescence quencher trypan blue to selectively image internalized a

280 olvents of differing polarities or by adding quenchers under high viscosity to evaluate the transient

281 ses, a fluorophore unit at the 5'-end, and a quencher unit at the 3'-end.

282 amer subunits result in the digestion of the quencher units and the autonomous recycling of the analy

283 em, GO was used as an efficient fluorescence quencher upon the adsorption of MBs, which reduced the b

284 y of rhodamine spirolactam as a fluorescence quencher via electron transfer, and the slow kinetics of

285 tamers were raised against the aniline-based quencher via in vitro selection (SELEX).

286 rded, and a solution of membrane impermeable quencher was passed through the flow cell to quench the

287 A membrane-impermeant quencher was used to distinguish intra-PL NBD-CQ from ex

288 tioxidant Trolox, and as pyrene-fluorescence quenchers, was compared in the three emulsions.

289 (change), which lead to the creation of the quencher We conclude that the minimum requirements for N

290 ing a series of substituted borohydride hole quenchers, we show that it is possible to increase the n

291 olestatrienol, and a variety of fluorescence quenchers, we studied the transbilayer distribution of s

292 rk, a "broken beacon" in which the fluor and quencher were located on separate but complementary olig

293 fications and flanked with a fluorophore and quencher, were activated upon degradation by purified MN

294 nched by the interaction of terminal dye and quencher when not hybridized.

295 magnetic 'enhancer' and a superparamagnetic 'quencher', where the T1 magnetic resonance imaging (MRI)

296 ization of a MB using graphene oxide (GO) as quencher, where an amino and FAM (6-carboxyfluorescein)

297 ASP design utilizes both a fluorophore and a quencher which are respectively modified at the two term

298 phenomenon transpires via interaction of the quencher with Arg residues positioned on the peptide sub

299 and synthesized a new azobenzene-based dark quencher with excellent solubility in aqueous media, whi

300 and increased susceptibility to collisional quenchers without causing similar effects on tested mamm