ライフサイエンスコーパス: question as to

1 Treg cell-specific Dicer ablation, raised a question as to a specific miRNA contribution.

2 As such, these fossils pose major questions as to growth patterns, functional morphology,

3 RNase E and RNase G orthologues, raising the question as to how 16S rRNA processing occurs in these o

4 ent absence of physiological cues raises the question as to how and why MYRF is processed.

5 This poses the critical question as to how DNA replication can progress through

6 These findings have raised the question as to how E-proteins exert these different acti

7 is not significantly amplified, raising the question as to how ErbB3 overexpression is achieved.

8 for GATA-1 in megakaryopoiesis and raise the question as to how GATA-1 influences megakaryocyte matur

9 This prompts the question as to how macrophages infiltrate obese adipose

10 zymes and biosynthetic routes underscore the question as to how major jumps in the biosynthetic route

11 then to form dorsal appendages, raising the question as to how Notch activity is spatially and tempo

12 h narrow constrictions at one end, leaving a question as to how protons enter the channel.

13 HIV-1 infection of CD4 T cells, raising the question as to how quiescent lymphocytes, representing a

14 carefully regulated spiking times poses the question as to how spike timing-based dynamics may suppo

15 highlighted role of T cells in IRI raises a question as to how T lymphocytes interact with the innat

16 tion occurs in a Cdc42-dependent manner, the question as to how the beta cell utilized RhoGDI for dif

17 This raises the question as to how the DNA gets into the central channel

18 f biochemical network motifs, and raises the question as to how these effects are managed in real bio

19 t) behavioral responses in vivo, raising the question as to how these growth factors affect individua

20 ld strength transmission lines prompting the question as to how these high levels of exposure affect

21 This raises the question as to how these Ints bind their DNA substrates,

22 This raises the fundamental question as to how these PDZ domains discriminate ligand

23 ntal cortex in the case of value, raises the question as to how they are integrated during human deci

24 , multi-synaptic cortical loops, begging the question as to how they coordinate their outputs in real

25 However, the question as to how to achieve timely introduction of pea

26 Referring physicians were questioned as to how the additional information provided

27 They also raise questions as to how a dimeric receptor functions when on

28 neurons is controversial, leaving unanswered questions as to how and where Parkin-mediated mitophagy

29 he findings in animal models now raise major questions as to how B cells and Abs carry out these func

30 aureus and Bo. burgdorferi CoADRs, but leave questions as to how BACoADR can interact with both pyrid

31 This central role of cells frames the basic questions as to how cells work and how cells come to be

32 the backbone of mismatched DNA, raising new questions as to how clamp domains enhance mismatch recog

33 e genetic nature of these experiments leaves questions as to how direct may be their contribution to

34 These recent findings raise intriguing questions as to how enduring changes at synapses are acc

35 e onerous nature of section 7 but also raise questions as to how federal agencies could apply this to

36 63) pore (approximately 12 angstroms) raises questions as to how large molecules such as LF and EF ca

37 ed stimulus presentations raises provocative questions as to how noncoincidence is detected and repre

38 These recent findings raise exciting questions as to how proteasomal activity can regulate sy

39 a common phosphorylation site motif, raising questions as to how substrate specificity is achieved.

40 been shown to evolve very rapidly, prompting questions as to how such changes arise and are tolerated

41 ty of viruses promises to answer fundamental questions as to how the activity and recruitment of the

42 aged humans, there are still many unanswered questions as to how the genetic pathways that regulate a

43 ernative roles in cells, raising interesting questions as to how the responses to the interferons int

44 nearly every single cell of the body raises questions as to how this gives rise to rhythmic physiolo

45 s strongly associated with asthma, there are questions as to how this relates to asthma symptoms.

46 These observations raise serious questions as to how to achieve the rational design of a

47 pora inhabits nitrogen-fixing nodules raised questions as to its potential ecological role.

48 multiple effects on cell functions, raising questions as to its suitability for this purpose.

49 This poses a question as to the exact role of different amygdala nucl

50 and, if it is nitrogen as nitride, raises a question as to the existence of a family of molecular ir

51 These and other recent reports raise the question as to the metabolic role of glutamate in gastri

52 These findings raise the question as to the potential mechanisms of JNK1 activati

53 unction architectures and answers a critical question as to the role of the anion and excess organic

54 of the TRC40 receptor subunits and raise the question as to the role of the excess CAML in the mammal

55 hilic or electrophilic addition, raising the question as to the timing and mechanism of proton loss f

56 new cases are still being reported, raising questions as to the ability to identify patients likely

57 eukaryotic N-glycosylation pathways, raising questions as to the basic architecture and detailed func

58 tor-expressing cells directly but leave open questions as to the basis for the recruitment of central

59 These differences raise questions as to the certainty of T/F HCV genome inferenc

60 (MMPs) are structurally homologous, raising questions as to the degree of distinction, or overlap, i

61 the substrate specificity of ZK896.9 raises questions as to the evolutionary ancestry of this group

62 decreases in total translation, which raises questions as to the evolutionary expression of GEF compl

63 s and 4% of endemic (African) cases, raising questions as to the exact role EBV in the disease.

64 f an intriguing regulatory network and poses questions as to the functional compatibility and specifi

65 enetic mark of repressed chromatin and raise questions as to the functional distinctiveness of differ

66 olubilised under some conditions have raised questions as to the generality of this phenomenon and th

67 This work poses intriguing questions as to the genetic and molecular nature of the

68 ne and cytoplasmic domains in cubilin raises questions as to the means by which it can mediate endocy

69 om Tyr194 in the glycogenin structure raises questions as to the mechanism for the attachment of the

70 ]3 homotrimer has not been detected, raising questions as to the mechanism of chain assembly and why

71 ic MHC Ags is weak in rodent livers, raising questions as to the mechanisms that might control respon

72 The problem raises fundamental questions as to the nature and interrelation of pathways

73 is and hypertriglyceridemia in mice, raising questions as to the net effects of these compounds on th

74 These data raise fundamental questions as to the origin and evolution of tyrosine pho

75 review highlights, there are common research questions as to the origin and spread of the viruses, th

76 Our findings raise important questions as to the possible roles of divalent metals in

77 onship of this symbiont to R. montana raised questions as to the potential origin of pathogenic SFG r

78 Unanswered questions as to the regulatory mechanisms and routes rem

79 stinguishable from dopamine neurons, raising questions as to the reliability of past findings.

80 he bulge cycle abnormally, raising important questions as to the role of 14-3-3sigma in the bulge.

81 before apoptosis induction raise interesting questions as to the role of BCL-xL in conferring apoptos

82 ate and not always present, which raises new questions as to the role of cellular inflammation in ear

83 from human and mouse studies together raise questions as to the role of microglia in disorders of br

84 xpressed in Prochlorococcus, raising further questions as to the role of phycobilins in the host and

85 uring obesity, starvation and exercise raise questions as to the role of stearoyl-coenzyme A desatura

86 New questions as to the safety and effectiveness of a laparo

87 osition via precipitation worldwide, raising questions as to the sources of high Arctic Hg loading.

88 Furthermore they raise interesting questions as to the spatial organization of protein degr

89 However, there are questions as to the stability of this procedure over mul

90 lt in substantial amino acid changes raising questions as to their biological consequence.

91 nctions as independent polypeptides, raising questions as to their evolutionary derivation.

92 rgans but are abundant in the liver, raising questions as to their function in immune responses to in

93 not in its central catalytic domain raising questions as to their impact.

94 ms ranging from prokaryotes to humans raises questions as to their structural and evolutionary relati

95 ID in gene expression raises the fundamental question as to what extent, if any, TAF1 contributes to

96 The question as to what proportion of this complexity is tru

97 ired for their initiation, but it is an open question as to what the sources of those inhomogeneities

98 The question as to what triggers stomatal closure during lea

99 ements in cellular infrastructure raises the question as to what ultimately limits the level of molec

100 Our data raise intriguing questions as to what drove the loss of both Mx1 and Mx2

101 e important for weight regulation but raises questions as to what self-reported sleep duration is mea

102 ts is often a contiguous helix, thus raising questions as to what the linker contributes and what def

103 We have addressed the question as to where this equilibrium is established for

104 This raises questions as to where the pathology in HD begins and als

105 These studies have also raised the question as to whether 'catch up' growth following early

106 lamellar vesicles (SUV), they leave open the question as to whether a similar pattern is followed by

107 This raises the intriguing question as to whether a single administration of cocain

108 ons associated with this procedure raise the question as to whether all low-risk patients need a comp

109 alian aging, however, and it remains an open question as to whether and to what extent the pathways t

110 In particular, question as to whether animal movement is predominantly

111 This raises the question as to whether arthropods do not express specifi

112 The question as to whether chromosomal DNA replication also

113 We pose the question as to whether clinical trials could be modified

114 sordered protein complex and leaves open the question as to whether completely disordered dimers (or

115 This raises a fundamental question as to whether delayed relaxation and/or stiffen

116 y times in ferric and ferrous Mbs raises the question as to whether electron transfer may also be ope

117 This variability raises the question as to whether estimates of the time taken for (

118 The question as to whether FA heterozygotes are at increased

119 merase and repair enzymes in vitro raise the question as to whether Fapy.dG elicits similar effects i

120 These results raise a significant question as to whether fatty acids differentially modula

121 d surfaces via the adhesin FimH, raising the question as to whether FimH forms catch bonds that are s

122 to G6Pase in vitro is disputed, raising the question as to whether G6P is a physiologically importan

123 It is still an open question as to whether genome size (GS) variation is sha

124 t directly impact health directly raises the question as to whether global measures of genomic variat

125 tion.SIGNIFICANCE STATEMENT There is an open question as to whether human amygdala function tracks th

126 uinidine, a selective I(K) blocker, raises a question as to whether I(K) consists of two components t

127 ole in retinal progenitor cells, raising the question as to whether Ikaros/Hunchback proteins could b

128 However, this raises the question as to whether individuals with sensitive feet b

129 It remains an open but important question as to whether innate restriction factors such a

130 on euarthropod relationships centers on the question as to whether insects, crustaceans, and myriapo

131 This raises the question as to whether it is possible to build a safer g

132 lf is not located in mitochondria raises the question as to whether LFG in the ER participates in Fas

133 nsistent with memory precursors, raising the question as to whether loss of Id2 impairs the different

134 ansformations of main-group species pose the question as to whether metal catalysts could be avoided

135 membrane interaction, posing an interesting question as to whether modifying the tips of tubes may h

136 This begs the question as to whether mosquito feeding assays should be

137 We therefore raised the question as to whether myeloid cell-mediated T cell supp

138 This raises a question as to whether or not the entire I(K) passes thr

139 ity of the complex, it is still an unsettled question as to whether or not these continuum solvation

140 rferon and NF-kappaB signalling, raising the question as to whether other host factors participate in

141 RNA synthesis by HCV polymerase, raising the question as to whether our phosphoramidate ProTide appro

142 Although it remains an open question as to whether oxidative stress is a causative f

143 oviding CD28 costimulation, which raises the question as to whether p110delta activity plays a role i

144 Thus, it remains an open and important question as to whether p53 inhibits HIF-1alpha-mediated

145 ts of a possible genetic predisposition, the question as to whether patients with tardive dystonia ha

146 The presence of this maximum raises the question as to whether plants regulate transpiration thr

147 ion to the infectious form, thus raising the question as to whether proteasome inhibitors might facil

148 rotein tyrosine kinase 2 (Pyk2), raising the question as to whether Pyk2 also participates in driving

149 These opposing inputs raise the key question as to whether reduced Sac3 protein levels and/o

150 Thus, we examined the question as to whether Rrn3 functions catalytically or s

151 4 is still unknown, even regarding the basic question as to whether S4 is close to the pore domain.

152 eories of affective disorders and raises the question as to whether SERT and NET exhibit a functional

153 irable satellite droplets and also raise the question as to whether similar dynamical transitions ari

154 present in all aerobic organisms raises the question as to whether SOD is absolutely required for an

155 This raised an intriguing question as to whether sphingolipids are involved in pat

156 hown in a few mammalian species, raising the question as to whether such a high-level function may be

157 rs of the MAPK pathway prompts the important question as to whether such inhibitors might be therapeu

158 plete responses of up to 25% have raised the question as to whether surgery can be avoided in a selec

159 ne materials, the NMR solution data pose the question as to whether the absence of solvent shifts ind

160 It has been a long-standing question as to whether the activation of Notch by its li

161 ifiable into four major syndromes, raise the question as to whether the deficiencies are primary or s

162 This raises the question as to whether the enhanced excitability produce

163 ., insulin), the present study addressed the question as to whether the enhancing effect of sleep on

164 However, the question as to whether the full-length type I IL-1 recep

165 a1 with p53, the present study addressed the question as to whether the functions of h-TRbeta1 could

166 These findings from early studies raised the question as to whether the ghrelin system is an essentia

167 logues found in human gut bacteria raise the question as to whether the indole-3-acetic acid degradat

168 sive mitral valve surgery to help answer the question as to whether the minimally invasive approach s

169 bation of atherosclerosis, which prompts the question as to whether the monocytosis in childhood obes

170 An important nutritional question as to whether the ratio of omega-6 (n-6) to ome

171 approximately GapLength, and thus raises the question as to whether the read length (as opposed to Ga

172 This finding raises the question as to whether the reduction in cytotoxicity and

173 between NUP98/NSD1 and FLT3/ITD, raising the question as to whether the reported poor outcome is due

174 ression of the huntingtin protein raises the question as to whether the selective vulnerability of th

175 This raises the question as to whether the telomerase subunit was presen

176 To address the question as to whether the UVM response is accompanied b

177 gions of the human genome, thus inviting the question as to whether the virus has evolved mechanisms

178 ns can occur in a single tubulin allele, the question as to whether the wild-type and mutant transcri

179 This finding raises the question as to whether there are uncharted opportunities

180 ure and prevented renal lesions, raising the question as to whether these beneficial effects of insul

181 us-specific plasmablast responses raises the question as to whether these cells might have a role in

182 This raises the question as to whether these essential RNA processing fu

183 embrane-bound phagosomes, there remains some question as to whether these phagosomes fuse with macrop

184 s populate the meninges, raising the central question as to whether these structures relate to the B

185 ter activity in B cells, there has been some question as to whether these two octamer-binding factors

186 ary progressive multiple sclerosis raise the question as to whether they actually represent separate

187 ing of the T cell repertoire have raised the question as to whether they are produced intrathymically

188 ols and bipolar subjects, which raises a key question as to whether this alteration represents an ada

189 This reactivity raised the question as to whether this class of chelate is redox-ac

190 of GP IIIa and coronary syndromes raise the question as to whether this inherited variation may cont

191 steinyl-tRNA synthetase (CysRS), raising the question as to whether this latter aminoacyl-tRNA synthe

192 Antigen specificity of RTL raises the question as to whether this treatment would be successfu

193 It has been questioned as to whether polyplexes in the cytoplasm can

194 It has been rarely questioned as to whether the enrichment of specific bact

195 The results raise further questions as to whether abasic lesions are noninstructiv

196 This raises questions as to whether and to what degree currently ava

197 Although these results raise questions as to whether cellular transformations derive

198 Our findings also do only raise questions as to whether cholesterol-induced condensation

199 The review raises questions as to whether elderly patients entered on clin

200 erations that accompany tumour genesis raise questions as to whether experimental cancer-promoting mu

201 s a bona fide transcription factor and raise questions as to whether HSP2 serves as a functional prom

202 is listed as a provisional entity because of questions as to whether it is truly a disease or just an

203 rk with 8-chloro-cAMP (8-Cl-cAMP) has raised questions as to whether it works as a cAMP analogue or a

204 These observations raise questions as to whether multiple TGFbeta isoforms partic

205 Here, we address questions as to whether novelty-induced PRPs are able to

206 ls cost and higher efficiency, but there are questions as to whether the intrinsic stability of mater

207 carcinogenesis remain obscure, and there are questions as to whether the methylation changes are a ca

208 hesis, and raise important but controversial questions as to whether the same mechanisms could also r

209 s with several mumps virus MNVTs have raised questions as to whether the test can reliably discrimina

210 ility of tip links to acoustic trauma raises questions as to whether these fragile structures can be

211 in a majority of clinical cancers has led to questions as to whether these observations are causally

212 ever, different lines of investigation raise questions as to whether these views are fully correct.

213 n tetraploid complementation assays, raising questions as to whether they are sufficiently potent to

214 dely and, in some cases, are absent, raising questions as to whether they define a universal, or even

215 n a large number of different sHsps, raising questions as to whether they function redundantly or are

216 This situation raised questions as to whether this shift in technique was appr

217 This observation raises questions as to whether this suppression results from a

218 cytoplasmic compartment of the cell, raising questions as to whether vaccinia virus has access to nuc

219 There is a long-standing question as to which factors regulate these events.

220 These structures raise questions as to which form may exist in solution and wha

221 ere defects than do FN-null embryos, raising questions as to which integrin(s) are the key FN recepto

222 have clarified less and in fact raised more questions as to which mode of FGF2 dimerization, if any,

223 encoding during working memory, raising the question as to why mnemonic encoding is observed during

224 This raises an important question as to why mutagenesis studies indicate that an

225 These observations raise the question as to why Q(1) does not spontaneously undergo i

226 vely slow, which is part of the more general question as to why rearrangements of intermediates occur

227 high prevalence of HHV-8 in PBMC raises the question as to why there is no evidence for bloodborne v

228 Such an extent of conservation raises the question as to why, in contrast to all other shuttle pro

229 m, is currently of great interest and raises questions as to why HSC subtypes exist, how they are gen

230 he known speed of sound in proteins, raising questions as to why it is not apparent in computational