ライフサイエンスコーパス: question of how

1 specificity are counterselected, raising the question of how 4E10 was generated in the patient from w

2 cell Ag presentation to T cells raising the question of how a B cell might respond when presented wi

3 This work resolves an open question of how a key class of suspension-feeding organi

4 This opens the question of how a large subset of American states might

5 ness and self-renewal potential, raising the question of how a mutant HSC can sustainably outcompete

6 y doubles its cellular contents, raising the question of how a phagocyte may manage the excess metabo

7 These observations beg the question of how a single amino acid mutation may have su

8 c advances have helped answer the intriguing question of how a single molecule, such as a hormone, ca

9 To help answer the question of how a single receptor can recognize and resp

10 tissue-specific roles for ILCs; however, the question of how a small population has large effects on

11 The question of how a vapor-liquid interface affects freezin

12 ial hydrogen peroxide (H2O2), leading to the question of how Aa deals with this potent antimicrobial

13 This discrepancy begs the question of how AAV2 and HSV-1 can coexist in a cell pop

14 This raises the question of how actin polymerization occurs at the integ

15 This study reopens the question of how adenovirus enters cells in vivo.

16 This raises the question of how adhesion assembly occurs against opposit

17 The question of how allostery works was posed almost 50 year

18 We focus on the challenging questions of how allostery can both cause disease and co

19 The question of how, and how fast, magnetization can be reve

20 a simple water-filled pore, which raises the question of how anomalous water behavior affects the mec

21 these major human diseases, the fundamental questions of how apoE adjusts its structure upon binding

22 olutely require kinase activity, raising the question of how Arg might modulate actin assembly and tu

23 Our structure answers the key questions of how ATP hydrolysis leads to linker remodell

24 o bacteria, in particular with regard to the question of how bacteria generate and coordinate forces

25 the conducting bulk, providing input to the question of how ballistic transport may be limited in th

26 However, the question of how barites were able to precipitate from a

27 ous by their absence, leaving unresolved the question of how beak movements are affected during singi

28 y multiparameter time series and raising the question of how best to extract insights from such rich

29 The increasing use of TRT raises the question of how best to integrate TRT into multimodality

30 cases of donor-derived infections raise the question of how best to screen donors without excessive

31 Conflicting findings led to questions of how best to study the role of this variant

32 l interventions, were identified, along with questions of how best to use this body of information to

33 The fundamental question of how bone quality is affected in AIS remains

34 eration in different cell types, raising the question of how broadly mTOR regulates axonal regrowth a

35 rylates S84 as early as S phase, raising the question of how Cdk prevents inappropriate activation of

36 The question of how cell division orientation is determined

37 However, the question of how cells establish and maintain a specific

38 This raises the question of how cells orchestrate the timing of multiple

39 l system in which to investigate the general question of how cells regulate organelle size.

40 on can be substantially stochastic poses the question of how cells respond to dynamic environments us

41 tanding biofilm development, the fundamental question of how cells sense the environmental cues that

42 e use neural crest (NC) cells to address the question of how cells that have down-regulated cell-cell

43 We addressed the questions of how cerebral glucose transport and phosphor

44 They allow focus to be placed solely on the question of how changes in amino acid side-chain orienta

45 Here we address the long-standing question of how chaperones recognize client proteins.

46 Herein we address the question of how cholesterol crystal formation occurs in

47 romatin states in gene regulation, but a key question of how chromatin state segmentations vary under

48 The phenomenon raises important questions of how chromosome rearrangements can be confin

49 hbours are observed, and poses a fundamental question of how complex interactions on the triangular l

50 The main focus lay on the question of how complex object use compared with unspeci

51 astic downstream actuators, which raises the question of how coordinated response to a single input c

52 several PCs at the same position raised the question of how developmental time controlled muscle ide

53 extension helped to address the outstanding question of how DifA receives input signals from type 4

54 pts of recollection and familiarity, and the question of how different medial temporal lobe structure

55 Here, the intriguing question of how diffusion evolves in a single nanopartic

56 umption of an animal meal, we here asked the question of how Dionaea sequesters prey-derived potassiu

57 mary visual cortex (V1) circuitry, yet basic questions of how direction-selective (DS) receptive fiel

58 tion are expressed in gradients, raising the question of how discrete domains are generated.

59 The question of how dispersed mutations in one protein engen

60 across distantly related plants, raising the question of how diverse inflorescence architectures aris

61 ions, provides a tantalizing solution to the question of how diverse life can survive glaciations.

62 Considerable interest surrounds the question of how DNA glycosylases translocate efficiently

63 However, the question of how DNA is folded and the influence of such

64 DPP signaling but also highlight outstanding questions of how DPP coordinates patterning and growth d

65 This leads to the question of how each segment of lymphatic vessel respond

66 The question of how each tradition can learn from the other

67 We address the questions of how egg-associated cues elicit plant defens

68 To address the question of how endogenous glucocorticoids might influen

69 s lack of neurogenesis leaves unanswered the question of how enteric neuronal populations are maintai

70 These findings raise the question of how enzymes with such different evolutionary

71 of p38 MAP kinase, which posed the important question of how Epac2 engages p38 without simultaneously

72 ium entry (SOCE) regulation, the fundamental question of how ER morphology affects this process remai

73 osylase has not been identified, raising the question of how extracytoplasmic proteins are repaired a

74 e genitals has always been acknowledged, the question of how far these categories extend into human b

75 they explored a large arena, focusing on the question of how flies remain near the food.

76 However, the fundamental question of how force regulates actin dynamics is unclea

77 dividual DNA-binding enzymes, presenting the question of how formation of such structures is controll

78 Over a decade of studies have tackled the question of how FtsK/SpoIIIE translocases establish and

79 hin a common nondelimited space, raising the question of how functional compartmentalization of gene

80 mic data on human cancers poses the critical question of how genomic variations translate to cancer p

81 The question of how global cognitive factors affect correlat

82 pagate polarity: if correct, this raises the question of how gradients of Ft and Ds expression or act

83 dividuals, particularly when it comes to the question of how group-level traits are inherited or tran

84 The question of how HA2 and TAT affect the properties of one

85 n attractive model for exploring the general question of how habitat impacts the evolution of gene co

86 This raises the question of how Hh solubilization and spreading is achie

87 ut not all non-bilaterian phyla, raising the question of how Hox-TALE interactions evolved to provide

88 This raises the question of how human cells detect and respond to T. gon

89 uasive health messaging and speak to broader questions of how humans make decisions about how to beha

90 In the present study, we address the question of how hyperoxia-induced alterations in WM deve

91 se features of the B-cell response raise the question of how important antibody fine-specificity is f

92 This naturally raises the question of how important interfacial effects are to amy

93 rom the two PESs to the reaction, posing the question of how important is it to consider the ISC as o

94 Specifically, the question of how individual object information is represe

95 The question of how individuals in a population organize whe

96 However, the central question of how iNKT cells are activated by microbes has

97 n humans only by a pseudogene, and the major question of how innate and adaptive immune responses occ

98 These findings raise basic questions of how innate odor valence is extracted from o

99 o regulate cell fate decisions, although the question of how integrins initiate intracellular signali

100 To further investigate the question of how internal symmetry evolved, how symmetry

101 ance or limit hyperpolarization, raising the question of how intrinsic conductances shape pauses in d

102 RNA translation, which raises the intriguing question of how intronless KSHV transcripts are efficien

103 e fitness of bacterial colonies, raising the question of how it is regulated.

104 let by its lipidated N terminus, raising the question of how it monitors LPS.

105 The complexity of this network begs the questions of how it originated and what selective pressu

106 between them and contributes to the central question of how language evolves.

107 We address the question of how large a molecular object may become by g

108 ively at depolarized potentials, raising the question of how lidocaine-like compounds affect neurons

109 ligands secreted 50 microm away, raising the question of how long-distance Wg spreading occurs.

110 into clinical practice and will address core questions of how low LDL cholesterol can be safely reduc

111 d a high-resolution structure and raised the question of how LysRS is arranged (dimer or tetramer) in

112 The question of how many chains an elementary cellulose micr

113 of these methods do not directly address the question of how many clusters the data should be divided

114 in a gender-specific fashion and raises the question of how many maternal antibodies affect brain de

115 he human body continues to grow, raising the question of how many more species have yet to be identif

116 Threshold-seq addresses the critical question of how many reads need to support a short RNA m

117 ht into Plasmodium evolution and raising the question of how many species there are.

118 This raises the question of how many subtypes of reactive astrocytes exi

119 estrial vertebrates have been described, the question of how many terrestrial species exist is all bu

120 vious research is directly applicable to the question of how many US infants with CCHD might be ident

121 This raises the question of how MDM2 and MDM4 genes evolved.

122 The question of how mechanically gated membrane channels ope

123 and unique perspectives to help us solve the question of how microorganisms methylate mercury.

124 The question of how mismatch glycosylases attain specificity

125 in point, I found myself confronted with the question of how mitochondria and organelles, which canno

126 The second section primarily focuses on the question of how much low-density lipoprotein cholesterol

127 house gas emissions have ceased, raising the question of how much sea-level commitment is expected fo

128 The question of how much uncertainty on mixture composition

129 I further consider the as-yet unanswered questions of how much of the mind and brain are made up

130 This raises the interesting question of how mutator hitchhiking is suppressed or its

131 hese initial studies left open the important question of how MutM can recognize oxoG residues embedde

132 Here we address the question of how n-octadecylsilane (OTS)-derived self-ass

133 This poses the question of how NBP35 (Nucleotide-Binding Protein 35 kDa

134 suppress ubiquitination in vivo, raising the question of how neddylation/deneddylation exerts its eff

135 To investigate the fundamental question of how nervous systems encode, organize, and se

136 ilaterian nervous systems but also raise the question of how neural circuit compositions and architec

137 An outstanding open question of how neural coding supports Bayesian inferenc

138 siveness to external stimuli leaves open the question of how neural responses during sleep differ, if

139 temporal cortex ("face patches") raises the question of how neural selectivity for faces is organize

140 This fact raises the question of how NK cells expressing such activating rece

141 The question of how noncoding RNAs are involved in Polycomb

142 ne transfer in order to address an important question of how nonlethal deficits in early development

143 m, nuclei divide asynchronously, raising the question of how nuclear timing differences are maintaine

144 e to iron leakage from the core, raising the question of how (*)OH-mediated damage to Dps-1-bound DNA

145 This raises the question of how one transcription factor can be activate

146 However, the question of how other cell types may cooperate within th

147 regulated step in mRNA decay and raises the question of how other mRNA decay pathways release protei

148 s log singularity is suppressed, raising the question of how pairing occurs in the absence of a Fermi

149 d acts as a nuclear determinant, raising the question of how PAR-1 antagonises aPKC activity to promo

150 Here we address the question of how particular networks among the many diffe

151 nt decisions may be informed by attention to questions of how (pathways) and for whom (predisposition

152 d herein address conclusively the intriguing question of how PBDEs form PBDD/Fs, a matter that has be

153 in motor axon growth and they highlight the question of how PCP proteins, which form cell-cell compl

154 ssing current models to the still unresolved question of how piRNA precursors are selected and channe

155 deaf individuals.SIGNIFICANCE STATEMENT The question of how pitch is represented in the ear has been

156 The questions of how planets form and how common Earth-like

157 or longer, we still cannot easily answer the question of how plants sense low temperature.

158 This raises the important question of how plasticity is coordinated across the net

159 recent discovery of telomeric RNA raises the question of how POT1 faithfully binds telomeric ssDNA an

160 esis by archaeal KEOPS in vitro, raising the question of how precisely Pcc1-mediated dimerization imp

161 This raises the question of how protein-protein interaction specificity

162 This will solve the fundamental question of how proteins are distributed in the protein

163 In this study we address the question of how proteins sharing the same fold respond t

164 from the site of ligand binding, raising the question of how proteolytic sensitivity is achieved.

165 ensing regulated cooperation, which begs the question of how quorum sensing systems are maintained in

166 Here we address the question of how rapidly multiple drivers of marine ecosy

167 We address the question of how recent changes in ocean conditions will

168 The question of how resting-state functional connectivity (F

169 evel functional specialization, leads to the question of how rodents would perform on a categorizatio

170 d GTP-bound forms of the factor, raising the question of how SelB can fulfill its delivery function.

171 TER is useful to the community to answer the question of how sequence mutations affect the function o

172 of chromatin modifying proteins, but the key question of how SHP transduces BA signaling into repress

173 h multiple protein interactions, raising the question of how signaling and functional specificity are

174 egulate filamentous growth, which raises the question of how signals from multiple pathways become in

175 ent years by a number of publications is the question of how skewed allelic expression should be for

176 EAA supplementation is important because the question of how some detritivores are able to subsist on

177 "on-DNA" and "off-DNA." Here, we address the question of how SoxS and sigma(70) R4 coexist at class I

178 ce of one gene on distinct phenotypes-raises questions of how specific genes and their protein produc

179 CTD more like a random coil leaving open the question of how Src exerts its effects on the NMDA recep

180 Here we address the central questions of how stable isotropic growth of a branch at

181 nd a novel computational model to inform the question of how stimulus generalization is implemented i

182 A new paper in Cell addresses the important question of how STING-dependent signaling is normally co

183 0s; its abrupt extinction in 1914 raises the question of how such an abundant bird could have been dr

184 ically induces similar movement, raising the question of how such chemical modifications are balanced

185 This raises the question of how such cooperation can arise from natural

186 Thus, it raises an important question of how such evolutionary convergence could aris

187 This observation led to the question of how such loss of biological diversity will a

188 orks to generate long sequences, raising the question of how such networks are formed.

189 This poses the crucial question of how such neurons can produce stable activity

190 study was designed to answer the fundamental question of how such NPs are distributed in an in vivo m

191 ision theory, shining a new light on the old questions of how such judgments are formed.

192 r germline differentiation, leaving open the question of how Sxl promotes the transition from stem ce

193 cteria to host intestinal tissues raises the question of how symbiotic host-bacterial relationships a

194 a temporally delayed reward, which poses the question of how synaptic activity patterns associate wit

195 ntacts.SIGNIFICANCE STATEMENT To address the question of how synaptic connectivity is established dur

196 The question of how systemic IgG antibodies neutralize toxin

197 This raises the question of how target sites at silent genes become boun

198 mic input in sensory areas, which raises the question of how thalamocortical synapses formed in M1 in

199 This opinion article explores the question of how the active X is protected from silencing

200 spheric season occurred in 2011, raising the question of how the Arctic ozone chemistry in that year

201 that has so far been neglected concerns the question of how the brain forms attentional expectancies

202 e increasingly turned their attention to the question of how the brain implements decisions between d

203 Here we address the question of how the Cdk1 cell cycle oscillator changes b

204 The question of how the densely packed proteins of the inner

205 The question of how the dynamic epigenetic environment impac

206 e oligomeric nature of many aaRSs raises the question of how the functioning and oligomerization of d

207 n male and female alligators leaves open the question of how the genes responsible for sex determinat

208 This raises the question of how the gonococcus infects men if N-acetylla

209 Here we address the question of how the human skin microbiome develops early

210 e components and their interactions, the key question of how the kinase activity of the catalytic P4

211 syrphus balteatus (Syrphidae) to address the question of how the maternal regulation of gap genes evo

212 is crucial in overcoming this challenge, the question of how the nanoscale properties of the plant ce

213 These observations raise the important question of how the nervous system processes multiple so

214 mechanistic explanation to the long-standing question of how the network of 5'TOP mRNAs are coregulat

215 Here, we investigated the question of how the neuronal cytoskeleton protects axons

216 ia, and provide insight into the fundamental question of how the node represents the mechanistic 'nod

217 However, the fundamental question of how the otoacoustic emission exits the cochl

218 ell-autonomous molecular model and raise the question of how the pacemaker neuron transcription-trans

219 This raises the question of how the processed GAUT1 is retained in the G

220 elative to, the rat's head, which raises the question of how the rat might determine the position and

221 des important insights into the longstanding question of how the receptor transduces signals initiate

222 ene expression and resolve the long-standing question of how the RNA genome is transported to the ass

223 known as RASopathies, raising the important question of how the same mutation can contribute to both

224 ale connectivity, providing insight into the question of how the scales of micro-organization and mac

225 d glycosphingolipids, posing the interesting question of how the semi-invariant TCR can bind to such

226 Here we address the question of how the Short-root (SHR) proteins from Arabi

227 This mechanism may answer a long-standing question of how the soluble regulatory protein, arrestin

228 re-former and we have used it to address the question of how the spore coat is assembled from multipl

229 We tackled the question of how the strain and biochemical makeup of alg

230 In this study, we have addressed the question of how the T cell repertoire changes as a funct

231 In this review, we address the question of how the tip-growing pollen tube achieves its

232 The question of how the topological arrangement of the SNARE

233 s a second set of body flaps and reopens the question of how the two branches of arthropod legs evolv

234 This raises the question of how the underlying patterning mechanisms hav

235 In the present study we addressed the question of how the unit sized linear mtDNA of Candida p

236 he skin is one target tissue of HSV, and the question of how the virus overcomes the protective skin

237 While the question of how the visual system detects and senses mot

238 Here, we address the question of how the visual system identifies the dispari

239 avioral experiment in humans) to address the question of how the visual system maximizes behavioral s

240 shift in the focus of future research to the question of how the visuo-perceptual system represents a

241 orted, and address the important fundamental question of how the work function of small supported met

242 neural circuits have been proposed, but many questions of how the architecture of visual neuropils ev

243 nge within cells pervade biology and include questions of how the cytoskeleton sustains stresses on c

244 This raises questions of how the formation of toxic protein species

245 This raises questions of how the important embryonic and postnatal f

246 o functional sensory structures, raising the question of how their development is coordinated.

247 r-rich food most of their lives, raising the question of how these animals modulate food-seeking beha

248 lacks a DNA-binding domain which raises the question of how these bacteria regulate the synthesis of

249 y the sensory detection of food, raising the question of how these cells can promote feeding at all.

250 ers lipid metabolism, raising the intriguing question of how these effects might be related.

251 ping regions of the promoter, leading to the question of how these large factors reconcile their prom

252 res that are in the ER membrane, raising the question of how these nascent LDs bud from the ER as the

253 This raises the question of how these pathways interact to support conte

254 nse in terms of host defense, but raises the question of how these remarkable cells balance both thes

255 the encoded amino acid sequence, raises the question of how these signals and overlapping codes are

256 , inhibition, and disinhibition, raising the question of how these stimuli interact to induce plastic

257 However, the central question of how these sugars are perceived in the contex

258 ence of two enzymes in one complex poses the question of how these two enzymes cooperate during primi

259 the known ASF1-H3-H4 interface, raising the question of how these two proteins are found in complex

260 from different embryonic tissues raising the question of how they are aligned to form a functional ey

261 <3% of total flight muscle mass, raising the question of how they can modulate the vastly greater out

262 This raises the question of how they develop in register to form functio

263 d soon disappear from the lungs, raising the question of how they induce such durable immunosuppressi

264 around important regulatory genes raises the question of how they relate to 3D conformation of these

265 etween the E2 and the substrate, raising the question of how this distance is bridged in the ubiquiti

266 rdless of the original source of energy, the question of how this energy is transferred to the ICM re

267 This raises the intriguing mechanistic question of how this molecular machine can use a single

268 y components in several model organisms, the question of how this pathway achieved its current repert

269 ions and initiating MMR, and the fundamental question of how this protein targets specific sites in D

270 ant role in sensory coding, yet to date, the question of how this regularity alters the coding of tra

271 eadily dissociate from PKA, thus begging the question of how tightly bound cAMP is released from PKA

272 This raises the question of how tissue-specific protein-coding exons inf

273 Whereas the question of how to allocate scarce intensive care unit r

274 The question of how to best use information from known assoc

275 The question of how to build and evolve efficient screening

276 Machine learning addresses the question of how to build computers that improve automati

277 This has raised the question of how to determine and to quantify the sources

278 w no convincing answer has been given to the question of how to extend the scope of QKD beyond niche

279 nt of small-scale quantum devices raises the question of how to fairly assess and detect quantum spee

280 This raises the question of how to incorporate the microbiota into defin

281 rspective, this study raises the provocative question of how to make use of the valuable information

282 The question of how to meet rising food demand at the least

283 oughput screening efforts, is faced with the question of how to optimally leverage these data to move

284 ble platforms for addressing the fundamental question of how to reverse the adverse biochemical outpu

285 e search for a straightforward answer to the question of how to support teachers.

286 's rapidly growing population has raised the question of how to systematically utilize large genebank

287 to the Arctic confront policymakers with the question of how to weigh a century-scale warming with la

288 fSTREAM addresses core questions of how to relate fluorescence intensity to tum

289 esis machineries remain obscure, raising the question of how tumour cells efficiently coordinate and

290 This raises the important question of how two complexes that are highly isomorphic

291 The structures address the longstanding question of how UGM binds NAD(P)H and provide new opport

292 ight the potency of this model and raise the question of how useful it is for interpreting the system

293 n, few studies have attempted to address the question of how variation in learning and memory impacts

294 It also focuses attention on the question of how viruses have evolved to resist inhibitio

295 e been identified from IEM patients, but the question of how warmth triggers episodes of pain in IEM

296 site is 15 A from the membrane, raising the question of how water-soluble and membrane-embedded subs

297 from cognitive neuroscience that bear on the question of how we get from perception of sound patterns

298 We addressed the question of how we locate and identify objects in comple

299 escribe three lines of work that address the questions of how, when, and even whether the ancestor of

300 d for many DNA-binding proteins, raising the question of how widespread or specific to certain enzyme