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1 henyl as a preferred substitution on the N-3 quinazolinone.
2 developed for the synthesis of 2-substituted quinazolinones.
3 for the easy generation of new and bioactive quinazolinones.
5 4'-dihydroxyphenyl)-6-[127I/125I]iodo-4-(3H)-quinazolinone (127IQ2-OH,4-OH (2)/125IQ2-OH,4-OH (7)) wa
6 pine (2b) were modified to produce tricyclic quinazolinone 15-18 or benzothiadiazine 26-27 derivative
8 se efforts led directly to identification of quinazolinone 28 that displays high selectivity for PI4K
9 oted isomerization of iminobenzoxazine 33 to quinazolinone 34, an N-acyliminium ion cyclization that
10 olo[1,2-a]benzoxazinones 3 and pyrrolo[1,2-a]quinazolinones 4, respectively, in good overall yields.
13 MR spectroscopies show that deprotonation of quinazolinones and phenylacetylene in THF/pentane soluti
15 iscover four novel series of 53 compounds of quinazolinone based on the concept of molecular hybridiz
17 a program to develop practical syntheses of quinazolinone-based nonnucleoside reverse transcriptase
19 precursor for the synthesis of N-substituted quinazolinones by incorporation of a palladium-catalyzed
20 arylsulfonyl-piperazine and spiro-piperidine-quinazolinone classes were identified with up to approxi
23 gous to the earlier studies of the series of quinazolinone derivatives 3, we also found 3-isopropoxyp
24 eration of carbon-heteroatom bond leading to quinazolinone derivatives and aza-Michael adducts under
25 action-binding between a series of iodinated quinazolinone derivatives and human placental alkaline p
27 In our laboratories, piperidine-substituted quinazolinone derivatives were identified as a new class
30 enyl-3, 4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones DPC 082 and DPC 083 and the 4-alkynyl-3,
31 ynyl-3, 4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones DPC 961 and DPC 963 were found to exhibit
33 rnishes a series of substituted indolo[1,2-a]quinazolinones from the suitably fabricated indoles via
34 ficant molecules, such as benzoxazinones and quinazolinones, from simple anilides without installing
35 al products containing benzodiazepinone- and quinazolinone-fused ring systems can be assembled by non
37 the 1,2-addition of PhCCLi to an O-protected quinazolinone implicates reaction via trisolvated PhCCLi
39 ium 2-(2'-phosphoryloxyphenyl)-6-iodo-4-(3H)-quinazolinone (IQ(2-P)) was docked in silico into the X-
40 -(2',4'-diphosphoryloxyphenyl)-6-iodo-4-(3H)-quinazolinone (IQ2-P,4-P), having the most favorable cal
43 llowed by chemical synthesis of a library of quinazolinones, led to the discovery of (E)-3-(3-carboxy
45 ts, including benzophenones, acridinones and quinazolinones or quinazolines was identified and measur
47 on of methaqualone (2-methyl-3-o-tolyl-4(3H)-quinazolinone, Quaalude), an infamous sedative-hypnotic
48 ompound library and identified a substituted quinazolinone (Quin-C1, 4-butoxy-N-[2-(4-methoxy-phenyl)
49 piperidinyl)ethyl]-2,3-dihydro-2-thioxo-4(1H)quinazolinone (R59949), which blocks HIF-1alpha protein
54 n optimization effort was initiated around a quinazolinone screening hit 1 with promising cellular an
55 ges to the ethylene linker that connects the quinazolinone to the amide were also investigated but pr
58 ition of lithium phenylacetylide (PhCCLi) to quinazolinones was investigated using a combination of s
59 ynyl-3, 4-dihydro-4-(trifluoromethyl)-2-(1H)-quinazolinones were found to be potent non-nucleoside re
60 ically relevant 3-arylquinazolin-4(3H)-ones (quinazolinones) with high levels of enantioinduction ove
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