ライフサイエンスコーパス: quinine

1 o be involved in T2R4 binding to its agonist quinine.

2 serotonin production during incubation with quinine.

3 are the same orthosteric site as the agonist quinine.

4 ted ketones catalyzed by 9-amino(9-deoxy)epi quinine.

5 emical control at the chiral amine carbon of quinine.

6 rine (21b), completing a formal synthesis of quinine.

7 o a perithreshold concentration (0.01 mM) of quinine.

8 e addition of a chiral thiourea derived from quinine.

9 to react with other structural analogues of quinine.

10 d severe thrombocytopenia after ingestion of quinine.

11 reveal their important role in resistance to quinine.

12 esponses to the cues paired with sucrose and quinine.

13 or HCl prepulses attenuated the response to quinine.

14 on of solutions containing either sucrose or quinine.

15 HUS as in the 118 patients who had not taken quinine.

16 as 2,2'-bipyridine, 1,10-phenanthroline, and quinine.

17 h intravenous artesunate proving superior to quinine.

18 with an artemisinin derivative compared with quinine.

19 se thrombocytopenia in patients sensitive to quinine.

20 a samples after drinking of tonic containing quinine.

21 ne-free alcohol or saccharin with or without quinine.

22 is residual was abolished by the addition of quinine.

23 e predicted sucrose, while another predicted quinine.

24 ncomplicated falciparum malaria treated with quinine.

25 d (0.03 m), monosodium glutamate (0.2 m), or quinine (0.001 m).

26 atterns of electrical stimulation or natural quinine (0.1 mM) as a conditioned stimulus, rats specifi

27 which have structures similar to that of (-)-quinine 1.

28 ific potassium channel antagonists including quinine (100 microm) and high concentrations of extracel

29 specific genetic factors for PROP (72%) and quinine (15%).

30 he neuronal-specific gap junction uncouplers quinine (250 microM) and mefloquine (500 nM) both disrup

31 ted by sucrose (39 of 52, 75%) or excited by quinine (30 of 40, 75%) infusions.

32 104 patient reports with definite evidence (quinine, 34; cyclosporine, 15; tacrolimus, 12).

33 he chemosensitizers verapamil 240 mg bid and quinine 40 mg tid.

34 d a developmentally regulated sensitivity to quinine, a drug that blocks Cx50 gap junctions, but not

35 te pairing with an aversive stimulus such as quinine, a paradigm considered to model compulsive aspec

36 An aversive stimulus, quinine, activated noradrenergic signaling but inhibited

37 L-lysine (BCML) as competitive inhibitors of quinine-activated T2R4 with an IC50 of 3.2 +/- 0.3 muM a

38 acology, we examined the effect of intraoral quinine administration on nucleus accumbens dopamine sig

39 closerine also selectively reduced intake of quinine-adulterated alcohol, and D-cycloserine inhibited

40 oline antimalarial drugs (e.g., chloroquine, quinine, amodiaquine) function by preventing hemozoin cr

41 our tastants (0.1 M NaCl, 0.01 M HCl, 0.01 M quinine and 0.5 M sucrose) in separate trials.

42 Quinine and ajmalicine formed charge-stabilized hydrogen

43 the clinical drugs lumefantrine, mefloquine, quinine and amodiaquine.

44 ole in malaria chemotherapy progressing from quinine and artemisinin to ozonide-based compounds.

45 he involvement of alpha-gustducin in bitter (quinine and denatonium) and sweet (sucrose and SC45647)

46 ral avoidance of cycloheximide and PROP than quinine and denatonium, which also stimulate the CT, alb

47 ciated with the CS- also affects learning as quinine and distilled water enhanced the proportion of l

48 mical inhibition of mechanotransduction with quinine and EGTA protected against cisplatin-induced hai

49 therapy were treated with standard doses of quinine and followed for 28 days.

50 waves in astrocytes was also potentiated by quinine and inhibited by FFA and Gd(3+).

51 oxia, low sensitivity to 4-aminopyridine and quinine and insensitivity to tetraethylammonium ions.

52 2D mutation in contributing to resistance to quinine and its diastereomer quinidine.

53 Immune thrombocytopenia induced by quinine and many other drugs is caused by antibodies tha

54 erm exposure (4 h), artemisinin derivatives, quinine and mefloquine impacted H2O2 levels in mitochond

55 urned to the few alternatives, which include quinine and mefloquine.

56 increased susceptibility to artemisinin and quinine and minimally affected amodiaquine activity; hen

57 e anticancer agent vincristine, antimalarial quinine and neurotoxin strychnine, are synthesized in se

58 n with 40 mm HEPES attenuated the effects of quinine and NH(4)Cl.

59 e pipette solution eliminated the effects of quinine and NH4Cl on the csNSC currents, but only partia

60 y derived IC50 concentrations of mefloquine, quinine and pyrimethamine.

61 pair of the nitrogen atom instead, and both quinine and quinidine exhibit additional bonding via the

62 Mefloquine, a close derivative of quinine and quinidine that exhibits antimalarial and ant

63 ased on dimerized versions of the substrates quinine and quinidine.

64 n as well as the stereospecific responses to quinine and quinidine.

65 evertheless, may have some ability to act on quinine and quinidine.

66 their reactions at various concentrations of quinine and quinine congeners.

67 ndicate that a hybrid paratope consisting of quinine and reconfigured antibody CDR plays a critical r

68 nferring resistance to the second-line drugs quinine and sensitivity to the new alternatives mefloqui

69 neralized the aversion to 2 bitter tastants: quinine and urea.

70 In view of the low efficacy of quinine and wide availability of highly effective artemi

71 ized mAb with low affinity in the absence of quinine and with fivefold greater affinity (K(D) approxi

72 ntly mechanistically distinct synergism with quinine and with piperaquine.

73 metabolism of isoprenoid-derived molecules (quinines and tocochromanols), lipids, and carotenoid cle

74 ake (that persists despite adulteration with quinine) and consumption of quinine-free alcohol.

75 .g. fungiform papillae number, bitterness of quinine) and emerging receptor genotypes.

76 creased susceptibility to LUM, halofantrine, quinine, and ART.

77 ed K(+) channel (charybdotoxin, iberiotoxin, quinine, and Ba(2+)) nor inhibitors of the mitochondrial

78 -Ras in the NAc of mice did not alter water, quinine, and saccharin intake.

79 bitter compounds tested, including caffeine, quinine, and strychnine.

80 bility to antimalarials such as chloroquine, quinine, and sulfadoxine-pyrimethamine.

81 dopamine signaling by the aversive stimulus, quinine, and tested its ability to cause cocaine seeking

82 Compared to quinine, artemisinin treatment in the first trimester wa

83 s to be prevented, clinicians must recognize quinine as a possible cause.

84 e asymmetric synthesis of sulfinamides using quinine as auxiliary.

85 y to feed on noxious foods (adulterated with quinine) as the duration of deprivation increases.

86 gh inhibition of 5-HT receptor activation by quinine, as we observed here.

87 Quinine-associated thrombotic thrombocytopenic purpura-h

88 bnormalities were as severe in patients with quinine-associated TTP-HUS as in the 118 patients who ha

89 rsive 'disgust' reactions elicited by bitter quinine at all NAc shell sites.

90 s suggest that PfCRT accepts chloroquine and quinine at distinct but antagonistically interacting sit

91 The remarkable isoform selectivity found on quinine-based selectors is explained by van't Hoff plots

92 y treated malaria, which can occur with oral quinine because of the known poor adherence to 7-d regim

93 n implicated as triggers for this condition, quinine being one of the most common.

94 atable (0.3 m sucrose) and aversive (0.001 m quinine) benchmarks, while recording the activity of neu

95 sidues Asn-173 and Thr-174 are essential for quinine binding.

96 smon resonance (SPR) analysis, we found that quinine binds with very high affinity (K(D) approximatel

97 infusion 150 min after breakfast, containing quinine (bitter), rebaudioside A (sweet), monosodium glu

98 Quinine blocked Cx36 and Cx50 junctional currents in a r

99 imicked the electrophysiological response to quinine, but not when the temporal pattern was randomize

100 timuli indicated a common genetic factor for quinine, caffeine and SOA (22-28%), as well as separate

101 ains that mimic the response to the taste of quinine can produce a bitterlike sensation when delivere

102 ed the molecular recognition capability of a quinine carbamate ligand attached to silica as a powerfu

103 identical in requiring quinine or desmethoxy-quinine (cinchonidine) for reactivity and in failing to

104 ft should be made in health policy away from quinine + clindamycin therapy for malaria in pregnant wo

105 g combinations, atovaquone + azithromycin or quinine + clindamycin.

106 rnative ACT, which were given for 3 days, or quinine-clindamycin (QnC), which was given for 5-7 days,

107 In populations where, for example, quinine-color pairings were unreliable but quinine-odor

108 perience and reduced sensitivity to learning quinine-color.

109 LI-neurons elicited by intraoral infusion of quinine compared with water-stimulated controls.

110 netic analyses revealed that chloroquine and quinine compete for transport via PfCRT in a manner that

111 ryptophan hydroxylase (TPH2), we showed that quinine competitively inhibits TPH2 in the presence of t

112 value >/=0.997 in the range of 50-800 ng/ml quinine concentration.

113 ons at various concentrations of quinine and quinine congeners.

114 synaptic transmission; ethanol, sucrose, and quinine consumption; ethanol-induced loss of righting; a

115 The auxiliary quinine could be recovered and recycled.

116 sucrose than during the tone associated with quinine delivered upon licking.

117 uli evoked strong responses in ASH including quinine, denatonium, detergents, heavy metals, both hype

118 region of GPIIIa may be a favored target for quinine-dependent antibodies and may provide a basis for

119 cted GPIIIa mutants, we found that each of 3 quinine-dependent antibodies requires a 17-amino acid se

120 We studied a group of quinine-dependent antibodies that react with human glyco

121 e, we characterized the binding sites for 16 quinine-dependent antibodies thought on the basis of pre

122 Measurements of quinine-dependent binding of intact mAb and fragment ant

123 We addressed this question using quinine-dependent murine monoclonal antibodies (mAbs), w

124 Recently, quinine-dependent murine monoclonal antibodies were deve

125 ion toward another chiral molecule such as a quinine derivative.

126 A quinine-derived aminophosphine precatalyst and silver ox

127 .5:0.5 er) in the presence of CsOH.H2O and a quinine-derived ammonium salt.

128 cyclic allylic bromides using quinidine- or quinine-derived catalysts is described.

129 A zwitterionic quinine-derived entity generated by deprotonation of an

130 Quinine, dicyclohexylcarbodiimide, and Mg(2+), inhibitor

131 In contrast, quinine did not substantially block gap junction channel

132 The study shows that quinine disrupts both serotonin biosynthesis and functio

133 nin (5-HT), here we test the hypothesis that quinine disrupts serotonin function.

134 A chemical screening approach revealed that quinine effectively prevented heme effects on the cytosk

135 We conducted prospective quinine efficacy studies in 2 villages, Kolle and Faladi

136 the rostral CeA were highly correlated with quinine-elicited gapes.

137 The connexin hemichannel activator quinine evoked ATP release and Ca(2+) signaling in astro

138 STDRHI mice consumed more saccharin and less quinine, exhibited greater ethanol-induced conditioned p

139 er artemisinin (1.5% [95% CI 0.6%-3.5%]) and quinine exposures (1.2% [95% CI 0.6%-2.4%]).

140 turally occurring antimalarial compounds are quinine, extracted from cinchona bark, and artemisinin (

141 st Herapath mixed iodine with the urine of a quinine-fed dog.

142 al intravenous therapy (38 artesunate and 49 quinine) followed by oral treatments.

143 ites and threefold in parasites treated with quinine for 30 min.

144 assays to evaluate small-molecule analogs of quinine for suppressive effects on aberrant hemichannel

145 ol drinking, without altering consumption of quinine-free alcohol or saccharin with or without quinin

146 dulteration with quinine) and consumption of quinine-free alcohol.

147 stem was applied for selective extraction of quinine from human plasma.

148 They were inhibited by quinine, Gd3+, La3+ and the His modifier diethylpyrocarb

149 The method is demonstrated on a mixture of quinine, geraniol, and camphene in deuteriated methanol,

150 te that the cinchona alkaloids quinidine and quinine give rise to products (some in as few as three s

151 ence cinchonine > quinidine > cinchonidine > quinine > 6-methoxyquinoline > lepidine > quinoline.

152 oms--for example alkaloids like morphine and quinine-have the potential to treat a broad range of hum

153 M NaCl, 0.5 M sucrose, 0.01 M HCl and 0.01 M quinine HCl).

154 nsisted of 0.1 m NaCl, 0.5 m sucrose, 0.01 m quinine HCl, and 0.01 m HCl.

155 The perceived taste intensities of quinine HCl, caffeine, sucrose octaacetate (SOA) and pro

156 ): 0.5 sucrose, 0.1 NaCl, 0.01 HCl, and 0.01 quinine-HCl.

157 The quinine homodimer Q2, which was tethered by reversible e

158 ht that is paired with an aversive stimulus (quinine-humidity).

159 1min) of dH2O, sucrose (1.0M and 0.1M), and quinine hydrochloride (3mM and 0.3mM) were video recorde

160 e-mediated acceptability of both ethanol and quinine hydrochloride (bitter), but not sucrose (sweet).

161 nd NH(4)Cl, 0.032 m NaCl, and 3.2 mm HCl and quinine hydrochloride (QHCl).

162 wo structurally dissimilar bitter compounds, quinine hydrochloride and denatonium benzoate, despite t

163 um chloride (NaCl), 100 mM sucrose, and 1 mM quinine hydrochloride in mixtures were investigated in g

164 Guinea pigs did show weaker avoidance of quinine hydrochloride than did the mice, confirming pred

165 nt secondary metabolites (salicin, caffeine, quinine hydrochloride) and bitter protein hydrolysates (

166 al taste stimuli (0.032 M sucrose, NaCl, and quinine hydrochloride, and 0.0032 M citric acid) to inve

167 ison of parenteral artesunate and parenteral quinine in 9 African countries.

168 decreased susceptibility of P. falciparum to quinine in the field.

169 fusion of the intracellular alkalizing agent quinine increased the amplitude of the ASIC current by a

170 ated with appetitive sucrose versus aversive quinine, indicating that they behave like reward neurons

171 e-channel studies indicated that exposure to quinine induced slow transitions between open and fully

172 ound that the reduction of dopamine tone and quinine-induced cocaine seeking were eliminated by block

173 he behavior of antibodies from patients with quinine-induced immune thrombo-cytopenia in their reacti

174 During quinine-induced nausea and lipopolysaccharide (LPS)-indu

175 Moreover, when the quinine-induced pattern of neural activity in the second

176 r of antibodies found in human patients with quinine-induced thrombocytopenia in vitro and in vivo.

177 Quinine inhibited serotonin-induced proliferation of yea

178 alterations in water, saccharine/sucrose, or quinine intake were observed.

179 Quinine is a common cause of drug-associated TTP-HUS and

180 r results indicate that the binding site for quinine is intracellular, possibly within the pore.

181 anism of Plasmodium falciparum resistance to quinine is not known.

182 e or with the chemosensitizers verapamil and quinine is not promising therapy with respect to improve

183 s, a 7- to 10-day course of clindamycin plus quinine is often used to treat severe babesiosis.

184 PIIb beta propeller domain only when soluble quinine is present.

185 irely stereoselective total synthesis of (-)-quinine is reported.

186 Therefore, quinine is used despite its poor effectiveness.

187 trial comparing parenteral artesunate versus quinine (ISRCTN50258054).

188 furocoumarins, metal coordination complexes, quinine-like compounds, naphthaleneimides and pyrenyl-pe

189 ctly to the attenuated aversion to ethanol's quinine-like taste quality.

190 Experiments 1 and 2 indicated that CPC has a quinine-like taste quality.

191 Experiments with phenylhydrazine, KCl, quinine, merocyanine 540, the calpain inhibitor E-64d, a

192 r alkalinization following bath perfusion of quinine mimicked the potentiation of the csNSC currents

193 e first trimester (n = 37/671) compared with quinine (n = 96/945; adjusted hazard ratio [aHR] = 0.73

194 m treatments with artemisinin (n=183) versus quinine (n=842; HR 0.78 [95% CI 0.45-1.34]; p=0.3645) or

195 isk of stillbirth (artemisinins, n = 10/654; quinine, n = 11/615; aHR = 0.29 [95% CI 0.08-1.02], p =

196 e find increased sensitivity to learning the quinine-odor experience and reduced sensitivity to learn

197 , quinine-color pairings were unreliable but quinine-odor pairings were reliable, we find increased s

198 iving important new insight to the action of quinine on mammalian cells.

199 For quinine, one or more bitter receptor or salivary proline

200 Quinine or alternative artemisinin-based combination tre

201 Here we show that artemisinins, but not quinine or chloroquine, inhibit the SERCA orthologue (Pf

202 ypes of antibody were identical in requiring quinine or desmethoxy-quinine (cinchonidine) for reactiv

203 ed to be a cinchona alkaloid derivative (TMS-quinine or Me-quinidine).

204 treated with artemisinin derivatives versus quinine or no antimalarial treatment.

205 alternative ligands, prinomastat, quinidine, quinine, or ajmalicine, displaced both thioridazines.

206 ne displays a higher Kads than cinchonidine, quinine, or quinidine even though, according to previous

207 se was blocked by l-AP-4, meclofenamic acid, quinine, or strychnine but not by bicuculline.

208 of either appetitive (sucrose) or aversive (quinine) outcomes.

209 GSTP1 (A313G), or with the C allele of NADPH quinine oxidoreductase (C609T), although interactions we

210 activity of ARE-driven genes HO1 and NAD(P)H:quinine oxidoreductase 1 (NQO1).

211 of its downstream gene targets such as NADPH quinine oxidoreductase 1 and superoxide dismutase in cer

212 NRP/B also enhanced Nrf2-mediated NAD(P)H:quinine oxidoreductase 1 promoter activity.

213 sferases (GSTM1, GSTT1, and GSTP1) and NADPH quinine oxidoreductase] and apoptosis, altering steroid

214 ved brief intraoral infusions of sucrose and quinine paired with cues in a classical conditioning par

215 The major antimalarial drug quinine perturbs uptake of the essential amino acid tryp

216 philicity/pH profile of a weakly basic drug (quinine; pK(a) = 7.95) was sigmoidal with respect to -dF

217 WHO recommends prompt diagnosis and quinine plus clindamycin for treatment of uncomplicated

218 aquone-proguanil is best, with mefloquine or quinine plus tetracycline or doxycycline as alternatives

219 a combination of atovaquone and proguanil or quinine plus tetracycline or doxycycline or clindamycin

220 nctional OCT1 variants, OCT1 inhibition with quinine prevented sorafenib-induced toxicity.

221 We conclude that denatonium and quinine produce a unitary taste sensation, leaving open

222 9-Amino(9-deoxy)epi-quinine promoted the enantioselective desymmetrization,

223 implicated in responses to chloroquine (CQ), quinine (QN) and other drugs, and a putative transporter

224 ut does not measurably bind the related drug quinine (QN) at physiologically relevant concentrations.

225 s was their greatly increased sensitivity to quinine (QN) but reduced sensitivity to its enantiomer q

226 levels in responses to chloroquine (CQ) and quinine (QN) in field isolates.

227 Quinine (QN) remains effective against Plasmodium falcip

228 and the antimalarial drugs chloroquine (CQ), quinine (QN), and quinidine (QD).

229 re we show that mutant PfCRT also transports quinine, quinidine, and verapamil, indicating that the p

230 We found that quinine rapidly reduced dopamine signaling on two distin

231 plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indi

232 both disrupted 4-12 Hz oscillations but only quinine reduced the frequency of field population spikin

233 cal pharmacology with a component blocked by quinine, reduced by low extracellular pH and arachidonic

234 mbled the taste quality of either sucrose or quinine regardless of its intensity.

235 important because neither salt ingestion nor quinine rejection elicited analgesia.

236 nd loss of verapamil reversibility of CQ and quinine resistance.

237 imulation of awake rats with citric acid and quinine resulted in significant increases in the numbers

238 complex with terreic acid revealed that the quinine ring is covalently attached to the thiol group o

239 he depigmenting abilities of chloroquine and quinine salicylate were assessed in a human skin equival

240 uppression of CPC, because both CPC-salt and quinine-salt mixtures had similar effects.

241 This quinine-sensitive outward rectification contributes to s

242 Xenopus laevis oocytes and determination of quinine-sensitive sorafenib uptake by high-performance l

243 ting that rats intraorally infused with 3 mM quinine showed a robust population of FLI in the waist a

244 Randomization of the quinine simulation patterns resulted in generalization p

245 conditioned aversion training using either "quinine simulation" patterns of electrical stimulation o

246 gnificantly reduced intake of all three CSs (quinine, sodium chloride, and orange odor).

247 ) was paired with sucrose and the other with quinine solution (CS-).

248 We demonstrate that the antimalarial drug quinine specifically reduces currents through gap juncti

249 On the other hand, the quinine-squaramide was more efficient in that a wide var

250 ganocatalysts, viz. a quinine-thiourea and a quinine-squaramide.

251 egeneration of the GL after 52 days restored quinine-stimulated FLI to control values.

252 strocaudal gradient characterized the normal quinine-stimulated Fos response, with the greatest numbe

253 Here, the distribution of quinine-stimulated Fos-immunoreactive neurons in two tas

254 The distribution of quinine-stimulated Fos-like immunoreactivity (FLI) in se

255 rvation by either nerve restored, numbers of quinine-stimulated labeled cells in the rostralmost CeA

256 Quinine-stimulated neurons were found throughout the gus

257 We previously demonstrated that quinine-stimulated oromotor rejection reflexes and neura

258 in the number of gapes elicited by intraoral quinine stimulation that recovered, but only subsequent

259 either stimulus but had a medial bias after quinine stimulation.

260 The 3,5-bis(trifluoromethyl)phenyl- and quinine-substituted squaramide catalyst is shown to be t

261 Applying this strategy to quinine suggested complementary synthetic approaches to

262 and with the chemosensitizers verapamil and quinine (SWOG 9125) to assess effects on response, survi

263 "liking"/"disliking" elicited by sucrose or quinine tastes after D-Ala2-N-Me-Phe4-Glycol5-enkephalin

264 nd negative aversive reactions to sucrose or quinine tastes.

265 our hypothesis, GLX had a greater effect on quinine than cycloheximide (mean shift of 1.02 vs. 0.27

266 immunized with purified human GPIIb/IIIa and quinine that recognize the N terminus of the GPIIb beta

267 For quinine, the peak association was centered in a region t

268 In contrast, in response to quinine, there was a cluster of double-labeled neurons w

269 sence of two sets of organocatalysts, viz. a quinine-thiourea and a quinine-squaramide.

270 The quinine-thiourea provided the products possessing an alp

271 Quinine thus offers a potentially useful method to block

272 US are discussed: mitomycin C, cyclosporine, quinine, ticlopidine, and clopidogrel.

273 cyclosporine), and immune-mediated reaction (quinine, ticlopidine, clopidogrel).

274 nonvolatile repellents tested, ranging from quinine to denatonium, lobeline, and caffeine.

275 ) and 90% (Accelerate 2), with a switch from quinine to injectable artesunate for management of sever

276 ption despite punishment, assessed by adding quinine to the alcohol solution, compared with control r

277 monstrate specific, high-affinity binding of quinine to the complementarity-determining regions (CDRs

278 Because no detectable binding of quinine to the target integrin could be demonstrated in

279 ucleoside, in a process mediated by HATU and quinine, to deliver the coupled product in high chemical

280 Quinine treated but could not control malaria; its use r

281 d significantly, from 26.2% (n = 107) before quinine treatment to 46.3% (n = 54) after therapy (P = .

282 ms4760-1 among parasites before versus after quinine treatment was determined by direct sequencing.

283 nalyzed to compare outcomes of artesunate vs quinine treatment.

284 hasone with prednisone (VAD-P) or VAD-P plus quinine (VAD-P/Q).

285 idine, and type II cations (e.g., quinidine, quinine, verapamil, and rhodamine123) are also PMAT inhi

286 iminate among other taste stimuli, including quinine versus KCl, denatonium versus KCl, and NaCl vers

287 Quinine was determined in plasma samples after drinking

288 ardly learned and were weakly expressed when quinine was mixed with NaCl, and generalizations from mu

289 ity (K(D) approximately 2.2 x 10(-)(6)) when quinine was present.

290 respectively; Hill coefficients for block by quinine were about 2 for both connexins.

291 However, CTAs to quinine were hardly learned and were weakly expressed wh

292 estive and aversive responses to sucrose and quinine were similar between groups.

293 ol ova-albumin challenge, and chloroquine or quinine were tested in both prophylactic and treatment m

294 m sucrose, 0.01 m citric acid, and 0.0001 m quinine) were delivered for five consecutive licks inter

295 ies of quinolines, including chloroquine and quinine, were identified as potent pigmentation inhibito

296 mely, teicoplanin, cyclofructan, silica, and quinine, were packed in 0.5-cm-long columns for separati

297 5% in Africa and 34.7% in Asia compared with quinine, whereas adjunctive interventions have been unif

298 Type II responses could also be activated by quinine (which increased Ca(2+)(I)) thus suggesting a me

299 Second, quinine, which potently inhibited TWIK-1 (IC(50) = 85 mi

300 rience (the pairing of the aversive chemical quinine with color or with odor).