ライフサイエンスコーパス: quinolinate

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1 hesis of NAD (+) and clearing the neurotoxin quinolinate.

2 he phthalate catabolic pathway cometabolizes quinolinate.

3 This pathway results in quinolinate, an excitotoxin that is an NMDA receptor ago

4 e enzymatic product subsequently cyclizes to quinolinate, an intermediate in the biosynthesis of nico

5 In contrast, quinolinate, an NMDA receptor agonist, produced only min

6 elis complex is approximated by PRPP and the quinolinate analogue phthalate bound to the active site.

7 formation of nicotinate mononucleotide from quinolinate and 5-phosphoribosyl-1-pyrophosphate (PRPP).

8 o and singly bound forms with the substrates quinolinate and PRPP.

9 ntrastriatal injection of either malonate or quinolinate and systemic administration of 3-NP resulted

10 e "activity" reported does not correspond to quinolinate formation.

11 Quinolinate has also been implicated in important neurol

12 High levels of quinolinate have been correlated with the etiology of ne

13 Quinolinate-induced stimulation of intracellular NAD in

14 h necrotic morphologies were detected in the quinolinate-injected striata.

15 cted outside the needle track 10 hours after quinolinate injection and, on average, 20% of neurons ex

16 ced hippocampal cell death, are resistant to quinolinate, malonate, and 3-nitropropionic acid (3-NP).

17 Rats were killed 6, 8, 10, or 12 hours after quinolinate or vehicle injection.

18 of two metabolic pathways: the tryptophan to quinolinate pathway and the bacterial 2-nitrobenzoic aci

19 NCQDs were immobilized with an enzyme named quinolinate phoshphoribosyl transferase (QPRTase).

20 The fact that elevated levels of quinolinate phosphoribosyl transferase enhance growth on

21 A gene coding for an enzyme (quinolinate phosphoribosyl transferase) involved in the

22 e biosynthetic pathway including NtPMT1a and quinolinate phosphoribosyltransferase (NtQPT2), and lowe

23 Quinolinate phosphoribosyltransferase (QAPRTase, EC 2.4.

24 Quinolinate phosphoribosyltransferase (QAPRTase, EC 2.4.

25 ave one de novo pathway gene, nadC, encoding quinolinate phosphoribosyltransferase.

26 tructural similarities between phthalate and quinolinate: phthalate is a competitive inhibitor of thi

27 When supplied as the sole NAD precursor, quinolinate promoted B. bronchiseptica growth, and the a

28 Indeed, the quinolinate (Qa) phosphoribosyltransferase activity of N

29 Quinolinate (Quin), a metabolite in the kynurenine pathw

30 Quinolinate synthase (NadA) catalyzes a unique condensat

31 Quinolinate synthase (NadA) catalyzes a unique condensat

32 Quinolinate synthase (NadA) is a Fe4S4 cluster-containin

33 DHAP) and aspartate-enamine by the action of quinolinate synthase (NadA).

34 S cysteine desulfurase activity 70-fold) and quinolinate synthase activity.

35 ike and one with similarity to the bacterial quinolinate synthase, NadA.

36 study concludes that all currently annotated quinolinate synthases harbor a [4Fe-4S] cluster, that th

37 the biosynthetic pathway from tryptophan to quinolinate, the universal de novo precursor to the pyri

38 ratios of 3-sialyllactose to xanthosine and quinolinate to X-16397 and our previously reported urina

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