ライフサイエンスコーパス: quinoline

1 cule derived from tetrahydro-3H-cyclopenta[c]quinoline.

2 substituents on the carboxylic A-ring of the quinoline.

3 d by a 5, 6, or 7 membered carbocycle to the quinoline.

4 d selectively the E-isomer of pyrimido[1,6-a]quinoline.

5 y the synthesis of pharmaceutically relevant quinolines.

6 ecently published results focused on related quinolines.

7 alkyl quinolines as well as more common aryl quinolines.

8 ing closure to yield hydroxynaphthalenes and quinolines.

9 rogenation of tetrahydroquinolines to afford quinolines.

10 paration of a number of medicinally relevant quinolines.

11 oration and hydrosilylation of pyridines and quinolines.

12 ons of N-(2-iodophenylsulfonyl)tetrahydroiso-quinolines.

13 3 led to better results for the synthesis of quinolines.

14 ccess a variety of 2-substituted indoles and quinolines.

15 tetrahydroquinolines into the corresponding quinolines.

16 Starting from quinoline 1, which was identified in a biochemical mTOR

17 uted carbazole (6), benzothiophene (10), and quinoline (14) derivatives can be synthesized.

18 design led to the identification of 3-pentyl-quinoline-2-amine as a novel, human TLR8-specific agonis

19 the kynurenic acid analog 7-chloro-4-oxo-1H-quinoline-2-carboxylic acid (7-chlorokynurenic acid; 7-C

20 The use of a bidentate ligand, quinoline-2-oxazoline (Quinox), and TBHP((aq)) as the te

21 calculation, and the N-heterocyclic carbene quinoline-2-ylidene is not formed as a tautomer.

22 ith higher affinity, including indole 19 and quinoline 20.

23 hthalene ("proton sponge") 1 and quino[7,8-h]quinoline 2a have been examined.

24 n-3-yl]-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline -3-carboxamide; MQC) dose-dependently suppress

25 we show the synthesis of the tetrazolo[1,5-a]quinoline-3-carbaldehyde and tetrazolo[1,5-a]quinoline-3

26 -activity relationships, and binding mode of quinoline-3-carbohydrazide derivatives as allosteric mod

27 (4-methyl-1,4-diazepan-1- yl)sulfonyl)phenyl)quinoline-3-carbonitrile (NEU-924, 83) for T. cruzi and

28 1S)-1-(1-methyl-1H-pyrazol-3-yl)e thyl]amino}quinoline-3-carboxamide (74) as potent and highly select

29 Quinoline-3-carboxamide compounds (Q compounds) have dem

30 edure for the synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters is described.

31 quinoline-3-carbaldehyde and tetrazolo[1,5-a]quinoline-3-dimethyl acetal at room temperature in metha

32 rmacokinetic profile of 2,3,4-trisubstituted quinoline, 4, led to the discovery of two potent, select

33 ion of a phenotypic screening hit based on a quinoline-4-carboxamide derivative resulted in the highl

34 amoyl)-phenyl)-6,8-dimethyl-2-(pyridin-2- yl)quinoline-4-carboxamide], a selective GPR55 antagonist.

35 DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described.

36 any prefunctionalization and N-protection of quinoline-4-ones.

37 ising compounds led to the identification of quinoline 41 (RG7109), which was selected for advancemen

38 no-4-(4-fluorophenylamino)-1H-pyrazolo[4,3-c]quinoline (42) combined with chemotherapeutic CPT-11 tre

39 ioselective tandem synthesis of indolo[1,2-a]quinolines 4a-v and pyrrolo[1,2-a]quinolines 5a-k from 1

40 two compounds, 7-acetamido-2-(8'-quinolinyl)quinoline-5,8-dione (11) and 7-amino-2-(2-pyridinyl)quin

41 ne-5,8-dione (11) and 7-amino-2-(2-pyridinyl)quinoline-5,8-dione (23), showed selective cytotoxicity

42 all other compounds, NQO1 protected against quinoline-5,8-dione cytotoxicity.

43 of pore-size in a coordination network, [Cu(quinoline-5-carboxyate)2 ]n (Qc-5-Cu) ena+bles ultra-hig

44 azaguanine and 2-(2-(5-nitro-2-thienyl)vinyl)quinoline (5350150), which function by distinct mechanis

45 dolo[1,2-a]quinolines 4a-v and pyrrolo[1,2-a]quinolines 5a-k from 1-(2-bromophenyl)-1H-indole/pyrrole

46 ime, 10-dimethylamino derivatives of benzo[h]quinoline 6 and benzo[h]quinazoline 7a-e as mixed analog

47 n of a series of 7-oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamide derivatives as a novel chemotype

48 cation of the screening hit 11H-indolo[3,2-c]quinoline-6-carboxylic acid revealed structure-activity

49 ture determination of three 11H-indolo[3,2-c]quinoline-6-carboxylic acids cocrystallized with DYRK1A

50 -[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl )quinoline (8) was discovered from a highly selective hig

51 o-2,3-dihydro-1,4-dioxino[2,3-g]thieno[2,3-b]quinoline-8 -carboxamide (8), inhibited this interaction

52 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8- sulfonamide) have the combined properties o

53 p-tolyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4MP-TQS), together with all oth

54 n-2-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide ) and allosteric agonists such a

55 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide )] or an iodine atom [4IP-TQS (4

56 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) ] generated a compound that lac

57 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) and 3BP-TQS (4-(3-bromophenyl)-

58 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) interact at an intrasubunit tra

59 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide), rather than at the para positi

60 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide)] results in compounds that have

61 phenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide, is a strong positive allosteric

62 rylquinolines via Pd-catalyzed borylation of quinoline-8-yl halides and subsequent Suzuki-Miyaura cou

63 Eight 2-phenyl-3H-imidazo[4,5-b]quinoline-9-carbonitriles 15 are prepared in four steps

64 enyl ether affords 2-phenyl-3H-imidazo[4,5-b]quinoline-9-carbonitriles 15 in near quantitative yields

65 effect a three-component reaction between a quinoline, a terminal alkyne, and ethyl chloroformate.

66 ion of a variety of N-heteroarenes including quinolines, acridines, benzo[h], and 1,5-naphthyridine a

67 , we report on the effects of pyrazolo[4,3-c]quinolines acting as a new class of bacterial betaG-spec

68 Quinolines also form various complexes with soluble hema

69 f the pyrazole and amide substituents led to quinoline amide 21, which was advanced to preclinical de

70 The NPAHs 1,4-dihydro(iso)quinoline and (iso)quinoline can be synthesized through

71 ded to the synthesis and isotope labeling of quinoline and 1,2,3,4-tetrahydroquinoline derivatives.

72 Lower rim amide linked 8-amino quinoline and 8-amino naphthalene moiety 1,3,5-trideriva

73 licenes were synthesized utilizing versatile quinoline and 9-(2-ethylhexyl)-2,7-dimethoxycarbazole-3-

74 ABC transporter shown to be associated with quinoline and antifolate tolerance in Plasmodium falcipa

75 Potency was enhanced by methylation of the quinoline and by introduction of simple chiral moieties,

76 ew styryl dyes derived from 4-pyridine and 4-quinoline and having an ammonioalkyl N-substituent and b

77 s, revealing that high quantum yields of the quinoline and isoquinoline derivatives are a result of t

78 the results obtained for previously reported quinoline and isoquinoline derivatives.

79 onship between the electronically asymmetric quinoline and oxazoline ligand modules.

80 vity relationships (SAR) of a series of (iso)quinoline and quinazoline compounds that were synthesize

81 portant determinant of resistance to several quinoline and quinoline-like antimalarial drugs.

82 ular study revealed the necessity of hydroxy quinoline and the amine group for La(3+) ion binding and

83 tic aza-Michael/aldol cascade process toward quinolines and 1,4-dihydroquinolines depends on the choi

84 A total of 15 different quinolines and 14 different pyrimidines were synthesized

85 ch for the synthesis of 3-aryl-2-substituted quinolines and 4-arylacridines has been developed via th

86 ass of trans-fused hexahydro-1H-pyrano[3,4-c]quinolines and hexahydro-1H-thiopyrano[3,4-c]quinolines

87 strategy for the synthesis of pyrrolo[1,2-a]quinolines and indolizines from pyranoquinolines via sit

88 organozinc nucleophiles to N-acyl activated quinolines and isoquinolines is described.

89 , and sugar-derived ones, leading to desired quinolines and naphthydrines with good yields.

90 able, and practical synthesis of substituted quinolines and pyrimidines using combinations of 2-amino

91 and evaluated hitherto unexplored furo[2,3-c]quinolines and regioisomeric furo[3,2-c]quinolines deriv

92 erent polarities (naphthalene, acetophenone, quinoline, and 2-naphthol), and of the organocation para

93 lbenzofuran, dibenzofuran, dibenzothiophene, quinoline, and 6-methylquinoline were positive in the ER

94 eterocylces such as quinoxalines, pyridines, quinoline, and isoquinoline as well as quinones.

95 ng heteroaryl chlorides, including pyridine, quinoline, and isoquinoline derivatives.

96 sition metal-free acylation of isoquinoline, quinoline, and quinoxaline derivatives has been develope

97 lary SiNN pincer ligand that combines amido, quinoline, and silyl donors and gives rise to structural

98 lines in the presence of tert-butyl nitrite, quinoline, and the Sc(OTf)3 catalyst in DCE at 80 degree

99 tron-deficient N-heterocycles (isoquinoline, quinolines, and quinoxalines) and methylbenzenes leading

100 soquinoline derivatives differ from those of quinolines, and the most pronounced differences are foun

101 Several examples of the quinoline-annulated porphyrins were crystallographically

102 hts important implications for understanding quinoline antimalarial drug resistance and for future dr

103 tion and inhibition by chloroquine, a common quinoline antimalarial drug.

104 has been accepted that a number of effective quinoline antimalarial drugs (e.g., chloroquine, quinine

105 d in situ surface observations and show that quinoline antimalarials inhibit beta-hematin crystal sur

106 tion, classical or nonclassical; and whether quinoline antimalarials inhibit crystallization by seque

107 Quinoline antimalarials target hemozoin formation causin

108 ed sensitivity to chloroquine and some other quinoline antimalarials, but exhibit no or minimal chang

109 l mode of hemozoin growth inhibition for the quinoline antimalarials.

110 is and characterization of a triazole linked quinoline appended calix[4]arene conjugate, L, and its f

111 The 8-amino quinoline (AQ) directing group can easily be removed, al

112 ium carbonate modified with lead acetate and quinoline are widely employed industrially for the parti

113 Quinolines are common pharmacophores present in numerous

114 Difficult-to-access alkyl-substituted quinolines are formed directly from commercially availab

115 These quinolines are unethically used in beekeeping, and a zer

116 lective three-component synthesis of 2-alkyl quinolines as well as more common aryl quinolines.

117 ges, but a piperazinyl group adjacent to the quinoline, at least for the group of compounds studied h

118 A diformyl-quinoline based receptor (L1) exhibits selective colorim

119 However, quinoline-based ALLINIs impose a low genetic barrier for

120 ilar pocket at the IN dimer interface as the quinoline-based ALLINIs, the lead compound, 5, inhibited

121 Recently discovered quinoline-based allosteric IN inhibitors (ALLINIs) poten

122 Quinoline-based analogues showed lower inhibitory activi

123 hibited IN mutants that confer resistance to quinoline-based compounds.

124 exploration of potential replacements for a quinoline-based inhibitor of activation of AKT kinase le

125 een accomplished by using a combination of a quinoline-based ligand and a weakly coordinating amide d

126 A quinoline-based ligand effectively promotes the palladiu

127 The use of a newly developed quinoline-based ligand is essential for the cross-coupli

128 A quinoline-based ligand was shown to promote palladium-ca

129 Three pyridine- and quinoline-based ligands are developed to match different

130 c acid-derived amides was developed by using quinoline-based ligands.

131 We previously reported potent quinoline-based PDE5 inhibitors (PDE5Is) for the treatme

132 2-benzothiazole-, 4-pyridine-, and 2- and 4-quinoline-based styryl dyes containing an N-methylbenzoa

133 cascade delivering a series of pyrrolo[1,2-a]quinolines bearing phosphonate or phosphine oxide moieti

134 rido[1,2-a] benzimidazole, benzimidazo[1,2-a]quinolines, benzimidazo [1,2-a]pyrazine, benzo[4,5] imid

135 described for the synthesis of various fused quinoline, benzoquinoline, and naphthoquinoline derivati

136 which was prepared from a readily available quinoline building block via Wittig reaction followed by

137 etrazolyl)quinolines or 1,2,3-triazolo[1,5-a]quinoline by conventional flash vacuum pyrolysis (FVP) w

138 The reduction of quinoline by SmI2 results in an instantaneous [2 + 3] cy

139 ynthesis of 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinolines by a SnCl(2)-catalyzed multicomponent reactio

140 epared a number of di- and trifunctionalized quinolines by selective metalation of chloro-substituted

141 action cascade to give ring-fused indoles B, quinolines C, or quinolones D depending on the reaction

142 odies a quaterpyridine backbone but with the quinoline C8 providing an additional sp(2) center separa

143 The NPAHs 1,4-dihydro(iso)quinoline and (iso)quinoline can be synthesized through reaction of pyridyl

144 ficantly decreasing the rotation rate of the quinoline-carbinol bond, the relatively bulky CF(3) grou

145 with appropriately substituted pyridine and quinoline carboxaldehydes.

146 ecently we observed that the type II binding quinoline carboxamide (QCA) compounds were metabolically

147 Starting from the micromolar 8-quinoline carboxamide high-throughput screening hit 1a,

148 A novel series of 3-quinoline carboxamides has been discovered and optimized

149 This quinoline carboxylic acid directly inhibited dihydroorot

150 this paper the identification of a nontoxic quinoline carboxylic acid that reverts the inhibition of

151 We hypothesize that the antimalarial quinoline chloroquine exerts potent antiarrhythmic effec

152 n in malaria parasites and the target of the quinoline class of antimalarials.

153 ivity in the regioselective hydrogenation of quinoline, compared with PtNPs of 5.3 nm, allowing the r

154 vities of up to 94:6 e.r. with 2-substituted quinolines containing C8-amino functionality.

155 tilbene series, the 3,5,6,8-tetrasubstituted quinoline core was identified as replacement of the stil

156 Cyclic ether fused-quinolines could also be accessed using this fast, opera

157 Herein, we report a coumarin-quinoline (CQ) conjugate-based turn-on near-infrared (NI

158 The use of a quinoline derivative as a ligand also enables C(sp(3))-H

159 The amino-substituted quinoline derivative of THC, 1e, showed antioxidant acti

160 The reverse hydrogenation reaction of quinoline derivatives (H2 storage) was also optimized an

161 strategy, a library of 5-methyl-indolo[3,2-c]quinoline derivatives (IQc) with a range of alkyldiamine

162 4-[(4-piperidinyl)methoxy]-2H-pyrrolo[3,4-c]quinoline derivatives as new 5-HT(4)R ligands endowed wi

163 This approach resulted in quinazoline-quinoline derivatives as potent inhibitors of DNMT3A and

164 of a new series of hexahydro-2H-pyrano[3,2-c]quinoline derivatives as potent sigma1 receptor (sigma1R

165 Quinoline derivatives as well as a number of 3- and 5-su

166 A series of dicarboxylic quinoline derivatives bearing electron-releasing or -wit

167 e most potent ligand among the imidazo[1,5-a]quinoline derivatives described so far.

168 Moreover, due to the importance of quinoline derivatives for a variety of applications, the

169 A new approach to benzo[f]quinoline derivatives has been found by an effective for

170 In this study, a new series of more than 60 quinoline derivatives has been synthesized and evaluated

171 nternal alkynes proceeded smoothly to afford quinoline derivatives in good to excellent yields (up to

172 in the presence of KF gave 3-(2-hydroxyaryl)quinoline derivatives in good yields.

173 Novel quinoline derivatives of THC and zingerone have been syn

174 in 2-(2-vinylstyryl)oxazoles to form benzo[f]quinoline derivatives proceeds on the S1 PES via a stepw

175 strategies toward the synthesis of bioactive quinoline derivatives such as chloroquine analogues.

176 This method could also be applied to other quinoline derivatives using appropriate alkynes.

177 A series of imidazo[1,5-a]quinoline derivatives was designed and synthesized as ce

178 activities (RSA) of THC, zingerone and their quinoline derivatives were evaluated.

179 tom-economic way, generating a library of 24 quinoline derivatives.

180 rotective properties for these imidazo[1,5-a]quinoline derivatives.

181 lled C(sp(3))-H arylation using pyridine and quinoline derivatives: The former promotes exclusive mon

182 the generation of a variety of indolo[2,3-b]quinolines derivatives in good to moderate yields with a

183 ,3-c]quinolines and regioisomeric furo[3,2-c]quinolines derived via a tandem, one-pot Sonogashira cou

184 ecently reported Suzuki coupling reaction of quinoline-derived allylic N,O-acetals has been studied u

185 amily of potential autophagy blockers is the quinoline-derived antimalarial family, including chloroq

186 hysicochemical properties of 5H-indolo[2,3-b]quinoline (DiMIQ), lipophilic and hemolytic properties w

187 trate scope, and mechanistic experiments for quinoline-directed alkene oxyacylation.

188 e intramolecular oxyacylation of alkenes via quinoline-directed C-O bond activation.

189 is diversity shows that even closely related quinoline drugs may have quite different molecular pharm

190 alkaloid core is efficiently prepared from a quinoline, employing a method which relies on a newly de

191 prised of an NHS-carbamate reactive group, a quinoline fluorophore, and a tertiary amine for enhancin

192 ibenzothiophene, fluorenones, xanthones, and quinoline fractions.

193 lly, the one-pot multicomponent synthesis of quinolines from anilines, aldehydes, and olefins has als

194 gioselective synthesis of C-3-functionalized quinolines from azadienes (in situ generated from 2-amin

195 tandem synthesis of dihydroquinazolines and quinolines from N-alkylanilines using a TEMPO oxoammoniu

196 ation of 3-substituted and 3,4-disubstituted quinolines from stable starting materials (activated ace

197 Under acidic conditions, the quinoline group undergoes nondirected chlorination.

198 as (ii) the presence of the nitrogen on the quinoline group, and (iii) of a hydrophobic group on the

199 lithium reagents to non-activated imines and quinolines has been accomplished in green, biorenewable

200 etrahydro-4,4-tetramethylene-1H-cyclopenta[c]quinolines have been obtained through the Skraup-Doebner

201 re active for reduction of a wide variety of quinolines having functionalities at the 2-, 6-, and 8-

202 II) ion detection reagent, 10-hydroxybenzo[h]quinoline (HBQ), with an optical field enhanced silicon

203 revealed a surprising molecular diversity in quinoline-heme molecular interactions.

204 In this study, we identified the substituted quinoline HG-829 as a novel, noncompetitive, and potent

205 Selective reduction of an anthracenone-quinoline imine derivative, 2, using 1.0 equiv of NaBH(4

206 f 10 3-imidazo[1,2-a]pyridin-tetrazolo[1,5-a]quinolines in 28-94% yields via a novel one-pot Groebke-

207 quinolines and hexahydro-1H-thiopyrano[3,4-c]quinolines in good to excellent yields with high selecti

208 lkenyl iodides converted to multisubstituted quinolines in good to excellent yields.

209 ding pyrimidines, N-substituted piperidines, quinolines, indoles, N-substituted imidazoles, triazoles

210 The quinoline-indoles show only weak activity as inhibitors

211 In contrast to quinolines, introduction of amine side chains did not le

212 llowing HCAs: 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo-[4,5-f]quino

213 -IQ) formed by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a highly mutagenic and carcinogenic hete

214 trolled synthesis of very highly substituted quinolines is described.

215 ne, and quinoline, to prepare pyrimido[1,6-a]quinolines is reported.

216 Various pyridine, quinoline, isoquinoline, and pyrimidine N-oxides were co

217 Pyridine, quinoline, isoquinoline, azaindole, and pyrimidine N-oxi

218 es, azaindoles, deazapurines, benzimidazole, quinolines, isoquinolines, and pyridines were efficientl

219 The use of a tailor-made quinoline ligand is also crucial for this reaction to pr

220 ed by a mutually repulsive and electron-rich quinoline ligand.

221 covery of chiral acetyl-protected aminoethyl quinoline ligands that enable asymmetric palladium inser

222 catalyzed C(sp(3))-H bromination, enabled by quinoline ligands.

223 We report that binuclear benzo[h]quinoline-ligated Ni(II) complexes, upon oxidation, unde

224 inant of resistance to several quinoline and quinoline-like antimalarial drugs.

225 The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatibl

226 ine (IQ), 2-amino-3,4-dimethylimidazo-[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo-[4,5-f]qui

227 samides A-C are chlorinated pyrrolo[4,3,2-de]quinoline metabolites isolated from the marine-derived S

228 ly reported the therapeutic potential of the quinoline methanol Vacquinol-1 (1) that targets glioblas

229 A library of diamine quinoline methanols were designed based on the mefloquin

230 omycin A derivatives consisting of different quinoline moieties covalently liked to a 15-membered aza

231 By replacing naphthyl with quinoline moieties, we prepared active analogues with up

232 state places significant spin density on the quinoline moiety of the 1-isocyTPQA ligand positioned tr

233 ctor, it was shown that intercalation by the quinoline moiety of the ligand as assumed initially as t

234 By incorporation of an indole or a quinoline moiety to the 9H-pyrimido[4,5-b]indole core, w

235 henyl group adjacent to the oxime, forming a quinoline moiety.

236 pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (MP-10) in rodents and in monkeys.

237 o-triphenylmonoquinoline-annulated porphyrin quinoline N-oxide, possessing a slightly shifted and sha

238 Reactions of various 2-substitued quinoline N-oxides with ortho-(trimethylsilyl)aryltrifla

239 lecular hydrogen bond between the protonated quinoline nitrogen (N(+)-H) and an imide carbonyl (O hor

240 between the phenol oxygen (proton donor) and quinoline nitrogen (proton acceptor), dO...N, giving ris

241 tation due to steric interaction between the quinoline nitrogen and imide carbonyls.

242 Permeable quinoline nitrones 2 and 3 show potent combined antioxid

243 ic features of the bridging motif as well as quinoline nucleus were explored.

244 with positions 4 and 5 of the imidazo[1,5-a]quinoline nucleus.

245 The addition to pyridines and quinolines occurs under almost identical conditions and

246 icient preparation of selected pyrrolo[1,2-a]quinolines on multigram scale without any safety concern

247 ethylquinolines generated from (5-tetrazolyl)quinolines or 1,2,3-triazolo[1,5-a]quinoline by conventi

248 base-assisted dearomatization of a phosphine-quinoline (P~N) ligand.

249 ed for this reaction, such as isoquinolines, quinoline, phenanthridine, quinazoline, phthalazine, and

250 rid-2'-yl)-8-(1'',10''-phenanthrolin-2''-yl)-quinoline (ppq) embodies a quaterpyridine backbone but w

251 (1'',10''-phenanthrol-2''-yl)-2-(pyrid-2'-yl)quinoline (ppq), has been prepared by two sequential Fri

252 ence of dilute aqueous HCl to give the final quinoline products.

253 logy is further demonstrated in synthesis of quinoline-quinolone hybrid as well as 6-aryl-benzofuro[3

254 The reaction uses 2-(4,5-dihydro-2-oxazolyl)quinoline (quinox) as a ligand and is performed at ambie

255 The reaction uses 2-(4,5-dihydro-2-oxazolyl)quinoline (Quinox) as ligand and TBHP(aq) as oxidant to

256 iosynthesized by (18)F-introduction onto the quinoline rather than the pyrazole moiety of the MP-10 p

257 romatization cascade to give polysubstituted quinolines (right).

258 vealed that the geometric disposition of the quinoline ring at the C8 chiral carbon of cinchona-enami

259 to the phenyl group at the 4-position of the quinoline ring of tipifarnib and by replacing the amino

260 g through the adjacent carbonyl group on the quinoline ring resulted in successful predictions of obs

261 AR) of the 4-, 6-, and 8-substituents of the quinoline ring resulted in the identification of approxi

262 an annulation in the final step to close the quinoline ring, leading to a dihydroquinoline derivative

263 The quinoline rotor is based on a rigid N-arylimide framewor

264 ry of PSI-697 (1a), a C-2 benzyl substituted quinoline salicylic acid-based P-selectin inhibitor.

265 one hybrid as well as 6-aryl-benzofuro[3,2-c]quinoline scaffold.

266 design of this series centered on morphing a quinoline series recently disclosed in the patent litera

267 Compounds with a quaternary nitrogen on the quinoline show improved activity against the chloroquine

268 oups with respect to both the alkyne and the quinoline starting materials and the products are easily

269 s all contain a 2-methyl-4-amino-6,7-dioxolo-quinoline structure that is predicted from the modeling

270 Introduction of a benzo[g]quinoline substructure previously unknown in the context

271 reement with some of the previously reported quinoline syntheses, an alternative mechanistic pathway

272 l mechanism of the Skraup-Doebner-Von Miller quinoline synthesis remains controversial and not well u

273 any variant of the Skraup-Doebner-Von Miller quinoline synthesis.

274 tained through the Skraup-Doebner-Von Miller quinoline synthesis.

275 first generation of fluoroalkyl-substituted quinoline tau binding ligands with suboptimal physicoche

276 as palladium-catalyzed coupling to generate quinolines that can be substituted at every position of

277 partners, including pyridines, pyrimidines, quinolines, thiophenes, and piperidines.

278 t contain a coordinating Lewis base, such as quinoline, to be active for Cu(II).

279 oaddition, using sulfonyl azide, alkyne, and quinoline, to prepare pyrimido[1,6-a]quinolines is repor

280 These reactions are exclusively enabled by quinoline-type ligands.

281 component Povarov reaction forms 2,3-dialkyl quinolines under the same green conditions that enable t

282 eous iridium catalyst gives hydrogenation of quinolines under unprecedentedly mild conditions-as low

283 15a-g, a regioisomer of the bisindolo[1,2-a]quinolines used as organic single-crystal field-effect t

284 f [1,3,4]thiadiazolo[3',2':1,2]imidazo[4,5-c]quinolines using a Pictet-Spengler reaction.

285 he synthesis of densely substituted 4-alkoxy quinolines via an oxonium ion triggered alkyne carboamin

286 (4-(2,4-dinitrophenylsulfonyl)piperazin-1-yl)quinoline (VR23) as a small molecule that potently inhib

287 general method leading to polyfunctionalized quinolines was developed.

288 iodo-substituted tetrahydro-3H-cyclopenta[c]quinolines was synthesized as potential targeted imaging

289 Here, by reference to quinoline, we illustrate that the SABRE hyperpolarizatio

290 edlander and Combes syntheses of substituted quinolines were conducted in charged microdroplets produ

291 A series of 18 3-tetrazolyl-tetrazolo[1,5-a]quinolines were synthesized in 21-90% yields via a novel

292 d N10,O11-bis-alkylamine (3a-k) indolo[3,2-b]quinolines, were evaluated for their in vitro activity a

293 d a new displacer, 4-methyl-2-piperazin-1-yl-quinoline, which produced a more selective displacement

294 ble an important class of C-3-functionalized quinolines, which are difficult to access.

295 y selective metalation of chloro-substituted quinolines with metal amides followed by reaction with d

296 reaction of [(bzq)Pd(OAc)](2) (bzq = benzo[h]quinoline) with "CF(3)(+)" reagents to afford the monome

297 nistic activity profile in select furo[2,3-c]quinolines, with maximal potency conferred by a C2-butyl

298 For the quinophthalone type dye Quinoline Yellow (E104), the adsorption is also maximal

299 cluding Tartrazine (E102), Chrysoine (E103), Quinoline Yellow (E104), Yellow 2G (E107), Sunset Yellow

300 The interaction of a food colourant, quinoline yellow (Qy), and bovine serum albumin (BSA) wa