ライフサイエンスコーパス: quinolone

1 ine, thiazole, quinoxaline, benzoxazole, and quinolone.

2 which makes this enzyme produce the diketide quinolone.

3 ) to form the signal molecule 2-heptyl-4(1H)-quinolone.

4 pare patients treated with azithromycin vs a quinolone.

5 a promoter for the synthesis of substituted quinolones.

6 elective metalation of various chromones and quinolones.

7 s internal standards to quantify the (fluoro)quinolones.

8 milar enantioselectivities as the respective quinolones.

9 ute to protection of E. coli DNA gyrase from quinolones.

10 i as well as of man-made antibiotics such as quinolones.

11 to pyridyl 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolones.

12 ins (four cases), cephalosporins (41 cases), quinolones (15 cases), and pristinamycin (seven cases) w

13 ent publications report in vitro activity of quinolone 3-esters against the bc1 protein complex of Pl

14 4-Quinolone-3-carboxamide derivatives have long been recog

15 nt class of orally active antimalarial 4(1H)-quinolone-3-diarylethers.

16 The synthesis of the chromone- and quinolone-3-sulfonamide intermediates features formylati

17 of antibiotic resistance were in classes of quinolones (42.0%), sulfonamides (24.0%), tetracyclines

18 nd in-house screening of a limited number of quinolones (50 compounds) identified approximately 100 h

19 d out to downselect the most promising 4(1H)-quinolones, 7, 62, 66, and 67, which possessed low-nanom

20 Carboxanilides 6a-c and quinolones 9a-c and 11a were evaluated for DNA binding p

21 d the divalent metal ions that could support quinolone activity.

22 was associated with use of: later generation quinolones, (adjusted odds ratio [aOR]: 2.5 [95% CI 1.1-

23 olin: adjusted OR = 0.49; 95% CI, 0.34-0.71; quinolone: adjusted OR = 0.55; 95% CI, 0.35-0.87) for co

24 A novel quinolone alkaloid, vitiquinolone (5) together with eigh

25 elos that is involved in the biosynthesis of quinolone alkaloid.

26 Quinolone alkaloids, found abundantly in the roots of ba

27 Use of azithromycin alone or a quinolone alone for treatment of Legionella pneumonia wa

28 Quinolones alone were used in 28.8%, azithromycin alone

29 Drugs in known classes such as new quinolones, aminoglycosides, tetracyclines, and beta-lac

30 f orally efficacious antimalarials including quinolone analogue 20g, a promising candidate for furthe

31 es conducted in parallel revealed that 4(1H)-quinolone analogues are limited by poor solubilities and

32 activity relationship (SAR) studies on 4(1H)-quinolone analogues identified several key features for

33 r the anthranilate-derived production of the quinolone and acridone alkaloid by type III polyketide s

34 thaliana and that the plant is sensitive to quinolone and aminocoumarin antibiotics, compounds that

35 her that enzyme is indeed the target for the quinolone and aminocoumarin antibiotics.

36 o resistance to sub-lethal concentrations of quinolone and beta-lactam antibiotics primarily through

37 ions is a two-point hydrogen bonding between quinolone and catalyst enabling efficient energy transfe

38 Quinolone and fluoroquinolone antibiotics are potent, br

39 ruginosa PAO1-based 2-heptyl-3-hydroxy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone r

40 ing (QS) molecules, 2-heptyl-3-hydroxy-4(1H)-quinolone and N-(3-oxododecanoyl)-l-homoserine lactone,

41 d to compare the rate of perforation between quinolone and neomycin plus hydrocortisone ear drop-expo

42 occus aureus genes involved in resistance to quinolones and beta-lactams, such as those encoding the

43 vel class of N-linked aminopiperidinyl alkyl quinolones and naphthyridones that kills Mtb by inhibiti

44 racis topoisomerase IV, their sensitivity to quinolones and related drugs and their use of metal ions

45 l molecules including Pseudomonas-associated quinolones and rhamnolipids in feces, setting the stage

46 t-off values of beta-lactams, tetracyclines, quinolones and sulfonamides were determined to be 8 ng/m

47 of antibiotics (beta-lactams, tetracyclines, quinolones and sulfonamides) in milk within 20 min.

48 for the quantification of 14 antimicrobials (quinolones and tetracyclines) in fish.

49 for interactions between clinically relevant quinolones and topoisomerase IV and provide a likely mec

50 ng/mL for tetracyclines, 0.08-2.0 ng/mL for quinolones, and 0.1-3.98 ng/mL for sulfonamides, with li

51 id not bind GyrA fragments bound by CcdB and quinolones, and a set of strains resistant to a variety

52 ans, thiophenes, benzothiophenes, pyrazoles, quinolones, and chromones can be applied.

53 -level susceptibility to most macrolides and quinolones, and moderate susceptibility to most tetracyc

54 iously postulated antineoplastic activity of quinolones, and suggest that ciprofloxacin might be a si

55 In contrast to the quinolone- and acridone-producing A. marmelos QNS, C. mi

56 and microbiological evaluation of chromone-, quinolone-, and benzoxazinone-3-sulfonamide derivatives

57 oval of nalidixic acid (NAL), a recalcitrant quinolone antibacterial agent.

58 Quinolone antibacterials represent one of medicine's mos

59 Guidelines recommend azithromycin or a quinolone antibiotic for treatment of Legionella pneumon

60 Oxolinic acid (OA) is a widely used quinolone antibiotic in aquaculture.

61 Here we show that the quinolone antibiotic trovafloxacin is a novel PANX1 inhi

62 ed a third-generation cephalosporin and/or a quinolone antibiotic.

63 ingly, among these candidate inhibitors were quinolone antibiotics and HIV integrase inhibitors, whic

64 Quinolone antibiotics have antiviral properties against

65 raphic method for the determination of seven quinolone antibiotics in tissue of Atlantic salmon (Salm

66 s the capacity of magnetite to bind not only quinolone antibiotics such as nalidixic acid (NA) and fl

67 Comparing different quinolone antibiotics suggests that certain structural f

68 use of growth phase-dependent persistence to quinolone antibiotics.

69 occus aureus, and Mycobacterium smegmatis to quinolone antibiotics.

70 nes were shown to sensitize P. aeruginosa to quinolones, antibiotics that elicit a strong SOS respons

71 o failure/relapse or death: later generation quinolones, (aOR: 2.7 [1.7-4.3]), ofloxacin (aOR: 2.3 [1

72 ations to a natural flavone, isoflavone, and quinolone are shown.

73 Quinolones are antibiotics that are accredited in human

74 Although quinolones are the most commonly prescribed antibacteria

75 Although quinolones are widely used to treat bacterial infections

76 n led to the selection of 2-bisaryl 3-methyl quinolones as a series for further biological evaluation

77 reports have described possible activity of quinolones as antineoplastic agents.

78 a lyophilized egg material spiked with nine quinolones as sample in a proficiency test.

79 To guide the development of new quinolone-based agents, it is critical to understand the

80 llographic and biochemical studies show that quinolone binding involves a water/metal-ion bridge betw

81 structure of cleaved complexes, two modes of quinolone binding must exist.

82 he data support the existence of a secondary quinolone-binding mode in which the quinolone C7 ring sy

83 ificities and produces not only acridone and quinolone but also chalcone, benzophenone, and phloroglu

84 nvolves a water/metal-ion bridge between the quinolone C3-C4 keto-acid and amino acids in helix-4 of

85 econdary quinolone-binding mode in which the quinolone C7 ring system interacts with GyrA; the data a

86 ether the infected strains were resistant to quinolone can be performed simultaneously on a single ch

87 strains were susceptible to aminoglycosides, quinolones, carbapenems, and monobactams.

88 completely restored by treatment with benzyl quinolone carboxylic acid (BQCA) and benzoquinazoline-12

89 Benzyl quinolone carboxylic acid (BQCA) is an unprecedented exa

90 ated the actions at an M(1) DREADD of benzyl quinolone carboxylic acid (BQCA), a positive allosteric

91 ently described allosteric modulator, benzyl quinolone carboxylic acid (BQCA), behaves according to a

92 Therefore, we chose the quinolone ciprofloxacin for further study, based on its

93 sclosures of an independent discovery of the quinolone class of antibacterials have been almost entir

94 The quinolone class of antibiotics, which targets bacterial

95 cepts point to new approaches for developing quinolone-class compounds that have increased potency ag

96 up other than the commonly used pyridine and quinolone classes for Cp*Co(III) -catalyzed C(sp(3) )-H

97 ntiates antibiotics from the beta-lactam and quinolone classes.

98 norA transcription and reduced resistance to quinolone compared to the wild-type strain, indicating t

99 Quinolones containing the amine-based side chain were se

100 fly examined leading to the selection of the quinolone core as the key target for structure-activity

101 led subtly by manipulation of the privileged quinolone core at the 2 or 3 position.

102 itution pattern on the benzenoid ring of the quinolone core significantly influenced reactivity with

103 f heterocycles, within the side chain of the quinolone core, was carried out, and this approach led t

104 s, the most promising of which contained the quinolone core.

105 give ring-fused indoles B, quinolines C, or quinolones D depending on the reaction conditions employ

106 nes (tedizolid phosphate and radezolid), and quinolones (delafloxacin, nemonoxacin and JNJ-Q2).

107 The 6-amino-7-[4-(2-pyridinyl)-1-piperazinyl]quinolone derivative 8 proved to be the best compound of

108 ty of vosaroxin, a first-in-class anticancer quinolone derivative, plus cytarabine in patients with r

109 Fused pyrimidinone and quinolone derivatives that are of potential interest to

110 Vosaroxin, a quinolone-derived intercalating agent has several proper

111 We evaluated two quinolone disks and five fluoroquinolone disks for their

112 nt SIMS imaging at the same location detects quinolone distributions in excellent agreement with the

113 n resistance factors bind to and disrupt the quinolone-DNA-gyrase interaction is proposed.

114 that an A. thaliana mutant resistant to the quinolone drug ciprofloxacin has a point mutation in ATG

115 argeted DNA gyrase that is the target of the quinolone drug ciprofloxacin; this has important consequ

116 sistance to a family of antibiotics known as quinolones due to single-point mutations.

117 Patients exposed to quinolone ear drops had a higher risk of perforation, wi

118 Exposure of children with TT to quinolone ear drops is associated with increased risk of

119 This study investigated whether quinolone ear drops, with or without corticosteroids, in

120 tients/families accordingly when prescribing quinolone ear drops.

121 ification, resulting in metabolically stable quinolones effective against multi drug resistant (MDR)

122 its natural substrates and those of the Nor quinolone efflux pumps are unknown.

123 We show that the endochin-like quinolone (ELQ) class of compounds contains extremely po

124 mice using a combination of an endochin-like quinolone (ELQ) prodrug and atovaquone.

125 Endochin-like quinolones (ELQ) were prepared by a novel chemical route

126 cs, beta-lactam (ampicillin and penicillin), quinolone (enoxacin), aminoglycoside (kanamycin and neom

127 g modes raises the possibility that multiple quinolone-enzyme-DNA complexes can form, a discovery tha

128 preliminary structural optimization of 4(1H)-quinolone ester derivatives, a new series of antimalaria

129 We evaluated 16 quinolone/fluoroquinolone disks for their ability to det

130 ructure-activity relationship study on 4(1H)-quinolones, focusing on the reduction of cross-resistanc

131 A synthesis inhibitors (fluoroquinolones and quinolones), folic acid synthesis inhibitors (sulfonamid

132 athogen Pseudomonas aeruginosa employs alkyl quinolones for cell-to-cell communication.

133 tween the lowest energy hydroxyquinoline and quinolone forms is 27 and 38 kJ mol(-1), for 5Me-HQE and

134 ence for the preparation of functionalized 4-quinolones from 2-iodoanilines and alkynes via two diffe

135 s described to synthesize highly substituted quinolones from pyridones.

136 tivity of some aryl propionic acids, (fluoro)quinolones, furocoumarins, metal coordination complexes,

137 The quinolone-fused lactam LP99 is now reported as the first

138 losporin-related SCARs were able to tolerate quinolones, glycopeptides, and carbapenems.

139 isolates were found to be susceptible to the quinolone group of antibiotics (moxifloxacin followed by

140 rms and plays a functional role in mediating quinolone-gyrase interactions.

141 Indolo[3,2-c]quinolones have been efficiently synthesized via an acid

142 ely used to treat bacterial infections, some quinolones have unexplained side effects, including deat

143 ne known inhibitor, hydroxy-2-dodecyl-4-(1H)-quinolone (HDQ), and this was used along with a range of

144 cifically, our data indicate that 2-heptyl-4-quinolone (HHQ), a precursor of PQS, likely induces the

145 PQS in vitro using the substrates 2-heptyl-4-quinolone (HHQ), NADH and oxygen.

146 rther demonstrated in synthesis of quinoline-quinolone hybrid as well as 6-aryl-benzofuro[3,2-c]quino

147 One such compound is 4(1H)-quinolone ICI 56,780, which is known to be a causal prop

148 Deciphering the complexity of quinolone IDHR seems mandatory.

149 Cefazolin sodium and quinolone in combination with an anaerobic agent were as

150 JNJ-Q2 is a novel fluorinated 4-quinolone in development for treatment of acute bacteria

151 The determination of quinolones in eggs was carried out by a previously devel

152 nfection among isolates usually sensitive to quinolones in the levofloxacin group vs placebo (14/24 [

153 rylacrylamides are cyclized to substituted 2-quinolones in the presence of CuI, PPh(3), and KO-t-Bu i

154 +) concentration required to produce maximal quinolone-induced DNA cleavage and restricted the divale

155 Consequently, the mar locus reduces quinolone-induced DNA damage and the ability of tetracyc

156 A repair, thus reducing antibiotic entry and quinolone-induced DNA damage.

157 Quinolones inhibit bacterial type II DNA topoisomerases

158 hila AhQnr, is soluble, stable, and relieves quinolone inhibition of Escherichia coli DNA gyrase, thu

159 s are proposed to serve as a critical enzyme-quinolone interaction site by anchoring a water-metal io

160 water-metal ion bridge that is critical for quinolone interactions with other bacterial type II topo

161 mutation of both residues abrogated protein-quinolone interactions.

162 2-Amino-3-methylimidazo[4,5-f]quinolone (IQ), a heterocyclic amine found in cooked mea

163 Previous exposure to quinolones is common among patients with moxifloxacin re

164 quinolone signal (PQS; 2-heptyl-3-hydroxy-4-quinolone) is one of these signals, and it is known to b

165 sing resistance to multiple drugs, including quinolones, is associated with decreased susceptibility

166 tabolism is sufficient to sensitize cells to quinolone killing.

167 Here we present a unique generation of quinolone lead antimalarials with a dual mechanism of ac

168 quent Mtb screening of the complete in-house quinolone library (350 compounds) identified a further a

169 Homogenized fresh whole egg spiked with nine quinolones (marbofloxacin, norfloxacin, ciprofloxacin, d

170 ity, and suggest that re-engineering certain quinolones might help develop newer antibacterials.

171 and it controls the production of 2-alkyl-4-quinolone molecules which are important for pathogenicit

172 Included ear drops were quinolones (ofloxacin, ciprofloxacin plus hydrocortisone

173 for isoniazid, 98.7% for rifampin, 97.6% for quinolones (ofloxacin, levofloxacin, or moxifloxacin), 9

174 cin, sarafloxacin and difloxacin), and three quinolones (oxolinic acid, nalidixic acid and flumequine

175 Our findings link growth-dependent quinolone persistence to discrete impairments in respira

176 m beta-lactamase-producing type SHV-12), and quinolones (plasmid-mediated quinolone resistance gene q

177 l zinc ions detection was developed based on quinolone platform.

178 QS signal molecule 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS), a minimal medium containing PQS as the

179 n which the cytotoxicity of beta-lactams and quinolones predominantly results from lethal double-stra

180 Other quinolones presented (e.g., 6d, 6f, 14e) have the capaci

181 conditions to furnish the desired 2-alkyl-4-quinolone products.

182 The small molecule 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas Quinolone Signal [PQS]) is one of

183 izes the small molecule 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas quinolone signal [PQS]).

184 ient preparation of 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS) and a di

185 gen-containing heterocycles such as indoles, quinolones, pyrazoles, and others.

186 quality control material for the analysis of quinolone residues in egg samples has been prepared.

187 B (MDR-TB) was significantly associated with quinolone resistance (P = 0.01).

188 he topoisomerase genes, but plasmid-mediated quinolone resistance (PMQR) mechanisms have also been de

189 gyrB, parC, and parE and/or plasmid-mediated quinolone resistance (PMQR) mechanisms including qnr var

190 d for Escherichia coli with plasmid-mediated quinolone resistance (PMQR), extended-spectrum beta-lact

191 industrial region in India were analyzed for quinolone resistance (qnr) genes by quantitative PCR.

192 ffective therapy, but treatment failures and quinolone resistance are emerging.

193 The most common causes of quinolone resistance are mutations of a specific serine

194 t mutations at GyrA(A90) and GyrA(D94) cause quinolone resistance by disrupting the bridge-enzyme int

195 pe SHV-12), and quinolones (plasmid-mediated quinolone resistance gene qnrB7).

196 Quinolone resistance genes were detected in 42% of well

197 macrolide resistance as well as emergence of quinolone resistance has occurred.

198 Comprehensive data on the prevalence of quinolone resistance in Mycobacterium tuberculosis clini

199 y 0, 1 carried E. coli with a lower level of quinolone resistance on day 0, and 4 carried E. coli wit

200 No other presumptive quinolone resistance-associated mutations were identifie

201 evalence of resistance mutations outside the quinolone resistance-determining region (QRDR) of gyrA o

202 ium tuberculosis gyrA gene, often called the quinolone resistance-determining region (QRDR).

203 Mutations in the quinolone resistance-determining region of gyrA were fou

204 ant strains contained point mutations in the quinolone resistance-determining region of gyrA.

205 Mutations in the quinolone resistance-determining regions (QRDR) of gyrA

206 lmonella due to chromosomal mutations in the quinolone resistance-determining regions (QRDRs) of the

207 kely mechanism for the most common causes of quinolone resistance.

208 nolones that overcome existing GyrA-mediated quinolone resistance.

209 Here we outline the impacts of quinolone-resistance mutations in relation to the fitnes

210 Expression/purification of the quinolone-resistant A. thaliana gyrase yields active enz

211 gyrB, Rv2686c, Rv2687c, and Rv2688c genes in quinolone-resistant and year-of-diagnosis-matched M. tub

212 Emergence of quinolone-resistant Escherichia coli (QREC) is an increa

213 bacteriostatic activity for Cip-AcCl with a quinolone-resistant GyrA-G81C variant of Escherichia col

214 nt antibacterial activity, including against quinolone-resistant isolates, but suffer from hERG inhib

215 nother multivariate analysis performed among quinolone-resistant isolates, treatment failure was 3 ti

216 e fecal microbiota, no proof of selection of quinolone-resistant mutants from the initial microbiota

217 Quinolone-resistant N. gonorrhoeae and reduced cefixime

218 Quinolone-resistant N. gonorrhoeae has arisen multiple t

219 Quinolone-resistant Neisseria gonorrhoeae (QRNG) arise f

220 Acinetobacter baumannii [8], carbapenem- and quinolone-resistant Pseudomonas aeruginosa [26], and der

221 highly effective in treating macrolide- and quinolone-resistant strains.

222 s with varying substituents on the benzenoid quinolone ring and/or the 3-position were synthesized an

223 The quinolone ring is noted as participating in a pi-stackin

224 he general 6-chloro-7-methoxy-2-methyl-4(1H)-quinolone scaffold which were substituted at the 3-posit

225 ive antimalarial pharmacophores, such as the quinolone scaffold, to yield potent and highly efficacio

226 een appended to the C7 position of different quinolone scaffolds do not take advantage of specific co

227 e envisioned, and then created, novel 4-(1H)-quinolone scaffolds that target the cytochrome bc1 compl

228 Moreover we show that, as in bacteria, the quinolone-sensitive (wild-type) allele is dominant to th

229 Extensive physicochemical evaluation of the quinolone series was carried out to downselect the most

230 improve the overall efficacy, multiple 4(1H)-quinolone series with varying substituents on the benzen

231 by P. aeruginosa and whether the Pseudomonas quinolone signal (PQS) and the MucD periplasmic protease

232 tyl-4-hydroxyquinoline (HHQ) and Pseudomonas quinolone signal (PQS) are involved in the regulation of

233 The Pseudomonas quinolone signal (PQS) compound is a secreted P. aerugin

234 The Pseudomonas quinolone signal (PQS) is a component of P. aeruginosa Q

235 The Pseudomonas aeruginosa quinolone signal (PQS) is a quorum sensing molecule that

236 The Pseudomonas quinolone signal (PQS) regulates various virulence facto

237 Here, we show that the Pseudomonas quinolone signal (PQS) system also contributes to the re

238 ing, particularly in the rhl and Pseudomonas quinolone signal (PQS) systems, was significantly muted

239 nteracting with the iron-binding Pseudomonas quinolone signal (PQS), a cell-cell signalling compound.

240 so promote the production of the Pseudomonas quinolone signal (PQS), a quorum sensing molecule that a

241 modulation of the levels of the Pseudomonas quinolone signal (PQS), a quorum signal previously shown

242 romatic compounds, including the Pseudomonas quinolone signal (PQS).

243 s of the cell signaling molecule Pseudomonas quinolone signal (PQS).

244 hich encodes the key synthase of Pseudomonas quinolone signal (PQS).

245 The Pseudomonas quinolone signal (PQS; 2-heptyl-3-hydroxy-4-quinolone) i

246 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas Quinolone Signal [PQS]) is one of these signals and its

247 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas quinolone signal [PQS]).

248 h as the quorum-sensing molecule Pseudomonas quinolone signal and the exopolysaccharide Psl, is regul

249 eptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS) and a diverse range of structur

250 Analysis of mutants defective in quinolone signal synthesis revealed a critical role for

251 qsR acts as the receptor for the Pseudomonas quinolone signal, and it controls the production of 2-al

252 cteristic fatty acids (e.g., palmitic acid), quinolone signal, and riboflavin fragments were found to

253 ed that phz1 is regulated by the Pseudomonas quinolone signal, factors controlling phz2 expression ha

254 hranilate for synthesis of the P. aeruginosa quinolone signal.

255 ins, carbohydrates, and, for the first time, quinolone signaling molecules-in Pseudomonas-derived bio

256 m site of the catalyst and the delta-lactam (quinolone) site of the substrate.

257 nt agreement with the CRM, discerns multiple quinolone species which differ slightly in mass, resolve

258 from the kynurenine pathway or from an alkyl quinolone specific anthranilate synthase encoded by phnA

259 The quinolone-specific aptamers bound to ofloxacin, one of t

260 The functionality of quinolone-specific aptamers in real water samples was de

261 nd, shifting from 4-quinolone to 4-hydroxy-2-quinolone structure enabled the discovery of a novel cla

262 ment or scaffold modification to 4-hydroxy-2-quinolone structure.

263 a further approximately 90 hits across three quinolone subtemplates.

264 Since it was reported that quinolones such as ciprofloxacin show antitrypanosomal a

265 genetically characterized, and compared with quinolone-susceptible E. coli (QSEC) strains collected o

266 Of the 14 who carried QREC, 9 carried quinolone-susceptible E. coli on day 0, 1 carried E. col

267 For comparison, 3 control reference quinolone-susceptible strains were included.

268 Two novel type III polyketide synthases, quinolone synthase (QNS) and acridone synthase (ACS), we

269 ion of a novel Type III polyketide synthase, quinolone synthase (QNS), from A. marmelos that is invol

270 identification of a characteristic FabH-like quinolone synthase from Pseudomonas aeruginosa with high

271 RhlR and MvfR, and genes of the Pseudomonas quinolone system.

272 like the unrelated F-encoded toxin CcdB and quinolones, targeted the GyrA subunit and stalled the DN

273 tic elements and resistance determinants for quinolones, tetracyclines, and beta-lactamases are share

274 g-binding mode in which the other end of the quinolone, the C7 ring system, interacts with GyrA.

275 the critically important antimicrobials were quinolones, third- and fourth-generation cephalosporins,

276 On the other hand, shifting from 4-quinolone to 4-hydroxy-2-quinolone structure enabled the

277 raoxonase 2 (PON2) inhibitor (Triazolo[4,3-a]quinolone, TQ416) significantly affected recovering cell

278 acin show antitrypanosomal activity, a novel quinolone-type library was synthesized and tested.

279 The potent oral activity of 2-pyridyl quinolones underlines the potential of this template for

280 60-member library of tricyclic 2,3-dihydro-4-quinolones using a combination of solution-phase high-th

281 ivity by diversification of an azide-bearing quinolone via a sequence of [4 + 2] cycloadditions, N-ac

282 95% confidence interval [CI], 5.0%-8.2%) for quinolones vs 6.4% (95% CI, 5.0%-7.9%) for azithromycin

283 A quinolone was prescribed to at least 5 (50%) patients in

284 dium berghei in mice showed that these 4(1H)-quinolones were efficacious for the reduction of parasit

285 The quinolones were eluted without interferences using mobil

286 These novel quinolones were explored to recognize nitroaromatic comp

287 Examined quinolones were isolated from salmon tissue by extractio

288 Quinolones were prepared by the reaction of photochemica

289 no[2,3-c]- and thieno[3',2':4,5]thieno[2,3-c]quinolones were prepared.

290 The quinolones were resolved in <22min using a mobile phase

291 Carboxanilides and quinolones were tested for the antiproliferative activit

292 dary metabolites, including rhamnolipids and quinolones, were detected and visualized on both macro-

293 of QnrB1 on DNA gyrase toward inhibition by quinolones, whereas deletion of the smaller lower loop d

294 inhibition of the catalytic process by other quinolones, which could potentially compete with the bin

295 The biological evaluation illustrated that 4-quinolones with a benzylamide function in position 3 and

296 in, we report the lead optimization of 4(1H)-quinolones with a focus on improving both antimalarial p

297 erse range of structurally related 2-alkyl-4-quinolones with biological activity is presented.

298 ly diverse 6-chloro-2-methyl-7-methoxy-4(1H)-quinolones with EC(50) in the low nanomolar range agains

299 lected aptamers were shown to detect various quinolones with high specificity, while specific binding

300 rent in vitro assay identified several 4(1H)-quinolones with nanomolar EC(50) against erythrocytic st