ライフサイエンスコーパス: rabies

1 ndia, representing one-third of global human rabies.

2 nt for vaccine-induced antibody responses to rabies.

3 long-lasting and efficient vaccines against rabies.

4 nd dramatically reduced the health burden of rabies.

5 m Brazil, an otherwise healthy man developed rabies.

6 aerophobia were more common in dog-acquired rabies.

7 sures to potentially rabid animals died from rabies 18 months after transplantation.

8 nations for effective prevention of clinical rabies, a more rapidly protective vaccine is needed.

9 ollow-up survey, one was deemed to be due to rabies after a probable rabies exposure.

10 o counsel animal-bite victims on the risk of rabies and appropriate treatment, as well as the Haiti A

11 a few well-studied wildlife systems such as rabies and bovine tuberculosis.

12 proven to be efficient dual vaccines against rabies and emergent infectious diseases such as Ebola vi

13 y was confirmed by antigen ELISA, as well as rabies and pseudotype virus neutralization.

14 xplain the failure of bat culls to eliminate rabies and suggests that geographic coordination of cont

15 lyssavirus type 1 (EBLV-1), a virus causing rabies and transmissible to humans.

16 survival times than those with encephalitic rabies, and also had shorter incubation periods if they

17 at P-protein-STAT interaction is critical to rabies, and provide novel insights into the mechanism by

18 The pathogenic mechanisms for rabies are not well understood.

19 re more common in patients with bat-acquired rabies, as was increased cerebrospinal fluid protein (P

20 riven rabies transmission model fit to human rabies autopsy data and human rabies surveillance data f

21 efore critical for interpreting monosynaptic rabies-based tracing in the sensory system.

22 nectivity within PSC-derived cultures, using rabies-based trans-synaptic tracing, we found two broad

23 he circuitry of the target region and depict rabies-based transsynaptic tracing and LSFM as efficient

24 These results suggest that rabies-based unbiased screening of changes in input popu

25 ray dogs could cost-effectively reduce human rabies by almost 90%.

26 ements for the elimination of endemic canine rabies by mass dog vaccination in Region VI of the Phili

27 Rabies can be prevented with prompt postexposure prophyl

28 sk screening was initiated within 2 hours of rabies confirmation, and 95% of HCWs were assessed withi

29 Rabies continues to present a public health threat in mo

30 Rabies continues to present a public health threat in mo

31 Currently, rabies control in Tamil Nadu involves postexposure vacci

32 the multidisciplinary One Health approach to rabies control through the mass vaccination of dogs and

33 doses of either the RTS,S/AS01 vaccine or a rabies (control) vaccine.

34 We estimated that there would be four human rabies deaths among the 1478 people assessed by IBCM dur

35 ly, could very cost-effectively reduce human rabies deaths by 70% within 5 y, and a modest expansion

36 Over 20,000 rabies deaths occur annually in India, representing one-

37 mme, which would equate to a 65% decrease in rabies deaths.

38 We describe a patient who died of rabies despite a neuroprotective intervention.

39 e than 1,000 specimens submitted for routine rabies diagnosis were tested to directly compare the two

40 n, molecular methods have a place in routine rabies diagnostics within the United States.

41 Rabies virus (RABV) causes rabies disease resulting in >55,000 human deaths/year.

42 ity of microneedle patch vaccination using a rabies DNA vaccine in dogs.

43 os, assuming a basic reproduction number for rabies drawn from the literature.

44 Our findings provide new insights into rabies dynamics in raccoon populations and have importan

45 nds of people in developing countries die of rabies each year due to the inability to control dog pop

46 de potent human and animal pathogens such as Rabies, Ebola and measles.

47 vidence that culling fails to control canine rabies, efforts to reduce canine population density cont

48 l sequencing data provided confirmation that rabies encephalomyelitis may present after a long, multi

49 s prophylaxis after exposure in a low-income rabies-endemic setting.

50 Our results demonstrate that when rabies enters a suburban raccoon population, the likelih

51 Rabies exposure represents a major concern for HCWs and

52 deemed to be due to rabies after a probable rabies exposure.

53 ns of confirmed, probable, suspected, or non-rabies exposures.

54 13%) suspected exposures, and 1176 (80%) non-rabies exposures.

55 timated annual figure of almost 60,000 human rabies fatalities is probably an underestimate.

56 nvelopes bearing the extracellular domain of rabies fused to the cytoplasmic tail (CT) of gp41 and ps

57 sing pseudotype virus expressing mutagenized rabies glycoproteins.

58 Patients with paralytic rabies had longer survival times than those with encepha

59 Sylvatic rabies has been eradicated from most of Central Europe,

60 Although rabies has been the subject of large-scale public health

61 After a case of rabies, healthcare workers (HCWs) had fear of contagion

62 sitive results can occur in interpreting the rabies IFA test.

63 In order to diminish the requirements for rabies immunoglobulin (RIG) and multiple vaccinations fo

64 ministration of rabies vaccine together with rabies immunoglobulin (RIG) of either equine or human or

65 rdable vaccine to control canine-transmitted rabies in developing countries.

66 ealth" committee to address the challenge of rabies in dogs and humans.

67 The antemortem diagnosis of rabies in humans employs techniques that require accurac

68 other animals has virtually eliminated human rabies in industrialized countries.

69 how contact patterns influence the spread of rabies in raccoon populations in order to design effecti

70 The annual mortality rate of human rabies in rural Africa is 3.6 deaths per 100 000 persons

71 The subsequent reduction in cases of human rabies in such regions advocates the multidisciplinary O

72 or wildlife, have allowed the elimination of rabies in terrestrial carnivores in several countries wo

73 play an important role in the maintenance of rabies in the United States.

74 Control measures for canine rabies include vaccination and reducing population densi

75 ication coupled with inflammation in treated rabies, indicative of a neurological immune reconstituti

76 when there are no behavioural changes due to rabies infection.

77 root ganglia neurons, display resistance to rabies infection.

78 rapid and potent antibody responses against rabies infections will greatly increase our ability to p

79 development of a single-dose vaccine against rabies infections.

80 Rabies is a deadly disease, and current preexposure vacc

81 orts RABV particles through axons.IMPORTANCE Rabies is a fatal zoonotic disease with a nearly 100% ca

82 Survival from rabies is dependent upon the early control of virus repl

83 Rabies is endemic in most parts of the world, and more e

84 the world's population live in regions where rabies is endemic.

85 r of choice as a dual vaccine in areas where rabies is endemic.

86 ead depend strongly on the time of year that rabies is introduced into the population.

87 Rabies is one of the most deadly infectious diseases, wi

88 to elimination of the global burden of human rabies is to control canine rabies rather than expansion

89 he most efficient way to prevent and control rabies is to implement vaccination programs for domestic

90 ty globally include viral (for example, HIV, rabies, Japanese encephalitis virus, herpes simplex viru

91 Rabies kills many people throughout the developing world

92 Cocaine increased rabies-labelled inputs from the globus pallidus externus

93 However, the inherent cytotoxicity of the rabies largely prevents its implementation in long-term

94 FN-gamma production has antiviral effects in rabies, largely due to the induction of type I interfero

95 clude many well-known human pathogens (e.g., rabies, measles, and Ebola viruses), as well as emerging

96 nted negative strand (NNS) RNA viruses (e.g. rabies, measles, Ebola) contains five collinear sequence

97 mbine axon-initiated viral transduction with rabies-mediated trans-synaptic tracing and Cre-based cel

98 h different envelopes (vesicular stomatitis, Rabies, Mokola and Ross River viral envelopes) and self-

99 u that were validated by real-time livestock rabies mortality data.

100 Because IFA testing for rabies on human specimens may result in false-positive r

101 Rabies, one of the oldest infectious diseases, still pre

102 Both the magnitude of rabies outbreaks and the speed of rabies spread depend s

103 accoon populations are highly susceptible to rabies outbreaks, that the risk of large outbreaks varie

104 rovide a means for future studies addressing rabies pathobiology.

105 These findings improve our understanding of rabies pathogenesis, which may help in developing potent

106 e been no secondary cases after our sentinel rabies patient.

107 ent that will save the life of a symptomatic rabies patient.

108 5) strain expressing the glycoprotein (G) of rabies (PIV5-G) as a therapy for rabies virus infection:

109 Rabies post-exposure prophylaxis (PEP) currently compris

110 Because humans get rabies primarily through dog bites, stray dog population

111 IBCM programme to promote best practices for rabies prophylaxis after exposure in a low-income rabies

112 Rabies pseudotyped lentiviral vectors have great potenti

113 burden of human rabies is to control canine rabies rather than expansion of the availability of huma

114 Rabies remains a major public health threat around the w

115 Rabies remains a public health threat in most parts of t

116 Rabies remains a public health threat, with more than 55

117 In addition, identification of rabies-resistant neurons might provide a means for futur

118 Almost all cases of human rabies result from bites from infected dogs.

119 Accordingly, rabies should be considered in the diagnosis of any acut

120 A recent study employed a self-inactivating rabies (SiR) virus that enables recording or manipulatio

121 burban raccoon population and then simulated rabies spread across these networks.

122 gnitude of rabies outbreaks and the speed of rabies spread depend strongly on the time of year that r

123 e that elevation is associated with a slower rabies spread in a natural population.

124 d the effects of raccoon contact patterns on rabies spread using network modelling.

125 l fit to human rabies autopsy data and human rabies surveillance data from Tamil Nadu.

126 riate treatment, as well as the Haiti Animal Rabies Surveillance Program (HARSP) to examine the anima

127 ce of developing and deploying a large-scale rabies surveillance system based on mobile phones in sou

128 The cultural impact of rabies, the fatal neurological disease caused by infecti

129 Although there are effective vaccines for rabies, this disease still takes the lives of about 50,0

130 Although transmission of rabies to HCWs has never been documented, high-risk expo

131 ne vaccination also prevents transmission of rabies to humans.

132 Recent advances in connectomics and rabies tracing have yielded much higher estimates of ret

133 Monosynaptic transsynaptic rabies tracing indicated the pathway contacts multiple c

134 Monosynaptic rabies tracing reveals that CC neurons preferentially re

135 Given the lack of human-to-human rabies transmission from our own experience and the lite

136 We developed a data-driven rabies transmission model fit to human rabies autopsy da

137 as used to parameterise a spatially-explicit rabies transmission model with realistic dog movement an

138 Due to fear of rabies transmission, additional HCWs without direct pati

139 of this study suggest that efficacy of oral rabies vaccination by aerial delivery is associated with

140 Annual canine rabies vaccination campaigns conferred extraordinary val

141 Oral rabies vaccination of foxes is an effective method for c

142 nteers (aged 18-40 years) with no history of rabies vaccination were sequentially enrolled.

143 es for simple and potentially cost-effective rabies vaccination, and assess the safety and immunogeni

144 hich can broaden humoral responses following rabies vaccination.

145 receive three doses of either RTS,S/AS01 or rabies vaccine (both 0.5 mL per dose by intramuscular in

146 ly a total of 81 (57.0%) tested positive for rabies vaccine antibodies, possibly, due to the delayed

147 An efficacious and cost-effective rabies vaccine is needed.

148 In this study, a novel rabies vaccine that expressed murine IL-7 was developed.

149 (PEP) currently comprises administration of rabies vaccine together with rabies immunoglobulin (RIG)

150 e to the delayed uptake of bait in which the rabies vaccine was already inactivated.

151 ration of sequential doses of an intradermal rabies vaccine was shown to result in reduced vaccine im

152 ping potential therapeutics and an avirulent rabies vaccine.

153 guide the development of a single-dose human rabies vaccine.

154 fluenced the prevalence of antibodies to the rabies vaccine.

155 99 to receive RTS,S/AS01 and 101 to receive rabies vaccine.

156 recipients and 37 (36.6%, 27.3-46.8) of 101 rabies-vaccine recipients (relative risk 1.1, 95% CI 0.8

157 1 recipients and four (4.0%, 1.1-9.8) of 101 rabies-vaccine recipients died, but no deaths were deeme

158 1 recipients and 12 (11.9%, 6.3-19.8) of 101 rabies-vaccine recipients had at least one serious adver

159 case of Haemophilus influenza meningitis (1% rabies-vaccine recipients), and one case of tuberculosis

160 of pneumonia (1% RTS,S/AS01 recipients vs 3% rabies-vaccine recipients), five cases of gastroenteriti

161 troenteritis (3% RTS,S/AS01 recipients vs 2% rabies-vaccine recipients), five cases of malnutrition (

162 -vaccine recipients), one case of sepsis (1% rabies-vaccine recipients), one case of Haemophilus infl

163 malnutrition (2% RTS,S/AS01 recipients vs 3% rabies-vaccine recipients), one case of sepsis (1% rabie

164 While rabies vaccines are inactivated and thus have an excelle

165 implications in the development of efficient rabies vaccines.

166 crease our ability to produce more-effective rabies vaccines.

167 which may help in designing more-efficacious rabies vaccines.

168 r (GM-CSF) can enhance the immunogenicity of rabies vaccines.

169 need to develop single-dose and long-lasting rabies vaccines.

170 hich will help in designing more efficacious rabies vaccines.

171 Here we describe methods for construction of rabies viral vectors, recovery of G-deleted rabies virus

172 Understanding the interactions between rabies virus (RABV) and individual host cell proteins is

173 oviral vaccine vector platforms, recombinant rabies virus (RABV) and recombinant vesicular stomatitis

174 both survival from infection with attenuated rabies virus (RABV) and reduction of neurological sequel

175 Both canine distemper virus (CDV) and rabies virus (RABV) cause lethal disease in wild and dom

176 Rabies virus (RABV) causes rabies disease resulting in >

177 la virus (EBOV) vaccine based on inactivated rabies virus (RABV) containing EBOV glycoprotein (GP) in

178 Our studies demonstrate that wild-type (wt) rabies virus (RABV) does not activate DCs.

179 letion variant of the SAD-B19 vaccine strain rabies virus (RABV) has been the reagent of choice in mo

180 Rabies virus (RABV) maintenance in bats is not well unde

181 Rabies virus (RABV) P gene mRNA encodes five in-frame st

182 The rabies virus (RABV) phosphoprotein P is a multifunctiona

183 Rabies virus (RABV) postexposure prophylaxis (PEP) requi

184 dress this need, we developed an inactivated rabies virus (RABV) that contains the MERS-CoV spike (S)

185 In this study, a recombinant rabies virus (RABV) that expressed murine interleukin-7

186 l infections, we investigated the ability of rabies virus (RABV) to activate DCs.

187 ptive chimpanzees to test oral delivery of a rabies virus (RABV) vectored vaccine against Ebola virus

188 Its pathogen, rabies virus (RABV), can utilize its viral proteins, suc

189 Replication-deficient rabies virus (RABV)-based vaccines induce rapid and pote

190 ted GL261 tumor-bearing mice with attenuated rabies virus (RABV).

191 proteins in the brains of mice infected with rabies virus (RABV).

192 r the RNA-dependent RNA polymerase (RdRP) of rabies virus (RABV).

193 inserted into the genome of the recombinant rabies virus (rRABV) strain LBNSE, and the effect of the

194 tically from hindlimb extensor muscles using rabies virus (RV).

195 ion, we developed a self-inactivating DeltaG-rabies virus (SiR) that transcriptionally disappears fro

196 erlying geographic expansions of vampire bat rabies virus (VBRV) in Peru.

197 Using rabies virus -mediated monosynaptic retrograde tracing t

198 mples; 2) showing how cross species jumps of rabies virus among bat populations can be readily identi

199 against heterologous CDV strains.IMPORTANCE Rabies virus and canine distemper virus (CDV) cause high

200 hysiological recording system, combined with rabies virus and optogenetic cell-type identification, t

201 cles of two recombinant rhabdoviral vectors, rabies virus and vesicular stomatitis virus (VSV), expre

202 accinated subjects developed protective anti-rabies virus antibody titers.

203 Rabies virus antigen was detected in archived autopsy br

204 e the mouse IFN-gamma gene into a pathogenic rabies virus backbone, SPBN, to produce the recombinant

205 In this study, we demonstrate that rabies virus can infect sensory neurons in the somatosen

206 s backbone, SPBN, to produce the recombinant rabies virus designated SPBNgamma.

207 DFA) detection remains the gold standard for rabies virus diagnostics.

208 and the membrane proteins thought to mediate rabies virus endocytosis (neural cell adhesion molecule,

209 r spinal cord, which are the known sites for rabies virus entry into the CNS, and enhancements in bra

210 copy, we demonstrated that pseudotyping with rabies virus envelope glycoprotein (RV-G) enabled the ax

211 Rabies virus exhibits a small genome that encodes a limi

212 retrogradely labeled following injections of rabies virus expressing enhanced green fluorescent prote

213 Monosynaptically restricted rabies virus facilitates the anatomical investigation of

214 Rabies virus found worldwide and prevalent throughout th

215 Incorporation of IFN-gamma into the rabies virus genome highly attenuated the virus.

216 ding to the first 19 nucleotides (nt) of the rabies virus genome, we demonstrate that L alone initiat

217 f a prophylactic mRNA-based vaccine encoding rabies virus glycoprotein (CV7201).

218 (VSV) to encode a fluorophore and either the rabies virus glycoprotein (RABV-G) or its own glycoprote

219 ibution studies, nanoparticles modified with rabies virus glycoprotein (RVG29) were loaded with small

220 The neurotoxin-like region of the rabies virus glycoprotein inhibited acetylcholine respon

221 inding of this study is that a region in the rabies virus glycoprotein, with homologies to snake toxi

222 vitro, as did full length ectodomain of the rabies virus glycoprotein.

223 respective roles of ecology and evolution in Rabies virus host shifts.

224 haracterized, was demonstrated to neutralize rabies virus in a fluorescent antibody virus neutralizat

225 Using pseudotyped rabies virus in a transgenic Gpr151-Cre mouse line, mono

226 a set of gene sequences from an epidemic of rabies virus in North American raccoons.

227 sceptible to infection with EnvA-pseudotyped rabies virus in tumor virus A receptor transgenic mice,

228 Rabies virus induces drastic behaviour modifications in

229 es involved in innate immune response during rabies virus infection and that the M protein of wild is

230 IV5-G protected mice as late as 6 days after rabies virus infection.

231 sing vaccine for prevention and treatment of rabies virus infection.

232 tein (G) of rabies (PIV5-G) as a therapy for rabies virus infection: we have found that PIV5-G protec

233 n and that the M protein of wild isolates of rabies virus is a viral immune-modulatory factor playing

234 rapid production of murine IFN-gamma by the rabies virus itself would induce a more robust antiviral

235 Using rabies virus monosynaptic tracing, we mapped cocaine-ind

236 ary analyses indicate multiple barriers that Rabies virus must overcome through adaptation.

237 etermine the lowest dose of CV7201 to elicit rabies virus neutralising titres equal to or greater tha

238 V is a negative strand RNA virus, similar to rabies virus or Ebola virus, that has a unique mechanism

239 Here we show that inactivated rabies virus particles containing the MERS-CoV S1 protei

240 ndidates based on recombinant vaccine strain rabies virus particles, which concurrently display the p

241 jor unanswered research questions related to rabies virus pathogenesis, especially those connecting t

242 Despite its ability to infect all mammals, Rabies virus persists in numerous species-specific cycle

243 amma directly in the infected tissue reduces rabies virus replication and spread, limiting its pathog

244 tional significance of the components of the rabies virus replication machinery is incomplete.

245 erstand the molecular machinery required for rabies virus spread in the nervous system.

246 The matrix (M) protein of wild isolates of rabies virus such as Tha (M-Tha) was previously shown to

247 We used the monosynaptic rabies virus system, in conjunction with mice expressing

248 We used a monosynaptic rabies virus to define the circuit's functional connecti

249 We also show that engineering a lethal rabies virus to express IFN-gamma directly in the infect

250 Here, we used transneuronal transport of rabies virus to identify the areas of the primate cerebr

251 ice, recombinant adeno-associated virus, and rabies virus to produce sparse but binary labeling of se

252 Using rabies virus tracing strategies Weissbourd et al. (2014)

253 Using a modified rabies virus transsynaptic tracing strategy, we labeled

254 y recipient were consistent with the raccoon rabies virus variant and were more than 99.9% identical

255 Genetic analysis revealed a canine rabies virus variant found only in the patient's home co

256 virus (VSV) and related rhabdoviruses (e.g., rabies virus) mediate both cell attachment and membrane

257 nd to be an important restriction factor for rabies virus, acting directly or indirectly against vira

258 , lymphocytic choriomeningitis virus (LCMV), rabies virus, and Lassa virus.

259 s, including Ebola virus, Lassa virus, LCMV, rabies virus, and Marburg virus, which was substituted f

260 r stomatitis virus (VSV), like its relative, rabies virus, can cause neuropathy in mice if it enters

261 such as vesicular stomatitis virus (VSV) and rabies virus, catalyzes the transfer of 5'-phospho-RNA (

262 animals developed protective titers against rabies virus, illustrating that a bivalent rabies virus-

263 e order Mononegavirales, which also includes rabies virus, measles virus, and respiratory syncytial v

264 eurological disease caused by infection with rabies virus, registers throughout recorded history.

265 LORAB1, a recombinant, bivalent, inactivated rabies virus-based EBOV vaccine, in rhesus and cynomolgu

266 use primary visual cortex (V1) with modified rabies virus-based input mapping, we have determined the

267 Here we use a recombinant rabies virus-based method to label a specific type of lo

268 Rabies virus-based monosynaptic tracing has been used to

269 Rabies virus-based retrograde tracing has developed into

270 sults demonstrate an important limitation of rabies virus-based retrograde tracing of sensory neurons

271 Using a modified monosynaptic rabies virus-based transsynaptic tracing strategy, we sy

272 t rabies virus, illustrating that a bivalent rabies virus-based vaccine against CDV induces protectiv

273 Rabies virus-based vectors have been proven to be effici

274 Glycoprotein-deleted rabies virus-mediated monosynaptic tracing has become a

275 rategy combining retroviral birthdating with rabies virus-mediated putative retrograde trans-synaptic

276 ce immunized with LBNSE-CXCL13 produced more rabies virus-neutralizing antibodies (VNAs) and develope

277 ho would otherwise succumb to infection with rabies virus.

278 city, is an important restriction factor for rabies virus.

279 dangerous zoonotic pathogens, like Ebola or rabies virus.

280 , such as HSV, Zika virus, dengue virus, and rabies virus.

281 the behavioural changes in hosts infected by rabies virus.

282 Combining rabies-virus tracing, optical clearing (CLARITY), and wh

283 Finally, using rabies-virus-assisted monosynaptic tracing, we show that

284 Rabies-virus-based input mapping indicated that LC-NE ne

285 Attenuated rabies viruses (RABV) are unique tools to study CNS immu

286 er VLPs, as well as vesicular stomatitis and rabies viruses (VSV and RABV, respectively).

287 hereas all animals that received recombinant rabies viruses carrying only the CDV attachment protein

288 ts immunized twice with a mix of recombinant rabies viruses carrying the CDV fusion and attachment gl

289 rabies viral vectors, recovery of G-deleted rabies viruses from cDNA, amplification of the viruses,

290 Although modified rabies viruses have emerged as a powerful tool for traci

291 The rabies viruses infecting the donor and the deceased kidn

292 ent study, it was found that the recombinant rabies viruses rB2c-K1685A and rB2c-K1829A, carrying mut

293 synaptic infection from the spinal cord with rabies viruses that carry glycoproteins in their envelop

294 Here we generated recombinant inactivated rabies viruses that carry one of the CDV glycoproteins o

295 nables trans-synaptic spreading of G-deleted rabies viruses to directly connected, presynaptic neuron

296 RNA viruses, a group that includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerizatio

297 Using a monosynaptic rabies viruses-based transneuronal tracing method combin

298 been homogeneous, they would have eliminated rabies with high probability.

299 those connecting the disease progression of rabies with the complex dysfunction caused by the virus

300 s may be inadequate to prevent the spread of rabies within these populations.