ライフサイエンスコーパス: radial glia

1 ts of Notch signaling in human but not mouse radial glia.

2 locity of nuclear movement of FMRP-deficient radial glia.

3 cerebral cortex begins with the formation of radial glia.

4 genitors and the increased number of Sox2(+) radial glia.

5 correlated with an increasing quiescence of radial glia.

6 etion and reporter activation in a subset of radial glia.

7 g to irreversible changes in aging zebrafish radial glia.

8 enitors, including neuroepithelial cells and radial glia.

9 tectum that gives rise to neurons and other radial glia.

10 elating to neuroepithelial cells rather than radial glia.

11 ed role in inhibiting the differentiation of radial glia.

12 ivide asymmetrically to generate neurons and radial glia.

13 al cell development or is already present in radial glia.

14 bellar granule neuron precursors (CGNPs) and radial glia.

15 lls are born prenatally and are derived from radial glia.

16 ociation is essential for MARCKS function in radial glia.

17 eterminant of apicobasal polarity in retinal radial glia.

18 e from neuroepithelial cells to neuronogenic radial glia.

19 basement membrane, Cajal-Retzius cells, and radial glia.

20 e they are needed, two critical functions of radial glia.

21 monstrates that these cells are derived from radial glia.

22 mediates some aspects of Notch signaling in radial glia.

23 timely detachment of migrating neurons from radial glia.

24 generated both migratory neurons and guiding radial glia.

25 ted co-localizing with a subset of the BLBP+ radial glia.

26 exist regarding the neurogenic potential of radial glia.

27 hic factor (BDNF) and vimentin, a marker for radial glia.

28 alian target of rapamycin signaling in outer radial glia.

29 poptosis of neurons, and to a lesser extent, radial glia.

30 dual-labeled glial cells were tanycytes and radial glia.

31 s are produced from neural stem cells termed radial glia [1, 2].

32 We also identified a mitotic defect in outer radial glia, a progenitor subtype that is largely absent

33 xhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression res

34 ted by ablation of other CNS cell types, and radial glia ablation also compromises the subsequent for

35 We found that radial glia ablation in zebrafish embryos leads to exces

36 early up-regulation of markers of gliogenic radial glia after injury either at E11 or E15.

37 n of the apical ventricular zone and loss of radial glia alignment.

38 that spatially restricted subpopulations of radial glia along the dorsal-ventral axis acquire differ

39 ecent in vivo fate mapping experiments, that radial glia also generate neurons during embryonic devel

40 heir derived basal progenitors, to gliogenic radial glia and adult-like neural progenitors, together

41 ruption to the morphology and positioning of radial glia and an accumulation of olfactory axon debris

42 ruct, we identified Sox2-expressing cells as radial glia and as a component of the progenitor pool of

43 -forming oligodendrocytes and Schwann cells, radial glia and astrocytes.

44 We found that NFIB is strongly expressed in radial glia and corticofugal neurons throughout cortical

45 adial glia progenitors produce self-renewing radial glia and differentiating cells simultaneously in

46 The overgrown radial glia and emigrated neurons disrupted the overlyin

47 of neurogenic transcription factors in early radial glia and enriched activation of mammalian target

48 In the adult optic tract and tectum, radial glia and free astroglia coexist.

49 vely isolate distinct, viable populations of radial glia and intermediate cells for in vitro analysis

50 distinct populations of neural progenitors, radial glia and intermediate progenitor cells, are respo

51 Principal neurons originate locally from radial glia and intermediate progenitors (IPCs), whereas

52 s that does not require altered signaling in radial glia and is accompanied by changes in layer-speci

53 tivity inhibits this process in hypothalamic radial glia and is not required for their self-renewal.

54 The GLAST promoter is active in both radial glia and many astrocytes in the developing CNS bu

55 re;Erbb3(F/F) mice, which lack Erbb3 in both radial glia and neurons, exhibit impairments in balance

56 progenitors and is specifically required in radial glia and newly born pyramidal neurons migrating t

57 ebellar size due to reduced proliferation of radial glia and other glial precursors in late embryonic

58 During development, SC1 localizes to radial glia and pial-derived structures, including the v

59 (Sema6D) and Nr-CAM are expressed on midline radial glia and Plexin-A1 on chiasm neurons, and Plexin-

60 te during embryogenesis by transformation of radial glia and settle mainly in the lateral white matte

61 erret neocortex capable of repairing damaged radial glia and that it acts via one or more erbB recept

62 ry progenitors, from early and midneurogenic radial glia and their derived basal progenitors, to glio

63 Lineage analysis of individual radial glia and their progeny demonstrated that less tha

64 cess initially organized by primary cilia in radial glia and then refined by motile cilia in ependyma

65 epression favored in less lineage-restricted radial glia and transcriptional activation favored in mo

66 mulates two parallel events: detachment from radial glia and translocation of the cell soma to the to

67 They arise from asymmetric divisions of radial glia and undergo self-renewing asymmetric divisio

68 The apical domain of embryonic (radial glia) and adult (B1 cells) neural stem cells (NSC

69 anner, mainly in neuroepithelial stem cells, radial glia, and astrocytes.

70 r pool and generate basal progenitors, outer radial glia, and cortical neurons.

71 fab/Vegfr2 signaling: vegfab is expressed by radial glia, and genetic or pharmacological inhibition o

72 critically modulates the functional state of radial glia, and induction of ErbB2 in distinct adult as

73 1 is essential for all Blbp transcription in radial glia, and that BLBP expression is significantly r

74 Radial glia are among the first cells that develop in th

75 Polarized radial glia are crucial to the formation of the cerebral

76 In these mutants, radial glia are depleted due to an increased transition

77 Radial glia are highly polarized cells that serve as neu

78 Radial glia are integral components of the developing ne

79 We conclude that beta1 integrins in radial glia are required for the proper development of t

80 These data indicate that radial glia are the source of both neurons and astrocyte

81 progenitors derived from ventricular apical radial glia (aRG) that selectively lose their apical pro

82 ating heterogeneity in cell potential before radial glia arise.

83 Our results identify these radial glia as a previously unreported Sox1/Sox2/Sox9 po

84 ollowing birth, neurons use the processes of radial glia as scaffolding for oriented migration.

85 SVZ cells with long basal processes, and in radial glia at early postnatal times.

86 cell-specifically expressed in PAX3-negative radial glia at the midline of the neural tube during ear

87 actor capable of realigning the disorganized radial glia back toward their normal morphology.

88 Neocortical basal radial glia (bRG) and cerebellar Bergmann glia (BG) are

89 especially basal progenitors including basal radial glia (bRGs) and intermediate progenitor cells (IP

90 We sought to fate map dorsal radial glia by codelivering an adenovirus expressing Cre

91 s result, together with recent evidence that radial glia can be progenitors, suggested that Notch1 si

92 as, modest transcriptional differences among radial glia cascade into robust typological distinctions

93 nd, notably, a distinct human-specific outer radial glia cell layer.

94 LncND expression is enriched in radial glia cells (RGCs) in the ventricular and subventr

95 onic mouse brains prolongs the cell cycle of radial glia cells and extends cortical neurogenesis into

96 een demonstrated to promote the formation of radial glia cells and Notch signaling is one such signal

97 tical progenitors, resulting in an excess of radial glia cells at the expense of intermediate progeni

98 tor EphB1, which interacts with ephrin-B2 on radial glia cells at the optic chiasm to repulse VT axon

99 ly, LOC646329 is a lncRNA enriched in single radial glia cells but is detected at low abundance in ti

100 Ependymal cells are generated from radial glia cells during embryonic brain development and

101 Radial glia cells function as guide cells for neuronal m

102 Radial glia cells in the VZ primarily divide with a vert

103 using real-time imaging of cohorts of mouse radial glia cells, we show that the radial glial scaffol

104 to a prolonged cell cycle and maintenance of radial glia cells.

105 ts absence, ependymal cells fail to suppress radial glia characteristics, resulting in a defective la

106 These include radial glia comparable to Type E and Type B cells, and a

107 bar spinal cord, the majority of neurons and radial glia constitutively express high levels of COX-2

108 Interestingly, radial glia continued to transition into postnatal NSCs

109 we provide evidence that beta1 integrins in radial glia control the morphological differentiation of

110 Mechanistically, we find that radial glia control these processes via Vegfab/Vegfr2 si

111 Mechanistically, we determined that radial glia control this process via the Vegf decoy rece

112 r features to distinctive behaviors of outer radial glia, demonstrate the necessity of STAT3 signalin

113 born neurons, indicating CCM3 involvement in radial glia-dependent locomotion and possible interactio

114 poration, we expressed MrgA1 in slow cycling radial glia-derived B1 cells, i.e., NPCs.

115 urthermore, both radial glia in neonates and radial glia-derived cells in the adult lateral ventricul

116 the mechanism of the signaling hierarchy of radial glia developmental cascade promoted by Notch sign

117 n cortical progenitors results in precocious radial glia differentiation and a temporal shift of cort

118 neural progenitors and negatively regulates radial glia differentiation.

119 Here we show that CNS-resident radial glia direct the vascularization of neighboring ti

120 Cerebral cortical neurons arise from radial glia (direct neurogenesis) or from intermediate p

121 These results suggest that outer radial glia directly support the subventricular niche th

122 in two radial glia, whereas the majority of radial glia divide asymmetrically to generate neurons an

123 eled cells increased 20%, as the fraction of radial glia dropped and the proportion of neuronal proge

124 in attached to the process of their parental radial glia during the entire course of radial migration

125 teraction between migrating interneurons and radial glia during the switch from tangential to radial

126 o tissue preparation to mechanically isolate radial glia endfeet from the soma, and we use photoconve

127 revealed that early OL progenitor cells and radial glia expressed Olig1, whereas Olig2 was localized

128 However, in NfiB(-/-) cortices, radial glia failed to generate outer radial glia, subseq

129 eal a rich, regulated local transcriptome in radial glia, far from the soma, and establish a tractabl

130 In addition, the dorsal radial glia fate map to astrocytes lining the dorsal asp

131 cular zones of the pallium and migrate along radial glia fibers to reach the appropriate cortical lay

132 glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron precurs

133 e show that Notch signaling promotes Xenopus radial glia formation and that the Notch activation is s

134 that the Notch activation is sufficient for radial glia formation prior to neural tube closure.

135 Notch1-induced erbB2 promoter activation and radial glia formation selectively, without affecting Su(

136 er, these results show that Notch1 regulates radial glia formation through two distinct transcription

137 d that Oct-1 is sufficient and necessary for radial glia formation.

138 ownstream effector of Notch signaling during radial glia formation.

139 superficial tectum, we find no evidence that radial glia function as a scaffold for neuronal migratio

140 Radial glia function during CNS development both as neur

141 Here we demonstrate that Notch1 effects on radial glia gene expression are mediated by two downstre

142 During forebrain development, radial glia generate neurons through the production of i

143 During embryogenesis, dorsal radial glia generate pyramidal cell neurons but not inte

144 al precursors (nestin+), astroglia including radial glia (GFAP+, vimentin+), and oligodendrocyte prog

145 To directly test whether radial glia give rise to ependymal cells, we used a Cre-

146 We found that dorsal radial glia give rise to gray and white matter astrocyte

147 --> Tbr2 --> Tbr1 in the differentiation of radial glia --> intermediate progenitor cell --> postmit

148 d in the direct differentiation pathway from radial glia --> postmitotic projection neuron, in which

149 e used in vitro analysis to confirm that the radial glia had phagocytosed debris from olfactory axons

150 tecture; however, signaling mechanisms among radial glia have not been studied directly.

151 progenitors, and the subventricular (outer) radial glia, have been identified but the contribution o

152 These cells, later termed radial glia, have been studied primarily as migratory sc

153 After injuries, radial glia in aged brains are reactivated, and the perc

154 We show that radial glia in dorsomedial cortex retract their apical e

155 rogenesis has been observed, but the role of radial glia in generating these new neurons is unclear.

156 Furthermore, both radial glia in neonates and radial glia-derived cells in

157 ly label a restricted population of striatal radial glia in newborn mice.

158 Radial glia in the developing brain extend motile filopo

159 h1 receptor is critical for the formation of radial glia in the developing nervous system.

160 Radial glia in the developing optic tectum extend highly

161 Remarkably, radial glia in the embryo have a translational polarity

162 focused on FGFR2 because it is expressed in radial glia in the GEs where ActN1 increases FGF2 neuros

163 We found that some radial glia in the lateral ventricular wall transform to

164 ox recombination strategy to genetically tag radial glia in the neonatal brain and follow their proge

165 strocytes reportedly arise from two sources: radial glia in the ventricular zone and progenitors in t

166 us calcium waves sweeping through cohorts of radial glia in the ventricular zone can modulate their p

167 unctions of progenitors and the integrity of radial glia in the vMB, which leads to a severe reductio

168 Hypothalamic radial glia in the zebrafish larva thus exhibit several

169 zone at the EM and found a subpopulation of radial glia in various stages of transformation into epe

170 anipulating PKG1, Rac1, or RhoA signaling in radial glia in vivo to eliminate glial filopodia or impa

171 We find that genetic ablation of radial glia in zebrafish larvae leads to a complete loss

172 Ventral radial glia, in contrast, retract their processes to for

173 generate 3D structures containing polarized radial glia, intermediate progenitors, and a spectrum of

174 ression, suggesting a delay in maturation of radial glia into intermediate progenitors.

175 hanisms controlling the timely transition of radial glia into IPCs during forebrain development.

176 ar zone (SVZ) involves the transformation of radial glia into neural stem cells, in addition to the m

177 aging revealed the direct differentiation of radial glia into neurons.

178 We also show that AXL expression in radial glia is conserved in developing mouse and ferret

179 Moreover, mosaic overexpression of Vegfab in radial glia is sufficient to partially rescue the VTA fo

180 These cells coexpress markers for radial glia like GFAPdelta, nestin, and vimentin.

181 Recent studies have revealed a new class of radial glia-like (oRG) progenitor cells in the human bra

182 individual, quiescent, and nestin-expressing radial glia-like (RGL) precursors in the adult mouse den

183 The complex morphology of radial glia-like (RGL) stem cells suggests that these ce

184 -to-one relationship between GFAP-expressing radial glia-like cell bodies and their non-radial proces

185 were provided with a carpet of C6-R cells (a radial glia-like cell line), significantly more axons pr

186 signatures characteristic of (1) neurogenic radial glia-like cells (resembling neural stem cells in

187 gyrus that were in transition from stem-like radial glia-like cells (type 1) to immature transiently

188 human cell types, including five subtypes of radial glia-like cells and four progenitors.

189 Here we show that large numbers of radial glia-like cells and intermediate progenitor cells

190 We find that OSVZ radial glia-like cells have a long basal process but, su

191 These data show that GFAP-expressing radial glia-like cells in the dentate gyrus cradle newbo

192 hibit significant pathology in GFAP-positive radial glia-like cells in the dentate gyrus, and suffer

193 d doublecortin-positive immature neurons and radial glia-like cells in the hippocampal dentate gyrus

194 er, but the cell body of the GFAP-expressing radial glia-like cells is not as intimately associated w

195 The establishment of non-ventricular radial glia-like cells may have been a critical evolutio

196 e identified a pool of embryonically derived radial glia-like cells present in the meninges that migr

197 different stages of neurogenesis, including radial glia-like cells, intermediate progenitors, neurob

198 ntermediate phenotype, possibly representing radial glia-like meningeal cells differentiating to neur

199 In developing neural retina, radial glia-like Muller cells are generated late in neur

200 ive activity due to a reduced number of both radial glia-like neural stem cells (type-1 cells) and in

201 ere we used clonal lineage tracing of active radial glia-like neural stem cells in the adult mouse de

202 e adult mouse hippocampus, nestin-expressing radial glia-like quiescent neural stem cells (RGLs) resp

203 on, defects of the self-renewal capacity and radial glia-like stem cell outgrowth of postnatal GD3S-K

204 First, the radial glia-like, hypothalamic tanycytes show high DCL e

205 lly and spatially restricted trajectories of radial glia maturation and neurogenesis in developing hu

206 iquitin immunofluorescence was identified in radial glia, mature astrocytes, ependyma, and choroid pl

207 eas Pax2(+) optic nerve astroglia and Vim(+) radial glia may aid in early axonal guidance.

208 Although outer subventricular zone radial glia may generate the majority of human cortical

209 Although radial glia may guide axons as they navigate to the supe

210 we show that CNS progenitors, referred to as radial glia, modulate vascular patterning around the spi

211 rom the amplification of actively neurogenic radial glia of the embryonic telencephalon.

212 Radial glia of the mouse cerebral cortex emerge from neu

213 SARA is enriched at the apical endfeet of radial glia of the neocortex.

214 al aromatization, we identified aromatase in radial glia of the zebra finch brain.

215 NA expression signatures resembling those of radial glia, oligoneuronal precursors, neuronal precurso

216 Young neurons did not use radial glia or blood vessels as a migratory scaffold; in

217 progenitor cells merely expand the output of radial glia or instead generate distinct types of neuron

218 ogenitors in the mammalian brain derive from radial glia or specialized astrocytes.

219 hat partial genetic ablation of hypothalamic radial glia or their progeny causes a net increase in th

220 positions in the cortical plate along outer radial glia (oRG) cell fibers.

221 ut virtually absent in rodents, called outer radial glia (ORG), have been suggested to be crucial to

222 g early development of the olfactory system, radial glia play an important role in removing overexten

223 tage of cell cycle entry is increased in the radial glia population.

224 sion across single cells, we find that outer radial glia preferentially express genes related to extr

225 edominantly on white matter cells, including radial glia, premyelinating oligodendrocytes, and subpla

226 premature infants (25-37 PCW), we found that radial glia, premyelinating oligodendrocytes, and subpla

227 ding axons closely followed the filaments of radial glia present in the olfactory bulb during embryon

228 ressed in the Bergmann glia, a population of radial glia present in the Purkinje cell layer.

229 The first type, radial glia, produce neurons and glia, divide at the ven

230 ermediate progenitor cells, are derived from radial glia, produce only neurons, and divide away from

231 We found that mutant radial glia produced abnormally large numbers of Cux1-po

232 Here, we use time-lapse imaging to track radial glia progenitor behavior in the developing zebraf

233 erative capacity of rescued apical and outer radial glia progenitor cells.

234 cal/ventricular surface and the ascending of radial glia/progenitor fibers toward the pial/basal surf

235 In the developing cerebral cortex, radial glia progenitors (RGPs) generate nearly all neoco

236 ion and demonstrate that its inactivation in radial glia progenitors and nascent neurons produces sev

237 Centrosome duplication in dividing radial glia progenitors generates a pair of centrosomes

238 mother centriole is required for maintaining radial glia progenitors in the developing mammalian neoc

239 The generation of neurons and glia from radial glia progenitors is critical to proper neocortica

240 Asymmetric divisions of radial glia progenitors produce self-renewing radial gli

241 to constitute the future neocortex, renewing radial glia progenitors stay in the VZ for subsequent di

242 tion of proliferation, phenotypic changes in radial glia progenitors, and neurogenesis to spinal cord

243 cting different gene expression gradients in radial glia progenitors, intermediate progenitors, and p

244 in the VZ and is preferentially inherited by radial glia progenitors, whereas the centrosome containi

245 randomizes the cleavage plane orientation of radial glia progenitors.

246 nged mitosis is sufficient to alter fates of radial glia progeny and define a new paradigm to underst

247 t the onset of neurogenesis, Rbm8a regulates radial glia proliferation and prevents premature neurona

248 cellular signalling mechanisms that regulate radial glia proliferation are not well understood, it ha

249 The presence of aromatase in radial glia provides a mechanism of estrogen delivery to

250 However, the relative number of basal radial glia-recently proposed to be important in gyrific

251 sion of the cell polarity regulator Cdc42 in radial glia regulates glial endfeet activities and inter

252 of the olfactory bulb, axons degenerated and radial glia responded by phagocytosing the resulting deb

253 We find that ablation of radial glia results in vessel regression, concomitant wi

254 for the first time, rapid mRNA transport in radial glia, revealing that the basal process is a highw

255 rive in the cortex via tangential migration, radial glia (RG) are the main cell type present.

256 rofiles, characterizing them as a subtype of radial glia (RG) cells.

257 ew studies have shown that some glial cells--radial glia (RG) in development and specific subpopulati

258 types of proliferative astrocyte precursors: radial glia (RG) in the ventricular zone and a second ce

259 diverse repertoire of neuroepithelial cells, radial glia (RG), and intermediate neurogenic progenitor

260 aracterize because progenitors, particularly radial glia (RG), are rare and are defined by a combinat

261 Radial glia (RG), the progenitors of cortical neurons an

262 Folding of the cortex and the persistence of radial glia (RG)-like cells called Bergmann glia (BG) ar

263 ry neuronal progenitor pool that arises from radial glia (RG).

264 to the increased proliferative potential of radial glia (RG; neural stem cells) and their subventric

265 itors (IPs) are derived from the multipotent radial glia (RGs) and serve as the direct precursors for

266 radial glial activities within the evolving radial glia scaffold to coordinate the formation of cere

267 ired to maintain the overall polarity of the radial glia scaffold.

268 rtices, radial glia failed to generate outer radial glia, subsequently resulting in a loss of late ba

269 hest GLAST promoter activity was observed in radial glia, such as those located in the subgranular la

270 se belonging to the recently described outer radial glia, suggesting a mechanism by which ferret neur

271 dings reveal dynamism and interactions among radial glia that appear to be crucial contributors to th

272 In parallel, the radial glia that contact the ventricle develop distinct

273 developing mouse cortex from GFAP-expressing radial glia that generate neurons and oligodendrocytes.

274 vertebrate hypothalamus contains persistent radial glia that have been proposed to function as neura

275 the store-operated response in Muller cells, radial glia that perform key structural, signaling, osmo

276 ating along a route outlined by a cascade of radial glia, the Dlx2-positive population appears to mig

277 Radial glia, the neural stem cells of the neocortex, are

278 Radial glia, the neuronal stem cells of the embryonic ce

279 Several progenitors, such as the ventricular radial glia, the subventricular intermediate progenitors

280 controls the adhesive property of neurons to radial glia, thereby maintaining proper neuronal positio

281 Radial glia therefore provide an instructive structural

282 lecular and morphological differentiation of radial glia through the transcriptional activation of at

283 mapping and clonal analysis demonstrate that radial glia throughout the CNS serve as neuronal progeni

284 ave an important role in the transition from radial glia to astrocytes by stimulating somal transloca

285 Here we show that the transition from radial glia to intermediate progenitor cell is associate

286 ults indicate that FGFs normally repress the radial glia to progenitor cell transition during cortico

287 grate along the rostral migratory stream and radial glia, to reach their final destinations in the ol

288 Radial glia transform into astrocytes at the end of embr

289 gment epithelium, Kollicker's organ, and the radial glia triggers waves of intracellular Ca(2+) relea

290 r progeny demonstrated that less than 10% of radial glia undergo symmetric divisions resulting in two

291 ng to show that a population of hypothalamic radial glia undergoes self-renewal and generates multipl

292 Ablation of Nsdhl in radial glia using GFAP-cre resulted in live-born, normal

293 unit hypothesis, highlights the ventricular radial glia (vRG) scaffold as a key architectonic featur

294 tricular surface; in the retina, the Mueller radial glia were immunoreactive for Homer1, but not Home

295 atically improve the morphology of disrupted radial glia, whereas blockade of NRG1-erbB signaling pre

296 undergo symmetric divisions resulting in two radial glia, whereas the majority of radial glia divide

297 ExM enabled the tracing of fine processes of radial glia, which are not resolvable with diffraction-l

298 er successfully, owing to the recruitment of radial glia, which function as NSCs.

299 for abnormal laminar formation, the role of radial glia, which provide the environmental cues, in mo

300 elimination of Kif3a from a subpopulation of radial glia, which resulted in ablation of primary cilia

301 e CNS serve as neuronal progenitors and that radial glia within different regions of the CNS pass thr