ライフサイエンスコーパス: radiation-induced

1 Herein, we show enhanced radiation-induced (10 Gy) tumor growth delay in a syngen

2 ression suppresses the formation of ionizing radiation-induced 53BP1 and BRCA1 but not RNF168 foci, s

3 Additionally, radiation induced a marked shift away from a proneural e

4 Finally, both PARP inhibition and radiation induced a similar metabolic responses in BRCA-

5 mouse and human tumors and demonstrate that radiation induced a sustained cell-intrinsic mesenchymal

6 n vitro studies showed that rLOX-PP inhibits radiation-induced activating phosphorylations of ATM and

7 These data suggest that preventing the radiation-induced activation of the NF-kappaBeta pathway

8 find that Lnk suppresses the development of radiation-induced acute B-cell malignancies in mice.

9 of bone marrow (BM) and BM-derived cells in radiation-induced acute gastrointestinal (GI) syndrome i

10 Moreover, STING was essential for radiation-induced adaptive immune responses, which relie

11 nstrate a mutator phenotype characterized by radiation-induced and age-associated genomic instability

12 effect of some natural antioxidants against radiation induced apoptosis in the rat thymocytes, as we

13 with dasatinib also suppressed etoposide and radiation induced apoptosis in vitro.

14 phase cells, less susceptible to DNA damage, radiation-induced apoptosis and acquired enhanced migrat

15 MG132 treatment greatly reduced radiation-induced apoptosis in cultured osteoblastic cel

16 pre-treatment of mice with dasatinib blocked radiation-induced apoptosis in the salivary gland by >60

17 in preirradiated cells, independent of their radiation-induced arrest in the G2/M phase.

18 There were 17 (34%) visceral and 24 (49%) radiation-induced AS.

19 ficial versus visceral AS and de novo versus radiation-induced AS.

20 women if their fistula was not simple or was radiation-induced, associated with cancer, or due to lym

21 antly, ATM inhibition with KU55933 prevented radiation-induced ATM phosphorylation and abrogated the

22 Taken together, these findings indicate that radiation-induced autophagy can be either cytoprotective

23 iation was confirmed by the observation that radiation-induced autophagy was nonprotective in p53 nul

24 DNA fragments during the repair of high LET radiation-induced base damage, which contributes to the

25 5-desaturase, then UVR accelerates ionizing radiation-induced BCC carcinogenesis.

26 topical application of D3 inhibits ionizing radiation-induced BCC tumorigenesis.

27 MRI of irradiated spines detected radiation-induced BM vascular damage, measured by the si

28 1-34 and anti-sclerostin antibody attenuates radiation-induced bone damage by accelerating DNA repair

29 n these mice, they recover more rapidly from radiation-induced bone marrow ablation and are more resi

30 developing therapeutic agents to ameliorate radiation-induced bone marrow injury.

31 ient in processing topoisomerase adducts and radiation-induced breaks in human cells, suggesting that

32 of screening mammography; and the number of radiation-induced breast cancer cases and deaths associa

33 Life-years lost from radiation-induced breast cancer could not be estimated.

34 Estimates of risk for radiation-induced breast cancer from mammography screeni

35 Radiation-induced breast cancer incidence and mortality

36 breast cancer deaths averted (benefits) and radiation-induced breast cancer incidence and mortality

37 ntile were projected to develop 246 cases of radiation-induced breast cancer leading to 32 deaths per

38 f population) were projected to have greater radiation-induced breast cancer risk (266 cancer cases a

39 th large breasts may have a greater risk for radiation-induced breast cancer.

40 understood which individuals are at risk of radiation-induced breast carcinogenesis, the molecular g

41 Gamma-radiation induced browning inhibition in minimally proce

42 caffolding protein is exceptionally prone to radiation-induced bubbling.

43 The radiation-induced bystander effect (RIBE) refers to a un

44 However, the underlying mechanism(s) of radiation-induced bystander effect is still unclear.

45 translocation may occur as an early event in radiation-induced bystander responses and mediate TNFalp

46 d that the proportion of ultraviolet B (UVB) radiation-induced C>T transitions differed significantly

47 unique opportunity to study the mechanism of radiation-induced cachexia and will aid in efficacy stud

48 Here, we propose a non-human primate (NHP) radiation-induced cachexia model based on clinical and m

49 ng starting at age 50 years reduced risk for radiation-induced cancer 5-fold.

50 re obtained, mortality and predicted risk of radiation-induced cancer death were 3.6% (215 of 5914) a

51 d appendicitis), and LE loss attributable to radiation-induced cancer death.

52 formance but was insensitive to variation in radiation-induced cancer deaths.

53 odes et al, as well as lifetime estimates of radiation-induced cancer mortality for mammography and B

54 imated 2 to 11 screening-related deaths from radiation-induced cancer per 100,000 women using digital

55 le exposed as children have a higher risk of radiation-induced cancer than those exposed at older age

56 in patients with CF, using current models of radiation-induced cancer, and to put this risk in perspe

57 ting disease, such as CF, lowers the risk of radiation-induced cancer.

58 er than life expectancy loss attributable to radiation-induced cancers (24 days; 95% UI: 13, 35).

59 urement would cost $2.25 million and cause 9 radiation-induced cancers.

60 oses could dramatically reduce the number of radiation-induced cancers.

61 ation, arrhythmias, pericardial disease, and radiation-induced cardiotoxicity.

62 Finally, we demonstrate that radiation-induced caspase-1 activation occurs by a Nod-l

63 ed prostasphere formation with resistance to radiation induced cell death.

64 In conclusion, radiation-induced cell activation and tissue inflammatio

65 We found less radiation-induced cell apoptosis and immune cell loss in

66 taneous DNA breaks, and delays recovery from radiation-induced cell cycle arrest.

67 HDAC4 knockdown and HDAC inhibitor enhanced radiation-induced cell death and reduced homologous reco

68 own to sensitize both DU145 and PC3 cells to radiation-induced cell death determined in colony-format

69 of virulence, and molecular basis for gamma-radiation-induced cell death in malaria parasites.

70 delayed cell-death) as a means of modelling radiation-induced cell death.

71 translocations are hallmark of cancer and of radiation-induced cell killing, reflecting joining of in

72 ch contributes to the higher RBE of high LET radiation-induced cell killing.

73 in normal cells is responsible for ionizing radiation-induced cell senescence and protection against

74 contact, but did contribute to RAS(V12)- and radiation-induced cell-cycle arrest.

75 radioresistance in a manner associated with radiation-induced centrosome overduplication and mitotic

76 Radiation induced changes to the iron mineralogy may imp

77 Radiation-induced changes in the dermis and epidermis we

78 We found no evidence that patients with radiation-induced chronic gastrointestinal symptoms, inc

79 (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA) partakes in triple

80 Furthermore, exposure to high-LET radiation induced clonal expansion of a subset of progen

81 glia through CSF1R inhibition can ameliorate radiation-induced cognitive deficits in mice.

82 mals receiving the PLX5622 diet exhibited no radiation-induced cognitive deficits, and exhibited near

83 pocampal transplantation of hNSC ameliorated radiation-induced cognitive deficits.

84 These radiation-induced cognitive impairments are accompanied

85 ns together with XLF in response to ionizing radiation-induced complex DSBs, whereas they function re

86 st serious adverse event was an asymptomatic radiation-induced cyst in 1 patient.

87 overexpressing podocytes were protected from radiation-induced cytoskeletal remodeling.

88 meostasis, depletion of Lgr5(+) cells during radiation-induced damage and subsequent repair caused ca

89 enescence is a fundamental mechanism driving radiation-induced damage in the salivary gland and sugge

90 o produce a proliferative response following radiation-induced damage indicating a fundamental requir

91 myelinase-like phosphodiesterase 3b mediates radiation-induced damage of renal podocytes.

92 The ability to repair radiation-induced damage to the brain could dramatically

93 d, although involved in protecting ISCs from radiation-induced damage, it is non-essential in tissue

94 ated the yejH gene in the repair of ionizing radiation-induced damage.

95 ole during intestinal regeneration following radiation-induced damage.

96 NC1 locus influences the development of late radiation-induced damage.

97 o protected skin cells and rat skins against radiation-induced damage.

98 e materials with unprecedented resistance to radiation-induced damage.

99 ts into heterogeneous characteristics of the radiation-induced-damage zone.

100 we show that KD of E6AP sensitizes cells to radiation-induced death.

101 eling (RBS-C) spectra show that the range of radiation-induced defect clusters far exceed the theoret

102 s can absorb and eliminate a large number of radiation-induced defect clusters.

103 novoids in nanotwinned Cu efficiently absorb radiation-induced defects accompanied by gradual elimina

104 g of the interactions between interfaces and radiation-induced defects, such as voids.

105 rfaces capable of absorbing and annihilating radiation-induced defects.

106 chromatids in G-2 arrested cells of random, radiation-induced 'dirty' DSBs.

107 al cardiologists are increasingly exposed to radiation-induced diseases like cataract and the stochas

108 tion of EndoG activity significantly reduced radiation-induced DNA damage and oncogenic transformatio

109 T, leads to a clear increase in the level of radiation-induced DNA damage as assessed with gammaH2AX

110 y protect in multiple ways normal cells from radiation-induced DNA damage but also make cancer cells

111 ent detection of repair proteins at ionizing radiation-induced DNA damage foci that Wwox expression s

112 CSB counters radiation-induced DNA damage in both cells and zebrafish

113 Mechanistically, we found that AIM2 senses radiation-induced DNA damage in the nucleus to mediate i

114 n low LET radiation, mainly because high LET radiation-induced DNA damage is more difficult to repair

115 silenced genes in wild-type fibroblasts with radiation-induced DNA damage reduced tumor progression.

116 the salivary gland long after initiation of radiation-induced DNA damage was required for both senes

117 in preventing cutaneous cancer caused by UV radiation-induced DNA damage.

118 d to sustain stress-survival responses after radiation-induced DNA damage.

119 tumors while oxygen is essential to enhance radiation-induced DNA damages.

120 Ionizing radiation-induced DNA double-strand breaks (DSBs) can le

121 howed that IGF-1R depletion delays repair of radiation-induced DNA double-strand breaks (DSBs), unlik

122 sequently, NHEJ-dependent repair of ionizing-radiation-induced DNA double-strand breaks is compromise

123 Our study highlights the specific classes of radiation-induced DNA lesions that evade repair and resu

124 roteins and variably contributes to ionizing radiation-induced DSB repair in human and chicken cells.

125 In sum, these results indicate that radiation-induced DSBs cooperate with loss of Ink4 and A

126 tion; however, its contribution to repair of radiation-induced DSBs has not been characterized.

127 technique to monitor external-beam ionizing radiation-induced DSBs in peripheral blood lymphocytes (

128 However, the molecular basis of such a radiation induced effect is not known.

129 Dosimetry calculations and observed radiation-induced effects indicated that sufficient (211

130 While Hey2 silencing has no effect on radiation-induced EndoMT in vitro, Hey2 overexpression i

131 radiated HIMECs show phenotypic hallmarks of radiation-induced endothelial cell activation in vitro.

132 worthy finding supports the ultraviolet (UV) radiation-induced endothelial cell damage in these patie

133 ted the role of Hey2 transcription factor in radiation-induced endothelial-to-mesenchymal transition

134 r blockade or deletion of A2AR could prevent radiation-induced fibrosis.

135 ce of the interposition of healthy tissue in radiation-induced fistulas.

136 The sensing mechanism is primarily based on radiation induced fluorescence quenching of DPI-BP.

137 NA damage, and RAD51 recruitment to ionizing radiation induced foci (IRIF), which requires end resect

138 N221* fails to self-accumulate into ionizing radiation induced foci (IRIF).

139 The average number of radiation-induced foci (RIF) per cell increased over the

140 at specifically associates with the ionizing radiation-induced foci formation region of 53BP1.

141 exhibit reduced ATM activation and ionizing radiation-induced foci, they display apoptotic pannuclea

142 gesting indirect effect on the correction of radiation-induced follicular damage.

143 results provide compelling evidence that the radiation-induced formation of glycerol in low-temperatu

144 ees C, began transforming to alpha-SiC, with radiation-induced Frank dislocation loops serving as the

145 e S phase to the G2/M phase and functions in radiation-induced G2 checkpoint control.

146 , which has been extensively researched, and radiation-induced gastrointestinal toxicity.

147 RNA-sequencing studies revealed that most radiation-induced genes were strongly dependent on only

148 litates rather than suppresses chemical- and radiation-induced genetic instability and carcinogenesis

149 work identifies a novel mitotic pathway for radiation-induced genome damage, which occurs outside of

150 lverization thereby independently amplifying radiation-induced genome damage.

151 ding of mechanisms contributing to the acute radiation-induced GI syndrome (RIGS).

152 he most significant oncogenic event in these radiation-induced gliomas.

153 Concomitant radiation-induced grain growth was observed which, as a

154 , there is considerable debate about whether radiation-induced green-up during the dry season is real

155 is identified as a potential participant in radiation-induced gut damage and may represent an intere

156 possible survival benefit might be offset by radiation-induced heart disease.

157 allocated to no IMNI because of the risk of radiation-induced heart disease.

158 4 h to 28 d in nonhuman primates (NHPs) with radiation-induced hematopoietic syndrome (6.5 Gy exposur

159 therapeutics capable of mitigating ionizing radiation-induced hematopoietic toxicity could benefit b

160 etry is particularly suitable for minimizing radiation-induced hepatotoxicity.

161 Radiation-induced impairments in spatial, episodic and r

162 hotometric determination of Fe(II) reveals a radiation-induced increase in the rate and extent of fer

163 tion exposure and that allopurinol prevented radiation-induced inflammasome activation.

164 ecause of potentially confounding effects of radiation-induced inflammation, treatment response asses

165 targeting the inflammasome may help control radiation-induced inflammation.

166 pre-activated bone-marrow-derived MSCs under radiation-induced inflammatory condition (MSC(IEC-6(IR))

167 l the development of agents for ameliorating radiation-induced injuries.

168 ng-lived clones during homeostasis and after radiation-induced injury in vivo.

169 esponse for cell survival/self-renewal after radiation-induced injury is unclear.

170 al contributor to the progression of delayed radiation-induced injury to skin and other organs.

171 Recent evidence suggests that radiation-induced injury to the hippocampi could play an

172 hich emulates clinically relevant intestinal radiation-induced injury, can be used to assess radiopro

173 or during crypt regeneration after high-dose radiation-induced injury.

174 critically important for regeneration after radiation-induced injury.

175 ct that was sustained even in the setting of radiation-induced injury.

176 esophageal epithelial regeneration following radiation-induced injury.

177 le for restitution and function after severe radiation-induced injury.

178 rk, we present a novel mathematical model of radiation-induced intercellular signalling which incorpo

179 migration distances in nanograined YSZ allow radiation induced interstitials to reach the grain bound

180 l for studying the molecular determinants of radiation-induced intestinal damage and testing novel ra

181 SC-CM(IEC-6(IR)) and non-activated MSC-CM on radiation-induced intestinal injury (RIII).

182 ved agent for the prevention or treatment of radiation-induced intestinal injury.

183 Finally, Elp3 deficiency strongly impaired radiation-induced intestinal regeneration, in part becau

184 During radiation-induced intestinal regeneration, LIG4 mainly e

185 clin-dependent kinase 4/6 (CDK4/6), prevents radiation-induced lethal intestinal injury in mice.

186 HDAC4 signaling blockade enhances radiation-induced lethality in HCC cells and xenografts.

187 blation and are more resistant to whole-body radiation-induced lethality.

188 ribed in salivary glands in conjunction with radiation-induced loss of salivary gland function as wel

189 1 could be a potential therapeutic target in radiation-induced lung disease.

190 ine in BALF and exhibited significantly less radiation-induced lung fibrosis (P < 0.010).

191 Radiation-induced lung fibrosis (RILF) is a common side

192 r findings demonstrate that CD73 potentiates radiation-induced lung fibrosis, suggesting that existin

193 s unclear whether it plays a similar role in radiation-induced lung fibrosis.

194 nduced changes in the myeloid compartment in radiation-induced lung fibrosis.

195 r CD73 antibodies also significantly reduced radiation-induced lung fibrosis.

196 Radiation-induced lung injury (RILI) is a delayed effect

197 Differences in the pathogenesis of radiation-induced lung injury among murine strains offer

198 monstrate that IL-13 is a major regulator of radiation-induced lung injury and demonstrates that stra

199 minimally invasive biomarkers for predicting radiation-induced lung injury before symptoms develop.

200 tly labeled and injected into a rat model of radiation-induced lung injury via endotracheal (ET) or i

201 acute DNA damage promotes the development of radiation-induced lymphoma.

202 Radiation-induced lymphopenia (RIL) is associated with t

203 Moreover, ionizing radiation induced macrophage morphological alterations a

204 ses, although circularly polarized microwave radiation induced magnetoresistance oscillations observe

205 Radiation-induced magnetoresistance oscillations are exa

206 A comparative study of the radiation-induced magnetoresistance oscillations in the

207 etoresistance effect even in the presence of radiation-induced magnetoresistance oscillations, the ma

208 nts because of an increased lifetime risk of radiation-induced malignancies.

209 or use as a chemopreventive strategy for UVB radiation-induced malignancies.

210 aphy carries a nonnegligible risk for lethal radiation-induced malignancy.

211 uminescence methods were employed to monitor radiation-induced markers, as well as different chemical

212 an anti-CCR2 antibody results in blockade of radiation-induced MDSC infiltration.

213 y irradiation showed an impressive rescue of radiation-induced morbidity in terms of weight loss and

214 UCY2C signaling exacerbated RIGS, amplifying radiation-induced mortality, weight loss, mucosal bleedi

215 ell polyomavirus integration and ultraviolet-radiation-induced mutations, providing rationale for tre

216 This contributed to the development of gamma radiation-induced myeloproliferative disease in NQO2(-/-

217 tion of the NQO2 gene in mice leads to gamma radiation-induced myeloproliferative diseases.

218 cells of the heart did not sensitize mice to radiation-induced myocardial necrosis.

219 Limited data are available on radiation-induced myopathy (RIM) in adult cancer survivo

220 For radiation-induced nausea and vomiting, adjustments were

221 ocols might reduce the risk of RIM and other radiation-induced neuromuscular complications.

222 eatment of the cells with curcumin inhibited radiation-induced NF-kappaBeta activity and target prote

223 ne at the Australian Synchrotron, we studied radiation-induced nontargeted effects in C57BL/6 mice.

224 r therapeutic agents that selectively reduce radiation-induced normal tissue injury without reducing

225 on of NSCLC cells through the suppression of radiation-induced Notch-1 expression.

226 the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radi

227 in both cell lines, and rLOX-PP localized to radiation-induced nuclear DNA repair foci.

228 Radiation-induced optic neuropathy is an expected issue

229 ormed for potentially other reasons, such as radiation-induced optic neuropathy, or where visual outc

230 The most common side effects were radiation-induced optic neuropathy, retinopathy, and cat

231 el role of proteasome inhibitors in treating radiation-induced osteoporosis.

232 zomib is a novel therapeutic agent for focal radiation-induced osteoporosis.

233 of skin injury common to these exposures is radiation-induced oxidative stress.

234 treatment strongly but reversibly inhibited radiation-induced p53 activation, which blocked p53-upre

235 d prior to irradiation significantly reduced radiation-induced pain after 3, 7, and 21days by 53+/-4%

236 oustic beam, as opposed to previous acoustic radiation induced particle concentration where objects t

237 n interesting therapeutic target in cases of radiation-induced pelvic disease.

238 cate a potential role for SMPDL3b and RTX in radiation-induced podocytopathy.

239 dy investigates the role of sphingolipids in radiation-induced podocytopathy.

240 es of comet Halley suggest the presence of a radiation-induced polymer at the surface.

241 days IGF-1R-inhibited cells showed enhanced radiation-induced polyploidy and nuclear fragmentation,

242 ust be considered in the safety assessments, radiation induced processes constitute a key-component.

243 Tracking primary radiation-induced processes in matter requires ultrafast

244 Radiation-induced proctitis (RIP) is the most common cli

245 Using a murine model of radiation-induced proctitis, the prophylactic delivery o

246 Radiation induced production of MCSF by PDA cells.

247 nto epidemiological modelling of the risk of radiation-induced PTC.

248 Radiation-induced pulmonary fibrosis (RIPF) is a debilit

249 Radiation-induced pulmonary fibrosis (RIPF) is a debilit

250 prominent modification in a murine model of radiation-induced pulmonary fibrosis and in idiopathic p

251 Radiation-induced pulmonary fibrosis is a severe side ef

252 In both bleomycin- and radiation-induced pulmonary fibrosis murine models, hLYC

253 linical murine models of IPF, bleomycin- and radiation-induced pulmonary fibrosis.

254 othesis that IL-13 drives the progression of radiation-induced pulmonary fibrosis.

255 to unrecognized sequelae that contributes to radiation-induced pulmonary injury and IPF.

256 Quantification of radiation-induced recovery caused by alpha-particles dur

257 s (HIMECs) and whether EndoMT contributes to radiation-induced rectal damage in humans and in a precl

258 r Wnt-driven intestinal tumor initiation and radiation-induced regeneration by maintaining a subpool

259 While nuclease inhibition impairs radiation-induced replication protein A (RPA) chromatin

260 Here we report the current spikes due to radiation-induced resonant tunneling of fluctuation Coop

261 There was no clinical evidence (0%) of radiation-induced retinopathy, maculopathy, or optic neu

262 ed in 17 cases (11.6%), mostly attributed to radiation-induced retinopathy, optic neuropathy, and sec

263 We found that cranial ionizing radiation induced robust and durable PMT in tumors.

264 infer that E. coli is highly susceptible to radiation-induced ROS because it lacks an adequate suppl

265 ric oxide synthases uncoupling and augmented radiation-induced ROS.

266 ls and nitric oxide production and decreased radiation-induced ROS.

267 In this study, we used a mouse model of radiation-induced salivary hypofunction to investigate t

268 scopy and improves image quality by reducing radiation-induced sample motion.

269 It is thus essential to understand the radiation-induced segregation of native defects and impu

270 utathione and increased their sensitivity to radiation-induced senescence.

271 tant risk factors for solar ultraviolet (UV) radiation-induced skin cancer.

272 targeted antioxidant prevents and mitigates radiation-induced skin damage characterized by clinical

273 Radiation-induced skin damage ranges from photoaging and

274 NF-E2-related factor 2/GCH1/BH4 axis during radiation-induced skin damage.

275 related factor 2-mediated protection against radiation-induced skin injury by inhibiting ROS producti

276 Radiation-induced skin injury is a common side effect of

277 ausative role of oxidative stress in delayed radiation-induced skin injury, including impaired wound

278 e (50-500 bp) scale, obtained using ionizing radiation-induced spatially correlated cleavage of DNA w

279 We propose that radiation-induced STING activation is immunosuppressive

280 CIP, p21, and p53 and upregulates TCTP under radiation-induced stress.

281 Urethroplasty has durable outcomes for radiation-induced strictures, with a preference for exci

282 ood, but experimental evidence suggests that radiation-induced surface modification combined with a c

283 UV radiation-induced systemic immune suppression is a major

284 manipulation of SDF-1 gradients can improve radiation-induced thrombocytopenia in a manner additive

285 chymal transition (EndoMT) and its impact on radiation-induced tissue damage in mice.

286 al-dependent apoptosis plays a major role in radiation-induced tissue damage.

287 rinapant inhibited tumor growth and enhanced radiation-induced TNFalpha, tumor responses, and host su

288 ignificant proportion of patients experience radiation-induced toxicity due to damage to normal tissu

289 In this review, radiation-induced toxicity in the gastrointestinal (GI)

290 ct several cellular compartments affected by radiation-induced toxicity.

291 le of genetic variants in the development of radiation-induced toxicity.

292 his study, we determined if the frequency of radiation-induced transformation and cancer progression

293 ther, these results suggest that analysis of radiation-induced translatomes can provide new molecular

294 3 and CtIP enhance the formation of ionizing radiation-induced translocations; second, they promote l

295 Concerns on high-energy particle radiation-induced tumorigenic transformation of normal t

296 articles provided noninvasive information on radiation-induced vascular damage.

297 such as Takayasu arteritis, chemotherapy- or radiation-induced vascular inflammation, or foreign-body

298 ymptoms (pain, nausea, hot flashes, fatigue, radiation-induced xerostomia, prolonged postoperative il

299 e escalation clinical trial in patients with radiation-induced xerostomia.

300 ential therapeutic benefit for management of radiation-induced xerostomia.