ライフサイエンスコーパス: radical scavenger

1 th Trolox (a soluble vitamin E) or Tempol (a radical scavenger).

2 death, suggesting that AIF serves as a free radical scavenger.

3 nate parent and can function as an excellent radical scavenger.

4 s of central neurotoxins by acting as a free radical scavenger.

5 ged proteins, presumably by acting as a free radical scavenger.

6 o ascertain whether clonidine acts as a free radical scavenger.

7 inhibited by tetramethylthiourea, a hydroxyl radical scavenger.

8 rating that cleavage is suppressed by a free radical scavenger.

9 improved by in vivo treatment with the free radical scavenger.

10 esting that genipin may act as a direct free radical scavenger.

11 ), as well as its potential as a direct free radical scavenger.

12 m sulfate-inflamed mice, treated with a free radical scavenger.

13 fficient (*)OOH, and also presumably (*)OOR, radical scavenger.

14 effects are attenuated by the use of a free radical scavenger.

15 reaction occurred in the presence of a free radical scavenger.

16 robe concentration, and the presence of free-radical scavengers.

17 ior neuroprotective actions to those of free radical scavengers.

18 oxidation of ascorbate as well as effective radical scavengers.

19 deling of the extracellular matrix, and free radical scavengers.

20 solvent although subject to inactivation by radical scavengers.

21 e metal from the Fenton cycle, and effective radical scavengers.

22 These effects could be blocked by oxygen radical scavengers.

23 of 4-OHEN-mediated enzyme inhibition by free radical scavengers.

24 ne samples were found to be less potent free radical scavengers.

25 d by hydrogen peroxide and inhibited by free radical scavengers.

26 enerated in the presence of different oxygen radical scavengers.

27 nhibited by catalase, heme poisons, and free radical scavengers.

28 y nitric oxide synthase inhibitors or oxygen radical scavengers.

29 ization by the presence of H2O2 and hydroxyl radical scavengers.

30 poxia-induced response are inhibited by free radical scavengers.

31 en in the presence of high concentrations of radical scavengers.

32 adiated bivalents was rescued by addition of radical scavengers.

33 d by l-Trp, the heme ligand cyanide, or free radical scavengers.

34 redox active metal ions or inhibited by free radical scavengers.

35 microM for 6-keto-PGF1alpha) and other free radical scavengers.

36 mercaptopropionyl)-glycine and by the oxygen radical scavenger 2-acetamidoacrylic acid.

37 The free radical scavenger 2-mercaptoethanol completely suppresse

38 activity were inhibited by the nitrogen free radical scavenger 2-phenyl-4,4,5,5,-tetramethylimidazoli

39 of O(3) concentrations with or without a OH radical scavenger (2-butanol) on the SOA mass and therma

40 In addition, treatment with a free-radical scavenger, 4-hydroxytetramethylpiperidine-1-oxyl

41 V irradiation with one of the following free-radical scavengers: 40 mM D-mannitol, 40 mM imidazole or

42 inhibited NDMA formation in the presence of radical scavengers (ABTS and trolox) imply that O2 react

43 oiety of etoposide acts as an effective free radical scavenger, accounting for its antioxidant action

44 may significantly enhance intracellular free radical scavenger activity.

45 Recent studies have suggested that free radical scavenger administration reduces the rate of dev

46 f ECs was inhibited with 1% DMSO (a hydroxyl radical scavenger), allopurinol (a xanthine oxidase inhi

47 Treatment with the radical scavenger alpha-phenyl-tert-butyl nitrone (PBN)

48 Radical scavengers also reduced the irradiation-induced

49 nhibited by superoxide dismutase or hydroxyl radical scavengers, although it was strongly inhibited b

50 oxidase or pretreatment of capillaries with radical scavengers ameliorated DEP-induced P-glycoprotei

51 roduct of the pineal gland, is a direct free radical scavenger, an indirect antioxidant, as well as a

52 roxide, (ii) the effects are alleviated by a radical scavenger and (iii) the glutathione peroxidase g

53 Etoposide acted as an effective radical scavenger and antioxidant protector of phosphati

54 e, melatonin, which is an effective hydroxyl radical scavenger and antioxidant.

55 scherichia coli beta2 by hydroxyurea (HU), a radical scavenger and cancer therapeutic agent.

56 Furthermore, experiments with radical scavenger and inhibitor of intracellular glutath

57 A hydroxyl radical scavenger and inhibitors of inducible nitric oxi

58 is and, at the same time, an effective lipid radical scavenger and lipid antioxidant.

59 us, GSH, commonly viewed as a universal free radical scavenger and major intracellular antioxidant, a

60 re indeed generated by using tBuOH as the OH radical scavenger and measuring its product, formaldehyd

61 In HC animals, tissue endogenous oxygen radical scavengers and antioxidant vitamins were deplete

62 diet, and have been recognised as efficient radical scavengers and antioxidants.

63 Oxygen radical scavengers and calcium channel blockers have bee

64 is proposed on the basis of experiments with radical scavengers and DMSO-d6 and ESI-MS observations.

65 a, isotopic labeling studies, and the use of radical scavengers and electron transfer inhibitors.

66 ol (RES), and quercetin (QUE) are known free radical scavengers and have shown cardioprotective effec

67 eater degree of inhibition by solution-phase radical scavengers and higher rate of reactivity loss fr

68 ding magnetite + H2O2 one in the presence of radical scavengers and in a natural water matrix, but it

69 By combining radical scavengers and kinetic modeling, we have derived

70 phenolics may act as potent superoxide anion radical scavengers and reducing agents.

71 ro-beta-carboline and pinoline) were good OH radical scavengers and their activity was comparable to

72 ivation of caspase-3 and was reduced by free radical scavengers and Z-Val-Ala-Asp fluoromethylketone,

73 e measured the effectiveness of tempol (free radical scavenger) and creatine (enhances cellular energ

74 S inhibitor), dimethyl sulfoxide (a hydroxyl radical scavenger), and ascorbate (a peroxynitrous acid

75 is shown here to function directly as a free radical scavenger, and adducts formed as a result of thi

76 As a free radical scavenger, and cofactor, ascorbate (ASC) is a ke

77 wever, is also a potent antioxidant and free radical scavenger, and numerous studies have shown that

78 The influence of NaNO2 and H2O2, hydroxyl radical scavenger, and sunlight was assessed by an exper

79 damage and the effects of antioxidants, free radical scavengers, and overexpression of superoxide dis

80 wn to decrease inflammation, upregulate free radical scavengers, and prevent the formation of reactiv

81 PEGylated CNPs acted as efficient radical scavengers, and superoxide dismutase (SOD) activ

82 estigated concerning their active profile as radical scavengers, antimicrobials, estrogen-like activa

83 d mercaptopropionylglycine (MPG), a hydroxyl radical scavenger (antioxidant group).

84 r plate assay for the quantification of free radical scavengers (antioxidants) in food samples is des

85 These data suggest that free radical scavengers are effective in all cell types of th

86 e form of superoxide dismutase (SOD), a free radical scavenger, are limited because of its short half

87 discussed with reference to the use of free radical scavengers as potential anti-aging agents.

88 is reversed by co-administration of the free radical scavenger ascorbate.

89 and measuring the damage reduction from the radical scavengers ascorbic acid and beta-mercaptoethano

90 lcium influx into neurones or acts as a free radical scavenger at concentrations below 100 microM.

91 ride (7 micromol/L), each of which is a free radical scavenger, blocked protection, indicating that d

92 Intravitreal injection of membrane-permeable radical scavenger but not vehicle before ischemia preven

93 ssion was prevented by catalase and hydroxyl radical scavengers but not by superoxide dismutase.

94 SH) is a crucial intracellular reductant and radical scavenger, but it may also coordinate the soft C

95 that have been employed to evaluate the free radical scavenger capacity of carotenoid molecules are t

96 ls (nitric oxide, superoxide anion, hydroxyl radical scavenger capacity) and cellular antioxidants (s

97 urthermore, targeting mitochondria with free radical scavengers conferred superior protection against

98 ith PS conjugated to the oxygen-derived free radical scavenger DFO.

99 dismutase (an O( minus sign, dot below )(2) radical scavenger) did not show any inhibitory effects.

100 cavenger) or superoxide dismutase (an O(-.2) radical scavenger) did not show any inhibitory effects.

101 venger) or superoxide dismutase (an O(-.)(2) radical scavenger) did not show any inhibitory effects.

102 were unaffected by the presence of the free radical scavenger dimethyl sulfoxide (DMSO) or by freezi

103 Cotreatment of cells with the oxygen radical scavenger dimethyl sulfoxide significantly reduc

104 ntrations, absence vs presence of a hydroxyl radical scavenger (dimethyl sulfoxide, DMSO), and differ

105 Pretreatment of cells with the radical scavenger DMSO had no effect on the mutagenic in

106 The free radical scavenger DMSO or the gap junction inhibitor Lin

107 The addition of the free radical scavenger DMSO produces an insignificant effect

108 ent treatment of cells with arsenite and the radical scavenger DMSO reduced the fluorescent intensity

109 by H(2)O(2) was not affected by the hydroxyl radical scavenger DMSO, mannitol, or N-tert-butyl-alpha-

110 rradiation in the presence or absence of the radical scavenger DMSO, suggesting that DSB formation is

111 onsistent with our previous results with the radical scavenger DMSO, which reduced the mutagenicity o

112 rbic acid, and dithiothreitol but not by the radical scavengers DMSO, mannitol, or superoxide dismuta

113 alonitroalkane analogues relative to natural radical scavenger (e.g., carbonate) concentrations.

114 Furthermore, addition of free radical scavengers (e.g., DMSO, glycerol, and cationic t

115 is study, we tested the efficacy of the free radical scavenger edaravone in three cellular models of

116 The addition of oxygen radical scavenger enzymes (catalase, superoxide dismutas

117 polar extracts were the most efficient free-radical scavengers, Fe(2+) chelators and inhibitors of m

118 upport the concept of developing oxygen free radical scavengers for both AD and PD and further sugges

119 nced by the presence of the less potent free radical scavengers gallic and caffeic acids.

120 l)piperazine-1-sulfonamide possessing a free radical scavenger group (FRS), chelating groups (CHL), o

121 Free radical scavengers have failed to improve patient outcom

122 Procyanidins (PCs) are effective free radical scavengers, however, their antioxidant ability i

123 t significantly inhibited in the presence of radical scavengers (humic acid, carbonate), in complex a

124 The radical scavenger hydroxyurea and small molecule mimics

125 s 2.50-fold less sensitive than hRRM2 to the radical scavenger hydroxyurea, whereas EPR showed simila

126 ron transport chain as well as a potent free radical scavenger in lipid and mitochondrial membranes.

127 pha-Tocopherol acts as a peroxyl and alkoxyl radical scavenger in lipid environments, and thus it pre

128 Ascorbic acid is a potent free-radical scavenger in plasma, and also regulates intracel

129 n additional pressure on ascorbate as a free-radical scavenger in this population.

130 PH method: chlorogenic acid was the dominant radical scavenger in V. opulus P3 (74%), while epicatech

131 light the therapeutic potential of synthetic radical scavengers in Alzheimer disease.

132 analyzed the localization of superoxide free radical scavengers in different striatal neuron types in

133 synthesized and found to be equipotent free radical scavengers in solution as assessed by EPR analys

134 unt of radical generated and the presence of radical scavengers in solution.

135 Attenuation of the etching process by radical scavengers in the presence of oxygen, and the re

136 thiazolidine-4-carboxylic acid (OTZ), a free radical scavenger, in treating acute respiratory distres

137 not be effectively inhibited by the hydroxyl radical scavengers, including dimethylsulfoxide, mannito

138 kinase protein kinase-B is blocked with free radical scavengers, indicating a role for reactive oxyge

139 Interestingly, hydroxyl radical scavengers inhibited the response to pyocyanin,

140 Neuroprotective strategies, including free radical scavengers, ion channel modulators, and anti-inf

141 en suggested to serve as a proton buffer and radical scavenger, its physiological function remains my

142 Administration of the free radical scavenger L-N-acetylcysteine blocked MS-275-medi

143 y attenuated by coadministration of the free radical scavenger L-N-acetylcysteine.

144 (NF-kappa B) activation; moreover, the free radical scavenger L-N-acetylcyteine (LNAC) blocked borte

145 vascular expression and activity of the free radical scavengers manganese and extracellular superoxid

146 amage that was not prevented by the hydroxyl radical scavenger mannitol (50 mM).

147 The hydroxyl radical scavenger mannitol had no effect on the methacho

148 Addition of the hydroxyl radical scavenger mannitol or dimethyl sulfoxide to AMs

149 NOO- scavenger urate but not by the hydroxyl radical scavenger mannitol.

150 ive oxygen species, since neither a hydroxyl radical scavenger (mannitol) nor oxygen affects the yiel

151 Dexrazoxane, a free-radical scavenger, may protect the heart from doxorubici

152 Melatonin and AFMK, as potent free radical scavengers, may assist plants in coping with har

153 Furthermore, the free radical scavenger, melatonin (2 mM), prevented the enhan

154 reported neuroprotective action of the free radical scavenger, melatonin, against cerebral ischemia.

155 designed to evaluate the impact of the free radical scavenger metallothionein on high-fat diet-induc

156 impact of glutathione depletion and the free radical scavenger, metallothionein (MT), on cardiac func

157 ular oxygen from the reaction medium, by the radical scavengers methanol, ethanol, and mannitol, and

158 Catechin, a free radical scavenger, minimized the increase in free radica

159 The free radical scavenger Mn(III)tetrakis(4-benzoic acid)porphyr

160 EDTA and the free radical scavengers Mn(2+) and Trolox, a vitamin E analog

161 nylpropylamino)-benzoate (NPPB), or the free radical scavenger N-acetyl cysteine (NAC) each provided

162 tase or the application of the hydroxyl-free radical scavenger N-acetyl cysteine (NAC) to the Sig-1R-

163 The free radical scavenger N-acetyl cysteine blocked LAQ824-media

164 In addition, the free radical scavenger N-acetyl-L-cysteine attenuated ROS gen

165 fect of serum on lipolysis, whereas the free radical scavenger N-acetyl-l-cysteine completely inhibit

166 S inhibitor N(G)-methyl-l-arginine, the free radical scavenger N-acetyl-l-cysteine, or the NOS substr

167 PD184352/UCN-01 was not blocked by the free-radical scavenger N-acetyl-L-cysteine.

168 ed by pretreatment of PC cells with the free radical scavenger N-acetyl-L-cysteine.

169 minished, along with cell death, by the free radical scavenger N-acetylcysteine (NAC).

170 We further demonstrated that the free radical scavenger N-acetylcysteine blocked arachidonic a

171 In contrast, although treatment with the radical scavenger N-tert-butyl-a-phenylnitrone (PBN) als

172 mine whether delayed treatment with the free radical scavenger N-tert-butyl-a-phenylnitrone (PBN) is

173 Thiol-containing free-radical scavengers N-acetyl cysteine, dimethyl- and tetr

174 .4 atm); systemic administration of the free radical scavenger, N-acetylcysteine (NAC 150 mg kg(-1) i

175 uced permeability as treatment with the free radical scavenger, N-acetylcysteine, inhibited this effe

176 ated the protective nature of the known free radical scavenger, N-tert-butyl-alpha-phenylnitrone (PBN

177 ctivation of JNK were attenuated by the free-radical scavenger NAC, suggesting that oxidative damage

178 ons of aqueous O2, and studied the impact of radical scavengers on NDMA formation.

179 VD.CHO, 8 microgram intrastriatally), a free radical scavenger (OPC-14117; 600 mg/kg, orally) and eth

180 omplished in control experiments when a free radical scavenger or a melatonin analog were substituted

181 reatment of cells with sodium formate (an.OH radical scavenger) or superoxide dismutase (an O( minus

182 eatment of cells with sodium formate (an .OH radical scavenger) or superoxide dismutase (an O(-.)(2)

183 eatment of cells with sodium formate (an .OH radical scavenger) or superoxide dismutase (an O(-.2) ra

184 nthine oxidase inhibitor), Me2SO (a hydroxyl radical scavenger), or deferoxamine (an iron chelator).

185 sorbed-superoxide dismutase (PEG-SOD; a free-radical scavenger), or PEG-SOD alone.

186 N-2-mercaptopropionyl glycine (MPG), a free radical scavenger, or by 200 micromol/L 5-hydroxydecanoa

187 either dimethyl thiourea (DMTU), a hydroxyl radical scavenger, or SN50 peptide, a NFkappaB blocker.

188 IL-1beta, an effect inhibited by the oxygen radical scavenger PDTC.

189 chelerythrine (10(-7) M) or the O(-)(2) free radical scavengers polyethylene glycol superoxide dismut

190 this muscle and that pretreatment with free radical scavengers prevents lipid peroxidation and reduc

191 lator, or 1,3-dimethyl-2-thiourea, an oxygen radical scavenger, prior to addition of H(2)O(2) did not

192 ailed to inhibit 12/15-LOs, and is devoid of radical scavenger properties.

193 horbol-13-acetate , is blocked by the oxygen radical scavenger pyrrolidine dithiocarbomate.

194 Radical scavengers reduced the killing, indicating a rol

195 e found that supplementing vitamin E, a free radical scavenger, reduces the oxidative state in PHT ga

196 es can be prevented by treatment with a free radical scavenger, resulting in improved motility.

197 and challenged in the presence of a hydroxyl radical scavenger, results that indicated sensitivity to

198 N-Acetylcysteine (NAC) is a potent free radical scavenger shown in animal models to attenuate di

199 nificantly decreased by addition of the free radical scavengers, SOD, CAT or GPX.

200 The utility of using free radical scavengers such as CeO(2) nanoparticles to mitig

201 Endogenous radical scavengers such as superoxide dismutase (SOD) de

202 ansplantation and are degraded by endogenous radical scavengers such as superoxide dismutase (SOD).

203 ly all of these events were reversed by free radical scavengers such as the manganese superoxide dism

204 ibitor is encouraging and suggests that free radical scavengers, such as vitamin E, may have a potent

205 yields decreased in the absence of hydroxyl radical scavengers, suggesting that future research shou

206 The free radical scavenger superoxide dismutase attenuated respon

207 Exposure of the carotid sinus to the free-radical scavengers superoxide dismutase (SOD) and catala

208 thine oxidase (XO), with or without the free radical scavengers superoxide dismutase (SOD; 100 U/ml),

209 nsformed lymphoid cells, is reversed by free radical scavengers, synergizes with the antileukemic act

210 Endogenous radical scavenger systems such as superoxide dismutase (

211 activation of glutathione and ascorbate free radical scavenger systems.

212 This observation and experiments with a radical scavenger TEMPO do not support a homolytic mecha

213 In contrast, the free radical scavengers TEMPO and TEMPONE and the anti-oxidan

214 Treatment of TRPM2+/+ mice with the free radical scavenger Tempol or the PARP1 inhibitor 3-aminob

215 Addition of the superoxide radical scavenger tempol restored the ability of bradyki

216 The free radical scavenger Tempol, but not other classes of antio

217 y silencing BCL10 or by exposure to the free radical scavenger Tempol.

218 estigate the effects of a membrane-permeable radical scavenger (tempol) on the circulatory failure an

219 The free radical scavenger, tempol, is known to have cardioprotec

220 Experiments using the radical scavenger tert-butyl-alcohol provided the same p

221 y IL-1, we exposed the cells to the hydroxyl radical scavenger tetramethylthiourea (10 mmol/L) and ob

222 gesting that the nanotube itself is a better radical scavenger than the BHT-derivatized SWCNT.

223 l is an excellent but very unselective (*)OH radical scavenger that provides antioxidant protection t

224 The most potent free radical scavengers that we tested for in the wine sample

225 Two free radical scavengers, the salen-manganese complex EUK-134,

226 In addition to their action as radical scavengers, they act as activators for the intri

227 onsistent with this hypothesis, the hydroxyl-radical scavenger thiourea, when added to M. smegmatis c

228 cal microscopy, that was blocked by the free radical scavenger tiron but not by a caspase-2 inhibitor

229 for initiation to produce the radicals and a radical-scavenger to limit their lifetimes.

230 Both the free radical scavengers Trolox and Mn2+, and the metal chelat

231 ored with and without coincubation of a free-radical scavenger (trolox).

232 Treatment with the peroxynitrite-dependent radical scavenger urate inhibits the invasion of iNOS-po

233 As a free radical scavenger, uric acid has been postulated to prot

234 The free radical scavenger Vitamin E significantly attenuates thi

235 hange blocker (amiloride), or an oxygen free radical scavenger (vitamin E).

236 tial of G. diffusa aqueous extract to act as radical scavenger was assessed against DPPH(), superoxid

237 otective effect, and 4-hydroxy TEMPO, a free radical scavenger, was not protective.

238 ted sensitivity to all other classes of free radical scavengers we have tested.

239 control studies with and without oxygen and radical scavengers, we propose that boron-imidates form

240 Inhibitors of hydrogen peroxide and hydroxyl radical scavengers were capable of attenuating the effec

241 Nerve growth factor and free radical scavengers were inactive in this system.

242 l-Ascorbic acid is a versatile radical scavenger widely distributed in aerobic organism

243 indole was shown to act as a potent hydroxyl radical scavenger with a rate constant of 7.8x1010 mol l

244 elatonin, a pineal hormone and a potent free radical scavenger with neuroprotective actions, has been