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1 ained previously for 32P-orthophosphate, the radiochemical 117mSn(4+)DTPA yields up to an 8-fold ther
2 incorporation of the alpha-particle-emitting radiochemical ((210)Po-citrate) and 2 anticancer drugs (
4 assisted laser-desorption/time of flight and radiochemical analysis of the product generated in vitro
5 eatment procedures has been validated in the radiochemical analysis of total (99)Tc in caustic aged n
8 (13)C]-3, and [2',3'-(13)C]-3 as substrates, radiochemical and NMR analyses of incubation mixtures re
12 thelial cells, studies of drug release using radiochemical approaches showed that the presence of 10v
14 We have developed a simple and sensitive radiochemical assay to determine malonyl-CoA decarboxyla
17 This assay has an advantage over traditional radiochemical assays in that many substrates, the substr
18 luorescent assay combines the sensitivity of radiochemical assays with the simplicity of nonradiochem
21 diosynthesis of 5'-[(18) F]FDA, with overall radiochemical conversion (RCC) more than 3-fold higher t
23 beling of a variety of carboxylic acids with radiochemical conversions up to 50 %, representing a tar
24 erformance liquid chromatography (HPLC) with radiochemical detection to determine relative levels of
26 ontrol chemistries that are required for the radiochemical determination of total (99)Tc in caustic a
30 ypoxia could be useful tools that complement radiochemical imaging and immunohistochemical staining m
31 se findings were supported by the results of radiochemical in situ hybridization histology and quanti
34 ack of chemically diverse precursors, and of radiochemical methods allowing (18)F-incorporation in hi
36 ably, unlike prior studies using established radiochemical methods in synaptosomes, we determined 60%
37 h ruggedness tests, the application field of radiochemical methods used was extended successfully to
42 rably with those obtained by a commonly used radiochemical procedure, which measures transamination b
51 of the tributyltin analogues in high yields, radiochemical purities, and specific radioactivities.
52 yl]temozolomide (11), with good chemical and radiochemical purities, have been prepared and used in h
54 cal purity suitable for biologic evaluation (radiochemical purity > 95%, decay-corrected radiochemica
56 We synthesized [(14)C]TETS (14 mCi/mmol, radiochemical purity >99%) by reacting sulfamide with H(
59 des, can be synthesized in good chemical and radiochemical purity (>98%), satisfactory radiochemical
60 ochemical yield of 2 +/- 0.6% with excellent radiochemical purity (>99%) and showed complete stabilit
61 iochemical yield (36% +/- 7% [mean +/- SD]), radiochemical purity (>99%), and mean molar activity (1,
62 u]-NPs of uniform shape and size with a high radiochemical purity (>99%), specific activity of 2.2 mC
67 fluorination, affording a product with >99% radiochemical purity (RCP) and specific activity (SA) of
68 efficient, resulting in ADCs with 96% to 98% radiochemical purity after size-exclusion chromatography
70 A-hu14.18K322A was achieved at more than 95% radiochemical purity and a specific activity of 127-370
71 -fluoromaltotriose was synthesized with high radiochemical purity and evaluated in several clinically
74 vides radiolabeled peptides with high (>98%) radiochemical purity and greater than 80% radiochemical
76 g with 99mTc via 2-iminothiolane thiolation, radiochemical purity and radiostability were tested.
79 ing antibody trastuzumab and labeled in high radiochemical purity and specific activity with the radi
82 )(3)(ASMA) preparations had greater than 99% radiochemical purity and were stable in phosphate-buffer
84 btained in the (18)F-radiolabeled form, with radiochemical purity and yield suitable for preliminary
87 ined in 25 min (n = 5) with greater than 99% radiochemical purity at high specific activity (>111 GBq
89 up to 1.5 GBq of tracer were produced with a radiochemical purity greater than 95% in less than 30 mi
90 cluding work-up took about 20-30 min, with a radiochemical purity greater than 95% without the need f
91 ne, patient batches (>200 applications) with radiochemical purity greater than 98% and specific activ
93 y in the range of 888-3,774 GBq/mumol, and a radiochemical purity greater than 99% using an automatic
94 DFO-AC-10 with a radiochemical yield of 80%, radiochemical purity greater than 99%, and specific acti
103 ith a radiochemical yield of 15.1% +/- 5.6%, radiochemical purity of 96.7% +/- 2.0%, and specific act
104 overall recovery yield of 91 +/- 3%, average radiochemical purity of 99.9%, and production yields tha
107 specific activity of 52-224 MBq/nmol, and a radiochemical purity of more than 97% (90 min from end o
108 Anti-CD56 mAb was radiolabeled, achieving a radiochemical purity of more than 97% and a specific act
109 activity of approximately 20 GBq/mumol and a radiochemical purity of more than 98% for (64)Cu-NOTA-AE
115 ed with a (99m)Tc-tricarbonyl precursor, and radiochemical purity of the labeled products was determi
118 e (18)F-SO3F(-) was simple and afforded high radiochemical purity suitable for biologic evaluation (r
120 The radiolabeling efficiency was 80%-85%, radiochemical purity was 78%-89%, and specific activity
124 specific activity was 15-170 GBq/mumol, and radiochemical purity was greater than 97% (end of synthe
130 radiochemical yield (decay corrected), high radiochemical purity, and >90 GBq/mumol specific radioac
133 ontrol requirements for human use (including radiochemical purity, residual solvents, Kryptofix, chem
149 Additionally, the method results in high radiochemical recoveries and when compared to other dige
150 provides a self-diagnostic parameter for the radiochemical separation and overall instrument function
153 e complete process of the sample collection, radiochemical separation, and measurement procedure spec
157 rification, proteolytic peptide mapping, and radiochemical sequencing of labeled wild-type and mutant
159 ars, and the current trend suggests that the radiochemical space available for PET applications will
160 ese medicinally important motifs expands the radiochemical space available for PET applications.
164 p decay and its ramifications (including the radiochemical synthesis of one organometallic compound),
165 cific activity, higher affinity, and simpler radiochemical synthesis than (18)F-BF4(-) METHODS: The a
166 cific activity, higher affinity, and simpler radiochemical synthesis than (18)F-BF4(-) The ability of
167 PTK7, was labeled with (18)F using a 2-step radiochemical synthesis, which featured a direct 1-step
168 nd 14 control eyes; age range, 62-93 years), radiochemical techniques were used to determine the RPE
170 adiopharmaceutical compared with a reference radiochemical was quantitated as a dosimetric relative a
172 Zr, scVR1/Zr, and scVR2/Zr tracers with high radiochemical yield (>87%), high specific activity (>/=9
173 ively] were radiofluorinated at a reasonable radiochemical yield (13%-18%) by use of site-specific ox
174 iomers of [(18)F]FAMPe were obtained in good radiochemical yield (24-52% n = 8) and high radiochemica
175 cursor, (18)F-LY2459989 was prepared at high radiochemical yield (36% +/- 7% [mean +/- SD]), radioche
178 with fluorine-18 (t1/2 = 109.7 min) in high radiochemical yield (87%) by treatment of its synthesize
180 with [11C]methyl iodide in approximately 30% radiochemical yield (decay-corrected to end of bombardme
181 e synthesized in 45% (n = 5) and 42% (n = 4) radiochemical yield (decay-corrected to end of bombardme
182 and [(18)F](S)-FIPCT were synthesized in 5% radiochemical yield (decay-corrected to end of bombardme
183 c activity [123I]ZIET was synthesized in 33% radiochemical yield (decay-corrected) by treating the 2b
187 led peptide can be obtained with a 31 +/- 6% radiochemical yield (n = 4, decay-corrected from (18)F-f
188 ried (18)F and purified via a C18 cartridge (radiochemical yield 49.8% +/- 5.9% within 20-25 min) wit
189 (radiochemical purity > 95%, decay-corrected radiochemical yield = 31.6%, specific activity >/= 48.5
191 GMIB-Nanobody was produced in 50.4% +/- 3.6% radiochemical yield and exhibited a dissociation constan
193 (18)F-FNDP can be synthesized in suitable radiochemical yield and high specific radioactivity and
194 iolabeling method capable of generating high radiochemical yield and high specific radioactivity.
195 d a method for preparing [(18)F]11 in useful radiochemical yield and in high specific activity from [
196 through radiomethylation in a range of 5-10% radiochemical yield and over 95% radiochemical purity.
197 E) and (99m)Tc-PSMA-I&S in consistently high radiochemical yield and purity (>/=98%, n > 50 preparati
198 poration in high selectivity and efficiency (radiochemical yield and purity, specific activity, and r
199 mpounds (86)Y- 4: - 6: were obtained in high radiochemical yield and purity, with specific radioactiv
205 l of the compounds were produced in adequate radiochemical yield and specific radioactivity (>74 GBq/
206 n approach proved to be superior in terms of radiochemical yield and stability, as well as in vivo pe
209 4-(11)C-carbonyl]temozolomide (11) in 10-15% radiochemical yield from [(11)C-carbonyl]methyl isocyana
210 [3-N-(11)C-methyl]temozolomide (9) in 14-20% radiochemical yield from [(11)C-methyl]methyl isocyanate
211 -aspergillitine is prepared in 10 % isolated radiochemical yield from the corresponding phenyl(asperg
212 (18)F-FBzBMS 5 was synthesized with 0.54% radiochemical yield in 130 min, with an average specific
214 (11)C-Compound 1 was synthesized at an 8% radiochemical yield in 29 min with an average specific r
215 (11)C-BMS-5p 3 was synthesized with 1.5% radiochemical yield in 36 min, with an average specific
221 -trastuzumab-ThioFab) in 82 min with a total radiochemical yield of 13 +/- 3% and a specific activity
222 nstant, 1.73 nM) was prepared in 1 step in a radiochemical yield of 14% +/- 7%, specific radioactivit
223 orobenzoate, with an overall decay-corrected radiochemical yield of 15% +/- 5% calculated from the st
226 corresponding tosylate precursor in a modest radiochemical yield of 2 +/- 0.6% with excellent radioch
227 nd radiochemical purity (>98%), satisfactory radiochemical yield of 20-35% (n > 20, non-decay correct
228 d conditions, (18)F-TFB was synthesized in a radiochemical yield of 20.0% +/- 0.7% (n = 3, uncorrecte
231 rification, (68)Ga-HZ220 was obtained with a radiochemical yield of 56% +/- 8% (non-decay-corrected),
232 abeled efficiently with (18)F in an isolated radiochemical yield of 62% +/- 2%, non-decay-corrected b
233 action purification with a decayed-corrected radiochemical yield of 63% +/- 5% (n = 5) and passed all
234 r to give formulated (89)Zr-DFO-AC-10 with a radiochemical yield of 80%, radiochemical purity greater
235 is time was 120 min, and the decay-corrected radiochemical yield of [(18)F]- 1 was about 25-30% ( n =
237 Radiolabeling of cm09 was achieved with a radiochemical yield of greater than 96% at a specific ac
239 led at a specific activity of 40 MBq/nmol, a radiochemical yield of more than 98%, and a stability of
241 uct in approximately 20%-40% decay-corrected radiochemical yield to provide (18)F-nifrolidine specifi
242 ion (t(1/2) = 109.7 min) in moderately high radiochemical yield to provide potential radioligands th
243 -MMR 3.49 sdAb was synthesized with a 5%-10% radiochemical yield using an automated and optimized pro
251 [(76)Br]5 was prepared in a 51% +/- 19% radiochemical yield with high radiochemical purity (>/=9
253 The peptide was efficiently labeled (91-98% radiochemical yield) with Tc-99m in the presence of tric
254 ere synthesized within approximately 70 min (radiochemical yield, 35%-45%; specific activity, 650-870
255 lly pure l-[5-(11)C]-glutamine was obtained (radiochemical yield, 5% at the end of synthesis; radioch
256 igands succeeded after optimization efforts (radiochemical yield, approximately 20%-30% at the end of
259 Radiolabeling was accomplished with high radiochemical yield, purity, and specific radioactivity.
260 t 79% +/- 13% (n = 6) and 94% +/- 6% (n = 6) radiochemical yield, respectively, with excellent radioc
261 i) of [(18)F]fluoride in 50 min (uncorrected radiochemical yield, specific activity of 815 +/- 185 GB
266 ynthesis of tracers was accomplished in good radiochemical yields (15-39%), high specific activities
267 bioactive molecules and building blocks with radiochemical yields (RCY) ranging from 20% to 72% withi
268 r = Ph or 2-MeC(6)H(4), 85%) decay-corrected radiochemical yields (RCYs) of a single radioactive prod
269 of a variety of arenes and heteroarenes with radiochemical yields (RCYs, not decay-corrected) from 10
270 (18)F]5 was synthesized in reproducibly high radiochemical yields and purity (>98%) as well as high s
271 iolabeling with (89)Zr was performed in high radiochemical yields and purity (>99%), and binding affi
274 d lorlatinib is routinely prepared with good radiochemical yields and shows reasonable tumour uptake
275 thesized in 140 min with 24% and 10% overall radiochemical yields and specific activities of 10-127 G
277 ound 4-(11)C-MBZA was prepared in 46% +/- 7% radiochemical yields by reacting (11)C-methyltriflate wi
278 ound 4-(11)C-MBZA was prepared in 46% +/- 7% radiochemical yields by reacting (11)C-methyltriflate wi
279 precursor-based synthesis demonstrated high radiochemical yields in the large-scale production of ra
282 2 and 13, respectively, with decay-corrected radiochemical yields of 30% for [18F]16 and 20% for [18F
283 8F]SFB can be synthesized in decay-corrected radiochemical yields of 30%-35% and a specific radioacti
284 Fluorinated pH indicators were produced with radiochemical yields of 4%-11% at greater than 90% purit
285 taurine-conjugated bile acids proceeded with radiochemical yields of 61% (decay-corrected) or greater
286 7alpha-18F-FM-DHT and 7alpha-18F-FM-norT in radiochemical yields of about 30% and radiochemical puri
287 F]/F(-) and Kryptofix/K(2)CO(3) in DMSO with radiochemical yields of approximately 50-60% and specifi
288 t (67/68)Ga and (177)Lu labeling resulted in radiochemical yields of greater than 97% or greater than
289 ynthesized in 20% +/- 5% (n = 3) uncorrected radiochemical yields relative to (18)F-fluoride, with sp
292 (89)Zr-ACKR3-mAb was produced in 80% +/- 5% radiochemical yields with greater than 98% radiochemical
293 obtained in greater than 50% decay-corrected radiochemical yields with more than 99% radiochemical pu
296 obtained in 16.3%-36.8% non-decay-corrected radiochemical yields, with 40-207 GBq/mumol specific act
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