ライフサイエンスコーパス: radioisotope

1 equiring labeling protocols (fluorophores or radioisotopes).

2 therapy is commonly performed with a single radioisotope.

3 take up to 3 months depending on the probe's radioisotope.

4 ent amino acids each tagged with a different radioisotope.

5 ange, using tritium gas as the source of the radioisotope.

6 ing the most widely investigated therapeutic radioisotope.

7 racticable due to the need for platelets and radioisotope.

8 allow for a single-step labeling with (18)F radioisotope.

9 e-encapsulated chemotherapeutics, genes, and radioisotopes.

10 and contrast with conventional beta-emitting radioisotopes.

11 the tracer principle, which is not based on radioisotopes.

12 simply, quickly, and reliably without using radioisotopes.

13 ized for radiotherapy of tumors with rhenium radioisotopes.

14 afety concerns, and the cost of working with radioisotopes.

15 nd it can be used systemically with targeted radioisotopes.

16 short shelf life, and high handling costs of radioisotopes.

17 only be imaged in vivo using gamma-emitting radioisotopes.

18 validated using 2 SPECT gamma cameras and 2 radioisotopes.

19 uptake and metabolism, without the need for radioisotopes.

20 s quantified from the PET images for various radioisotopes.

21 ajectory of the positrons emitted by the PET radioisotopes.

22 ling in pancreatic islets, as assessed using radioisotopes.

23 t media for effective energy conversion from radioisotopes.

24 System, including the origin of short-lived radioisotopes.

25 herapy with a single versus a combination of radioisotopes.

26 ggest an advantage of using a combination of radioisotopes.

27 than 96% radiochemical yield for all terbium radioisotopes.

28 e, depuration, and organ distribution of the radioisotope (109)Cd were used to explore the internal k

29 This study used the radioisotopes (109)Cd and (65)Zn to explore the uptake,

30 nds is that they incorporate the short-lived radioisotope (11)C.

31 emical purity and specific activity with the radioisotopes (111)In and (177)Lu.

32 ear-infrared fluorescence fluorophores and a radioisotope ((111)In).

33 Using flux analyses with the short-lived radioisotope (13)N and electrophysiological, respiratory

34 PAR antibodies conjugated to the therapeutic radioisotope (177)Lu, found that they were effective at

35 Because of the radioisotope ((18)F) used for labeling, the radioligand

36 Here, we coupled a radioisotope, (188)Rhenium, to an attenuated (at) live L

37 The radioisotope(22)Na(+) was used to determine the kinetics

38 Targeted alpha-particle radiation using the radioisotope (225)Ac is a promising form of therapy for

39 emitted during the radioactive decay of the radioisotope (31)Si produced via the neutron capture rea

40 Radioisotopes (5-7 microCi) were added to the apical bat

41 redicted to eject [Formula: see text] of the radioisotope (60)Fe (half-life 2.61 Ma).

42 rate increased significantly with the use of radioisotope (87.6% to 88.9%) versus with the use of lym

43 Rapid radioisotope accumulation and clearance in the placenta

44 visualized due to the combination of higher radioisotope accumulation in the tumor and similar blood

45 his controversy was based on measurements of radioisotopes activated by thermal neutrons that suggest

46 emic arterial circulation for measurement of radioisotope activity and plasma epinephrine concentrati

47 approach is acceptable at the low levels of radioisotope administered for most diagnostic purposes,

48 Plasma sampling after rectal radioisotope administration provided quantitative estima

49 tive subareolar injection technique for both radioisotope (all 96 procedures) and blue dye (93 proced

50 identical chemical characteristics of these radioisotopes allow the preparation of radiopharmaceutic

51 bination of radioisotope and blue dye versus radioisotope alone was performed between March 2010 and

52 and radioisotope) and 325 patients receiving radioisotope alone.

53 axilla is sentinel lymph node biopsy with a radioisotope and blue dye (dual technique).

54 Sentinel nodes were identified with both radioisotope and blue dye in 22 (73%) of these women, wi

55 SLNB guided by a combination of radioisotope and blue dye injection yields the best iden

56 Using both radioisotope and blue dye may increase the success rate.

57 ontrolled trial comparing the combination of radioisotope and blue dye versus radioisotope alone was

58 Sentinel nodes were identified with radioisotope and blue dye; the procedure was technically

59 ostlabeling requires the use of an energetic radioisotope and considerable time and effort.

60 The separation of the radioisotope and photoaffinity labels along the primary

61 A 1-cm(2) piece of paper, soaked with a radioisotope and placed in air, was scanned, and the mag

62 f-concept study was to produce all 4 terbium radioisotopes and assess their diagnostic and therapeuti

63 d of positive clones using reduced levels of radioisotopes and enzyme.

64 significantly improved delivery to tumors of radioisotopes and potent anticancer drugs.

65 nt of protein deamidation without the use of radioisotopes and therefore offers significant advantage

66 s) coupled to highly toxic agents, including radioisotopes and toxic drugs (ineffective when administ

67 ents receiving the combination (blue dye and radioisotope) and 325 patients receiving radioisotope al

68 ndidates, radiolabeled them with fluorine-18 radioisotope, and determined their physicochemical and i

69 The nanotubes can carry fluorophores or radioisotopes, and are shown to selectively bind to canc

70 mens include debulking, radiotherapy with IP radioisotopes, and chemotherapies (IP, systemic, or both

71 rised of stable analogs, as proxies to these radioisotopes, and isobaric interferents were introduced

72 ng practice X-rays while training, work with radioisotopes, and radiotherapy for benign conditions di

73 evaporative light scattering detectors), or radioisotopes; and is capable of detecting less than 5 n

74 engineered antibody fragments, labeled with radioisotopes are being developed as radiotracers for th

75 efficacious in metastatic prostate cancer as radioisotopes are brought to tumor cells by targeting an

76 Radioisotopes are effective in providing pain relief wit

77 Blue dye and/or radioisotopes are efficient mapping agents but the lack

78 re analyzed; and stable isotopes rather than radioisotopes are used.

79 ns are close to air cavities and high-energy radioisotopes are used.

80 ry depletion analyses ensured that increased radioisotope associated with the brain was due to increa

81 The radioisotopes available for labeling of MIBG and related

82 dF) has several advantages over conventional radioisotope-based ddF, including: (1) analysis of large

83 nts and is more versatile than devices using radioisotope-based ionization.

84 In contrast to commonly used radioisotope-based methods, which require freshly prepar

85 aptotagmin I labeled with fluorochromes or a radioisotope binds to both apoptotic and necrotic cells.

86 Estimates of radioisotope bound to bone surfaces and marrow radiation

87 provides the position for incorporating PET radioisotopes C-11 or F-18.

88 The effectiveness of radioisotopes can be greater when they are combined with

89 despread availability and low cost, and both radioisotopes can be imaged with existing, high-resoluti

90 onist was labeled with the positron-emitting radioisotope carbon-11 and evaluated in ex vivo biodistr

91 Lym-1 Ab has proven to be an effective radioisotope carrier, even in small amounts, for targeti

92 fic monoclonal antibody IC2, modified with a radioisotope chelator for nuclear imaging, we showed tha

93 ization biosensor format obviates the use of radioisotopes common in radioactive methods for the dete

94 The mean maximum radioisotope concentration after N-9 receipt was 12.0 ti

95 The plasma radioisotope concentration peaked 1 hour after N-9 dosin

96 as well as widely varying amounts of uranium radioisotopes content.

97 Beads in proximity to the radioisotope convert the emitted beta(-) particles into

98 ining on-line liquid chromatography-accurate radioisotope counting (LC-ARC, advanced stop flow contro

99 homogenates of the same tissue (analyzed by radioisotope counting) allowed precise quantitation of d

100 ar imaging technique using positron-emitting radioisotopes coupled to specific ligands.

101 (188)Re is a useful generator-produced radioisotope currently under evaluation for a variety of

102 for sentinel lymph node biopsy that are not radioisotope dependent or that refine the existing metho

103 solution Chirp sonar sub-bottom profiler and radioisotope detection techniques to examine the storm-d

104 formance liquid chromatography (HPLC) with a radioisotope detector to determine the extent of its bio

105 d beta-particles emitted during the decay of radioisotopes differ in significant ways, proper selecti

106 se turnover and oxidation were determined by radioisotope-dilution techniques in patients with chroni

107 The use of monoclonal antibodies to deliver radioisotopes directly to tumor cells has become a promi

108 In contrast to older methods that rely on radioisotope disappearance, the tracer incorporation met

109 and PET technology allows the measurement of radioisotope distribution in maternal and fetal organs i

110 and MRI technology allows the measurement of radioisotope distribution in maternal and fetal organs.

111 twigs with (13) N2 -enriched air and imaged radioisotope distribution in needles, the first experime

112 has been limited mostly to slow, bulk-scale radioisotope distribution methods.

113 ts and indicated that the homogeneity of the radioisotope distribution was also much improved when co

114 contain evidence of now extinct short-lived radioisotopes (e.g., (26)Al, (41)Ca, and (182)Hf) synthe

115 optimal adsorption in vitro of commonly used radioisotopes (e.g., 99mTc or 111In) to activated charco

116 Using radioisotope experiments, we found that mobilization of

117 Radioisotope, fluorescence labeling, and heme analog stu

118 all solutes, as assessed quantitatively with radioisotope flux and patch-clamp studies.

119 Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview of

120 -, 0.579 MeV [39%]) has shown potential as a radioisotope for PET imaging and radiotherapy.

121 .655 MeV; 19%); beta- (0.573 MeV; 40%)] as a radioisotope for radiotherapy has been recently establis

122 a apheresis, and labeled with technetium-99m radioisotope for single-photon emission computed tomogra

123 eV (just above the K-edge of gold), an ideal radioisotope for such purposes.

124 le isotopes provides an alternative to using radioisotopes for carrying out drug metabolism studies.

125 that stable isotope methods are superior to radioisotopes for determining rates of DNA synthesis and

126 ator-free labeling of LDH nanoparticles with radioisotopes for in vivo PET imaging.

127 iotin offers an alternative to labeling with radioisotopes for pharmacokinetic studies in humans.

128 It is a cell- and radioisotope-free assay that has the advantage of allowi

129 described here, enables detailed, real-time, radioisotope-free interaction studies that can greatly f

130 t was used for rapid isolation of the (63)Zn radioisotope from the parent (63)Cu ions.

131 ossibility of obtaining radiochemically pure radioisotopes from an aqueous beam dump at a heavy-ion f

132 ity in ventilation studies involving inhaled radioisotope gas or radioaerosols.

133 ield of conventional energy conversion using radioisotopes has almost exclusively focused on solid-st

134 Parathyroid scanning using radioisotopes has evolved and now can localize adenomas

135 PET-based tracers using (68)Ga as the radioisotope have in most centers replaced SPECT-based t

136 on procedure, palladium-103, a brachytherapy radioisotope in clinical practice, was coated to monodis

137 Fluorine-18 is the most frequently used radioisotope in PET radiopharmaceuticals for both clinic

138 ue dye in 22 (73%) of these women, with only radioisotope in six (20%), and with only blue dye in two

139 nd long-term (7 to 14 days) exposures to the radioisotope in solutions of 0.56 mug Cd/L were followed

140 e with the addition of isosulfan blue dye to radioisotope in the identification of the SLN in the pre

141 led with near-infrared (NIR) fluorophores or radioisotopes in cell membranes of disease-associated pr

142 reagent and labor-intensive assays utilizing radioisotopes in DNA polymerase-based assays and/or chro

143 The increased use of copper radioisotopes in radiopharmaceutical applications has cr

144 Radioisotope incorporation in the presence of a viral DN

145 alphaH catalytic activities (determined by a radioisotope incorporation method) and enzyme protein ma

146 The mean time from radioisotope injection to incision was 19.9 minutes (SD

147 tient-reported breast pain immediately after radioisotope injection, using the Wong-Baker FACES pain

148 ale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemother

149 d with the subareolar injection technique of radioisotope, intraoperative injection would be feasible

150 therapy, the emission characteristics of the radioisotope is critical in determining the radiation do

151 Radioisotope is given preoperatively, without local anes

152 rug development process, although the use of radioisotopes is inherently coupled to issues concerning

153 Radioisotope labeled chimeric G250, a monoclonal antibod

154 (AChBPs), are frequently characterized with radioisotope-labeled alpha-bgtx-binding assays.

155 Analysis of radioisotope-labeled carbon flux from glucose to CO(2) i

156 Radioisotope-labeled formate uptake measurements showed

157 this end, we have developed fluorophore- and radioisotope-labeled immunoconjugates to target a DDR si

158 gested that they would be suitable to use as radioisotope-labeled ligands, and we therefore synthesiz

159 mpered by the inconveniences associated with radioisotope-labeled reagents.

160 ar-infrared imaging probe, as well as future radioisotope-labeled versions of it, should prove to be

161 combination of characteristics that warrant radioisotope labeling and further evaluation in tumor-be

162 se samples with slab gel electrophoresis and radioisotope labeling had not detected these changes wit

163 Regeneration speed was studied by radioisotope labeling of transported proteins and by ant

164 We show that the CAFE and radioisotope labeling provide the most consistent result

165 igand Assay (DRaCALA) with fluorescently and radioisotope-labelled c-di-GMP.

166 Radioisotope labels have drawbacks that hamper their app

167 67 of 200 (83.5%) SLNs were hot according to radioisotope localization.

168 The dependence on radioisotopes means that uptake of the procedure is limi

169 that this system enhances the sensitivity of radioisotope measurement for metabolite identification i

170 werful tool for improving the sensitivity of radioisotope measurement in metabolite identification st

171 mitochondria in a light absorbance assay, in radioisotope measurements of matrix volume, and in measu

172 5)Fe X-ray photovoltaic cell prototype for a radioisotope microbattery (also called a nuclear microba

173 f a fabricated prototype Al0.2Ga0.8As (55)Fe radioisotope microbattery photovoltaic cells over the te

174 Neither radioisotopes nor large amounts of material are needed a

175 In the past half-century, techniques using radioisotopes of beta-carotene and vitamin A, depletion-

176 ceptor and that are also easily labeled with radioisotopes of iodine for biochemical and imaging stud

177 by extrinsically labeling the products with radioisotopes of iron and zinc and carrying out whole-bo

178 luorescent dye) and shell (conjugated with a radioisotope) of a heart-homing liposome (CRPPR-conjugat

179 l advantages over existing methodology using radioisotopes or a solvent extraction procedure.

180 s that are intended for targeted delivery of radioisotopes or chemical agents to diseased tissues.

181 amers have potential for in vivo delivery of radioisotopes or cytotoxic agents.

182 ncement of antibodies labeled with cytotoxic radioisotopes or pulsed-HIFU exposure in addition to a c

183 or analyzing phospho-amino acid residues use radioisotopes or sequence-specific antibodies.

184 advantages over existing methodologies using radioisotopes or solvent extraction procedures.

185 possible using traditional decay counting of radioisotopes or stable isotope mass spectrometry due to

186 cer cells and using these to deliver toxins, radioisotopes, or cytotoxic drugs to the cancer cells.

187 model allows the noninvasive measurement of radioisotope pharmacokinetics in maternal and fetal brai

188 amplified from bisulfite-treated DNA, use of radioisotopes, polyacrylamide sequencing gel electrophor

189 activities were measured using the two-step radioisotope procedure (Thompson).

190 of cancer medicine concerned with the use of radioisotopes, radiolabelled molecules, nanoparticles, o

191 Intraoperative subareolar injection of radioisotope rapidly drains to the SLNs and allows immed

192 plasma epinephrine concentration, percent of radioisotope recovery, and mean carotid arterial blood p

193 esulted in a significant increase in percent radioisotope recovery, but not in plasma epinephrine con

194 in plasma epinephrine concentration, percent radioisotope recovery, or carotid arterial blood pressur

195 stal environment to (131)I and perhaps other radioisotopes released from nuclear accidents.

196 labeling a specific mAb with the therapeutic radioisotopes Rhenium-188 and Bismuth-213.

197 arities with aluminum and for its convenient radioisotope (Sc-46), which can be used as a tracer in s

198 livery, and a dimercaptosuccinic acid (DMSA) radioisotope scan at 3 months was done on those with VUR

199 r chromatography and were quantified using a radioisotope scanner.

200 r steroid metabolites and quantified using a radioisotope scanner.

201 lites, separated by TLC and quantified using radioisotope scanning.

202 es in administering the targeting vector and radioisotope separately and having the 2 components comb

203 Both blue dye and radioisotope should be used to maximize the yield and ac

204 The radioisotope SLN identification method up to the common

205 ds can be synthesized with the corresponding radioisotopes so as to serve as PET/SPECT probes for ima

206 cancer, the addition of 1% lidocaine to the radioisotope solution can improve patient comfort, witho

207 There were seven beta-particle-emitting radioisotope stents (32P, activity level 0.14 microCi) a

208 Radioisotope studies demonstrated significant (p < .05)

209 Radioisotope studies help to detect neuroinflammation an

210 ns may not be sufficient for estimating GFR; radioisotope studies may be needed for a better assessme

211 try to quantify minute amounts of long-lived radioisotopes such as (14)C.

212 eling of cells with low-energy beta-emitting radioisotopes such as [(35)S]methionine is often used to

213 roximately 100 keV/microm) of alpha-emitting radioisotopes, targeted alpha-particle therapy offers th

214 vide measures of brain metabolism similar to radioisotope techniques.

215 powerful techniques used in adults, such as radioisotope testing, are not appropriate for use in chi

216 ctor to reconstruct the 3D distribution of a radioisotope that emits alpha or beta particles, and sho

217 eV; beta-: 37%, E(beta- max) = 578 keV) is a radioisotope that has clinical potential for application

218 Strontium-89 and samarium-153 are radioisotopes that are approved in the USA and Europe fo

219 ternal beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clin

220 We anticipate that combined radioisotope therapy will ultimately supplant single rad

221 tope therapy will ultimately supplant single radioisotope therapy, much as combination chemotherapy h

222 moregulin-specific antibodies will deliver a radioisotope to prostate tumor cells and metastases.

223 approach to many applications, from medical radioisotopes to aneutronic energy production.

224 ugates promising vectors for the delivery of radioisotopes to cancer cells; however, their long pharm

225 d soil fractionation and stable isotopes and radioisotopes to explore changes in soil organic carbon

226 been conjugated to toxic payloads, PEGs, or radioisotopes to increase and optimize their therapeutic

227 ectively, attached to chemotherapy agents or radioisotopes-to treat those with acute myeloid leukemia

228 were found to clear rapidly, thus mitigating radioisotope toxicity, and were shown to be therapeutica

229 This study utilized a commonly used radioisotope tracer (excess (210)Pb, (210)Pbxs) from 32

230 cular fingerprints of algal productivity and radioisotope tracers of sedimentation to document eight

231 Our radioisotope tracers revealed reciprocal C-for-phosphoru

232 e overcomes many drawbacks inherent to using radioisotope tracers.

233 Fluorescence and electron microscopy, and radioisotope tracing revealed that anti-ICAM NCs specifi

234 cean emigrants acquire the (134)Cs signal, a radioisotope undetectable in Pacific biota prior to the

235 method for laboratories wishing to minimize radioisotope use.

236 Radioisotopes used for PET emit photons via Cerenkov rad

237 uring spontaneous breathing and quantitative radioisotope V/Q scan (QVQS) results were available for

238 d by the excretion of the most commonly used radioisotope via the urinary tract, making pelvic imagin

239 diolabeling of 7 with no carrier added (18)F-radioisotope was accomplished starting from iodonium sal

240 bodies labeled with alpha- and beta-emitting radioisotopes was significantly more efficient in killin

241 Understanding how and when short-lived radioisotopes were added to the Solar System is necessar

242 Carrier-free terbium radioisotopes were obtained after purification, with act

243 quired the addition of isosulfan blue dye to radioisotope when an SLN was identified on a preoperativ

244 r imaging and preclinical research involving radioisotopes will be significantly accelerated in the n

245 ing somatostatin receptor ligand linked to a radioisotope with intermediate half-life and favorable p

246 ociated with tritium ((3)H) make it an ideal radioisotope with which to conduct ADME studies early in

247 Terbium offers 4 clinically interesting radioisotopes with complementary physical decay characte

248 rmacologic half-lives necessitate the use of radioisotopes with long physical half-lives, a combinati

249 s, together with the large panel of suitable radioisotopes with unique physicochemical properties, al

250 le values for the elements, and particularly radioisotopes, with no or sparse data.

251 was illuminated by a standard 206 MBq (55)Fe radioisotope X-ray source and characterised over the tem

252 ature, and under illumination from an (55)Fe radioisotope X-ray source, X-ray spectra were accumulate

253 binds MX-DTPA (tiuxetan), which chelates the radioisotope yttrium-90.