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1 addition, these drugs are relatively easy to radiolabel.
2 simplified design for single-step kit-based radiolabeling.
3 hydrazino-nicotinamide (S-HYNIC) followed by radiolabeling.
4 ers, using positron emission tomography with radiolabeled [11C]ABP688, which binds to an allosteric s
6 hereby inflammatory activation and uptake of radiolabeled 2-deoxyglucose was assessed before and afte
10 velopment of an N-terminally truncated GAD65 radiolabel, (35)S-GAD65(96-585), which improved the perf
15 nostic marker and demonstrate the utility of radiolabeled ACKR3-mAb for in vivo visualization of ACKR
19 , it was thought that internalization of the radiolabeled agonist was mandatory for sstr-mediated ima
20 d into a protocol for the synthesis of (18)F-radiolabeled aliphatic CF3-containing compounds, enablin
21 t translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that redu
22 transport studies with aap8 mutants fed with radiolabeled amino acids and by leaf exudate analyses.
23 demonstrated good agreement with established radiolabelled amino acid incorporation assays: TGFbeta1
25 he purified (67)Cu material was then used to radiolabel an anti-EGFR antibody, Panitumumab, and injec
28 ous system, numerous adrenoceptor drugs were radiolabeled and potent radioligands were prepared in or
29 onsidered to have non-obvious strategies for radiolabeling and require a more customized approach.
31 )Zr-DFO-AMG102 was successfully synthesized, radiolabeled, and validated in vitro and in vivo to sele
33 the significantly higher tumor uptake of the radiolabeled antagonist than of the agonist as measured
36 he aim of this study was to assess whether a radiolabeled anti-FAP antibody could be used to monitor
39 n practice, but also could spread the use of radiolabeled antibodies beyond locations with cyclotron
41 otestosterone ((18)F-FDHT), and a variety of radiolabeled antibodies targeting downstream effectors,
42 ct platform not only could enable the use of radiolabeled antibodies to become a common practice, but
47 njugation, providing a promising alternative radiolabeling approach that maintains the native in vivo
48 ver, we employed shRNA library screening and radiolabeling approaches, as well as in vitro and in viv
49 8)F-fluoroethyl)-l-tyrosine ((18)F-FET) is a radiolabeled artificial amino acid used in PET for tumor
50 , we explored the in vivo biodistribution of radiolabeled asparaginase, using a combination of imagin
59 , CdWO4) is placed in close proximity to the radiolabeled cells, where it converts the radioactive de
60 ailure to identify the SLN relative to using radiolabeled colloid +/- blue dye (P = 0.006; OR = 3.82;
61 was higher when mapping was performed using radiolabeled colloid alone or with blue dye compared wit
62 te was 78.6% with blue dye alone; 91.4% with radiolabeled colloid and 93.8% with dual mapping agents.
63 nt imaging properties but greatly simplified radiolabeling compared with other (68)Ga-PSMA conjugates
66 , we synthesized two different types of dual-radiolabeled conjugates, including 1) (111)In-2P-EPI-(12
67 selective picomolar inhibitor of MMP-13, the radiolabeled counterpart [(18)F]4 was successfully synth
69 sing candidates for the development of (18)F-radiolabeled COX-2 inhibitors for imaging purposes with
71 Molecular imaging with recently developed radiolabeled CXCR4 ligands could facilitate the selectio
72 tently and equally suppressed the release of radiolabelled d-[(14) C]aspartate and [(3) H]taurine.
73 characterization of a M2R subtype-preferring radiolabeled dibenzodiazepinone-type antagonist ([(3)H]U
75 the study of small-molecule transport (e.g., radiolabeled drugs, metabolic precursors and nuclear med
77 5 degrees C for 2h) of (52)Mn gave excellent radiolabeling efficiencies of 97-100% and 98-100% respec
78 of one radiolabeling precursor, which can be radiolabeled either with (68)Ga for diagnosis or with (1
79 of the techniques, the different methods of radiolabeling erythrocytes, the procedure, useful indica
84 cintigraphy quantified the uptake of studied radiolabelled f-MWNT in the whole brain parenchyma and c
86 for quantitative metabolite profiling, i.e., radiolabeling followed by high-performance liquid chroma
87 ration, and pathways were monitored by (14)C-radiolabelling followed by high-voltage electrophoresis.
94 functional studies included incorporation of radiolabeled Glc, linkage analysis, and imaging of cellu
95 rinsulinemic-euglycemic clamps combined with radiolabeled glucose to assess liver and muscle insulin
96 vivo and in vitro labeling experiments using radiolabeled GPI precursors showed that GPI underglycosy
97 overexpressed in human prostate cancer, and radiolabeled GRPr affinity ligands have shown promise fo
98 As a result of our investigations, a novel radiolabeled GRPr agonist with a high tumor uptake and a
101 nnocuous, appending nanoparticles with these radiolabeling handles can have dramatic effects on impor
103 ccinyl-glycine (HSG) trivalent BsMAb TF2 and radiolabeled HSG peptide (IMP288) present good features
108 ter conjugation to a DFO chelator and (89)Zr radiolabeling, in assays including cell uptake, internal
110 This is further supported by transfer of radiolabels into product from both alpha and gamma phosp
114 he FP an anti-chelated radiometal trap for a radiolabeled ligand (yttrium[Y]-DOTA) captured by a very
115 an uptake as percentage injected activity of radiolabeled ligand per gram of tissues (%IA/g) was eval
116 mproved on administration of higher doses of radiolabeled ligand, suggesting that certain binding sit
118 Positron emission tomography (PET) using radiolabeled ligands selective for the 18 kDa translocat
123 nformation on the whole-body distribution of radiolabeled mAbs and antibody-related therapeutics.
124 ed the kinetics of intraperitoneally infused radiolabeled mAbs in humans and showed the benefit of in
125 Our results show that high-specific-activity radiolabeled mAbs that are bound to a tumor surface will
127 Native gel-shift assays revealed a shift in radiolabeled MALAT1 ENE+A RNA upon addition of HEK293T c
128 educing terminus based on the degradation of radiolabeled maltodextrins, although recent reports chal
129 ine) of solids T1/2 (time taken for half the radiolabelled meal to empty from the stomach), measured
131 l advanced models that account for uptake of radiolabeled metabolites were evaluated, including a var
132 We present a novel solid-phase based (45)Ti radiolabeling methodology and the implementation of (45)
133 generated a range of innovative chelate-free radiolabeling methods that exploit intrinsic chemical fe
139 ential losses were tracked using three model radiolabeled molecules, namely BPA, DEHP and 4n-NP.
140 ine concerned with the use of radioisotopes, radiolabelled molecules, nanoparticles, or microparticle
142 the biokinetics of intraperitoneally infused radiolabeled monoclonal antibodies (mAbs) were modeled u
150 timizing the tumor targeting properties of a radiolabeled [Nle(14)]BBN(7-14) moiety, novel BBN(7-14)-
154 on profile compared with previously reported radiolabeled NTR1 ligands, (111)In-3BP-227 is an ideal c
156 nation at RT was successfully applied to the radiolabeling of [(18)F]-2-fluoroethylamines in which th
157 20.3 min) possesses the unique potential for radiolabeling of any biological, naturally occurring, or
159 ortant and versatile building blocks for the radiolabeling of biomolecules via Huisgen cycloaddition
160 eous sodium chloride (NaCl)-based method for radiolabeling of chelator-modified peptides for molecula
163 development of these modalities through the radiolabeling of somatostatin analogs with various radio
164 The TF-targeted tracer was developed through radiolabeling of the anti-human TF monoclonal antibody (
167 ned its ability to metabolically incorporate radiolabeled oleic acid into TAG, accumulate lipid dropl
169 r determining target occupancy include using radiolabeled or irreversible surrogates, which can be te
171 acid oxidation in primary hepatocytes using radiolabeled palmitate and in mice using indirect calori
173 the pharmacokinetics and biodistribution of radiolabeled pembrolizumab in vivo, while providing deta
174 e of the study was to analyze the ability of radiolabeled pentixafor to detect CXCR4 expression on in
175 rm a comparative effectiveness evaluation of radiolabelled peptide p5+14 with p5 and SAP, in amyloid-
177 ically stable trans-amide bond surrogates in radiolabeled peptides in order to improve their tumor ta
178 arameters such as the internalization of the radiolabeled peptides into PC3 and AR42J tumor cells, th
183 through optical imaging (OI) and the use of radiolabelled polymer-drug conjugates demonstrated conju
184 recurrent prostate cancer by the use of one radiolabeling precursor, which can be radiolabeled eithe
185 e not inhibiting DNA biosynthesis using (3)H-radiolabeled precursors in macromolecular synthesis inhi
186 c strategy that affords modular synthesis of radiolabeling precursors via a copper-catalyzed 'click'
189 r potentially nucleophilic residues, and the radiolabeled products were synthesized and purified in l
196 er for imaging PSMA expression that could be radiolabeled simply by addition of (68)Ga generator elua
197 ctive decays occurring stochastically within radiolabeled single-cells into an integrated, long-lasti
198 g CT, MRI, and (18)F-FDG PET, as well as new radiolabeled small molecules, antibodies, and antibody f
201 nt the design and synthesis of novel gallium-radiolabeled small-molecule sulfonamides targeting CA IX
203 atum corneum exposed to aqueous solutions of radiolabeled sodium chloride, tetraethyl ammonium bromid
205 preliminary clinical evidence indicates that radiolabeled somatostatin (sst) receptor antagonists per
206 eatment of neuroendocrine tumors (NETs) with radiolabeled somatostatin analogs represent a milestone
211 peptide receptor radionuclide therapy using radiolabeled somatostatin receptor (SSTR) agonists are s
213 r QNB or NMS slow down dissociation of their radiolabeled species from all five subtypes of muscarini
214 )-dAph(Cbm)-Lys-Thr-Cys)-dTyr-NH2)), a novel radiolabeled sst receptor antagonist with a high affinit
216 mparing the therapeutic antitumor effects of radiolabeled SSTR agonists versus antagonists are lackin
217 f peptide receptor radionuclide therapy with radiolabeled sstr agonists, such as [(90)Y-DOTA(0),Tyr(3
218 studies have demonstrated the superiority of radiolabeled SSTR antagonists for imaging purposes, desp
219 who proposed in 2006 the paradigm shift that radiolabeled sstr antagonists may perform better than ag
220 these results, we concluded that the use of radiolabeled SSTR antagonists such as JR11 might enhance
225 Here, we describe a general method for using radiolabeled substrate flux assays to determine coupling
226 PbENT1 in purine auxotrophic yeast and used radiolabeled substrate uptake to characterize its functi
227 sociations of SLC2A14 with IBD.The uptake of radiolabeled substrates into Xenopus laevis oocytes expr
230 lecular imaging of PARP using fluorescent or radiolabeled tags has followed on the success of therape
234 is exemplified by measurements made on three radiolabeled test compounds--caffeine, testosterone, and
235 ng confirmed the predominant accumulation of radiolabeled tetrazine in the tumor and low nontumor ret
236 es the number of TCO groups per diabody) and radiolabeled tetrazine to optimize the TCO modification
240 ions, we synthesized a series of candidates, radiolabeled them with fluorine-18 radioisotope, and det
245 e localization was shown in tumors, when the radiolabeled tracer was injected 4 h after an injection
248 spectrometric, fluorescence microscopic and radiolabeled uptake evidence that trehalose traverses th
250 pling partners, make it amenable for in vivo radiolabelling using pretargeting methodologies, which a
253 rgeted imaging of alpha V beta 3 activity (a radiolabeled version, (64)Cu-NOTA-PEG4-cRGD2, for PET im
259 ectrospray ionization-mass spectrometry, and radiolabeling was monitored by instant thin-layer chroma
262 1)In-2P-EPI-(125)I (polymeric carrier 2P was radiolabeled with (111)In and drug EPI with (125)I), and
265 5)I-2P-EPI-(111)In (polymeric carrier 2P was radiolabeled with (125)I and drug EPI with (111)In).
267 n with an albumin-binding domain (ABD), were radiolabeled with (125)I and intravenously injected into
269 luate novel AD diagnostic agents that can be radiolabeled with (64)Cu, a radionuclide with a half-lif
273 rea-based PSMA inhibitor was synthesized and radiolabeled with (68)Ga by adding generator eluate dire
274 chelator-free method, the nanoparticles were radiolabeled with (68)Ga without having to alter their s
275 -10 was conjugated with a DFO B chelator and radiolabeled with (89)Zr to give formulated (89)Zr-DFO-A
279 The anti-CD56 monoclonal antibody (mAb) was radiolabeled with 99mTc, and in vitro quality controls w
282 , RO6931643, and RO6924963 were successfully radiolabeled with a PET nuclide at high specific activit
285 core have been synthesized and successfully radiolabeled with carbon-11, fluorine-18, and gallium-68
289 glutaric acid-4,7-diacetic acid (NODAGA) and radiolabeled with the positron-emitting radionuclide (64
290 The mouse antihuman CD30 antibody AC-10 was radiolabeled with the positron-emitting radionuclide (89
292 rolled conjugation and polymerization before radiolabeling with (64)Cu for PET imaging in an apolipop
293 lator p-SCN-Bn-DFO was conjugated to AMG102, radiolabeling with (89)Zr was performed in high radioche
300 -methoxyphenyl)iodonium salt and its [(18)F] radiolabeling within a one-step, fully automated and cGM
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