ライフサイエンスコーパス: radioresistant

1 ports suggest that mast cells are relatively radioresistant.

2 ons in the Atm-/- central nervous system are radioresistant.

3 to radiotherapy, whereas adjacent CSCs were radioresistant.

4 astoma stem-like cells (GSC) that are highly radioresistant.

5 ISCs in mice can cycle rapidly yet still be radioresistant.

6 Consequently, EGFRvIII-expressing tumors are radioresistant and continue to grow following whole-brai

7 Further, Krt15+ cells were radioresistant and contributed to esophageal epithelial

8 The critical FcgammaRII(+) cells are radioresistant and could not be reconstituted with splen

9 Thus, in vivo both radioresistant and hemopoietic cells play key nonredunda

10 Glioblastomas (GBM) are highly radioresistant and lethal brain tumors.

11 precursors, whereas the other was relatively radioresistant and long-lived.

12 radioresistant cells and PAFR engagement on radioresistant and radiosensitive cells in the lung prom

13 mice revealed that TLR and RLH signaling of radioresistant and radiosensitive cells was required for

14 demonstrated that Ifitm3 functioned in both radioresistant and radiosensitive cells, as higher level

15 Deinococcus radiodurans, a highly radioresistant and stress-resistant bacterium, encodes t

16 Uveal melanomas are notoriously radioresistant and thus necessitate treatment with extre

17 In bone marrow chimeras, radioresistant and, likely, nonhematopoietic cells were

18 to encounter B27 in the thymus, and residual radioresistant and/or extrathymically derived host T cel

19 elative contributions of the nonhemopoietic (radioresistant) and the hemopoietic (radiosensitive) com

20 o a later onset of lymphoma development, are radioresistant, and lack serum Ig throughout life.

21 ompared with differentiated cells, GSCs were radioresistant, and this correlated with a higher mitoch

22 We found that radioresistant antigen-presenting cells and, specificall

23 ed both I-A glycoproteins and high levels of radioresistant APC activity.

24 ast to radiosensitive Atm-/- fibroblasts and radioresistant Atm-/- neurons, survival of Atm-/- astroc

25 cQ family member, the RecQ helicase from the radioresistant bacterium Deinococcus radiodurans encodes

26 moted by the RecA protein from the extremely radioresistant bacterium Deinococcus radiodurans is the

27 We found that SPARC deficiency in the radioresistant BM stroma compartment impairs myelofibros

28 HER2(+)/CD44(+)/CD24(-/low)) isolated from a radioresistant breast cancer cell population after long-

29 human cancers, including chemoresistant and radioresistant breast cancer cells, but its functional c

30 to explore Rac1 as a therapeutic target for radioresistant breast cancer cells.

31 ere used as companion biomarkers to identify radioresistant breast cancer xenografts highly amenable

32 The radioresistant C33A and CaSki cell lines, but not the ra

33 The selection of radioresistant cancer cells during fractionated radiatio

34 The up-regulation of the PrxII protein in radioresistant cancer cells suggested that human peroxir

35 sing the subpopulation of chemoresistant and radioresistant cancer stem cells (CSC).

36 s for tumoricidal treatment of traditionally radioresistant cancers while sparing critical adjacent s

37 n of TLR9/STAT3 signaling may help eliminate radioresistant cancers.

38 of allogeneic bone marrow was mediated by a radioresistant CD8(+)TCR-alphabeta(+)NK1.1(-) T cell pop

39 that MyD88 and the IL-18R were required in a radioresistant cell in the sensitization phase of the CH

40 een the presence of an active and relatively radioresistant cell population, demonstrable in vitro, a

41 In both tumorigenic and radioresistant cell populations, a phenotypic switch occ

42 ce using bone marrow chimeras and found that radioresistant cells (presumably LC) were able to cross-

43 cation of TLR3 signaling by nonhematopoietic radioresistant cells and enhanced mouse protection to ho

44 imeric mice revealed that CD36 engagement on radioresistant cells and PAFR engagement on radioresista

45 tained gammaH2AX for a greater duration than radioresistant cells and tumors.

46 e measured DC activation in a model in which radioresistant cells can or cannot respond to lipopolysa

47 migration induced by LPS is unimpaired when radioresistant cells cannot respond to the stimulus.

48 NLRP6 signalling in both haematopoietic and radioresistant cells contributed to increased susceptibi

49 eleration mainly involved HVEM expression by radioresistant cells in the Rag(-/-) recipients interact

50 One method to make hypoxic, radioresistant cells more radiation sensitive has been t

51 TNF-alpha, IL-12, and IL-6 cytokines and the radioresistant cells most of the KC, IP-10, and MCP-1 cy

52 We observed that radiosensitive and radioresistant cells played distinct roles in the innate

53 e marrow-derived and non-bone marrow-derived radioresistant cells to induce hemagglutinin-specific an

54 a U251 cells and moderately sensitized these radioresistant cells to radiation.

55 In bone marrow chimeras, synthesis of C3 by radioresistant cells was necessary and sufficient to con

56 ure IL-7 availability in vivo, we found that radioresistant cells were the source of IL-7 for both CD

57 Mice lacking IL-1R on radioresistant cells, but not hematopoietic cells, faile

58 Finally, disruption of IL-12p70 in radioresistant cells, such as LCs, but not in BMDCs resu

59 a STAT1 and IFN-gamma receptors expressed on radioresistant cells, suppresses fibrin deposition.

60 y in both donor hematopoietic cells and host radioresistant cells.

61 ersely correlated with expression of Chk1 in radioresistant cells.

62 hematopoietic cells and the IL-1 receptor on radioresistant cells.

63 p90 interaction and HIF-1alpha expression in radioresistant cells.

64 s absent or limited to radiosensitive versus radioresistant cells.

65 We established three radioresistant cervical cancer cell lines by exposure of

66 blasts from IFN receptor 1 knockout mice are radioresistant compared with wild-type mouse embryonic f

67 We report that recognition of LPS by the radioresistant compartment is sufficient to induce local

68 uced by hematopoietic cells is sensed by the radioresistant compartment to promote bone disease.

69 (MTP), as well as deletion of HSP110 in the radioresistant compartment.

70 C is often resistant to radiotherapy, making radioresistant CRPC an incurable disease.

71 d ATM expression and mitigated the growth of radioresistant CRPC tumors.

72 tore the cytotoxic effects of irradiation in radioresistant CSC populations.

73 on profiling of prostate cancer cells, their radioresistant derivatives, ALDH(+) and ALDH(-) cell pop

74 led to more residual chromosome aberrations, radioresistant DNA synthesis (a hallmark of genomic inst

75 ataxia telangiectasia-like disorder undergo radioresistant DNA synthesis (RDS), failing to suppress

76 n the intra S phase checkpoint, resulting in radioresistant DNA synthesis (RDS)-the failure to suppre

77 langiectasia mutated (ATM) kinase and elicit radioresistant DNA synthesis after gamma-irradiation(2).

78 Cells deficient in MLL showed radioresistant DNA synthesis and chromatid-type genomic

79 rexpression of wild-type ATR complements the radioresistant DNA synthesis phenotype of cells lacking

80 imics human t(11;16) leukaemia show a severe radioresistant DNA synthesis phenotype.

81 This 'radioresistant DNA synthesis' (RDS) is a phenotypic hall

82 nt of A549 cells with wortmannin resulted in radioresistant DNA synthesis, a characteristic abnormali

83 astoid cell lines, we used radiosensitivity, radioresistant DNA synthesis, and irradiation-induced au

84 cancer predisposition, radiosensitivity and radioresistant DNA synthesis-S phase checkpoint deficien

85 ation and p53 serine 18 phosphorylation, and radioresistant DNA synthesis.

86 itosis, and S-phase-irradiated cells exhibit radioresistant DNA synthesis.

87 tion-induced DNA damage, a phenomenon termed radioresistant DNA synthesis.

88 ective DNA-PKcs(-/-) tumor cell line and its radioresistant DNA-PKcs(+/+)-transfected counterpart wer

89 cytes and cognate self-antigens expressed by radioresistant elements in the thymus have been shown to

90 Unexpectedly, radioresistant FcRgamma-expressing cells in an organ dis

91 small cell lung carcinoma 54A and the highly radioresistant glioblastoma multiforme U87, respectively

92 We found that these radioresistant glioma cells are susceptible to Fas-media

93 quely radiosensitive GM cell line but not in radioresistant GM cell lines.

94 nsitivity: radiosensitive, radio-normal, and radioresistant groups.

95 stant C33A and CaSki cell lines, but not the radioresistant HeLa cell line, exhibited significantly i

96 ating from nonhematopoietic tissues and from radioresistant hematopoietic cells are neither sufficien

97 lysis class, number of brain metastases, and radioresistant histology.

98 mda5 was required in both marrow-derived and radioresistant host cells for adaptive responses.

99 as generated by both bone marrow-derived and radioresistant host cells.

100 Specific targeting of radioresistant host NK cells allows for a significant re

101 Thus, radioresistant host T cells are a significant barrier to

102 Radioresistant host T cells significantly affect the abi

103 Radioresistant HT29 and OVCAR cells demonstrate BrdU foc

104 ically as experimental sensitizing agents in radioresistant human cancers, and there is a direct corr

105 Radioresistant human glioblastoma cells in which erbB re

106 n, ICP0, from the viral genome, rendered two radioresistant human glioblastoma multiforme cell lines

107 at 2-4 h after IR (450-600 cGy) in confluent radioresistant human malignant melanoma (U1-Mel) cells.

108 on or immunoreactivity in radiosensitive and radioresistant human tumor cell lines and xenografted tu

109 Two murine models of radioresistant hypoxic cancer were used to study the eff

110 eathing is potentially useful to reoxygenate radioresistant hypoxic cells and improve the radiotherap

111 ggests that CHL was especially pronounced in radioresistant hypoxic cells possessing a larger transme

112 n by BM-derived cells and TNFR expression by radioresistant IECs.

113 to respond to alloantigens and deplete host radioresistant immune cells in GVHD recipients, alloreac

114 group composed of tumor cell lines that were radioresistant in culture (D0 > 2 Gy) and derived from k

115 ls are highly radiosensitive in the soma and radioresistant in the germline.

116 of p53 does not make these epithelial cells radioresistant in vivo to doses of 8 Gy and above.

117 Axl and Mer are expressed in radioresistant intestinal macrophages, and the loss of t

118 The role for FcgammaRIIb expression on radioresistant intrinsic renal cells in the protection f

119 We propose the name "sessile" for the radioresistant Kupffer cells that do not participate in

120 Sequential exposure of radioresistant LNCaP (wild-type (wt) p53), LNCaP/Bcl-2 (

121 lts indicate that HA14-1 potently sensitizes radioresistant LNCaP and PC3 cells to gamma radiation, r

122 vival and angiogenic activity in a subset of radioresistant lung cancer cell lines by elevating HIF-1

123 sed the survival and angiogenic potential of radioresistant lung cancer cells in vitro.

124 Likewise, siRNA silencing of TRAF2 in radioresistant lung cancer H1299 cells caused growth sup

125 First, before radiation exposure the radioresistant LYar cells expressed significantly greate

126 the CNS in both Bax-/- and Atm-/- mice were radioresistant, mice nullizygous for both Bax and Atm sh

127 purpose was to examine whether targeting of radioresistant NK cells and/or T cells in the recipient

128 These data suggest that radioresistant non-LC present self-Ag in K14-OVAp mice a

129 lized OVA requires the expression of Jak3 in radioresistant nonhematopoietic cells.

130 ppears to be associated with a population of radioresistant nonlymphoid cells.

131 lignancy among women worldwide and is highly radioresistant, often resulting in local treatment failu

132 and Rickettsia prowazekii, and the extremely radioresistant organism Deinococcus radiodurans.

133 from a neutral sphingomyelinase generates a radioresistant phenotype as measured by a marked decreas

134 lular GSH levels, and consequently induced a radioresistant phenotype in a HIF-1-dependent manner.

135 y the oncogenic small GTPase, Ras, display a radioresistant phenotype in response to ionizing radiati

136 -3 kinase (PI-3K) with LY294002 reverted the radioresistant phenotype in the immortalized astrocytes.

137 The radioresistant phenotype was reversed when the cells wer

138 st that cancer cells acquire antioxidant and radioresistant phenotypes through UCHL1-HIF-1-mediated m

139 ciated enrichment of CD44 subpopulations and radioresistant phenotypes.

140 PC-F vaccine can induce specific immunity to radioresistant populations of mammary tumor cells and, t

141 has been associated with the antioxidant and radioresistant properties of cancer cells, gene networks

142 ensitization, and hindered tumorigenicity of radioresistant prostate cancer cells.

143 hydrogenase (ALDH) activity is indicative of radioresistant prostate progenitor cells with an enhance

144 and that the marker-identified population is radioresistant relative to the marker-negative cells.

145 ired IRF-1 expression by both leukocytes and radioresistant renal cells, the latter identified as S3

146 CBCs are relatively radioresistant, repairing DNA by homologous recombinatio

147 ld be a useful approach for the treatment of radioresistant solid tumors such as glioblastomas.

148 inases (CDKs) to convert normal cells into a radioresistant state by inducing reversible cell cycle a

149 whereas concomitant TLR and RLH signaling of radioresistant stroma cells as well as of radiosensitive

150 B virus infection through its action within radioresistant stromal cells and not bone marrow-derived

151 ressing NK cell precursors and LT-responsive radioresistant stromal cells are necessary for NK cell d

152 sis function required expression of CD137 by radioresistant stromal cells as well as by bone marrow-d

153 est not in hematopoietic cells but rather in radioresistant stromal cells needed for the development

154 ion by both radiosensitive hematopoietic and radioresistant stromal cells prevented exacerbation of a

155 -based vaccine that specifically targets the radioresistant subpopulation of tumor cells.

156 tes radiosensitivity and is downregulated in radioresistant subpopulations of breast cancer cells, an

157 ] are involved, we analyzed their profile in radioresistant (SW480) and radiosensitive (SW48) human c

158 CD62L(-) T cells were able to deplete host radioresistant T cells and facilitate hematopoietic engr

159 val assays that GSCs were significantly more radioresistant than paired tumor bulk populations.

160 s, but not fibroblasts, were moderately more radioresistant than their wild-type counterparts, sugges

161 t survive large radiation doses are not more radioresistant than unirradiated cells and tumors, and a

162 s postirradiation and are substantially more radioresistant than wild-type cells.

163 her doses of radiation are given to the more radioresistant tissue.

164 not induce elevations in Bax or apoptosis in radioresistant tissues such as heart, skeletal muscle, b

165 This suppression was radioresistant to 25 Gy.

166 ted stable myeloid leukemia HL60 cell clones radioresistant to either gamma-rays or alpha-particles t

167 high-risk group (nonresponse), which proved radioresistant to treatment.

168 (IR) treatment resulted in the selection of radioresistant tumor (nu61) that overexpresses the signa

169 by IR and enhanced cell death in irradiated radioresistant tumor cells.

170 ion of effector T cells capable of targeting radioresistant tumor cells.

171 induction of apoptotic tumor cell death in a radioresistant tumor model both in vitro and in vivo.

172 Conversion into a radioresistant tumor phenotype when implanted in SCID(as

173 ingle high-grade epidural lesion caused by a radioresistant tumor who also have an estimated survival

174 preliminary data indicate their utility for radioresistant tumors adjacent to highly critical struct

175 d to salivary gland malignancies and certain radioresistant tumors such as sarcomas.

176 ating the mechanisms involved in sensitizing radioresistant tumors to ionizing radiation (IR) treatme

177 r proton radiotherapy for the same subset of radioresistant tumors where neutrons show a benefit over

178 ropriate for some subgroups of patients with radioresistant tumors, but routine avoidance of WBRT sho

179 Renal-cell carcinoma is considered to be a radioresistant tumour, but this notion might be wrong.

180 l treatment for malignant melanoma and other radioresistant tumours.

181 NA and reveal a new therapeutic strategy for radioresistant tumours.

182 Instead, we find radioresistant tyrosinase mRNA expression in lymphoid co

183 Radioresistant variants isolated from MCF-7 human carcin

184 of autophagy rendered the Bak/Bax(-/-) cells radioresistant, whereas overexpression of ATG5 and Becli

185 receptor 2-positive tumors seemed to be most radioresistant, whereas triple-negative tumors had the l

186 s, Krt19(+) cancer-initiating cells are also radioresistant, while Lgr5(+) stem cells are radiosensit