ライフサイエンスコーパス: radiosensitive

1 her response and lower dose were labelled as radiosensitive.

2 ozygotes in the human population may also be radiosensitive.

3 l that assumes all tumor cells are uniformly radiosensitive.

4 growth defects and are generally considered radiosensitive.

5 radioresistant, while Lgr5(+) stem cells are radiosensitive.

6 ere unable to resolve DNA damage, and became radiosensitive.

7 tributions, and the mutants were only mildly radiosensitive.

8 Lgr5(-) reserve stem cells are surprisingly radiosensitive.

9 l lines lacking functional ATM are extremely radiosensitive.

10 s, we conclude that CLL and non-CLL are both radiosensitive.

11 radiation therapy, as hypoxic cells are less radiosensitive.

12 r human papillomavirus (HPV) are exquisitely radiosensitive.

13 tradicts this model, in that they are highly radiosensitive.

14 ssion of ATG5 and Beclin-1 made the WT cells radiosensitive.

15 (cs) and, like Atm(-/-) mice, are viable and radiosensitive [4-8].

16 uring the G2 delay when compared to the more radiosensitive A2780 cell line.

17 mary malignant brain tumor in children, is a radiosensitive and chemosensitive tumor.

18 In addition, Artemis mutants are radiosensitive and chromosomally unstable, which has bee

19 gene that encodes nibrin, and NBS cells are radiosensitive and defective in S-phase checkpoint activ

20 Tumor growth inhibition was relatively radiosensitive and dependent on host-derived CD8+ T cell

21 ermal Langerin(+) dendritic cells (DCs) were radiosensitive and displayed a distinct cell surface phe

22 that NHEJ-deficient 2BN cells derived from a radiosensitive and immune-deficient patient lack XLF due

23 atterns, however, discriminated well between radiosensitive and more resistant lines, possibly being

24 Female BALB/c mice are unusually radiosensitive and more susceptible than C57BL/6 and oth

25 tion was of indeterminate origin, being both radiosensitive and not replenished by donor bone marrow.

26 We observed that radiosensitive and radioresistant cells played distinct

27 aH2AX focus formation or immunoreactivity in radiosensitive and radioresistant human tumor cell lines

28 One subset was radiosensitive and rapidly replaced from hematogenous pr

29 even at very high levels, remained as chemo/radiosensitive and repair deficient as the parental cell

30 ATM-deficient cells are radiosensitive and show impaired cell cycle arrest and i

31 ost markedly in mammary tissue, and are both radiosensitive and susceptible to radiogenic mammary can

32 ta argue that Lgr5(-) reserve stem cells are radiosensitive and that Lgr5(+) cells are crucial for ro

33 Mutant rhp6-788 is slightly HU sensitive, radiosensitive, and exhibits normal checkpoint responses

34 against either class I or class II Ags, was radiosensitive, and required cell-cell contact.

35 and clinical features, F96-224 cells are as radiosensitive as Artemis null cell lines.

36 However, in contrast to radiosensitive Atm-/- fibroblasts and radioresistant Atm

37 In contrast, TCR revision is radiosensitive, B cell, CD28, and inducible costimulator

38 potential protective effect of receptors on radiosensitive, bone marrow-derived cells.

39 that these DNA-PKcs null mutants were highly radiosensitive but also that upon IR treatment, p53 accu

40 that has the interesting phenotype of being radiosensitive, but having only a modest defect in VDJ r

41 Malignant plasma cells are very radiosensitive, but the potential role of radioimmunothe

42 ataxia telangiectasia gene are indeed highly radiosensitive, but their numbers are very small.

43 Cells from radiosensitive, cancer-prone BALB/c mice showed ineffici

44 Testing in other radiosensitive cancers is warranted.

45 es revealed that the IL-1R was required in a radiosensitive cell in the sensitization phase of the CH

46 180BR is a radiosensitive cell line defective in DSB repair, which

47 We show that a radiosensitive cell line, mutant for the RAD51 homolog X

48 In the third group, composed of radiosensitive cell lines derived from tumors associated

49 In addition, the radiosensitive cell populations (crypt or stem cells) ar

50 cceptance is associated with the presence of radiosensitive cells in the donor liver that may interac

51 The simulated absorbed doses to radiosensitive cells in the GI tract for 99mTc and 123I

52 ls and PAFR engagement on radioresistant and radiosensitive cells in the lung promote allergic respon

53 n the innate response to flagellin, with the radiosensitive cells producing the majority of the TNF-a

54 TLR and RLH signaling of radioresistant and radiosensitive cells was required for efficient protecti

55 IL-1beta blockade, IL-1beta deficiency in radiosensitive cells, and CCR2/CCR7 double deficiency bu

56 Ifitm3 functioned in both radioresistant and radiosensitive cells, as higher levels of WNV were obser

57 ined with a layer of endosteum that contains radiosensitive cells.

58 oietic (radioresistant) and the hemopoietic (radiosensitive) compartments, we measured both innate an

59 is directly required for the accumulation of radiosensitive dermal-derived langerin(+)CD103(+) DCs in

60 A radiosensitive DNA repair-deficient xrs-5 cell line was

61 rminal modification renders mice exquisitely radiosensitive due to defects in HSC/progenitor prolifer

62 ts suggest that there may be a donor-derived radiosensitive element that enhances allograft survival

63 Radiosensitive elements in kidney allograft may be respo

64 Although the disease is radiosensitive, external beam radiation leads to signifi

65 p53 or interfering RNA to inhibit p21 stayed radiosensitive for 24 hours after drug treatment.

66 are hyperproliferative and potentially more radiosensitive) for patients treated with previous chemo

67 inducing a protective autophagy response in radiosensitive gastrointestinal tissues.

68 , TRADD expression was induced in a uniquely radiosensitive GM cell line but not in radioresistant GM

69 The choice of therapeutic modality in this radiosensitive group of patients should be made on a cas

70 However, NOD/LtSz-scid mice are highly radiosensitive, have short life spans, and a small numbe

71 ave not gained success in patients except in radiosensitive hematological neoplasms, or in settings i

72 , nitric oxide synthase 2 production by both radiosensitive hematopoietic and radioresistant stromal

73 licited in the absence of Ag presentation by radiosensitive host hematopoietic-derived APCs after all

74 e reported that in the absence of functional radiosensitive host hematopoietic-derived APCs, H-Y Ag p

75 r T cells will induce GVHD in the absence of radiosensitive host hematopoietic-derived APCs.

76 ld indeed represent a societally-significant radiosensitive human subpopulation.

77 of radioresistant stroma cells as well as of radiosensitive immune cells is needed to effectively pro

78 cond group, composed of cell lines that were radiosensitive in culture (D0 approximately 1 Gy) but de

79 al epithelial (SIE) cells are among the most radiosensitive in the body.

80 ponse to radiation; these animals are highly radiosensitive in the soma and radioresistant in the ger

81 ls expressing AS-IGF1R transcripts were more radiosensitive in vitro and in vivo than controls.

82 the ATM gene (ATM(+/-)) may be slightly more radiosensitive in vitro, it remained to be determined wh

83 We found that these stem cells are highly radiosensitive, in contrast to their isogenic differenti

84 ased localization of radiopharmaceuticals in radiosensitive kidney subregions can potentially lead to

85 tor, but not other innate immune sensors, in radiosensitive leukocytes protects against tumour format

86 Another radiosensitive line, mutant for XRCC3 and defective in H

87 ken together, these data identify c-MYC as a radiosensitive locus, implicating this oncogenic transcr

88 rays to survey common CNVs in a cohort of 50 radiosensitive lymphoblastoid cell lines (RS-LCLs) deriv

89 immunosuppressive agent that acts by killing radiosensitive lymphocytes.

90 ance the oncolytic potency of MV-Edm against radiosensitive malignancies and to facilitate noninvasiv

91 eriments and in clinical trials conducted in radiosensitive malignancies, particularly B-cell lymphom

92 Multiple myeloma is a radiosensitive malignancy that is currently incurable.

93 On the other hand, a radiosensitive mutant (irs-20) of DNA-PKcs with a defect

94 DNA-PK-deficient cell lines are radiosensitive mutants lacking either the catalytic subu

95 protein carbonylation than is the much more radiosensitive nematode Caenorhabditis elegans.

96 e basis of the DNA repair strategies of more radiosensitive organisms.

97 determine normalized dose data for maternal radiosensitive organs and embryo/fetus from 256-slice CT

98 iminary tests of shielding other superficial radiosensitive organs frequently included at diagnostic

99 Mitochondrial p53 accumulation occurred in radiosensitive organs like thymus, spleen, testis, and b

100 Organ and surface dose to specific radiosensitive organs were estimated by using software f

101 rofile of the cumulative uptake over time of radiosensitive organs.

102 tion is associated with massive apoptosis in radiosensitive organs.

103 nce animal survival or crypt regeneration in radiosensitive p21 KO-recipient mice.

104 in a redistribution of the cells into a more radiosensitive phase of the cell cycle or in an increase

105 Tachpyridine arrested cells at G2, a radiosensitive phase of the cell cycle, and enhanced the

106 ortion of cells in G2-M (27% versus 5%), the radiosensitive phase of the cell cycle.

107 partial synchronisation of cells in the most radiosensitive phase of the cell-cycle.

108 e DNA glycosylases in mutant cells confers a radiosensitive phenotype and an increase in the number o

109 ns in the LRR can only partially reverse the radiosensitive phenotype and V(D)J recombination deficit

110 Initially this was because of the unusual radiosensitive phenotype of cells from A-T patients, and

111 isolated as a second-site suppressor of the radiosensitive phenotype of seeds defective in the repai

112 ulature in wild-type mice that resembled the radiosensitive phenotype of tumor vessels in SCID mice.

113 t mechanisms may be responsible for the more radiosensitive phenotype.

114 of multiple myeloma, an incurable but highly radiosensitive plasma cell malignancy.

115 myelination appears to be mediated by a CD8+ radiosensitive population, which is induced on infection

116 Interestingly, two radiosensitive primary fibroblast cell lines, derived fr

117 three patient subgroups of radiosensitivity: radiosensitive, radio-normal, and radioresistant groups.

118 g agents and absence of B and T lymphocytes (radiosensitive severe combined immune deficiency [RS-SCI

119 Radiosensitive severe combined immune deficiency in huma

120 oss of ARTEMIS function therefore results in radiosensitive severe combined immunodeficiency (RS-SCID

121 The Artemis nuclease is defective in radiosensitive severe combined immunodeficiency patients

122 Human radiosensitive severe combined immunodeficiency results

123 tive in ataxia telangiectasia and a class of Radiosensitive-Severe Combined Immunodeficiency (RS-SCID

124 Multiple myeloma is a highly radiosensitive skeletal malignancy, but bone-seeking rad

125 on of PAX7 positive cells, we show that this radiosensitive skeletal muscle progenitor pool contribut

126 ase was 1.7- and 1.3-fold for the moderately radiosensitive small cell lung carcinoma 54A and the hig

127 More strikingly, we also can create a radiosensitive state when the select let-7 family of miR

128 um response was more pronounced for the more radiosensitive strain.

129 P, the bladder tumour cell line MGH-U1 and a radiosensitive subclone S40b.

130 population includes genetically predisposed radiosensitive subsets.

131 Skin is radiosensitive, suggesting it is well-oxygenated.

132 image but reduced the amount of radiation to radiosensitive superficial structures.

133 their profile in radioresistant (SW480) and radiosensitive (SW48) human colorectal cell lines.

134 discovered as the gene inactivated in human radiosensitive T(-)B(-) severe combined immunodeficiency

135 trating that children are not, in fact, more radiosensitive than adults in the radiologic imaging dos

136 ion, in particular for children who are more radiosensitive than adults.

137 e of the DNA-PKcs variants are slightly more radiosensitive than cells completely deficient in DNA-PK

138 or ataxia telangiectasia (A-T) are much more radiosensitive than cells from unaffected individuals.

139 od) and CFU-GM(blood) were considerably more radiosensitive than femoral progenitors, thereby providi

140 hree SCAN1 lines examined were slightly more radiosensitive than normal cells, but only for fractiona

141 ective in undergoing apoptosis but were more radiosensitive than the WT cells in autophagy.

142 heir DT, i.e. the faster cells grow the more radiosensitive they are.

143 compared with non-stem cells within several radiosensitive tissue niches and culture models.

144 rogeneity of radioactivity in this important radiosensitive tissue.

145 Active bone marrow is one of the more radiosensitive tissues in the human body and, hence, it

146 e potential for complications to nontargeted radiosensitive tissues might be reduced.

147 (177)Lu-DOTA-Bn), that leads to high TIs for radiosensitive tissues such as blood (TI = 73) and kidne

148 tion (IR) induces p53-dependent apoptosis in radiosensitive tissues, suggesting that p53 is a determi

149 nt-related toxicities, based on high TIs for radiosensitive tissues.

150 rpin RNA renders the IR-resistant nu61 cells radiosensitive to IR.

151 However, radiosensitive tumor cells and xenografts retained gamma

152 umor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of pa

153 Although CTCL is a highly radiosensitive tumor, the complex topography of acral su

154 The loss in effectiveness is most severe for radiosensitive tumors.

155 Inclusion of the radiosensitive variable improved lasso logistic regressi

156 ass I MHC expression is absent or limited to radiosensitive versus radioresistant cells.

157 significant difference in expression between radiosensitive versus radiotolerant strains, suggesting

158 licular lymphoma has been shown to be highly radiosensitive with responses to doses as low as 4 Gy in