ライフサイエンスコーパス: radiosensitization

1 tion, impaired G2 checkpoint proficiency and radiosensitization.

2 dioresistance and abrogated miR-125-mediated radiosensitization.

3 -1 head and neck cancer cells also conferred radiosensitization.

4 om ROS generation leads to curcumin-mediated radiosensitization.

5 ecreased phospho-Akt and was associated with radiosensitization.

6 pect to the mechanisms by which they produce radiosensitization.

7 vity was associated with significant thermal radiosensitization.

8 etween these molecules and, in turn, causing radiosensitization.

9 R inhibitors can potentiate cytotoxicity and radiosensitization.

10 vel approach for specific ATM inhibition and radiosensitization.

11 ns for the complexity underlying FTI-induced radiosensitization.

12 al basis for targeting this gene network for radiosensitization.

13 and on angiogenesis, tumor oxygenation, and radiosensitization.

14 ted p53 were able to counteract drug-induced radiosensitization.

15 ectable in cells resistant to 17DMAG-induced radiosensitization.

16 lar mechanisms of heat-induced apoptosis and radiosensitization.

17 ls of DNA repair in bladder cancer cells and radiosensitization.

18 ing activity is necessary for 17DMAG-induced radiosensitization.

19 defective DNA double-strand break repair and radiosensitization.

20 HDR as a significant contributor to caffeine radiosensitization.

21 d breaks (DSBs) in the mechanism of caffeine radiosensitization.

22 and DNA-PK as a powerful strategy for tumor radiosensitization.

23 ould provide new molecular targets for tumor radiosensitization.

24 cer cells (HCT116) to IdUrd cytotoxicity and radiosensitization.

25 human colon cancer cells leading to greater radiosensitization.

26 inhibition of ribonucleotide reductase) and radiosensitization.

27 source of molecular targets for glioblastoma radiosensitization.

28 ptor, is examined as a target for tumor cell radiosensitization.

29 mismatch repair (MMR) would exhibit greater radiosensitization.

30 ions was sufficient to reverse IDH1-mediated radiosensitization.

31 NHEJ) repair and that FBXW7 depletion causes radiosensitization.

32 illing and did not influence AV1Y28-mediated radiosensitization.

33 Fv) directed against Ras proteins results in radiosensitization.

34 ncer cells resistant to TRAIL/Apo2L-mediated radiosensitization.

35 domethacin and is involved in the process of radiosensitization.

36 d exceeded that reported to achieve in vitro radiosensitization.

37 ue-1 (MLH1)-deficient human cancer cells for radiosensitization.

38 ys might offer a rational strategy for tumor radiosensitization.

39 kpoint response is not sufficient to explain radiosensitization.

40 A levels, and consequently, analogue-induced radiosensitization.

41 checkpoint abrogation is not sufficient for radiosensitization.

42 because bromodeoxyuridine was able to induce radiosensitization.

43 ive in HRR, similarly shows reduced caffeine radiosensitization.

44 and MSH2-deficient, drug-resistant cells for radiosensitization.

45 of dThd analogue DNA incorporation and tumor radiosensitization.

46 were consistent with clinically significant radiosensitization.

47 concentrations similar to those that induce radiosensitization.

48 offer a relative sparing of the mucosa from radiosensitization.

49 t correlated closely with those required for radiosensitization.

50 ll killing, a phenomenon termed hyperthermic radiosensitization.

51 ding activity of Ku may lead to hyperthermic radiosensitization.

52 activity did not correlate with hyperthermic radiosensitization.

53 tigations of the use of FGFR1 inhibitors for radiosensitization.

54 active AKT in GSCs compromised hyperthermic radiosensitization.

55 t GW6471 abolish the effect of clofibrate on radiosensitization.

56 eveal MKP1 as a novel therapeutic target for radiosensitization.

57 sed nanoparticles for multimodal imaging and radiosensitization.

58 erally applicable druggable target for tumor radiosensitization.

59 being tested in phase I clinical trials, in radiosensitization.

60 naling and induced cell rounding, leading to radiosensitization.

61 5) and beclin1 increased NVP-BEZ235-mediated radiosensitization.

62 enomic biomarkers of EGFR inhibitor-mediated radiosensitization.

63 focused on the tumor stroma as a target for radiosensitization.

64 ly showed was required for curcumin-mediated radiosensitization.

65 aDu cells nearly abolished curcumin-mediated radiosensitization.

66 cell cycle status on EGFR inhibitor-mediated radiosensitization.

67 ation-induced DNA damage play a role in heat radiosensitization.

68 decreases their clonogenicity and results in radiosensitization.

69 H2AX/MDC1/53BP1 complex plays a role in heat radiosensitization.

70 ctive drug target for anticancer therapy and radiosensitization.

71 anced G(2)-M arrest, growth suppression, and radiosensitization.

72 umbilical vascular endothelial cell (HUVEC) radiosensitization.

73 repaired before irradiation, would result in radiosensitization.

74 RbAp48 overexpression induced radiosensitization (1.5- to 2-fold) when compared with m

75 isomerase I is essential in the induction of radiosensitization: (a) higher concentrations of camptot

76 linked to anticancer, anti-inflammatory, and radiosensitization activities through a mechanism that i

77 IF-1 tumors growing in C3H mice demonstrated radiosensitization after Gd-tex treatment before single

78 RAD51 paralogs XRCC2 and XRCC3 show reduced radiosensitization after treatment with caffeine, thus i

79 Furthermore, this radiosensitization also carried over to the in vivo situ

80 Hyperthermia caused apoptosis and radiosensitization and decreased 26S proteasome activity

81 imal model of xenograft irradiation produced radiosensitization and prevention of relapse.

82 critical role of TxnRd1 in curcumin-mediated radiosensitization and suggest that TxnRd1 levels in tum

83 is a target involved in indomethacin-induced radiosensitization and that NF-kappaB may be one downstr

84 mation correlated with the magnitude of heat radiosensitization and was modulated by the molecular ch

85 hylation event triggered apoptosis, promoted radiosensitization, and hindered tumorigenicity of radio

86 hibition of TRIP12 expression further led to radiosensitization, and overexpression of TRIP12 was ass

87 e that genetic disruption of CREB results in radiosensitization, and that this effect can be explaine

88 DDFP plus carbogen caused dramatic radiosensitization, and the radiation response of cells

89 IdUrd-related cytotoxicity and/or radiosensitization are correlated with the extent of IdU

90 dermal growth factor receptor inhibition for radiosensitization are put into perspective for larynx c

91 While the degree of GNP-mediated radiosensitization as seen from the in vitro study may b

92 D54 cells were not resistant to radiosensitization because bromodeoxyuridine was able to

93 Ku86 in modulating topoisomerase I-mediated radiosensitization, but not cytotoxicity, in mammalian c

94 down of Akt1, p110alpha, or mTOR resulted in radiosensitization, but not to the same degree as with N

95 on of NPM significantly reduces heat-induced radiosensitization, but reduced NPM level does not alter

96 Radiosensitization by AZD7762 was associated with abroga

97 Radiosensitization by beta-lap was blocked by the NQO1 i

98 ng fraction dose, sequence, and time course; radiosensitization by chemo- and biologic therapy; and t

99 This differential dual mode of radiosensitization by combining IUdR and caffeine-like d

100 Because radiosensitization by dFdCyd has been correlated with it

101 lting from wild-type p53 induction prevented radiosensitization by dFdCyd.

102 ay play an important role in Ad/p16 mediated radiosensitization by enhancing or restoring apoptosis p

103 or several specific genes that may influence radiosensitization by erlotinib including Egr-1, CXCL1,

104 hus, our data indicate a common mechanism of radiosensitization by erlotinib or cetuximab across dive

105 nt role for MLH1 and implicate mismatches in radiosensitization by FdUrd.

106 nd this forms a novel molecular mechanism of radiosensitization by FTI.

107 Radiosensitization by FTIs, however, seemed to involve o

108 (MCF-7 and U-87 MG) were further tested for radiosensitization by Gd-tex under hypoxic conditions.

109 dertook independent efforts to further study radiosensitization by Gd-tex.

110 Previous studies have shown that radiosensitization by gemcitabine is accompanied by simu

111 Radiosensitization by IC87361 was eliminated in SCID tum

112 , Msh2-/- cells are selectively targeted for radiosensitization by IdUrd.

113 onstrate significant tumor and normal tissue radiosensitization by low-dose gemcitabine.

114 ced IUdR-DNA incorporation and IUdR-mediated radiosensitization by partially inhibiting repair (remov

115 between the presence of a KRAS mutation and radiosensitization by the EGFR inhibitors erlotinib and

116 were therefore studied to determine whether radiosensitization by the specific inhibitor of DNA-PK,

117 lling by lapatinib and obatoclax, as well as radiosensitization by this drug combination.

118 s not induce any radiodermatitis, suggesting radiosensitization by vemurafenib.

119 ting that p53 induction was not required for radiosensitization by wortmannin.

120 Despite the reduced radiosensitization, caffeine effectively abrogates check

121 Importantly, MMAE radiosensitization can be localized to tumors by targete

122 GNP)-mediated radiation dose enhancement and radiosensitization can be maximized when photons interac

123 Radiosensitization can result from chemotherapy-induced

124 the MLH1-inactivated cells exhibited greater radiosensitization compared with MMR-wild-type cells [ra

125 inase 1/2 (MEK1/2) blocked curcumin-mediated radiosensitization, demonstrating that the sustained ERK

126 d fibroblasts from AT patients show caffeine radiosensitization despite the checkpoint defects associ

127 This results in tumour growth inhibition and radiosensitization despite the use of a sevenfold lower

128 ox target that contributes to parthenolide's radiosensitization effect in prostate cancer cells.

129 esquiterpene lactone, selectively exhibits a radiosensitization effect on prostate cancer PC3 cells b

130 cl2 : Bax ratio and this caused the enhanced radiosensitization effect.

131 Furthermore, the gastrointestinal radiosensitization engendered by the loss of atm has rec

132 oteins (GLUTs) and possess hypoxia-selective radiosensitization features, are now reported.

133 We have also demonstrated a radiosensitization for several phenotypic endpoints of r

134 investigate the mechanism of the GNP induced radiosensitization, GNP-induced mitochondrial depolarisa

135 wever, predictive genomic biomarkers of this radiosensitization have remained elusive.

136 he resistance of OC-14 cells to heat-induced radiosensitization, hydrogen peroxide, and cisplatin.

137 that senescence is a prominent mechanism of radiosensitization in 45% of cell lines and occurs not o

138 clude that DDX3 inhibition with RK-33 causes radiosensitization in breast cancer through inhibition o

139 PUMA expression elicits profound chemo- and radiosensitization in cancer cells, inhibition of PUMA e

140 of clonogenic survival, we have demonstrated radiosensitization in cell lines with oncogenic H-ras mu

141 ll killing in 96-h viability assays and true radiosensitization in colony formation assays.

142 topoisomerase I as a biochemical mediator of radiosensitization in cultured mammalian cells by campto

143 hat depleted dATP >90%, also did not produce radiosensitization in D54 cells.

144 ely induce growth suppression, apoptosis and radiosensitization in diverse human cancer cells, withou

145 investigated the mechanisms of hyperthermic radiosensitization in GSCs by a phospho-kinase array tha

146 in increased IdUrd-induced cytotoxicity and radiosensitization in mammalian cells.

147 biquitination patterns of MRE11 and mediated radiosensitization in response to HDAC inhibition.

148 the DNA-PK kinase activity, and hyperthermic radiosensitization in rodent cells immediately after hea

149 cells, inhibits DSBR and induces significant radiosensitization in the absence of E1B-55K.

150 inder vinblastine induced enhanced levels of radiosensitization in the Ku86-deficient cells, Ku86 see

151 tment induced significantly higher levels of radiosensitization in the Ku86-deficient Chinese hamster

152 d both camptothecin-induced cytotoxicity and radiosensitization in the vector-alone, as well as the K

153 exposure to 2DG might be capable of inducing radiosensitization in transformed cells via perturbation

154 r decreased Akt phosphorylation and enhanced radiosensitization in U251MG and U87MG glioblastoma cell

155 nd that deregulation of c-Jun induced marked radiosensitization in vivo and in vitro, which was rescu

156 N4924-induced aneuploidy, G(2)/M arrest, and radiosensitization, indicating a causal effect.

157 role of Ku86 in DNA topoisomerase I-mediated radiosensitization induced by camptothecin in mammalian

158 to uniquely affect topoisomerase I-mediated radiosensitization induced by camptothecin.

159 Knockdown of AIF by shRNA rescues the radiosensitization induced by E4orf6.

160 and bromodeoxyuridine (BrdUrd), and thereby radiosensitization induced by these analogues, indirectl

161 ll effect on HDR, indicating that similar to radiosensitization, inhibition of checkpoint signaling i

162 s correlation suggested that AV1Y28-mediated radiosensitization involved the inhibition of radiation-

163 an important mechanism of celecoxib-induced radiosensitization involves inhibition of COX-2-derived

164 gest a novel mechanism for curcumin-mediated radiosensitization involving increased ROS and ERK1/2 ac

165 hanging tumor oxygenation, establishing that radiosensitization is a component of the response.

166 Both thrombospondin-1- and CD47-dependent radiosensitization is cell autonomous because vascular c

167 We propose that caffeine radiosensitization is mediated by inhibition of stages i

168 The role of thrombospondin-1 in radiosensitization is specific because thrombospondin-2-

169 ignaling may be necessary for 17DMAG-induced radiosensitization, it is not sufficient.

170 ze cells to IR and suggests that therapeutic radiosensitization may only require ATM inhibition for s

171 This decrease correlated with in vitro radiosensitization measured by clonogenic assays, and th

172 d-type cells, FdUrd (IC(50)) did not produce radiosensitization nor did it increase the mutation freq

173 nt to the cytotoxic effect of dFdCyd, and no radiosensitization occurred at any concentration of dFdC

174 n-activated protein kinase (MAPK) results in radiosensitization of cancer cells.

175 n ALDH(+) tumor progenitor population and to radiosensitization of cancer cells.

176 or inducing S-phase stasis and promoting the radiosensitization of checkpoint-deficient cancer cells.

177 ibitor of Bmx, LFM-A13, produced significant radiosensitization of endothelial cells as measured by c

178 ition of PARP and ATR resulted in a profound radiosensitization of GSCs, which was of greater magnitu

179 51 complex in DNA repair may be a target for radiosensitization of HCC.

180 her EphB4 receptor targeting can enhance the radiosensitization of HNSCC.

181 tumor growth inhibition in athymic mice and radiosensitization of human squamous carcinoma cells tra

182 aveolin-1 inhibitors resulted in significant radiosensitization of malignant glioma cells, which will

183 ry have described increased and preferential radiosensitization of mismatch repair-deficient (MMR(-))

184 attenuates NF-kappaB signaling to elicit the radiosensitization of NSCLC.

185 s may protect quiescent tumor cells, whereas radiosensitization of proliferating cells may be caused

186 dow model was used to assess IC87361-induced radiosensitization of SCID and wild-type tumor microvasc

187 1 (TxnRd1) is required for curcumin-mediated radiosensitization of squamous carcinoma cells.

188 (IR) resulted in significant dose-dependent radiosensitization of these cells.

189 t that such treatment might be useful in the radiosensitization of these tumors.

190 Likewise, disulfiram radiosensitization of tumor cells was copper-dependent.

191 IC87361 induced radiosensitization of tumor microvasculature in wild-typ

192 ated PI3K as a potential target for specific radiosensitization of tumors.

193 he therapeutic effectiveness of heat-induced radiosensitization of tumors.

194 53-independent G1-S checkpoint that mediates radiosensitization produced by fluorodeoxyuridine.

195 and neck is less certain, and results of its radiosensitization properties have been variable.

196 and, in preclinical models, it demonstrates radiosensitization properties.

197 We combined the radiosensitization property of topotecan and the specifi

198 cover targets for developing molecular-based radiosensitization protocols for tumors resistant to rad

199 teraction of heat and radiation that lead to radiosensitization remain to be elucidated.

200 he role of DNA repair inhibition in caffeine radiosensitization remains uncharacterized, and it is un

201 xact mechanism by which these events produce radiosensitization remains unknown.

202 Gold nanoparticle radiosensitization represents a novel technique in enhan

203 f MLH1 this concentration produced excellent radiosensitization (RER = 1.6 +/- 0.10 and 1.5 +/- 0.06,

204 on was attenuated in thermotolerant and heat radiosensitization-resistant cells.

205 e, near-infrared (NIR)-excited deep PDT, and radiosensitization, respectively, all of which contribut

206 IdUrd cytotoxicity and radiosensitization result, in part, from induction of DN

207 glioma and endothelial cells (ECs) and that radiosensitization results from inhibiting mTOR signalin

208 isomerase I (TOP1) mediates the induction of radiosensitization (RS) by camptothecin derivatives in m

209 nt studies of fluoropyrimidine (FP)-mediated radiosensitization (RS) have focused on the molecular me

210 y siRNA was not sufficient to ablate miR-890 radiosensitization, signifying that miR-890 functions by

211 yielded results that paralleled the in vitro radiosensitization studies of both single and fractioned

212 The time dependency of R115777-induced radiosensitization suggested that the initial FTI target

213 n induces significant tumor cytotoxicity and radiosensitization, suggesting a potential therapeutic u

214 e, catalytic polypeptide (DNAPK) as an ideal radiosensitization target.

215 , displays significantly diminished caffeine radiosensitization that can be restored by expression of

216 ese findings reveal that p16 participates in radiosensitization through influencing DDR and support t

217 aging and treatment planning, as well as for radiosensitization to improve the therapeutic ratio.

218 Inhibition of HDR and cell radiosensitization to killing shows similar dependence o

219 Radiosensitization to mda-7/IL-24 is dependent on JNK si

220 solution in LNCaP-LN3 cells, suggesting that radiosensitization tracks with the ability of IGF-1R to

221 ernative therapeutic paradigm for ErbB-based radiosensitization using antibodies to restrict radiosen

222 of BER in modulating IdUrd cytotoxicity and radiosensitization using genetically matched Chinese ham

223 that exposure to 2DG causes cytotoxicity and radiosensitization via a mechanism involving perturbatio

224 Radiosensitization was also assessed in vivo using a tum

225 transformed immortalized rat cells, and this radiosensitization was also inhibited by treatment with

226 Radiosensitization was also, in part, dependent upon c-J

227 Ascorbate radiosensitization was associated with an increase in ox

228 Heat radiosensitization was attenuated in 53BP1-null cells, i

229 To investigate whether the PTEN-induced radiosensitization was attributable to impaired sensing

230 Thermal radiosensitization was characterized biochemically and f

231 Radiosensitization was evidenced by decreased clonogenic

232 th radiosensitizers, a significantly greater radiosensitization was found in p53-deficient human tumo

233 The mechanism of action of NP Wtmn radiosensitization was found to be through the inhibitio

234 The mechanism of radiosensitization was investigated in DC3F cells.

235 Radiosensitization was not affected by androgen dependen

236 No radiosensitization was observed in either case.

237 for 16 h before ionizing radiation exposure, radiosensitization was observed with a sensitizer enhanc

238 POH-induced radiosensitization was partially inhibited in glioma cel

239 gested that the initial FTI target for early radiosensitization was short-lived, and that a p21-direc

240 PARP1-dependent radiosensitization was suppressed by a pan-caspase inhib

241 When this novel concept of radiosensitization was tested in cancer models, small in

242 etermine the effect this might have on tumor radiosensitization, we did tumor regrowth assays with xe

243 To identify the mechanism of this radiosensitization, we examined the level of proteins in

244 cycle redistribution in gemcitabine-mediated radiosensitization, we investigated the role of checkpoi

245 To identify molecular target(s) for radiosensitization, we screened a small interfering RNA

246 To assess the importance of this process in radiosensitization, we used the autophagy inhibitors 3-m

247 Interestingly, senescence and radiosensitization were linked to an increase in residua

248 , these effects of caffeine on IUdR-mediated radiosensitization were not found in p53-proficient cell

249 cantly higher levels of camptothecin-induced radiosensitization were observed in the vector-alone sub

250 er H1299 cells caused growth suppression and radiosensitization, whereas overexpression of WT TRAF2 e

251 Radiosensitization with antimetabolites has improved cli

252 Studies of repair pathways involved in radiosensitization with antimetabolites implicate base e

253 of the dATP pool imbalance was important for radiosensitization with dFdCyd, and, therefore, cells de

254 lts demonstrate that MMR deficiency promotes radiosensitization with dFdCyd.

255 e prior to irradiation is also important for radiosensitization with dFdCyd.

256 Although radiosensitization with FdUrd requires dTTP depletion an

257 ator to assess the biological consequence of radiosensitization with gold nanoparticles.