ライフサイエンスコーパス: raft

1 have been often used as a model system for 'rafts'.

2 r membranes in clusters, often called 'lipid rafts'.

3 olution of ordered microdomains (i.e., lipid rafts).

4 n regions and colony morphologies (puffs and rafts).

5 se C activities, and both clathrin and lipid rafts.

6 to specific regions of cell membranes called rafts.

7 that are consistent with the notion of lipid rafts.

8 normally restricted to juxtaparanodal lipid-rafts.

9 pted to the single cells isolated from these rafts.

10 rdered, lipid-driven assemblies termed lipid rafts.

11 isordered (Ld) "lakes" are formed within the rafts.

12 with caveolin 1 targeting Kv1.3 to caveolar rafts.

13 how that soluble klotho binds membrane lipid rafts.

14 hieves full activity when recruited to lipid rafts.

15 nt treatment translocates Galphas from lipid rafts.

16 ments and microtubules but also affect lipid rafts.

17 y be incorporated into microdomains or lipid rafts.

18 diverse antidepressants accumulate in lipid rafts.

19 the M-PMV MA did not co-localize with lipid rafts.

20 brane structure in unique regions like lipid rafts.

21 GPI)-anchored proteins localize in the lipid rafts.

22 cede Gag association with, or nucleation of, rafts.

23 aling pathways and the formation of membrane rafts.

24 neration can modulate the structure of lipid rafts.

25 Ret activation but does not translocate into rafts.

26 membrane sequence redirects PrP(C) away from rafts.

27 ral membrane proteins and formation of lipid rafts.

28 ral domains, including lipid-driven membrane rafts.

29 ing high concentrations of sterol-rich lipid rafts.

30 nd sphingolipid-rich membrane regions called rafts.

31 aturally occurring nanodomains such as lipid rafts.

32 ll as on their lateral accumulation in lipid rafts.

33 ratum for oceanic dispersal of organisms via rafting.

34 survival and dispersal of coastal species by rafting.

35 apse, where it regulates filamin A and lipid raft accumulation, as well as T cell activation, in a no

36 Mechanical disruption of the lipid rafts activates PLD2 by mixing the enzyme with its subst

37 raft association, here we directly quantify raft affinity for dozens of TMDs.

38 a mechanistic, physical model that predicts raft affinity from the protein sequence.

39 ls that plasma membrane proteins have higher raft affinity than those of intracellular membranes, con

40 sible addition-fragmentation chain-transfer (RAFT) agents.

41 Rac1 binding-deficient allele of p110beta to rafts alleviated the requirement for p110beta-Rac1 assoc

42 at HtrA and p66 may reside together in lipid rafts also.

43 Klotho binding to rafts alters lipid organization, decreases membrane's pr

44 o document that SHOC2(S2G) localizes both in raft and non-raft domains, and that it translocates to t

45 thacin (IND) leads to the formation of lipid rafts and activation of caveolin-1; however, no such obs

46 Importantly, LMP1 trafficking to lipid rafts and activation of NF-kappaB and PI3K/Akt pathways

47 The distribution of membrane lipid rafts and adhesion receptors were analyzed by imaging fl

48 e HIV-1 Gag polyprotein, retains it in lipid rafts and blocks HIV-1 virion production and spread.

49 ial constituents of cell membranes and lipid rafts and can modulate signal transduction events.

50 confirmed that US9 is associated with lipid-rafts and can target functional enzymes to membrane micr

51 and in vivo demonstrate that membrane/lipid rafts and caveolin (Cav) organize progrowth receptors, a

52 asses of antidepressants accumulate in lipid rafts and effect translocation of Galphas to the non-raf

53 tient IgG colocalized with markers for lipid rafts and endosomes.

54 miR-33 augments macrophage lipid rafts and enhances proinflammatory cytokine induction an

55 lacks the ability to redistribute into lipid rafts and is glycoengineered for augmented antibody-depe

56 on of normal prion protein (PrP(C)) in lipid rafts and lipid cofactors generating infectious prions i

57 twist promotes the formation of finite-sized rafts and mediates a repulsion that distributes them eve

58 20 nm, with implications for the symmetry of rafts and nanoclusters in cell membranes, which have sim

59 We observed that SFK and FAK in the lipid rafts and nonrafts are differently regulated by fluid fl

60 Kv1.3 localizes in lipid rafts and participates in the immunological response.

61 hospholipase A2 from PrP-containing membrane rafts and reduced the activation of cytoplasmic phosphol

62 , we characterized the distribution of lipid rafts and the E-selectin counterreceptor CD44 on the mon

63 ce of PrP(res) not associated with host cell rafts and without the potential influence of endogenous

64 targeting to detergent-resistant membranes (rafts) and to caveolin-1.

65 d that apoA1 rapidly disrupts membrane lipid rafts, and as a consequence, dampens the PI3K/Akt signal

66 , protein kinase A or the formation of lipid rafts, and does not require ion flux through the channel

67 increases membrane fluidity, disrupts lipid rafts, and redistributes CD44, which is the primary medi

68 zation in a 2:1 v/v ethanol/water mixture or RAFT aqueous emulsion polymerization, respectively.

69 Nanoscale rafts are believed to play an important functional role,

70 anchoring and the localization of PrP(C) to rafts are crucial to the ability of PrP(C) to propagate

71 Here we show that lipid rafts are dynamic compartments that inactivate the signa

72 Lipid rafts are hypothesized to facilitate protein interaction

73 Rafts are involved in most plasma membrane functions by

74 the notion that sialogangliosides and lipid rafts are membrane receptors for sKlotho and that the KL

75 Thus, these leukocyte-adhesive HA rafts are now identified as HC3-HA complexes that could

76 Lipid rafts are specialized dynamic microdomains of the plasma

77 Lipid rafts are widely believed to be an essential organizatio

78 erol-rich liquid-ordered (Lo) lipid domains (rafts) are thought to be important organizing elements i

79 rimarily since cholesterol enriched regions, rafts, are known to play a special role in protein funct

80 nt membrane nanodomains, also known as lipid rafts, are the primary response element in EF sensing.

81 However, the mechanisms governing stabilized raft assembly and function remain unclear.

82 lpha on CPT2, the lipid droplet and ER-lipid-raft associated PLIN3 and Erlin1.

83 metries of intact Nanodiscs containing lipid-raft associated sphingomyelin.

84 HA and NA, while raft associated, reside in distinct domains, reflecting

85 ntaining a cholesterol binding motif, is not raft associated.

86 lthough an integral membrane protein, is not raft associated.

87 membrane liquid order and localization of a raft-associated ciliary membrane calcium sensor.

88 , PTEN null tumor cells critically rely upon raft-associated PI3K activity.

89 otein transmembrane domains (TMDs) determine raft association, here we directly quantify raft affinit

90 of BACE1 S-palmitoylation and reduced lipid raft association.

91 sible addition fragmentation chain transfer (RAFT)-based dynamic covalent chemistry is incorporated i

92 The RAFT-based bond exchange process, which leads to stress

93 uid flow, while inhibition of SFK in the non-rafts blocked FAK activation by the cytokines.

94 Inhibition of FAK in the lipid rafts blocked SFK response to fluid flow, while inhibiti

95 ation of PDGFR specifically located in lipid rafts but not outside rafts, implying the role of lipid

96 colocalized with GM1 ganglioside-rich lipid rafts, but MHC I clusters retracted to smaller subsets o

97 hat P2Y2R interaction with Cav-1 in membrane-raft caveolae of 1321N1 cells modulates receptor couplin

98 ble addition - fragmentation chain transfer (RAFT) chain transfer agent, with and without pre-conjuga

99 nism and is reversible by interventions upon raft cholesterol and by ABC transporter-inducing liver X

100 ipid-poor apolipoprotein AI (apoAI) packages raft cholesterol into soluble particles that are eventua

101 ction in uninfected cells to fine-tune lipid raft cholesterol that regulates innate immunity to adeno

102 d augment TLR signaling in macrophages via a raft cholesterol-dependent mechanism.

103 nflammatory responses due to augmented lipid raft cholesterol.

104 surface glycosaminoglycans and induces lipid raft clustering, increasing the incorporation of CXCR4 r

105 tightly regulated by cholesterol-rich "lipid rafts." Collectively, these data show that RIDalpha util

106 tsunami, to examine the relationship between rafting community diversity and both habitat area and st

107 ce for an attractive interaction among these raft components into some sort of cluster.

108 ective Ret signaling owing to improper lipid raft composition or function.

109 y specimens (plugs) or organotypic cultures (rafts) consisting of ChHV5-positive turtle fibroblasts i

110 Although raft-constituent ordered lipid domains are thought to be

111 f CD1d accompanied by an alteration in lipid raft content on the plasma membrane of thymocytes and an

112 ANGPTL4-deficient CMPs have higher lipid raft content, are more proliferative and less apoptotic

113 assemblies in cell membranes known as lipid rafts, coself-assembly of 1-decanol into cetyltrimethyla

114 cell invasion was studied using organotypic raft cultures and in vivo significance was assessed via

115 ayer cultures and their derived organotypic (raft) cultures, although it exhibits only a minimal leve

116 Results show that ice-rafted debris accumulated constantly throughout the core

117 that--on the basis of our comparisons of ice-rafted debris and polar planktonic foraminifera--abrupt

118 unced surface cooling and the arrival of ice-rafted debris at a site southwest of Iceland over the pa

119 One major difficulty is dating ice-rafted debris deposits associated with Heinrich events:

120 high-temporal-resolution records of iceberg-rafted debris derived from the Antarctic Ice Sheet, and

121 , a Southern Ocean (Atlantic-sector) iceberg rafted debris event appears to have occurred synchronous

122 nt of key climate data sets spanning iceberg-rafted debris event Heinrich 3 and Greenland Interstadia

123 Ocean, leaving behind distinct layers of ice-rafted debris in the ocean sediments.

124 aminiferal assemblages, the abundance of ice-rafted debris, and sortable silt grain size data.

125 d), its naturalin vivotarget cells, by lipid raft-dependent macropinocytosis.

126 could mediate HCV RNA replication in a lipid raft-dependent manner, as the depletion of cholesterol,

127 In vivo, raft-dependent PI3K signaling is up-regulated in klotho-

128 gliosides enriched in lipid rafts to inhibit raft-dependent PI3K signaling.

129 domains for endocytosis, and down-regulates raft-dependent PI3K/Akt signaling.

130 In addition, the EPA-induced lipid raft disorganization, caveolin-1 inactivation, and cellu

131 provide cytoprotection, consequent to lipid raft disorganization.

132 Diblock copolymer vesicles are prepared via RAFT dispersion polymerization directly in mineral oil.

133 PSEM stabilizer surface density using either RAFT dispersion polymerization in a 2:1 v/v ethanol/wate

134 ll-contact dependent and unaffected by lipid raft disruption of donor TEC.

135 Pretreatment with lipid raft disruptor (Methyl-beta-cyclodextrin, MbetaCD) and o

136 complex formation and changes the NHE3 lipid raft distribution, which cause changes in specific aspec

137 ied proteins and LMP1 was localized to lipid raft domains and was dependent on LMP1-induced signaling

138 nts of transmembrane protein partitioning to raft domains are not fully understood.

139 ning lipids enhance the stability of ordered raft domains by increasing the order difference between

140 domains, and that it translocates to the non-raft domains following stimulation.

141 he long-held hypothesis that CTxB stabilizes raft domains via a lipid crosslinking mechanism and esta

142 at SHOC2(S2G) localizes both in raft and non-raft domains, and that it translocates to the non-raft d

143 be concentrated in cholesterol-rich membrane raft domains, whereas M2, although containing a choleste

144 to regulate the properties and physiology of raft domains.

145 le stages possess chemically different lipid rafts due to different sterol utilization.

146 The trafficking behavior of the lipid raft-dwelling US9 protein from Herpes Simplex Virus stri

147 In order to test the importance of the raft environment on prion propagation, we developed a no

148 controlled homo and block co-polymers by Enz-RAFT (enzyme-assisted reversible addition-fragmentation

149 hed an extraordinary transoceanic biological rafting event with no known historical precedent.

150 dal monolayers with thermodynamically stable rafts exhibiting chiral structure and repulsive interact

151 The forces that drive lipid raft formation are poorly understood.

152 itch-activated protein 70 (SWAP-70) in lipid raft formation of dendritic cells.

153 The ins and outs of lipid asymmetry, raft formation, and interdigitation in plant membrane bi

154 largely overlooked as major players in lipid raft formation.

155 rinsically dynamic interactions that lead to raft formation.

156 blocked its LPS-induced accumulation in the raft fraction of RAW264 cells.

157 concentration of several antidepressants in raft fractions, as revealed by increased absorbance and

158 to co-fractionate in light-density membrane-raft fractions, co-localize via confocal microscopy, and

159 FR1 and gamma-secretase co-localize in lipid raft fractions, with increased gamma-secretase accumulat

160 tidepressant activity did not concentrate in raft fractions.

161 n of cholesterol, a major component of lipid rafts, from autophagosomes abolished HCV RNA replication

162 GM3, a lipid raft ganglioside synthesized by GM3 synthase (GM3S), reg

163 rgetically unfavourable for membrane fusion, rafts have long been implicated in many biological fusio

164 membrane domains, often referred to as lipid rafts, have been highly debated by cell biologists for m

165 cholesterol is a critical component of lipid rafts, here we tested the hypothesis of whether the caus

166 Canalicular BSEP, mostly present in raft (high cholesterol) microdomains in control rats, wa

167 cally located in lipid rafts but not outside rafts, implying the role of lipid microdomains as segreg

168 n animals suspended from a commercial mussel raft in the urban Bronx River Estuary, NY, in waters clo

169 We found that p110beta localizes to membrane rafts in a Rac1-dependent manner.

170 ly, GFRalpha1 correctly partitioned to lipid rafts in brain tissue.

171 resembles the assembly process of the lipid rafts in cell membranes and triggers orders of magnitude

172 (Galphas) is increasingly localized to lipid rafts in depressed subjects and that chronic antidepress

173 t lacks sphingolipids-a crucial component of rafts in eukaryotes.

174 ade, which requires Fyn-Src kinase and lipid rafts in human taste bud cells (TBCs).

175 ning of TMDs and support the central role of rafts in membrane traffic.

176 sibility and also points to a role for lipid rafts in milk product secretion.

177 specialized signalling domains called lipid rafts in schistosomes and propose that correct signallin

178 in detergent-resistant outer membrane lipid rafts in which conversion to the pathogenic misfolded fo

179 tudy of naturally occurring domains, such as rafts, in biological membranes.

180 E3 complex size, reduced expression in lipid rafts, increased BB mobile fraction, and reduced binding

181 r factors (e.g. actin cytoskeleton and lipid rafts) influence the assembly of ligand-receptor complex

182 esters, and vinyl amides were polymerized by RAFT/iniferter and ATRP methods using Gel-PTH and a read

183 sible addition-fragmentation chain-transfer (RAFT) initiator complex.

184 sence of both model membranes, with tetramer-raft interactions giving rise to the rearrangement of ke

185 ry structure-dependent inter-dimer and inter-raft interfaces.

186 recruitment of autophagic molecules to lipid rafts is a dominant strategy to deregulate autophagy in

187 how that clustering of gangliosides in lipid rafts is important.

188 in components believed to be associated with rafts is quite limited owing, in part, to the small size

189 holesterol-rich membrane microdomains (lipid rafts), its compartmentalization has not been demonstrat

190 h reduced IFNG signaling by disrupting lipid rafts, leading to reduced phosphorylation (activation) o

191 pic, fusiform (tufts), spherical (puffs) and raft-like colonies that provide a pseudobenthic habitat

192 The MAM region of the ER is a lipid raft-like domain closely apposed to mitochondria in such

193 s complicated by HA and NA residing in lipid raft-like domains, whereas M2, although an integral memb

194 the lipids have been proposed to explain how raft-like microstructures involving cholesterol affect m

195 Conversely, if 1:2 DOPC/DPPC raft-like model membranes are used, cholesterol accelera

196 , we observed the formation of low-polarity, raft-like nanodomains upon cholesterol addition or chole

197 imaging of stable nanoscopic platforms with raft-like properties diffusing in the plasma membrane.

198 A binding to liposomes designed to mimic non-raft-like regions of the membrane, suggesting the possib

199 lement-independent manner and required lipid raft localization for CSC maintenance and cisplatin resi

200 Analysis of the structural determinants of raft localization may both help to explain the hysteresi

201 In BCR signaling, raft localization of HGAL facilitates interaction with S

202 ampal expression of Cav-1 and membrane/lipid raft localization of postsynaptic density protein 95, NM

203 rovide a mechanistic account of how membrane raft localization regulates differential activation of d

204 Raft localization was dependent on ATP stimulation and C

205 their molecular properties obtained through RAFT/MADIX polymerization.

206 nd ordering mechanism using the well-studied raft marker cholera toxin B pentamer (CTxB) that binds u

207 As a consensus raft marker, we chose monomeric GFP linked via a glycosy

208 In turn, increased ocean rafting may intensify species invasions.

209 lesterol content, decreased BSEP presence in rafts may contribute to BSEP activity decline in 17alpha

210 dependent preferential containment of Fyn in rafts may contribute to its lower transformation potenti

211 l electrosensing and provide a role in lipid raft mechanotransduction.

212 c mechanisms, clathrin-mediated and caveolar/raft-mediated endocytosis.

213 of intracellular membranes, consistent with raft-mediated plasma membrane sorting.

214 Furthermore, macropinocytosis and lipid raft-mediated were shown here as mechanisms of MkMP upta

215 d effect translocation of Galphas to the non-raft membrane fraction, where it activates the cAMP-sign

216 being affected to a greater extent than the raft membrane.

217 Co-existing disordered and ordered (raft) membrane domains exist in Borrelia burgdorferi, th

218 Analysis of membrane-associated and raft microdomain proteins reinforces this possibility an

219 ine residue enables Fas to localize to lipid raft microdomains and induce apoptosis in cell lines.

220 the MAGUK family, recruits Kv1.3 into lipid-raft microdomains and protects the channel against ubiqu

221 persistent PrP(res) propagation, implicating raft microdomains as a location for conversion.

222 l in the monolayer region enabled to develop raft microdomains through coarsening of nanorafts.

223 Membrane-raft microdomains, such as caveolae, and their constitue

224 Many channels localize in lipid raft microdomains, which are enriched in cholesterol and

225 and predicts AC frequency-dependent cell and raft migration.

226 ble reversible switching of lipid domains in raft-mimicking supported lipid bilayers (SLBs).

227 nd gcsA mutants displayed growth defects and raft mislocalization, which were accompanied by reduced

228 tro demonstrate that neuronal membrane/lipid rafts (MLRs) establish cell polarity by clustering progr

229 Membrane lipid rafts (MLRs) within the plasma membrane of most cells se

230 presence of a pure POPC or cholesterol-rich raft model membrane.

231 In RAFT, nearly half of the patients developed postrandomiz

232 These findings have yielded a raft of potential new therapeutics, centered on naive T-

233 findings illuminate differences in the lipid rafts of an organism employing life cycle-specific stero

234 ith interleukin-2 and -15 receptors in lipid rafts of T cells.

235 ude that VHH JM4, when targeted to the lipid rafts of the plasma membrane, efficiently neutralizes HI

236 hment signal, VHHs are targeted to the lipid rafts of the plasma membranes.

237 hment signal, VHHs are targeted to the lipid rafts of the plasma membranes.

238 ) keratinocyte maturation induced by raising raft or biopsy cultures to the air-liquid interface.

239 sible addition-fragmentation chain-transfer (RAFT) or anionic polymerization, are assembled with coil

240 es by inducing several signals through lipid raft organization after membrane incorporation, whereas

241 at correct signalling to ERK requires proper raft organization.

242 rillation in Ambulatory Heart Failure Trial (RAFT) participants without permanent AF, who were random

243 d physical model establish general rules for raft partitioning of TMDs and support the central role o

244 physical features that independently affect raft partitioning, namely TMD surface area, length, and

245 By developing cytocompatible PET-RAFT (photoinduced electron transfer-reversible addition

246 ROAMP followed by RAFT polymerization yields hybrid poly-(o-phenylene ethy

247 sible addition-fragmentation chain transfer (RAFT) polymerization of acrylic acid as verified by wate

248 sible addition-fragmentation chain transfer (RAFT) polymerization.

249 sible addition-fragmentation chain-transfer (RAFT) polymerization.

250 between the postrandomization AF/AT and the RAFT primary composite outcome of all-cause mortality or

251 the absence of subsequent triggering of the RAFT process, the (dis)order in the LCN and its associat

252 e addition-fragmentation chain transfer (PET-RAFT) process.

253 Current models of lipid rafts propose that lipid domains exist as nanoscale comp

254 er ones often called lipid domains or "lipid rafts." Recent findings highlight the dynamic nature of

255 Despite both proteins being raft resident, HA and NA occupy distinct but adjacent me

256 The RAFT (Resynchronization in Ambulatory Heart Failure Tria

257 surface of silica microparticles following a RAFT (reversible addition-fragmentation chain transfer)

258 nd HER2 within specific actin-rich and lipid raft-rich membrane signaling domains.

259 hHV5-positive turtle fibroblasts in collagen rafts seeded with turtle keratinocytes and (ii) keratino

260 ly, inhibition of myosin-9, actin, and lipid-rafts, shown to be involved in PNX1-hemichannel function

261 lin and signaling proteins further stabilize raft structure and feed-forward downstream signaling eve

262 dynamic spatiotemporal control of the lipid raft structure with light.

263 oteins, and at pH5.0, it locks the E protein raft structure, suggesting that it prevents the structur

264 ETHODS AND All ventricular arrhythmias among RAFT study participants were downloaded and adjudicated

265 colipid-rich membrane regions known as lipid rafts, suggesting that HtrA and p66 may reside together

266 The membrane rafts surrounding desialylated PrP(C) contained greater

267 d gangliosides and cholesterol than membrane rafts surrounding PrP(C).

268 Moreover, expression of lipid raft-targeted Bif-1 or Beclin1 was sufficient to induce

269 est the role of glycolipid crosslinking as a raft targeting and ordering mechanism using the well-stu

270 Raft targeting of p110alpha allowed its EGFR-mediated ac

271 eleton necessary for the clustering of lipid rafts, TCR, and costimulatory receptors toward the T:APC

272 ke HA cables but occur in distinct sheets or rafts that can capture and embed leukocytes from cell su

273 We have designed a system of DNA origami rafts that exponentially replicates a seed pattern, doub

274 is very much resembles the role of the lipid rafts that sharply increases the reaction rate of biomol

275 n, cholesterol, and select proteins in lipid rafts-the dynamic functional subdomains of the plasma me

276 of Lyn are required for its accumulation in rafts, thereby determining the negative regulation of TL

277 hosphorylation and redistribution from lipid raft to bulk membrane and cytoplasm, followed by degrada

278 t HCV could induce the localization of lipid rafts to autophagosomes to mediate its RNA replication.

279 results identify ganglioside-enriched lipid rafts to be receptors that mediate soluble klotho regula

280 loped viruses utilize cholesterol-rich lipid rafts to bud from the host cell membrane, and it is thou

281 se-containing gangliosides enriched in lipid rafts to inhibit raft-dependent PI3K signaling.

282 as a tool to study the contribution of lipid rafts to neurodegenerative disease conditions where amyl

283 relocalization of gamma-secretase from lipid rafts to nonlipid rafts where it cleaved Notch.

284 aloganglioside GM1, commonly associated with rafts, to create a gradient of GM1 in response to an ele

285 Endogenous Galphas redistributes from raft- to nonraft-membrane fractions after chronic antide

286 mal LMP1 release that is distinct from lipid raft trafficking.

287 sor was further targeted in or outside lipid rafts via different lipid modification signals.

288 adhesion clustering of integrin and membrane rafts via Thy-1's glycophosphatidylinositol tether.

289 lain why klotho preferentially targets lipid rafts we show that clustering of gangliosides in lipid r

290 ecifically modify Galphas localized to lipid rafts, we sought to determine whether structurally diver

291 A2, which are proteins associated with lipid rafts, were also identified.

292 gamma-secretase from lipid rafts to nonlipid rafts where it cleaved Notch.

293 her than oxidized DJ-1 translocated to lipid rafts, where it associated with Lyn, an interaction that

294 uitment to invadopodia is dependent on lipid rafts, whereas ezrin/moesin proteins mediate podoplanin

295 Caveolae, specific lipid rafts which concentrate caveolins, harbor signaling mole

296 vation is key in TLR4 recruitment into lipid rafts, which in turn up-regulates NF-kappaB translocatio

297 specifically induce the association of lipid rafts with autophagosomes for its RNA replication.IMPORT

298 The association of lipid rafts with autophagosomes was specific to HCV, as it was

299 The association of lipid rafts with HCV-induced autophagosomes was confirmed by W

300 ts indicated that a fully stocked G. demissa raft would clear an average 1.2 x 10(7) L of Bronx River