ライフサイエンスコーパス: ragweed

1 DNA (AIC) in 25 adults who were allergic to ragweed.

2 anasal challenge (s.i.n.) with either OVA or ragweed.

3 change for boys except an increase in IgE to ragweed.

4 e for SPP in allergic sensitization to short ragweed.

5 ty and erythema skin prick reaction to short ragweed.

6 When their PBMC were cultured with ragweed Ag (RA), peak IgE responses occurred on day 10;

7 e were immunized and challenged with a short ragweed Ag extract, known to induce a selective eosinoph

8 During the entire season, ragweed AIT of 1.5, 6, and 12 Amb a 1-U reduced TCS by 1

9 During peak ragweed season, ragweed AIT of 1.5, 6, and 12 Amb a 1-U reduced TCS by 9

10 ximately 52 weeks of daily self-administered ragweed AIT of 1.5, 6, or 12 units of Ambrosia artemisii

11 In this trial, ragweed AIT of 12 Amb a 1-U was effective and tolerable

12 Here, we present structures of methylated ragweed allergen Amb a 8, Amb a 8 in the presence of pol

13 studies with TLR-9 vaccines conjugated to a ragweed allergen demonstrate that they reduce symptoms o

14 mg/day for 3 days before and 13 days during ragweed allergen immunization) in BALB/c and C57BL/6 mic

15 ty and efficacy of a sublingual standardized ragweed allergen immunotherapy liquid extract for the tr

16 that permitted daily self-administration of ragweed allergen immunotherapy.

17 xposing participants with ragweed allergy to ragweed allergen in an environmental exposure chamber mo

18 have induced eosinophilic peritonitis using ragweed allergen in P-selectin-deficient, intracellular

19 ger a seasonal increase in IgE antibodies to ragweed allergen in the immunotherapy group after two ye

20 ffects of intranasal challenge with DEP plus ragweed allergen on local humoral immune responses.

21 The ragweed allergen repertoire has been recently expanded w

22 Patients sensitive to the ragweed allergen were challenged intranasally with aller

23 TRGTT motif prevented conalbumin-induced and ragweed allergen-induced allergic inflammation in mice.

24 ized, placebo-controlled crossover trial, 19 ragweed allergen-sensitive subjects who had previously p

25 hil recruitment, and decreased the number of ragweed allergen-specific IgE-producing cells.

26 nifestations of asthma in mice sensitized to ragweed allergen.

27 and challenged them intranasally with short ragweed allergenic extract (SRW).

28 Ragweed allergens affect several million people in the U

29 The results suggest that ragweed allergens associated with lesser IgE reactivity

30 s for T cell and IgE responses for the other ragweed allergens did not correlate.

31 To date, only two ragweed allergens, Amb t 5 and Amb a 11, have their stru

32 ent of the hierarchy of T cell reactivity in ragweed allergens, which is distinct from that observed

33 ) (on Days 1, 2, 9, and 16) in three groups: ragweed allergic asthmatics with dual phase airway react

34 g-term clinical efficacy in the treatment of ragweed allergic rhinitis.

35 used a segmental Ag challenge (SAC) model in ragweed-allergic asthmatics and nonasthmatic patients an

36 he GCR binding affinity (Kd) was observed in ragweed-allergic asthmatics during ragweed pollen season

37 characterized T cell responses from atopic, ragweed-allergic subjects to Amb a 1, Amb a 3, Amb a 4,

38 dred twenty-eight patients with a history of ragweed allergy and positive skin prick test responses t

39 y contribute to the increasing prevalence of ragweed allergy in Lombardy plain.

40 estion induced by exposing participants with ragweed allergy to ragweed allergen in an environmental

41 s revealed that 50 (54%) of 92 patients with ragweed allergy were sensitized to a 37-kDa allergen dis

42 ity to activate basophils from patients with ragweed allergy, were confirmed.

43 ional trial of this therapeutic modality for ragweed allergy.

44 era from 92 American or European donors with ragweed allergy.

45 for molecule-based diagnosis and therapy for ragweed allergy.

46 Intranasal challenge with ragweed alone induced inconsistent and low levels of muc

47 Ragweed alone stimulated the production of IL-4 (0.6 ng/

48 As compared with challenge with ragweed alone, challenge with both DEP and ragweed induc

49 ophagoides farinae, dog, cat, timothy grass, ragweed, Alternaria alternata, egg, peanut, milk, and Ge

50 ic-related pollution on the allergenicity of ragweed (Ambrosia artemisiifolia L.) pollen through a fi

51 range of a globally invasive species, common ragweed (Ambrosia artemisiifolia L.), from a temperature

52 Short ragweed (Ambrosia artemisiifolia) allergies affect more

53 llen allergy in humans, focusing upon common ragweed (Ambrosia artemisiifolia) in Europe.

54 Allergy to pollen from short ragweed (Ambrosia artemisiifolia) is a serious and expan

55 Ragweed (Ambrosia artemisiifolia) is a strong elicitor o

56 Allergy to the short ragweed (Ambrosia artemisiifolia) pollen is a major heal

57 to simulate the invasion of Europe by common ragweed (Ambrosia artemisiifolia), a globally invasive p

58 s (dust mite (Dematophagoides farinae), cat, ragweed (Ambrosia artemisiifolia), and timothy grass (Ph

59 Ragweed (Ambrosia artemisiifolia), the major cause of la

60 Here we report that duration of the ragweed (Ambrosia spp.) pollen season has been increasin

61 h OVA but also with two unrelated allergens (ragweed and BSA) induced Vgamma4(+) cells capable of sup

62 g PBMC from atopic asthmatics with allergen (ragweed and cat) versus Candida albicans.

63 Ragweed and mugwort are closely related weeds that repre

64 IgE to mite and cat and decreases in IgE to ragweed and timothy from 2 to 4 years of age, whereas th

65 (controls) were cultured in the presence of ragweed and/or chitin for 3 days (recall responses).

66 ity to the aeroallergens Der P 1 and 2, cat, ragweed, and mouse was compared in cases and controls.

67 lences of sensitization to Der p 1, Der p 2, ragweed, and mouse were low and similar in the two group

68 hay-fever symptoms, skin-test sensitivity to ragweed, and sensitivity to bronchial challenges and inc

69 We conclude that ragweed antigen causes neutrophil recruitment into the a

70 fluid (BALF) before and 24 h after segmental ragweed antigen challenge in 18 asthmatic subjects at ba

71 We administered ragweed antigen to an isolated, superfused tracheal segm

72 a associated with natural populations of the ragweed aphid, Uroleucon ambrosiae.

73 Aeroallergens such as Amb a I from short ragweed are important in the development of allergic air

74 l challenges and increased IgG antibodies to ragweed as compared with the placebo group; there was no

75 For regionally occurring pollen allergens (ragweed, birch, cypress), IgE sensitization was signific

76 The model predicts the region in which ragweed can reach reproductive maturity before frost kil

77 Among subjects challenged with ragweed, cat dander, or house dust mite, there were no d

78 t to eosinophil peritoneal recruitment after ragweed challenge.

79 hmatic serum and bronchoalveolar lavage from ragweed challenged animals on the BMSCs in vitro.

80 BAL fluid compared to the OVA-sensitized and ragweed-challenged or nonsensitized mice.

81 Ragweed/chitin stimulation resulted in significant decre

82 l cross-sectional area (A(min)) after bolus (ragweed) complete nasal allergen challenge at screening

83 Moreover, ragweed did not affect the integrity of the intestinal e

84 ll responses correlated with conservation of ragweed epitopes with sequences of other well-known alle

85 r adults with asthma exacerbated by seasonal ragweed exposure had positive effects on objective measu

86 notherapy for asthma exacerbated by seasonal ragweed exposure.

87 r airway challenge with nebulized Amb a I or ragweed extract in mice sensitized to Amb a I or ragweed

88 f bronchial epithelial cells stimulated with ragweed extract only if adenosine was present.

89 eed extract in mice sensitized to Amb a I or ragweed extract, respectively.

90 were randomly assigned to receive placebo or ragweed-extract immunotherapy in doses that increased we

91 (PBMCs) from donors positive for IgE towards ragweed extracts after in vitro expansion for secretion

92 Ragweed extracts contain five different isoforms of the

93 Subjects were then challenged with grass or ragweed extracts on each inferior turbinate.

94 studied blood eosinophils from patients with ragweed hay fever.

95 n cells (4 x 106 cells/ml) isolated from the ragweed-immunized mice (controls) were cultured in the p

96 These ragweed-immunized mice were given ragweed intratracheall

97 orms might be a more attractive strategy for ragweed immunotherapy.

98 icited after out-of-season exposure to short ragweed in a PCC and during the natural season for giant

99 ynergy was also observed between the DEP and ragweed in altering the profile of epsilon mRNAs generat

100 h ragweed alone, challenge with both DEP and ragweed induced markedly higher ragweed-specific IgE but

101 In this study, using a ragweed induced mouse asthma model, we studied if BMSCs

102 betaTCR(+)) CD4(+)CD25(+) T cells suppressed ragweed-induced airway hyperresponsiveness and inflammat

103 Adenosine aggravated ragweed-induced allergic lung inflammation.

104 extract enzymatically to analyze its role in ragweed-induced allergy.

105 et (AIT; SCH 39641/MK-3641) for treatment of ragweed-induced AR/C in the first large randomized, doub

106 Adults (n = 784) with short ragweed-induced AR/C were randomly assigned to approxima

107 In a separate inflammatory model (ragweed-induced peritoneal eosinophilia), we demonstrate

108 nflammatory ocular changes associated with a ragweed-induced type-1 hypersensitivity reaction.

109 These ragweed-immunized mice were given ragweed intratracheally on day 11.

110 of international trade have accelerated the ragweed invasion.

111 Ragweed is a major cause of seasonal allergy, affecting

112 se, adults with asthma who were sensitive to ragweed kept daily diaries and recorded peak expiratory

113 ctive was to assess the clinical efficacy of Ragweed MATA MPL (short ragweed pollen allergoid adsorbe

114 evaluate the clinical efficacy and safety of Ragweed MATA MPL compared with placebo by using controll

115 n improvement in total symptom scores in the Ragweed MATA MPL group was statistically significantly g

116 dy demonstrated that an ultrashort course of Ragweed MATA MPL is efficacious in reducing allergy symp

117 In addition, in the presence of ragweed, mouse dendritic cells upregulated their activat

118 o mountain cedar (n = 21), oak (n = 34), and ragweed (n = 23) recorded TSSs during separate out-of-se

119 dust mite, ryegrass, and fungi but not cat, ragweed, or food sources.

120 tic characteristics, efficacy, and safety in ragweed- or birch pollen-induced seasonal allergic rhini

121 significantly reduced after incubation with ragweed (p < 0.001) or cat allergen (p < 0.001) compared

122 Mature pollen grains were collected from ragweed plants grown along main roadsides and in vegetat

123 receptor blocks and a total of 100,938 giant ragweed plants were screened with glyphosate applied at

124 In contrast, challenge with both ragweed plus DEP resulted in decreased expression for Th

125 derstand the effects of chemically processed ragweed pollen (Ambrosia elatior) on the innate immune s

126 This study has shown that in response to ragweed pollen all these cells release inflammatory cyto

127 all minor (Amb a 3, 4, 5, 6, 8 and 9) short ragweed pollen allergen repertoire as well as NADH oxida

128 cross-reactivity might be Amb a 1, the major ragweed pollen allergen, and Art v 6, a highly homologou

129 gest that traffic-related pollution enhances ragweed pollen allergenicity, which may contribute to th

130 clinical efficacy of Ragweed MATA MPL (short ragweed pollen allergoid adsorbed to L-Tyrosine + MPL) v

131 Our quantitative estimates indicate that ragweed pollen allergy will become a common health probl

132 molecule for diagnosis and immunotherapy of ragweed pollen allergy.

133 measured mass spectra from materials such as ragweed pollen and road dust that are likely to form a b

134 PCC and during the natural season for giant ragweed pollen are highly correlated.

135 Various components of ragweed pollen are thought to play a role in the develop

136 elated with spatial and temporal patterns of ragweed pollen concentrations, which are fully independe

137 Hosts sensitized cutaneously with short ragweed pollen developed cutaneous immediate hypersensit

138 PL compared with placebo by using controlled ragweed pollen exposure in an EEC.

139 After cellular oxidative insult induced by ragweed pollen extract (RWE) exposure, we have identifie

140 We recently reported that ragweed pollen extract (RWPE) requires Toll-like recepto

141 Upon Th2 priming of murine B cells, ragweed pollen extract caused a dose-dependent increase

142 challenge with Amb a 1, the major antigen in ragweed pollen extract that does not possess NADPH oxida

143 Instillation of ragweed pollen extract, but not of the major allergen or

144 Aqueous ragweed pollen extract, the low molecular weight fractio

145 days under Th2-like conditions with aqueous ragweed pollen extracts (Amb-APE) or its constituents.

146 Ragweed pollen grains release subpollen particles (SPP)

147 these participants were challenged to short ragweed pollen in a PCC for 3 hours per day for up to 4

148 entify critical factors for allergenicity of ragweed pollen in a physiological model of allergic airw

149 ergic rhinoconjunctivitis symptoms caused by ragweed pollen in an environmental exposure chamber (EEC

150 symptomatology after exposure to VLO, MC, or ragweed pollen in the PCC.

151 A second model simulated current and future ragweed pollen levels.

152 Ragweed pollen proteins were submitted to high-resolutio

153 en source planted in the center and GS giant ragweed pollen receptors surrounding the center in eight

154 Ragweed pollen represents a major allergy risk factor.

155 r MS sequencing of the protein combined with ragweed pollen RNA sequencing.

156 a significant increase in the length of the ragweed pollen season by as much as 13-27 d at latitudes

157 served in ragweed-allergic asthmatics during ragweed pollen season compared with PBMC obtained before

158 o 16 weeks before and through the end of the ragweed pollen season.

159 that besides transporting the vaccine cargo, ragweed pollen shells have additional immunomodulatory p

160 ted in a concentric design with the GR giant ragweed pollen source planted in the center and GS giant

161 e sensitized by topical application of short ragweed pollen to the nasal mucosa followed by a challen

162 OT fractions as novel allergens of the short ragweed pollen, as previously described.

163 imental Ag, OVA, or a common allergen, short ragweed pollen, induced no or minimal immune responses t

164 include respiratory allergens from birch and ragweed pollen, midge larvae, and horse dander; food all

165 protein extract (APE) using sera from short ragweed pollen-sensitized patients.

166 without conjunctivitis (AR/C) on exposure to ragweed pollen.

167 topically for 7 consecutive days with short ragweed pollen.

168 imaging revealed that macrophages can engulf ragweed pollen.

169 otease Amb a 11 as a new major allergen from ragweed pollen.

170 ate the presence of undescribed allergens in ragweed pollen.

171 trial of a vaccine consisting of Amb a 1, a ragweed-pollen antigen, conjugated to a phosphorothioate

172 en-derived adenosine is a critical factor in ragweed-pollen-induced allergic airway inflammation.

173 Ragweed pollens did not cause significant cell membrane

174 Ragweed pollens were also found in the subepithelial reg

175 the most prevalent allergies (e.g. grass and ragweed pollens, dust mites, and cat) and those that ind

176 symptom score [TSS]) during the VLO, MC, and ragweed pollinating seasons and during 2 consecutive PCC

177 n cedar (MC)-positive, 8 MC-negative, and 26 ragweed-positive participants recorded AR symptoms (tota

178 0.34, 0.54, and 0.65 for VLO(+), MC(+), and ragweed-positive participants, respectively).

179 will increase in countries with an existing ragweed problem (e.g., Hungary, the Balkans), but the gr

180 Mice were sensitized with ragweed (RW) and PCF (RW/PCF), PCF alone, or RW alone an

181 ts of IFN-gamma-inducing factor (IL-18) in a ragweed (RW) mouse model of allergic asthma.

182 Ascaris suum (A. suum) eggs concurrent with ragweed (RW) sensitization (RW/acute) or by repeated ino

183 tions starting in 1950 accurately reproduced ragweed's current distribution, including the presence o

184 process-based model estimated the change in ragweed's range under climate change.

185 cant change in IgE antibody titer during the ragweed season (P=0.19).

186 acebo (n = 136) subcutaneously just prior to ragweed season and repeated during the pollen season eve

187 the AIC or placebo vaccine before the first ragweed season and were monitored during the next two ra

188 ymptoms for 15 days during the natural giant ragweed season in San Antonio, Texas.

189 During peak ragweed season, ragweed AIT of 1.5, 6, and 12 Amb a 1-U

190 During the first ragweed season, the AIC group had better peak-season rhi

191 of AIC were again observed in the subsequent ragweed season, with improvements over placebo in peak-s

192 y symptom/medication score (TCS) during peak ragweed season.

193 uce symptoms of allergic rhinitis during the ragweed season.

194 compared with PBMC obtained before and after ragweed season.

195 eason and were monitored during the next two ragweed seasons.

196 Thirty-one ragweed-sensitive participants recorded symptoms for 15

197 We collected nasal lavages from ragweed sensitized subjects at different times after nas

198 antly increased in the blood of serum IgE(+) ragweed-sensitized (RS) compared with serum IgE-nonatopi

199 an isolated, superfused tracheal segment of ragweed-sensitized dogs.

200 Interestingly, ragweed-sensitized patients also displayed an IgG respon

201 hy grass SLIT-tablet trials (n = 3094) and 2 ragweed SLIT-tablet trials (n = 658) and during the last

202 In grass and ragweed SLIT-tablet trials, overall improvement in TNSSs

203 cts on nasal symptoms with timothy grass and ragweed SLIT-tablets were nearly as great as with MFNS a

204 The IgE elevation was not ragweed specific.

205 both DEP and ragweed induced markedly higher ragweed-specific IgE but not total IgE levels or IgE-sec

206 early and late dosages, strikingly decreased ragweed-specific serum IgE, tracheal ring reactivity to

207 terize the proteomes and allergomes of short ragweed SPP and total pollen protein extract (TOT), and

208 Control of ragweed spread may be an important adaptation strategy i

209 Assumptions about the rate at which ragweed spreads throughout Europe had a large influence

210 ular basis of immune responsiveness to short ragweed (SRW) (Ambrosia artemisiifolia) extract, and gro

211 ce were sensitized in the footpad with short ragweed (SRW) allergen and challenged topically for seve

212 and later challenged intranasally with short ragweed (SRW) allergenic extract.

213 naive A/J mice, A/J mice sensitized to short ragweed (SRW) pollen by intraperitoneal injection and th

214 tal allergic conjunctivitis induced by short ragweed (SRW) pollen, typical allergic signs, stimulated

215 phils and eosinophils toward supernatants of ragweed-stimulated bronchial epithelial cells was analyz

216 isolated from the chitin-treated mice showed ragweed-stimulated IFN-gamma production (15 U/ml) and si

217 For ragweed, such forecasts are extremely important as the s

218 /c allergic hosts was analyzed using a short ragweed (SWR) pollen model of allergic conjunctivitis.

219 kroach, dog, Dermatophagoides farinae, short ragweed, timothy grass, and egg.

220 dog, Dermatophagoides farinae (Der F), Short Ragweed, Timothy grass, egg, milk and peanut.

221 nt (GR) to glyphosate-susceptible (GS) giant ragweed under simulated field conditions using glyphosat

222 gens from short and giant (Ambrosia trifida) ragweed using transgenic mice expressing DQ6 (HLA-DQA1*0

223 /J mice sensitized and challenged with short ragweed was used to test immunostimulatory DNA sequences

224 Seeds of GS giant ragweed were harvested from the pollen receptor blocks a

225 gy and positive skin prick test responses to ragweed were randomized and received 4 weekly injections

226 to a clinically relevant neo-allergen (i.e., ragweed) were investigated.

227 (house dust, mixed grasses, mixed trees, and ragweed); wheal size was measured at 20 min.

228 ry estimates indicated that sensitization to ragweed will more than double in Europe, from 33 to 77 m

229 halation allergen (cat, mite, orchard grass, ragweed, wormwood, dog, cockroach, Japan cedar).