ライフサイエンスコーパス: raise the possibility that

1 This finding raises the possibility that (41)K/(39)K can be used as a

2 ructural determinants of domain swapping and raise the possibility that a single ion channel subtype

3 These results raise the possibility that a unique Pf4-dependent, Mpl-i

4 This finding raises the possibility that a phenotypically similar nuc

5 otype and phenotype in choanoflagellates and raises the possibility that a protein with C-type lectin

6 Na(+) to regulate Smoothened in our assays, raising the possibility that a Na(+) gradient provides t

7 nal parent-of-origin effects in female mice, raising the possibility that a similar mechanism may con

8 alling in lifespan regulation in C. elegans, raising the possibility that a similar process may occur

9 roteins (Env) in the CD4-bound conformation, raising the possibility that accumulating CD4 at the sur

10 for the etiology of human uveitis, but also raise the possibility that activation of autoreactive TC

11 (CD80 upregulation) signaling mechanisms and raise the possibility that activation of P2X7R could pla

12 This requirement raises the possibility that adaptation of HIV-1 Env to t

13 s unravel a new regulatory role for ADAR and raise the possibility that ADAR mediates the differentia

14 The findings raise the possibility that adults presenting with the AD

15 stream of the BCR is dampened in GC B cells, raising the possibility that Ag presentation and competi

16 iated at least in part through beta-catenin, raising the possibility that agents that modulate beta-c

17 They also raise the possibility that aggresome formation may contr

18 ctors are sex-specific disease modifiers and raising the possibility that aggressive anti-MIF treatme

19 -lysosomal pathway and retromer function and raise the possibility that alterations in these pathways

20 d in energy metabolism and oxidative stress, raising the possibility that AMA may be found in patient

21 Our results raise the possibility that an immune-related imbalance i

22 This raises the possibility that an epigenetic process might

23 evolution than was previously understood and raising the possibility that an age-related clonal proce

24 This raises the possibility that anatomical connectivity betw

25 ntly, however, molecular dating methods have raised the possibility that angiosperms may have existed

26 This finding raises the possibility that anisotropic mechanical const

27 This work also raises the possibility that another residue or physiolog

28 These findings raise the possibility that antagonists of the canonical

29 This raises the possibility that anthropogenic LMH declines m

30 ainst TGF-beta-induced pro-fibrotic activity raises the possibility that anti-lipidogenic therapy may

31 ast Hsp90 (Hsp82) conformation and function, raising the possibility that appearance of this PTM in h

32 Taken together, these results raise the possibility that AREG and other low- or high-a

33 Collectively, our findings raise the possibility that ARF4-dependent polarized exoc

34 Our data raise the possibility that ASXL1 truncation mutations co

35 This raises the possibility that, at least for some CS mutati

36 These results raise the possibility that bacterial infections can indu

37 In addition, these findings raise the possibility that basic dysfunction in primary

38 This finding raises the possibility that beliefs about God can mitiga

39 These findings raise the possibility that beta-lactam rings can be regi

40 eristics of early HIV/SIV infection in mind, raising the possibility that better performance could be

41 enescence in individuals with HCV infection, raising the possibility that blocking this negative-sign

42 This raises the possibility that BND cells could represent pr

43 These data also raise the possibility that c-di-GMP enhances the express

44 Our data raise the possibility that C1, while governing the assoc

45 Taken together, our studies raise the possibility that Ca(2+) responses to extracell

46 interaction between the receptor and c-Cbl, raising the possibility that Cbl-b is necessary for c-Cb

47 These findings raise the possibility that CD8 T cell responses to infec

48 This raises the possibility that cell volume may be the reaso

49 This study raises the possibility that certain ventral frontal neur

50 duced by simple morphological variation, and raise the possibility that changes in swimming pattern m

51 aptic localization and also binds zinc, thus raising the possibility that changing zinc levels modula

52 TOR promotes cholesterol synthesis, our data raise the possibility that cholesterol synthesis and mTO

53 also perturbed in orthologous mouse models, raising the possibility that ciliary dysfunction contrib

54 are relevant to many types of CNS pathology, raising the possibility that CNS precursors could be man

55 which thalamic axons do not grow internally, raised the possibility that Co cells might have an ances

56 esponsive hypothalamo-pituitary-adrenal axis raises the possibility that cocaine-related impairments

57 hat exit the Golgi region toward the surface raised the possibility that compartments distal to the T

58 rotein-protein interactions with each other, raising the possibility that coordination facilitates co

59 Our results raise the possibility that correcting the metabolic defe

60 These observations raise the possibility that cortical connectivity with th

61 However, they raise the possibility that CP-AMPAR accumulation in the

62 However, they raise the possibility that CP-AMPAR accumulation in the

63 e Zika and Dengue viruses' envelope proteins raise the possibility that cross-reactive antibodies ind

64 Taken together, our results raise the possibility that CTLA4 targeting on melanoma c

65 These data raise the possibility that CXCR6-directed tropism in CCR

66 tributed pathway to mount a complex response raises the possibility that danger sensing is an evoluti

67 Further they raise the possibility that decreased colonization resist

68 This raises the possibility that defectors can lead to condit

69 Our findings raise the possibility that defects in motor neuron funct

70 Our results raise the possibility that, depending on the structure a

71 This raises the possibility that different populations have e

72 imilar pattern was not found for WM lesions, raising the possibility that different factors promote t

73 The immunogenicity of Id-3F7.A10 raises the possibility that diverse Ids of nucleosome-sp

74 Recent epigenetic studies have raised the possibility that DNA methylation has signific

75 emerged prior to monkeys' choice initiation, raising the possibility that dopamine impacts impending

76 Our findings thus raise the possibility that DR15-associated mechanisms ma

77 This observation raises the possibility that DSBs might be arising as a r

78 sis between gut microbiota and host immunity raises the possibility that dysbiosis of the intestinal

79 These results raise the possibility that dysfunction of this system ma

80 /HER2 overexpression, E2f3a is up-regulated, raising the possibility that E2F3a is a critical effecto

81 es of multiple middle Pliocene hominins have raised the possibility that early hominins were as speci

82 ipid signals modulate immune cell responses, raising the possibility that early inhibition of iPLA2be

83 iezo1 is amenable to chemical activation and raise the possibility that endogenous Piezo1 agonists mi

84 These findings raise the possibility that endometrial exposure to semin

85 These results raise the possibility that endophilin B1 participates in

86 localization of tight junction proteins and raise the possibility that endothelial S1P1 inhibition m

87 e amount of adducts formed by endogenous FA, raising the possibility that epigenetic mechanisms may c

88 Htt-induced neuronal dysfunction and death, raising the possibility that epigenetic strategies targe

89 h as grid cells, could depend on plasticity, raising the possibility that experience plays a critical

90 These results raise the possibility that expression of certain V regio

91 Drugs also bind FABPs, raising the possibility that FABPs similarly regulate dr

92 n-positive intranuclear neuronal inclusions, raising the possibility that failure of protein quality

93 nt of myelin produced during development and raise the possibility that Fbxw7 could be a target of my

94 Our results raise the possibility that fixation is determined by bio

95 erminants of K. pneumoniae pathogenicity and raises the possibility that functional mutations in CD36

96 Results from this study raise the possibility that GDH2-specific inhibition may

97 This has raised the possibility that genes are commonly regulated

98 These results raise the possibility that genetic variants affect behav

99 nsferase Dnmt3b with H3K36me3-rich chromatin raises the possibility that genic DNA methylation is inf

100 These findings raise the possibility that glutamine depletion can be us

101 grid cell network in the entorhinal cortex, raising the possibility that grid cells contribute to st

102 ify a non-pyroptotic function for GSDMD, and raise the possibility that GSDMD pores represent conduit

103 methylation of lysine 9 on histone 3 (H3K9), raising the possibility that H3K9Me2, a repressive chrom

104 These findings raise the possibility that HDAC4/Ubc9/Rad51 complex in D

105 Our results raise the possibility that high dietary salt is an envir

106 This raises the possibility that HMBA or related small molecu

107 fferentiation and adiponectin secretion, and raise the possibility that human ARL15 haploinsufficienc

108 sNA segments to initiate unwinding they also raise the possibility that hUPF1 has significantly reduc

109 Analysis from TCGA raised the possibility that hyperactive PPAR signaling,

110 ure to hypoglycemia and increased mortality, raising the possibility that hypoglycemia has adverse ca

111 rain injury and mTOR are linked to epilepsy, raising the possibility that IGF-1 may be epileptogenic.

112 These discoveries raise the possibility that in addition to their role as

113 These data raise the possibility that, in addition to its establish

114 Subgroup analyses raise the possibility that, in patients with less severe

115 We raised the possibility that, in a mouse model of physiol

116 This raises the possibility that, in healthy-functioning indi

117 Our data raise the possibility that inadequate recruitment of MDM

118 important regulator of CD8+ T cell fate and raise the possibility that increasing proteasome activit

119 These overexpression results raise the possibility that individual components of slee

120 These findings raise the possibility that infection and inflammation ma

121 However, it does raise the possibility that infection can affect mosquito

122 Here, we raise the possibility that inflammation-associated leuko

123 These findings raise the possibility that influenza antigenic diversity

124 c neurons produces acute aversive states and raises the possibility that inhibiting AMPA transmission

125 limiting mitochondrial lipid utilization and raise the possibility that inhibition of fatty acid oxid

126 als that promote resistance to chemotherapy, raising the possibility that inhibitors of KV11.1 could

127 Such universality raises the possibility that invariant properties exist t

128 This finding raises the possibility that inversions are a prerequisit

129 systematically with imposed conditions, this raises the possibility that it may be used as a strain m

130 cific and developmentally controlled manner, raising the possibility that it influences developmental

131 odified other than a single disulphide bond, raising the possibility that it might require additional

132 by data from both animal and human studies, raising the possibility that kidney DDAH1 expression exa

133 vents at polymerizing microtubule plus-ends, raising the possibility that Kif15 motors may synchroniz

134 These findings raise the possibility that KOR activation-as occurs upon

135 Our findings raise the possibility that landscapes of AML genomes mig

136 ing a major impact on wild populations, this raises the possibility that life histories may be influe

137 ls are a major site of virus replication and raised the possibility that, like papillomaviruses, EBV

138 y, with reported values between 6.8 and 9.1, raising the possibility that linear chain synthesis may

139 Overall, our observations raise the possibility that local production of astrocyte

140 mph nodes after SVV reactivation in monkeys, raising the possibility that macrophages and dendritic c

141 y glacial-interglacial changes in sea level, raising the possibility that magmatic flux acts as a neg

142 These findings raise the possibility that maladaptive decision making i

143 These findings raise the possibility that many other uncharacterized CD

144 (e.g. type I fibers and cardiomyocytes), and raises the possibility that Mb also serves as an acylcar

145 MDA in wounded Arabidopsis thaliana leaves, raising the possibility that MDA is metabolized.

146 Our findings raise the possibility that MDD may be independently asso

147 This raises the possibility that memory consolidation or othe

148 4 is sufficient to cause memory impairments, raising the possibility that memory problems seen in AD

149 everal smoking-related diseases than whites, raising the possibility that menthol cigarettes contribu

150 This study raises the possibility that metabolic inhibitors, such a

151 tive disorders, such as Parkinson's disease, raising the possibility that microbiota-ENS interactions

152 of heart defects in the cohesinopathies, and raise the possibility that mild mutations in cohesin gen

153 ion in the mitochondrial life cycle and also raise the possibility that mitochondrial turnover events

154 cells from triple A syndrome patients, which raises the possibility that mitotic errors may underlie

155 Our findings raise the possibility that MMOSI effects in electrochemi

156 arning may also involve dopamine modulation, raising the possibility that model-based learning may co

157 Ac in behavioral responses to AMPH, and they raise the possibility that modulation of PV+ interneuron

158 In BD, our findings raise the possibility that morning peaks of anxiety depe

159 Elevation of DA release in the global KO raised the possibility that motor deficits in a Parkinso

160 ne improved coronary microvascular function, raising the possibility that MR blockade could have bene

161 ational modifications in PB accumulation and raise the possibility that mRNP dynamics are posttransla

162 These findings raise the possibility that MtDef5 might be useful as a n

163 The unheralded existence of tripartite ICEs raises the possibility that multipartite elements reside

164 atumoral heterogeneity and cancer stem cells raise the possibility that multiple breast cancer subtyp

165 mena produced by crowding of orientation and raises the possibility that multiple classes of object r

166 ss and in vivo muscle mitochondrial function raises the possibility that muscle mitochondrial mechani

167 These findings raise the possibility that mutations in RAD51 itself may

168 orally inoculated pigs with a mouse bioassay raises the possibility that naturally exposed pigs could

169 These findings in cell culture raise the possibility that nephrotoxicity of APOL1 risk

170 ing studies in substance-use disorders, thus raising the possibility that neural processing of negati

171 These findings raise the possibility that neurotransmitter switching co

172 These results raise the possibility that Notch/DLL4 signaling is bidir

173 These findings raise the possibility that novel approaches to treating

174 ness of commissural axons at the midline and raise the possibility that nuclear signaling may be a co

175 Our study also raises the possibility that Nup35 polymorphisms could co

176 Therefore, our results raise the possibility that observed differences in age-s

177 the increased cardiovascular risk in RA, and raises the possibility that optimizing pain management m

178 They raise the possibility that other bacterial species in th

179 These results raise the possibility that other TPR domains may be simi

180 If this event is not unique, this raises the possibility that other evolutionarily new pla

181 dback unfavourably on metabolism and growth, raising the possibility that other venting mechanisms be

182 in Duffy-null Africans have been documented, raising the possibility that P. vivax, a virulent pathog

183 are disabled for this activity, our findings raise the possibility that p53 mitigates oncogenic disea

184 Our results raise the possibility that passage through the mitosis-G

185 acterial variants arise during infection and raise the possibility that pathogen diversification occu

186 These data raise the possibility that pathological aggregation coul

187 However, disparities in fistula placement raise the possibility that patient factors have a role i

188 pluripotent stem cell (iPSC) technology has raised the possibility that patient-specific iPSCs may b

189 These findings raise the possibility that patients with IFN-alpha/beta-

190 d Sca1(+) cells increased MSC proliferation, raising the possibility that PDGF-BB enhances expansion

191 FRbeta, define the underlying mechanism, and raise the possibility that PDGFRbeta-mediated diseases i

192 d (IBA)-mediated auxin homeostasis in roots, raising the possibility that PEN3 exports multiple funct

193 These data raise the possibility that persistent or occult neurolog

194 at BRD2 supports boundary activity, and they raise the possibility that pharmacologic BET inhibitors

195 Our findings raise the possibility that pharmacologic inhibitors of M

196 re consistent with previous observations and raise the possibility that pikas might play a previously

197 factor for stroke and myocardial infarction raised the possibility that pioglitazone, which improves

198 This raises the possibility that Pol III is involved in agein

199 observed to increase throughout development, raising the possibility that posttranslational modificat

200 observed a strong neuronal signature, which raises the possibility that PPAR agonists may be targeti

201 es relevant to visually guided behaviors and raise the possibility that propagating activity patterns

202 pha-helix and components of the active site, raising the possibility that RAG2 binding alters the str

203 more complex than previously envisioned and raise the possibility that RE splicing might generate fu

204 sations of the tibia, fibula, and footplate, raising the possibility that re-emergence of hindlimbs d

205 This raises the possibility that repeated HRV infections in c

206 s and neurodegenerative disorders, our study raises the possibility that replication fork progression

207 tase (catalytic subunit) in some cell lines, raising the possibility that RMRP might play a role in t

208 Binding between C3PO and PLCbeta raises the possibility that RNA silencing activity can a

209 , the noncleaved form is involved in memory, raising the possibility that secreted and full-length AP

210 Our results raise the possibility that septic patients have impaired

211 We also raise the possibility that sex differences in the brain

212 inant-negative effect on other E3s in vitro, raising the possibility that short circuiting also may s

213 to the size of their closest competitor and raise the possibility that similar plastic responses to

214 re essential for ant social organization and raise the possibility that, similar to mammals, receptor

215 signalling that precedes pathogen encounter, raising the possibility that small molecules targeting S

216 These unexpected observations raise the possibility that some aspects of BNR yield env

217 These results raise the possibility that some of these spatially corre

218 This experience raises the possibility that some CM attacks originate ou

219 However, this mechanistic approach raises the possibility that some ecological function cou

220 have been identified in some invertebrates, raising the possibility that some of these genes may pla

221 Our analysis of MIS 14 raises the possibility that southern insolation forcing

222 e of cells in the central nervous system has raised the possibility that specific immune-mediated mec

223 Our data raise the possibility that spinal cord axons may make us

224 They raise the possibility that such function may also be imp

225 A lack of studies on aquatic trackmakers raises the possibility that such traces may be ignored o

226 This raises the possibility that sympathetic co-release of AC

227 nous genes that affect virus replication and raise the possibility that synthetic transcription facto

228 the vesicle docking C2B-PIP2 interaction and raise the possibility that Syt1 rings could pre-form on

229 hanced susceptibility to seizures in CJD and raise the possibility that targeting IL-1beta with clini

230 These findings raise the possibility that targeting NRP1 or its NCD int

231 be critical modulators of disease pathology, raising the possibility that targeting aberrant splicing

232 lfactory structures susceptible to aging and raise the possibility that the age-related changes that

233 These results raise the possibility that the daily oscillation of Ap e

234 Chimeric receptor analyses raise the possibility that the Lrp4 extracellular domain

235 The results of our study raise the possibility that the temporal sequence of acti

236 These observations also raise the possibility that the transposome might have ad

237 We also raise the possibility that the two VQIINK structures rep

238 DNA) in early-stage Alzheimer's disease (AD) raised the possibility that the same neurodegenerative e

239 This raises the possibility that the alternate terminal bd-ty

240 onstriction, which would potentiate hypoxia, raises the possibility that the bioelectric impact of ne

241 Taken together, this raises the possibility that the farnesylated but nonpalm

242 nfirms earlier reports of mixed isolates and raises the possibility that the host range of C. hominis

243 toms; however, the lack of a placebo control raises the possibility that the observed antidepressant

244 ificant percentage of renal cell carcinomas, raising the possibility that the activity of SETD2 is tu

245 y, this activity is reduced in SMA patients, raising the possibility that the aetiology of SMA is lin

246 , which we confirmed using other techniques, raising the possibility that the modification affects th

247 for altered regulation of MLH1 and LRRFIP2, raising the possibility that the modifier affects regula

248 ARL13b that occurs during cilia resorption, raising the possibility that the sensitivity of ARL13b s

249 the presence of JAK/STAT pathway mutations, raising the possibility that the therapeutic potential o

250 the insect chemosensory receptor family and raise the possibility that their ancestral role was in e

251 This raises the possibility that therapeutic interventions ta

252 This raises the possibility that therapeutic interventions ta

253 These results also raise the possibility that therapeutically modulating TF

254 These studies raise the possibility that therapeutics targeting the IF

255 e pathogenesis of this enigmatic disease and raise the possibility that therapies specifically direct

256 e than has been previously appreciated, thus raising the possibility that there may be unexpected fun

257 It also raises the possibility that these and similar environmen

258 old into defined structures and bind ligands raises the possibility that these too might be capable o

259 gions are disproportionately in the tropics, raising the possibility that these ecosystems may be par

260 sion of several RhoGAP genes in BLBC tumors, raising the possibility that these genes may be oncogeni

261 go bulk increases in response to DNA damage, raising the possibility that these linkages are largely

262 c to tumor cells but not normal osteoblasts, raising the possibility that these may be tractable targ

263 ccumulation and associated oxidative stress, raising the possibility that these metabolites play a ro

264 till able to bind Sia on human erythrocytes, raising the possibility that these viruses can use multi

265 play essential roles in parasite infectivity raised the possibility that they could be targeted by pr

266 uish between folded and unfolded EGF repeats raised the possibility that they participate in a qualit

267 ominence as key modulators of host immunity, raising the possibility that they could influence the ou

268 nents from genomes of many lower eukaryotes, raising the possibility that they have been lost or alte

269 s and are reported to promote thermogenesis, raising the possibility that they interact to direct an

270 e efferent neurons inhibit inner hair cells, raising the possibility that they play a role in the pro

271 ional 5' RNA cap structure in eukaryotes and raise the possibility that this 5' NAD(+) cap could modu

272 nown Golgi apparatus-targeted cargos, and we raise the possibility that this nonclassical pathway is

273 These observations raise the possibility that this pathway evolved in respo

274 tic open/closed conformational change, which raises the possibility that this assumption may not be v

275 for the conservation of Tasmanian devils and raises the possibility that this species is particularly

276 tients compared with hormone naive patients, raising the possibility that this could serve as a bioma

277 ith structural homology to Kdo transferases, raising the possibility that this enzyme is responsible

278 was large and the sample fraction was small, raising the possibility that this estimation bias could

279 reduced early in the life span of Q140 mice, raising the possibility that this may occur in human HD

280 cking, synaptic currents, and spine density, raising the possibility that this mutation may contribut

281 kable number of different ion channel types, raising the possibility that this protein might be invol

282 orm under intracellular reducing conditions, raising the possibility that this unusual dimer might ha

283 Our work also raises the possibility that trace-element contamination

284 nd central memory CD4(+) T-cell populations, raising the possibility that transmitted viral phenotype

285 It also raises the possibility that treatment and/or prophylaxis

286 ion and to be induced by activated Th2 cells raises the possibility that TSLP may be involved in a po

287 opies of adenine- and uridine-rich elements, raising the possibility that undefined trans-acting fact

288 This study raises the possibility that under certain conditions of

289 These findings raise the possibility that, under nonpathological condit

290 en identified in human cancers, our findings raise the possibility that unresolved RNA:DNA hybrid str

291 This raised the possibility that USP19 might regulate muscle

292 Moreover, they raise the possibility that value representations reflect

293 balance and can scavenge and store antigens, raising the possibility that vesicular or transcellular

294 This raises the possibility that vigor during the free viewin

295 teraction that is necessary for viral entry, raising the possibility that viral escape from antibody

296 Recent gene therapy progress has raised the possibility that vision loss caused by inheri

297 This raises the possibility that vitamin D supplementation co

298 This raises the possibility that we can improve mouse models

299 activated in tumors by somatic alterations, raises the possibility that well tolerated inhibitors ta

300 governing the switch to multicellularity and raises the possibility that YlbF, YmcA and YaaT broadly