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1 and the low sensitivity of biological tests raise the question of a possible role of P. ovale varian
3 denced postmortem in cases of fatal disease, raising the question of a possible link between these tw
4 cells is mediated by endothelial activation, raising the question of a potential role for endothelial
5 arance of aggregated proteins, these results raise the question of beneficial use of NPs in biomedici
8 Both these features of the B-cell response raise the question of how important antibody fine-specif
9 rning of bilaterian nervous systems but also raise the question of how neural circuit compositions an
10 ults highlight the potency of this model and raise the question of how useful it is for interpreting
11 mergence of several PCs at the same position raised the question of how developmental time controlled
12 zed to yield a high-resolution structure and raised the question of how LysRS is arranged (dimer or t
14 g the world's rapidly growing population has raised the question of how to systematically utilize lar
17 refore not a simple water-filled pore, which raises the question of how anomalous water behavior affe
20 tiple stochastic downstream actuators, which raises the question of how coordinated response to a sin
21 ate and propagate polarity: if correct, this raises the question of how gradients of Ft and Ds expres
25 etal health in a gender-specific fashion and raises the question of how many maternal antibodies affe
28 ey inferior temporal cortex ("face patches") raises the question of how neural selectivity for faces
31 potentially regulated step in mRNA decay and raises the question of how other mRNA decay pathways rel
33 TOR)-also regulate filamentous growth, which raises the question of how signals from multiple pathway
34 in the 1800s; its abrupt extinction in 1914 raises the question of how such an abundant bird could h
36 mbers of bacteria to host intestinal tissues raises the question of how symbiotic host-bacterial rela
38 t for thalamic input in sensory areas, which raises the question of how thalamocortical synapses form
42 ientation relative to, the rat's head, which raises the question of how the rat might determine the p
44 tein ligase lacks a DNA-binding domain which raises the question of how these bacteria regulate the s
46 is makes sense in terms of host defense, but raises the question of how these remarkable cells balanc
47 addition to the encoded amino acid sequence, raises the question of how these signals and overlapping
49 stribution around important regulatory genes raises the question of how they relate to 3D conformatio
51 e development of small-scale quantum devices raises the question of how to fairly assess and detect q
53 radicals due to iron leakage from the core, raising the question of how (*)OH-mediated damage to Dps
54 s with 4E10 specificity are counterselected, raising the question of how 4E10 was generated in the pa
55 to enhance B cell Ag presentation to T cells raising the question of how a B cell might respond when
56 competitiveness and self-renewal potential, raising the question of how a mutant HSC can sustainably
57 t essentially doubles its cellular contents, raising the question of how a phagocyte may manage the e
58 does not absolutely require kinase activity, raising the question of how Arg might modulate actin ass
59 igh-frequency multiparameter time series and raising the question of how best to extract insights fro
60 t axon regeneration in different cell types, raising the question of how broadly mTOR regulates axona
61 and phosphorylates S84 as early as S phase, raising the question of how Cdk prevents inappropriate a
62 regionalization are expressed in gradients, raising the question of how discrete domains are generat
63 s conserved across distantly related plants, raising the question of how diverse inflorescence archit
64 lular denitrosylase has not been identified, raising the question of how extracytoplasmic proteins ar
65 coexist within a common nondelimited space, raising the question of how functional compartmentalizat
66 nt in some but not all non-bilaterian phyla, raising the question of how Hox-TALE interactions evolve
67 may also enhance or limit hyperpolarization, raising the question of how intrinsic conductances shape
70 most effectively at depolarized potentials, raising the question of how lidocaine-like compounds aff
71 ngless (Wg) ligands secreted 50 microm away, raising the question of how long-distance Wg spreading o
72 s found in the human body continues to grow, raising the question of how many more species have yet t
74 after greenhouse gas emissions have ceased, raising the question of how much sea-level commitment is
75 n this system, nuclei divide asynchronously, raising the question of how nuclear timing differences a
76 stroyed, this log singularity is suppressed, raising the question of how pairing occurs in the absenc
77 6)A biosynthesis by archaeal KEOPS in vitro, raising the question of how precisely Pcc1-mediated dime
78 site remote from the site of ligand binding, raising the question of how proteolytic sensitivity is a
79 and GDP- and GTP-bound forms of the factor, raising the question of how SelB can fulfill its deliver
80 tion paradoxically induces similar movement, raising the question of how such chemical modifications
81 rctic stratospheric season occurred in 2011, raising the question of how the Arctic ozone chemistry i
82 ecursors into functional sensory structures, raising the question of how their development is coordin
83 nded by sugar-rich food most of their lives, raising the question of how these animals modulate food-
84 in seconds by the sensory detection of food, raising the question of how these cells can promote feed
85 like structures that are in the ER membrane, raising the question of how these nascent LDs bud from t
86 tered within the known ASF1-H3-H4 interface, raising the question of how these two proteins are found
87 etina arise from different embryonic tissues raising the question of how they are aligned to form a f
88 account for <3% of total flight muscle mass, raising the question of how they can modulate the vastly
89 y impasse and soon disappear from the lungs, raising the question of how they induce such durable imm
90 miRNA biogenesis machineries remain obscure, raising the question of how tumour cells efficiently coo
91 The active site is 15 A from the membrane, raising the question of how water-soluble and membrane-e
92 d or proposed for many DNA-binding proteins, raising the question of how widespread or specific to ce
93 The presence of PLP-EGFP expression in OPCs raises the question of its role in this migratory popula
94 idea and Unionoidea but not in Etherioidea), raising the question of its origin in these bivalves.
95 nt when other processing enzymes are absent, raising the question of its primary physiological role.
97 amily have been detected in the A13 nucleus, raising the question of possible roles of these factors
101 lants, including freezing-sensitive species, raising the question of SFR2 function beyond freezing to
102 a gain in enzyme selectivity is achieved but raise the question of the binding mode operating with th
103 creased levels of RNA editing in squids thus raise the question of the nature and effects of these ev
104 2 genes and their limited biological impact raise the question of the potential role of dysregulated
105 ry of a charge order in underdoped YBa2Cu3Oy raised the question of the interplay between superconduc
106 responses in patients with low tumor burden raised the question of the mechanisms of DC dysfunction.
107 mal products have been identified, which has raised the question of the relative contributions of dai
109 istance to autism from genetic causes, which raises the question of the fate of female carriers.
110 rtheless useful for quantum key distribution raises the question of the feasibility of a quantum key
111 en in optimal superconducting samples, which raises the question of the nature of the sample regions
112 mes in relation with comorbid conditions and raises the question of the relevant endpoints in clinica
113 ealed two resveratrol binding pockets, which raises the question of the role of MAT2B in resveratrol
114 sted the presence of putative Jumonji genes, raising the question of the conservation of this family
115 3N2 IAVs circulating during the past decade, raising the question of the degree of immunity that the
116 d to isolate the many contributing variants, raising the question of the existence of alternate proce
117 soform usage across tissues is nonconserved, raising the question of the extent of its functional imp
118 genetic characteristics with the gonococcus, raising the question of the extent to which these strain
119 lex with single-strand DNA binding proteins, raising the question of the mechanism behind their prote
120 ct immunofluorescence is routinely negative, raising the question of the mechanism of formation of th
121 ficant decrease in their catalytic activity, raising the question of the occurrence of the conformati
122 scence establishment, maintenance, and exit, raising the question of the physiological raison d'etre
124 ut in many organisms, only Nbp35 is present, raising the question of the unique roles played by Cfd1
125 he high diversity of the plant lipid mixture raises the question of their respective involvement in t
127 itor cells have been localized to PAH lungs, raising the question of their role in disease progressio
128 e potentially wide range of STAT3 activities raises the question of tissue- and gender-specificity as
131 plant lineages like the Brassicaceae, which raises the question of what alternative nutrition strate
134 se plate invalidates this interpretation and raises the question of what events actually do lead to N
136 The existence of such transcription units raises the question of what happens when RNA polymerase
137 r very little further tumor evolution, which raises the question of what is the real window of opport
138 TRIP8b and PEX5, this difference in function raises the question of what mechanism accounts for their
139 during female meiosis in most animals, which raises the question of what prevents the sperm DNA from
143 ct powerful suppression of CbN cell spiking, raising the question of what activity patterns favour ex
144 grow vegetatively without TMG caps, thereby raising the question of what cellular transactions, if a
149 rmation at very low Abeta concentrations and raise the question of whether amyloid formation in vivo
151 gnized cause of acute leukemia in adults-and raise the question of whether children represent a subpo
152 stibular dysfunction in these Dfnb31 mutants raise the question of whether DFNB31-deficient patients
154 presentations of NRXN1 mutations in patients raise the question of whether heterozygous NRXN1 mutatio
155 echanisms involved are unclear, our findings raise the question of whether in utero exposures may aff
158 perspective on T-cell polyfunctionality and raise the question of whether maintaining polyfunctional
159 at express an alkyltransferase-like gene and raise the question of whether or not O(6)-alkylguanine l
161 to explain the observed Cdc42p dynamics, and raise the question of whether such Cdc42p traffic actual
162 monic differences within and between species raise the question of whether the human ability is suppo
163 , the accurate predictions of this framework raise the question of whether the multidrug response in
164 expression patterns, and knockout phenotypes raise the question of whether the two proteins have redu
166 ucting gap in single-unit-cell FeSe/STO(110) raised the question of whether a similar mechanism appli
168 ould be returned in the clinical setting has raised the question of whether comparable recommendation
169 nd elimination efforts thus far, the WHO has raised the question of whether global eradication of mea
170 n of CXCL2 and CXCL1 inflammatory chemokines raised the question of whether IL-17 contributes to chem
171 abnormalities in RTT and mouse models of RTT raised the question of whether maintaining MeCP2 functio
172 e serum response factor (SRF) signalling has raised the question of whether MRL proteins employ alter
175 ricellular proteolysis of ECM substrates and raised the question of whether other zebrafish PCP prote
177 Moreover, recent findings in MS patients raised the question of whether primary neurodegenerative
178 nd Japan's Ministry of Health, have recently raised the question of whether seemingly innocuous mater
179 the cyclic heptapeptide sanguinamide A have raised the question of whether steric occlusion of polar
180 iscovery of high-temperature superconductors raised the question of whether such strong electron-phon
183 reports of EVD in equatorial and West Africa raised the question of whether the two outbreaks were li
184 ralizing monoclonal antibody (nmAb) IgG1 b12 raised the question of whether the unusual shape observe
186 pancies between several of these models have raised the question of whether these differences arise f
188 a1 activation by mechanical stimuli in vitro raised the question of whether this phenomenon was relev
191 an GPCRs and 16 different Galpha genes, this raises the question of whether a universal allosteric me
193 ective human leukocyte antigen (HLA) alleles raises the question of whether and how these alleles inf
194 usually intended to capture livestock, which raises the question of whether and how these livestock a
196 sm of alternative splicing of the Drd2 gene, raises the question of whether both isoforms may equally
197 wever, a striking lack of empirical evidence raises the question of whether chimeras are indeed chara
202 However, the widespread influence of GABA raises the question of whether interindividual variabili
205 known, but its repeated convergent evolution raises the question of whether it may result from or con
206 iomes with no apparent effect on tree growth raises the question of whether iWUE calculations reflect
208 t a surprising loss of KIT expression, which raises the question of whether loss of KIT in these tumo
212 at often extend beyond local transcripts and raises the question of whether patterns of cis or trans
216 cept of what the TCR can recognize, but also raises the question of whether such a T cell could be of
217 ve been done in high-income countries, which raises the question of whether such care is relevant and
221 in, including the midcingulate cortex (MCC), raises the question of whether these areas contribute to
222 ion that Dorsal levels also change with time raises the question of whether these dynamics are instru
223 ehavioural variability and cellular response raises the question of whether these two traits are inde
227 eration of data generated in our "omics" age raises the question of whether we even have (or need) a
228 iatus after the big El Nino event in 1997/98 raises the questions of whether terrestrial hydrological
229 ve active brown adipose tissue (BAT) depots, raising the question of whether activation and recruitme
230 e intracellularly prior to receptor binding, raising the question of whether alternative protein-prot
231 ct molecular and biological characteristics, raising the question of whether an earlier, "naive" stat
232 costriatal neurons are closely intermingled, raising the question of whether and how information flow
233 n and PAF-PCNA interactions are competitive, raising the question of whether beta-catenin might regul
234 nhibitors have been less promising, however, raising the question of whether BTK kinase activity is a
235 eeding occurs at the level of pit membranes, raising the question of whether capillary failure is an
236 iers regulate lifespan in several organisms, raising the question of whether changes in chromatin sta
237 are higher in African Americans than whites, raising the question of whether classification of diabet
238 al nephrectomy and during high-salt feeding, raising the question of whether collectrin has any direc
239 (Solyc06g083450) is missing the first exon, raising the question of whether cultivated tomato has a
240 ions of early endosomes have been described, raising the question of whether different internalizatio
242 homolog in the Entamoeba histolytica genome, raising the question of whether E. histolytica MIF (EhMI
243 exhibits increased tyrosine phosphorylation, raising the question of whether enhanced tyrosine kinase
244 ere are multiple cognitive control networks, raising the question of whether error-related activity c
245 erindividual variation in scallop sequences, raising the question of whether fish may analyze scallop
246 ast, humans encode a single functional NAIP, raising the question of whether human NAIP senses one or
247 p, to make various social calculations, thus raising the question of whether individuals can sort thr
248 omal DNA is actually favored over naked DNA, raising the question of whether integration target DNA i
249 stened by conditions that decrease lifespan, raising the question of whether it can also be slowed, f
250 ugment the rate of CD20.mAb internalization, raising the question of whether ITIM phosphorylation pla
251 from mice causes early embryonic lethality, raising the question of whether La is required by mammal
252 an compromise speech perception performance, raising the question of whether long-term oral-motor imp
253 hat are driven by BCR and TLR corecognition, raising the question of whether MBCs are generated in th
254 notochord, floor plate and dorsal endoderm, raising the question of whether midline tissues also ari
255 me than do evolutionarily conserved regions, raising the question of whether nonconserved but biochem
256 ors target additional kinases including KIT, raising the question of whether off-target effects contr
257 e unexpected functions in DNA damage repair, raising the question of whether other amino acid metabol
258 racellular fatty acids into membrane lipids, raising the question of whether pathogens use host fatty
259 lidation-promoting factors in humans [9-14], raising the question of whether physical exercise can be
260 technique called expansion microscopy (ExM), raising the question of whether physical magnification,
261 eprogrammed, functionally compromised cells, raising the question of whether pluripotency is required
262 eoclastic cells within the bone environment, raising the question of whether resorptive osteoclasts c
263 espond to light at 5days post-fertilization, raising the question of whether responsiveness is correl
264 members during prostate cancer progression, raising the question of whether SFKs display functional
265 reducing the abuse liability of amphetamine, raising the question of whether similar positive finding
266 trongly biased toward the symmetric outcome, raising the question of whether symmetry confers some be
267 A1 presynaptic boutons contain mitochondria, raising the question of whether synapses without mitocho
268 measurements and global circulation models, raising the question of whether the abundant dunes and e
269 ally larger portion is biochemically active, raising the question of whether the additional elements
270 hanges in cytoarchitectural characteristics, raising the question of whether the anatomical connectio
271 that limit its utility as an antidepressant, raising the question of whether the clinically tolerated
272 T2 expression to high VGLUT1 and low VGLUT2, raising the question of whether the developmental increa
273 represent an antigen-experienced population, raising the question of whether the liver is a site of N
274 ever, behavioral outcomes were not improved, raising the question of whether the newly sprouted axons
275 B4 used ligands shared with other receptors, raising the question of whether the observed responses a
276 lex contains two separate ion-binding sites, raising the question of whether the power stroke is driv
277 collateral excitation is weak in adult mice, raising the question of whether the primary role of this
278 , while high-frequency firing is maintained, raising the question of whether the proposed blocking ac
279 ophysiology of neurodevelopmental disorders, raising the question of whether there are sex difference
280 or over time, as many as 10% die by suicide, raising the question of whether there is a high-risk sui
281 e mutant for either Tet1 or Tet2 are viable, raising the question of whether these enzymes have overl
282 causative agent of malaria, Plasmodium, thus raising the question of whether these parasites can sens
283 imetals consist of disjoint, open Fermi arcs raising the question of whether they can be observed by
284 nsory afferents (likely Ia) and motor axons, raising the question of whether they interact during Ren
285 nt in the Exome Sequencing Project database, raising the question of whether they were uncommon polym
286 unusual level of microstructural plasticity, raising the question of whether this contributes to adap
287 dually shifted to high-frequency match-runs, raising the question of whether this harms the number of
288 induce the formation of the kinked geometry, raising the question of whether this occurs by passive s
290 lower seed production than selected annuals, raising the questions of whether there is a fundamental
293 The heterodinuclear nature of the cofactor raises the question of which site, 1 or 2, contains the
294 early experiences influence adult behavior, raising the question of which mechanisms underlie infant
295 rogenitors within the ventricular zone (VZ), raising the question of which source of netrin1 promotes
296 orla-Wagner rule is often not optimal, which raises the question of why a rule with such properties s
297 earing 1% of coding sequences in some cases, raises the question of why bacteria need so many GGDEF e
298 e phenotype was not rescued by healthy rods, raising the question of why cones are not protected by t
299 bed caspase-6 in the canonical conformation, raising the question of why the intermediate between the
300 n is prevalent among consumers worldwide but raises the question of will the use of any concurrent an
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